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10 Things You Can Do To Up Your Mental Health In 2016

We're all guilty of sitting in our own minds when it comes to mental health issues. As the world gets more and more progressive, people are beginning to accept themselves. No shame, no expectations, if you're experiencing a hard time, don't worry. There are many things you can do to help improve your mental health in the coming year and for the rest of your life.
I've taken a lot of strides, in consciously trying to improve my mood, and though at times, it feels like pulling teeth, I can assure, you as someone whose been there: things do get better. Here's a list of some fun, introspective and just plain zen things you can do to help yourself out in the new year.

1. Forget about pleasing others.

The new year may bring on lots of resolutions that revolve around changing yourself in order to be seen in a certain way by others. They are doomed. No matter what he reason, if you're trying to change something, it needs to be for you or else it won't stick, and you'll just end up spinning your wheels.

2. Allow yourself to spend money on things that make you happy.

I just attended a concert, and for a moment I was like "wait, I don't have money for that", but you know what? NO. I do have money for that, because when something makes you that happy,if I can impart any wisdom from this year it's that. My mood instantly changes when I'm surrounded by things that make me smile. Seriously, it sounds dumb, but just try it.

3. Listen to more music.

It's scientifically proven that music can change your brain and boost your mood. So like, turn it up. Discover some new bands, hang out and get into good spirits. Music is a huge thing for me, and I could tell you countless stories about being on the edge and music bringing me back. Hell, they're on this site! But anyway, I digress.. Music is the key!

4. Listen more, talk less.

Mental health is all about perception. If we have a bad perception of the things happening around us, then we're just going to feel bad all the time. But if we listen in, check things out and hang back a bit more without acting first? We might just gain some perspective. My M.O. in life is to jump the gun, and every day, I try to listen a little bit more than I talk, even if I think I'm right. It's a good practice.

5. Write more than you type.

Nothing compares to the physical act of writing something down. I've talked and talked about planners and journals, but unless you actually commit to it, you can't help yourself. Getting your thoughts out as a physical expression, and then seeing it on the page is unlike any other feeling. You'll thank yourself.

6. Spend more time outside.

This might seem logical, because the sun gives you Vitamin D and all that stuff, but it's a lot harder to get outside if you have a job that requires you to be indoors, or you're busy with class or whatever. But just being outside, whether you drag your laptop with you or not, is really good for you. Instant mood boost.

7. Pick a few books to read, and then read them.

Sometimes I buy books and I don't actually read them. They sit on shelves for months, collecting dust and age. The pages get yellow, and the words just fall away. If you go to a bookstore and drop your precious money, just make sure you're actually going to read them, because you could gain some much needed perspective.

8. Sit up straight and hold up your head, literally.

Walking around with a gloomy, collapsed spine isn't only bad for your physical health, it dogs on your mental health as well. If you stand up straighter, and walk a little taller, you'll end up feeling more upright, and more adjusted. Sometimes you have to trick your body into feeling better. I'm not sure, but it works for me!

9. Reflect

Mental health is all about coming to terms with the things we don't view as ideal. For me, sitting down and doing a sort of self-examination always helps. Don't fixate for too long, just reflect and move.

10. Go easy on yourself.

Mental health is almost 100 percent about self-perception. If we can go a little bit easier on ourselves, we might be able to live happier and more fulfilling lives. I'm still working on this, but together, we can figure it out.

"If we are to save the mind we must ignore its gloomy virtues and celebrate its strength and wonder." - Albert Camus

I hope you all have a happy and healthy new year.
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So no anime😭 jk I would never give up anime or manga
OF course @AaliyahNewbell my pleasure. I'm working on it too. Helps to be mindful!
Right @Titplum gotta keep reading. I have a lot of books to get through, specifically beat generation stuff. :)
@TessStevens Happy new year to you too. What you're saying about books is so true! I love books and at times it makes me happy to buy one but then I abandon it on a shelf instead of reading it. It's not wasted because I'll end up reading it at some time or another but still... Good advices.
An inspiring piece! I love these advices. I can relate to quite a number of them and they give me a new perspective (reading and listening more is actually super important). Let's work together!
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Prolectin-M: First Oral Antiviral Class of Drug to Block SARS-CoV-2 Entry
In order to truly grasp the magnitude of the finding in this latest journal article about blocking SARS-CoV-2 entry, the audience needs to first understand the mechanism of action (MOA) of the different types of antivirals. The classic definition of an antiviral is a drug that interferes with the replication process of the virus once it has entered the host cell. All antiviral drugs like Paxlovid, Molnupiravir, Remdesivir, Bemnifosbuvir, Bequinar, Tollovir, and Tempol ultimately interfere with the replication process inside the cell at least via one mechanism. The other school of thought is to keep the virus outside the cell and prevent it from entering. This subset of antiviral drugs is called an entry inhibitor. All viruses need help getting inside a host cell and what viruses can do is actually trick the cell into opening up the door to let them in. The primary entry receptor in SARS-CoV-2 is the ACE2 receptor along with TMPRSS as an essential primer. The idea behind entry inhibitors is to block the cellular receptors making docking with the cell impossible. Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities Another way to stop cellular entry is to simply bind with the spike protein. This is actually the primary function of neutralizing antibodies. Antibody formation is the immune system’s typical response to viral or bacterial infection that prevents cellular entry. Monoclonal antibodies from Regeneron, Eli Lilly, AstraZeneca, and GSK/Vir Biotechnology were developed to attach to the tip of the spike protein. Not only did these monoclonal antibodies prevent the virus from entering the cell, but it also marked the viral particle for destruction by the immune systems phagocytes. Monoclonal antibodies are not only expensive to produce, but also very vulnerable to viral mutations leading to immune escape whereby the antibody might be able to attach to the virus but it cannot neutralize it and prevent cellular entry. With the advent of the latest BA.5 variant, the utility of the vaccines to neutralize infection is over based on a recent NEJM article. Vaccinated, unvaccinated, and people with immunity from prior infection are all vulnerable to the latest BA.5 variant which is now comprising 65% of infections in the United States. CDC Variant Proportions ProLectin-M (PL-M) mimics the functionality of an antibody, but behaves in a very different manner. It clearly interferes with the cellular entry as this peer reviewed journal concluded. The prevailing theory is that the molecule binds in some fashion to a conserved region on the spike protein commonly referred to as the galectin fold which is a concave region located on the side of the spike protein that mimics the carbohydrate recognition domain (CRD) of a galectin, particularly galectin-3. Additional tests would be needed to elucidate the MOA with respect to where and how it binds, but this journal article demonstrates that glycans which are a crucial part of viral entry could be disrupted with a galectin antagonist. In general, when attempting to elucidate the MOA of a drug, most atomic-level tests conducted are proximity tests that simply tell if the molecules are close. For example, in most cases, the tests would measure the change in color when two molecules get close. Its a proximity indicator to help elucidate the MOA via figuring out what molecules bind to each other, but its not really to the level of proof of a smoking gun. The significance of using Nuclear Magnetic Resonance (NMR) spectroscopy is that this methodology, actually pioneered by Dr. David Platt, answers the question of where a molecule binds and how tightly it binds. The conclusion that Prolectin-M binds strongly to Galectin-3 at a micro molar level is supported by NMR spectroscopy should not be taken lightly. The graphic that shows the shifts is difficult to understand for those not versed in the science. There are blue and red contour lines. The blue peaks contour lines represent Galectin-3 and the red peak contour lines represent PL-M. Ideal binding isn’t represented by alignment of the peaks but rather by a combination of changes in contour density and a longitudinal shift in the peaks. These contours tell where the binds are happening and shifts indicate the strength of the binding, but it is more complicated and must be analyed in conjunction with the chemical shift map. The overall conclusion is that “PL-M binds specifically to Gal-3 in the micromolar range” leaving little doubt that PL-M is an oral Galectin-3 inhibitor. Another highlight of the journal article is a toxicity study that revealed there were no-toxic side effects in the vero cells when PL-M was administered. An interesting anecdote is that PL-M actually increased the cell viability. This is not a surprise given PL-M’s use in clinical trials showed no safety signals and that other galectin inhibitors have shown positive effects for the host cells in inflammatory diseases. The next highlight were tests using two different protocols that showed that PL-M was able to effect a 99% or 2 Log viral load reduction in viral RNA copies. One protocol (Protocol 1) let the virus multiply in the cell culture before adding PL-M, measuring viral reduction (red line going up is good); the other protocol (Protocol 2) added the virus to the cell culture with PL-M and measured viral presence (red line going down is good). The molecule also showed increasing concentrations of the drug correlated to increasing levels of viral reduction. The viral mutations have seemed to evolve with increasing viral loads which translates to increasing infectivity. Given the toxicity profile (or lack thereof), greater amounts of PL-M could be employed to combat any future increase in infectivity of the virus. What is so significant about this journal article is that this is the first time in the new emerging field of Glyco-virology science that an optimized complex carbohydrate chemical structure was used to block the viral entry to cells. In essence, PL-M was able to achieve blockage of the SARS-CoV-2 coronavirus by interfering with the viral entry mechanism into host cells. This research by itself is groundbreaking, but when looking at the big picture all this journal article did is elucidate findings in the preliminary clinical data results from BioXyTran’s first peer-reviewed journal article using PL-M, whereby these human clinical trial results showed elimination of viral load to undetectable levels within a few days (p<0.029). The power of galectin inhibition on viruses is unmistakable. Clinical research is currently in development, but it is worth reiterating that PL-M was able to achieve undetectable viral load in a few days. It’s hard to ignore the comparison to Paxlovid which required 20 days to get 30% of the patient population to undetectable levels. The R-naught (R0) index is a measure of contagion whereby anything under 1.0 will eventually fizzle out and anything over 1.0 represents the number of infections that would be spread by one person. Given R0 of BA.5 is currently sitting a 18.6 and similar to measles it might be time for a shift in policy that starts looking at ways to control contagion instead of hospitalization. For comparison purposes the original Wuhan strain had an R-naught of 3.3. At the crux of the debate, the issue can be distilled down to which is better; eliminating contagion in 3 days or eliminating 30% of contagion in 20 days using Paxlovid, the most effective drug in the COVID-19 arsenal. This journal article represents a major breakthrough in the potential treatment of COVID-19 using a novel antiviral MOA. There is clear evidence that PL-M could be classified an an entry inhibitor which is a subset of antiviral. Drugs capable of binding to a conserved region of the spike protein should be able to block entry of any new variant. Reducing infectivity of the virus using a non-toxic drug may have great value in turning the pandemic into an endemic disease. Prolectin-M is an orally administered experimental new drug candidate that targets the Carbohydrate Binding Domain portion on the SARS-CoV-2. As promising as the theory is discussed in the journal article, readers should be aware that ProLectin-M is not currently approved to prevent, treat, or cure any disease.
Kawaii Shopping Experience in Japan
What's the first thing you think about when you think of a Kawaii Shop I'm not sure if you are a fan, but I love kawaii plushies. They look great and are very practical. During my Japan itinerary I found many Japanese Kawaii shops that sold cute items such as tops, dresses, and cute food. A Kawaii shop is a wonderful place to be, even for adults. All things are made to be touched. Kawaii Shops are designed to make our lives easier. It is surprising to discover that Kawaii shops aren't just for children, as I thought. I'm surprised that so many adults are buying everyday items from Kawaii Shops. This makes me wonder why other countries haven’t adopted the idea of a shop with squishy. WHY DOES EVERYBODY LOVE A GOOD KAWAII SHOP This is a fact that both males and females love kawaii shops. This misconception is because kawaii products are only for women. Here's why. This is all about the survival of our species. Because we are wired to see human babies, we are naturally drawn to cuteness. We need to respond to cute baby features by having a protective reaction. The urge to love cute things does not stop with babies. However, it is well-known that humans love all babies, no matter what species they are, including baby cats, bunnies, and bears. You will see that you can feel compelled to buy all the merchandise next time you visit the Kawaii shop. BEST KAWAII SHOP Japan is home to the world's best Kawaii Shop. Japan actually has Harajuku, which is a designated area for various Kawaii Shops. There are many cute things to find, including fashion accessories and other kawaii merchandise. You can also find delicious edible dishes. When I was last in Japan, I could not stop going to all the Kawaii shops in search of adorable kawaii plushies. There were so many items that I couldn't decide which ones to buy. I was able to find a way to share my favorites with you. Take a look at this Kawaii Shop to find the cutest product possible!
Les critères à considérer lors du choix d'un e-liquide
Vous êtes débutant dans le monde du vapotage ou avez une certaine expérience ? Il y a quelques éléments à prendre en compte lors du choix d'un e-liquide pour votre e-cigarette. Dans un premier temps, pensez à définir votre consommation quotidienne de cigarettes pour comprendre la bonne dose de e-liquide. Ensuite, veillez à choisir un e liquide cbd de qualité pour plus d'efficacité. La meilleure technique consiste à choisir des produits d'intérêt thérapeutique qui peuvent vous apaiser par leurs effets. Maintenant, vous pouvez identifier deux types de vape CBD : l'un est un e-liquide à usage direct et l'autre est conçu avec des cristaux de poudre. Nous vous précisons que vous pouvez concevoir vous-même votre e liquide cbd. Cette technique s'est avérée efficace car elle permet de déterminer le goût et la force de votre vape cbd sans oublier le choix de l'arôme. Le choix de l'huile pour e-cigarette est très important. Si vous choisissez votre e-cigarette, le e-liquide de qualité inférieure gênera votre adhésion à la e-cigarette et vous empêchera d'arrêter de fumer. Il est donc très important de bien choisir, surtout si vous n'y croyez pas la première fois, n'abandonnez pas. Avec les e-cigarettes, il faut parfois faire quelques tests pour être pleinement convaincu ! Il y a tellement de e-liquides que vous ne tomberez certainement pas dans la sensation parfaite du premier coup. Donc, s'il s'agit de votre premier achat, veuillez lire attentivement ce guide. Malgré nos conseils, vous pourriez être un peu déçu au début, alors ne baissez pas les bras ! Avant de tout vous expliquer sur les e-liquides, pour les plus pressés qui n'ont pas envie de lire tous nos supers articles, voici quelques e-liquides simples et efficaces pour débuter. Nous avons sélectionné les e-liquides les plus adaptés aux débutants, les e-cigarettes attirant le plus de monde, et nous avons trié ces e-cigarettes par saveur. Alors si vous êtes débutant, ces liquides devraient vous plaire. Pour le reste, après avoir découvert les liquides les plus simples, vous pourrez tester des arômes et des mélanges plus complexes. 1. Arôme e-liquide au choix : Pour le choix de l'arôme, c'est simple, même si cela semble parfois ridicule. La saveur de l'huile de cigarette électronique est mélangée à une saveur comestible et à un matériau de base. Ainsi, la chose remarquable à propos des e-cigarettes est que nous pouvons offrir presque toutes les saveurs disponibles, du tabac doré classique à l'arôme de "toast au beurre"… Le nom ou la description du produit est très convaincant, il suffit donc de choisir en fonction de nos envies et de notre curiosité. Pour les débutants, ceux qui essaient pour la première fois, nous conseillons évidemment les saveurs tabac ou menthe. Non pas qu'ils soient meilleurs, mais les personnes qui arrêtent de fumer recherchent une sensation et une odeur de cigarette. Il pourrait trouver absurde l'idée d'une e-cigarette aromatisée à la pomme ou au chocolat. Le choix des différents arômes se fait définitivement dans le deuxième ou le troisième : la grande majorité des vapoteurs débutent par des arômes tabac puis testent progressivement des arômes fruités ou gourmands. Le but est de vous éloigner en permanence de la cigarette. Après 1 mois à fumer des pommes, vous ne pourrez plus fumer une autre cigarette et vous vous sentirez très mal à l'aise. 2. Saveur du tabac : Attention à la saveur du tabac : vous ne trouverez jamais la saveur exacte d'une cigarette. Dans un e-liquide CBD, il n'y a pas de goudron, pas de papier brûlant, pas de brûlure... il est donc quasiment impossible de connaître exactement le goût exact d'une cigarette. Certains liquides s'en approchent, mais ce ne sera plus jamais pareil. Les arômes de tabac sont plus neutres et agréables tout au long de la journée. Comme le tabac, ils sont difficiles à décrire car ils ne vous font penser à rien de spécial. Et il sera difficile de choisir. Par conséquent, nous vous recommandons d'acheter pour la première fois des liquides pour tabac, qui sont nos meilleures ventes. C'est un gage de qualité, ce qui signifie que nous le recommandons et l'apprécions. Si vous fumez du menthol, nous vous conseillons le menthol liquide. Dans les deux cas, vous devrez essayer plusieurs fois pour trouver le liquide parfait pour vous. Alors n'abandonnez pas au premier essai ! 3. La teneur en nicotine : Le choix du taux de nicotine est vraiment ce qui compte. Que souhaitez-vous savoir: HIT, la sensation de grattement dans la gorge lorsque vous tirez une bouffée d'une e-cigarette est en grande partie due à la nicotine. Le HIT est absolument fondamental dans les e-cigarettes, tout comme dans les cigarettes, ça donne l'impression de sucer quelque chose à la place du vent, ça fait tousser, ça fait plaisir... Si important : le e-liquide sans nicotine ne produit pas de HIT. Avec les e-liquides sans nicotine, vous sentirez le vent. Totalement déconseillé pour un premier achat.