For starters nobody would fall for this.
Seriously everyone in the world would know about the Science Bros. and they definitely wouldn't let these two borrow their names.
Who you gonna call?
Depends, is the problem local, alien, or angelic? The world would probably need a special phone book just for their specific world-ending problems.
This guy would probably be in good company.
Can anyone else imagine John Constantine trading tips with Dean Winchester? They both have way too much in common. Maybe they'd make a facebook group for demon slayers.
Imagine the day the boys meet Iron Man.
How long would it take Tony to ask them to find their chill?
... okay who else needs this crossover?
Started as a joke and now I'm here.