Edward Elric vs. Prof. Franken Stein Two very skilled fighters, both with great combat experience and genius level tactics.
The Fullmetal Alchemist is skilled with multiple weapons and is a great hand to hand fighter using his alchemy to combine dangerous combos on his opponents. He is smart in battle and quick thinking, he is fast on his feet and is quite keen when he's on the defensive.
Professor (Franken) Stein
My favorite character from Soul Eater, Prof. Stein is a versatile fighter, skilled in hand to hand combat, as well as multiple weapon skills. He has been seen to use tonfa's as well as a scythe when fighting. Activating his soul resonance with his weapon can increase his combat skillset.