Okay so who is the best anime villain???
One of my favorite anime villains has got to be Doflamingo. Oda did a great job with his character. He's a strong antagonist that takes a lot for the crew to take down, but a great baddie none the less.
And my other favorite villain is Father, from Full Metal Alchemist: Brotherhood. I love his overall character. He was one of the best baddies in FMA:B in my opinion.