Maria Ross. While not a huge role, she acts like a guardian to Edward and Al, and is tested by the fundamentals of being a soldier. Up until Brotherhood, she's gotten more backstory and she was one of the most interesting character I wanted to know more about, mew.
Final battle in Gurren Lagann. This was insane, mew. The entire galaxy, DNA strands, mech fights. My god, it didn't make any sense, but it was so pretty and fun to watch.
This fucking kid, mew. There are other annoying characters, but this wimp buries them all. And that's all I gotta say.