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Cómo tratar la fibromialgia con marihuana

Esta patología afecta a entre 6 y 12 millones de personas, sólo en los Estados Unidos, y es incurable. El dolor crónico, la fatiga o la dificultad para conciliar el sueño son algunos de los síntomas con los que estos pacientes tienen que lidiar en su vida diaria y que pueden ser minimizados con la ayuda del cannabis. Si quiere saber cómo puede ayudarle este tratamiento a mejorar su salud, le invitamos a quedarse hasta el final del post.

Variedades de cannabis para la fibromialgia
Desde la prehistoria, esta planta se ha utilizado tanto como fibra textil como para uso medicinal, debido a sus numerosas propiedades y beneficios para la salud. Hoy en día, el cannabis medicinal para la fibromialgia es uno de los tratamientos más eficaces. Sin embargo, hay un sinfín de variedades en el mercado. ¿Cómo saber cuál es la mejor para esta condición médica?

Hay muchas variedades que pueden ayudar a combatir los síntomas de la fatiga, el dolor, la ansiedad y el insomnio como: Arlequín, Purple Kush, Himalaya Gold, OG Kush, G13 o White Rhino, entre otras.

Tratamientos
En cuanto a la cannabis y la fibromialgia, hay varios tratamientos. Tenga en cuenta que cada persona es diferente y, al igual que con las diferentes variedades, lo mejor es intentarlo hasta que encuentre lo que mejor le funcione.

Parches de cannabis
Los parches de cannabis para la fibromialgia consisten en adhesivos que se colocan en la piel y contienen CBD. De esta manera, la dosis exacta de cannabinoides se absorbe a través de la epidermis, llegando al torrente sanguíneo y, posteriormente, al sistema nervioso. Allí actuará para mitigar la transmisión de las señales de dolor y, en consecuencia, reducir el dolor del paciente.

Uno de los aspectos más positivos de los parches es su rendimiento, ya que dosifican las propiedades del CBD con mayor precisión y lentitud que otro tipo de tratamientos. Esto hace que los efectos duren más tiempo.

Aceite de cannabis
El aceite de cannabis para la fibromialgia es un producto con un alto contenido de CBD, un compuesto presente en ciertas variedades de marihuana. El CBD es actualmente muy popular y se utiliza a menudo para combatir otras enfermedades como el asma, la artritis o la epilepsia. Además, se destaca porque no es psicoactiva.

¿Qué es lo mejor para la fibromialgia?
Como hemos dicho, no existe una receta exacta para tratar la fibromialgia; cada cuerpo responde mejor a unos estímulos que a otros. Siempre es aconsejable mantenerse informado sobre cada uno de los tratamientos y experimentar hasta encontrar el producto o la combinación de productos que den los mejores resultados.

Además, hay que tener en cuenta que la fibromialgia tiene diferentes manifestaciones, por lo que es conveniente saber qué es la variedad de cannabis y cómo administrarla para que funcione mejor para ese síntoma en particular.
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How COVID-19 Impacted on Neurorehabilitation Devices in Healthcare Industry ?
COVID-19 Impact on Neurorehabilitation Devices in Healthcare Industry OVERVIEW AFTERMATH OF COVID-19 AND GOVERNMENT ROLE The first case of the COVID-19 pandemic was found in Wuhan, China. This pandemic has influenced the whole planet with its major impacts on the economy and businesses across the globe. The COVID-19 spread worldwide in unprecedented ways due to its high infectious and contagious nature. The virus has spread across all regions ranging from North America, Europe, Asia-Pacific, Middle East, and Africa up to South America. The COVID-19 has been declared as a pandemic by WHO due to its increased spread across the globe. Various countries announced the complete lockdown just after the declaration of COVID-19 as a pandemic, such as the U.S., India, Germany, and China, to protect them from the spread of the disease. The government imposed lockdown rules, and it had significantly impacted the market. The neurorehabilitation process makes a possible reduction in impairments and disabilities and eventually improves the life of the patient. Examples of neurorehabilitation devices are invasive stimulators, non-invasive stimulators, brain-computer interfaces, and neurorobotics, among others. Current rehabilitation is supported by advanced methods based on biofeedback, transcranial brain stimulation system, and BCI system. The prevalence of neurological diseases, rise in technological advancement, the emergence of robotic rehabilitation, and the effectiveness of gaming systems in neurorehabilitation are factors that are propelling the demand of the global neurorehabilitation devices market. However, the shortage of skilled personnel, the high cost of treatment, stringent government regulation may hamper the global neurorehabilitation devices market. IMPACT ON PRICE Neurological rehabilitation is a program designed for the treatment of people suffering from a disorder or any injury in the nervous system. The devices include non-invasive brain stimulators, robotic neuro systems, brain-computer interfaces, and wearable devices, among others. Due to the pandemic, there is the delay associated with various types of limitations faced by the manufacturers to fulfill the end product order, which has resulted in the less availability of neurorehabilitation devices in the market and due to which the cost of available devices has increased with the several factors. Also, due to the coronavirus disease (COVID-19) pandemic outbreak, manufacturers are forced to find new contract manufacturers and suppliers for more manufacturing activities to different or new facilities locations that are less impacted by the outbreak. IMPACT ON DEMAND Neurorehabilitation is an important part of the recovery process that has undergone some brain injury. In the COVID-19 pandemic, various charities have worked effortlessly to provide treatment and support to patients suffering from brain injury. During the pandemic, the demand for neurorehabilitation devices was high, but companies were not able to supply the devices to end-users as various restrictions were imposed by the government, such as a travel ban, closed borders, among others. Coronavirus disease (COVID-19) is an infectious disease caused by a SARS-CoV-2 virus, while a large pool of the population is affected by this COVID-19 virus. Coronavirus disease (COVID-19) causes acute respiratory illness ranges from mild to severe pneumonia with respiratory failure. In order to minimize the spread of COVID-19, nearly all the countries have taken action, such as the implementation of lockdown and social distancing restrictions. Due to affirmative restrictions, sudden shrink took place in various surgeries. Moreover, the decrease in the revenue of the key market players depicted in their quarterly results, such as Medtronic, among others, gave evidence of the decline in the demand for the medical device due to the emergence of the COVID-19 pandemic. For instance, · Medtronic reported a decline of 1% in its brain therapies net sales of the financial results of 2020 as compared to 2019. The reduction was largely motivated by the detrimental effects of the COVID-19 pandemic and the subsequent deferral to companies of medical procedures The decline in revenue of brain therapy suggests the detrimental effect of COVID 19 on the neurorehabilitation devices market and hence impacted the demand-supply concept. IMPACT ON SUPPLY CHAIN The consequences of COVID 19 cannot be underestimated. The product and service providers of neurorehabilitation have made efforts by providing services virtually to meet the demands as people were not frequently visiting the hospitals or clinics for the treatment. The COVID-19 pandemic has transformed many organizations’ business environments; supply availability has been hampered by a number of issues, including export and travel restrictions by some manufacturing countries and lockdowns that have forced suppliers to (temporarily) shut down. In various countries, neurorehabilitation units have reduced their number of beds, in-patients and out-patient neurorehabilitation centers are restricted to a particular area in order to tackle the pandemic situation To manage such a critical situation, many organizations are looking forward to improving and diversifying the supply chain model in all aspects. Diversified supply chain model anticipated minimizing the export of medical devices as well as increase end-to-end visibility STRATEGIC DECISIONS BY MANUFACTURERS As the reality of COVID-19 dawned upon the world, the manufactures and production units of the companies in the global neurorehabilitation devices market swiftly planned for strategies to cope with the effect of the crisis. Major players in the market took various initiatives to cope up with the situation. For instance, · In July 2020, Abbott announced that it had received FDA approval for the use of the Patient Controller App on compatible personal Apple smartphone devices. The approval will allow the patient living with neurological conditions to manage their therapy directly from the personal smartphone · In 2019, Mount Sinai Health System announced an innovative tele-neurorehabilitation program for stroke patients. This therapy can be taken by patients while at their homes with virtual backing from clinicians · In 2020, Esko Bionics Holdings, Inc. announced that it had received FDA 501(k) go-ahead to promote its EksoNRTM robotic exoskeleton for patients with acquired brain injury. It is cleared by FDA for spinal cord injury, stroke, or acquired brain injury rehabilitation These strategies helped the company in coping with the pandemic and ensure business operations, minimize the impact of COVID-19, and providing full support to the government in their efforts to combat the disease and help the front-line workers. CONCLUSION The market is expected to decline due to increased restrictions imposed by various governments leading to the closing of non-emergent healthcare facilities, including procedures such as neurorehabilitation procedures. It can be concluded that the COVID-19 pandemic situation has an adverse impact on the market, affecting the price, supply, and demand of neurorehabilitation devices. However, in the crisis call, market players, government bodies, and healthcare organizations are work closely with healthcare professionals, customers, and patients for the betterment of public health. The increasing need of neurorehabilitation devices with increasing number of neurological diseases is expected to drive the market in coming years.
Ways To Intentionally Improve Your Health
Health is a choice. In order to achieve optimum health, we must educate ourselves about it and follow a plan to optimize it. Here are eight tips that will help you optimize your health and well-being. Use Your Executive Function Human beings have an amazing organ: the brain. One part of the brain, the prefrontal cortex, gives us the ability to reason and make good decisions. It is responsible for our executive decisions. Use your executive faculty to develop, write down, and commit to the practices that will bring you optimal health. These practices include regular exercise, a good diet, using dietary supplementation, continued learning, and recognizing the connection between the body and the mind. Realize that Body and Mind Are Connected Your body is not the whole of you. Your mind is critically important as well. In order for the body to be healthy, the mind must be sound too. And vice versa!  The body-mind connection is not made-up junk science. Indeed, many scientific studies support the efficacy of practices such as biofeedback, guided imagery, and meditation.  Exercise Intelligently In order for the body to be at optimum health, it must receive regular physical exercise. Use your executive function to schedule and keep up with a periodic and intelligent exercise program. What is meant by intelligent exercise? This simply means that you don't engage in exercise habits that are beyond your skill or health level so as to avoid injury. Some of the best exercises for cardiovascular health with minimal injury potential include walking, stationary bike riding, and swimming. Muscle training is important as well but remember to engage in an intelligent strength-training program. This means not lifting weights that are too heavy, stretching beforehand, and using proper form. You Are What You Eat In order to maintain good health, you must eat properly. Countless scientific studies have demonstrated that eating a wide variety of fruits and vegetables every day is very important for your health. Not only are they generally low in calories, but they also provide vitamins and numerous micro-nutrients that furnish the body with disease-fighting abilities. Likewise, minimizing the consumption of sugary foods and simple carbohydrates such as white bread and pasta contributes to keeping your cardiovascular system in top working order. Use Dietary Supplements For Maximum Results  Cerian dietary supplements are scientifically proven to contribute to optimum health. Some of these, such as vitamin C and vitamin D you may be aware of. Others, such as green tea extract, COQ10, white willow bark, and curcumin may be less well known to you. Le-Vel Thrive is a product that includes specific dietary supplementation to help in maintaining peak health. Thrive side effects are minimal to non-existent and it is completely safe to use. Stay Calm and In Control  When you properly use your executive function, you will make better decisions. This is in part because your executive function operates best when you are calm and not in an emotionally upset state. Therefore, strive to keep a balanced and calm approach in your daily activities. Your health will improve. Feed Your Spirit Engage in activities and practices that feed and nurture your human spirit. These include meditation, prayer, volunteering, and creative hobbies such as writing, painting, and music. If you don't know where to start, look into getting a life coach to teach you tools and provide support. When the human spirit is engaged and cared for, physical health will likely follow suit. Read Quality Literature Make sure that you read a wide variety of quality health-related books, articles, and blogs. Numerous well-known physicians and other health professionals have published books and maintained websites that offer the opportunity for continued learning about the cutting-edge of maintaining good health. Never before in human history has so much been known about maintaining good health. But, if you are now aware of it, it is essentially of no use.  By following and practicing these health tips, you will put yourself on a trajectory to optimal health. You'll feel better, be able to do more, and will be less likely to come down with illness or disease. 
6 Easy Ways To A Smooth Neck
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Significant COVID-19 Impact on Non-Small Cell Lung Cancer Diagnostics in Healthcare Industry
COVID-19 Impact on Non-Small Cell Lung Cancer Diagnostics in Healthcare Industry The novel coronavirus has profoundly impacted all fields, including healthcare, medical device services, automotive, pharmaceutical and many others. This pandemic has led to shutdowns of mass production and disruptions in the supply chain that have impacted the economies of virtually every nation in the world. The pandemic also affected the non-small cell lung cancer diagnostic industry. The patient's fear of contracting the virus compels patients to stay home instead of undergoing diagnosis and treatment. During the COVID-19 pandemic, countries worldwide witnessed a large number of patients suffering from COVID-19 and post COVID-19 complications such as cardiovascular disease, diabetes and kidney problems. As the COVID-19 cases were rising, the healthcare system had shifted its focus in curbing the disease, thereby delaying diagnosis and treatment of other chronic conditions as cancer. Thus, a negative impact is expected on the non-small cell lung cancer diagnostics market due to the pandemic scenario As a result, the hospitals and clinics were filled up with COVID-19 patients and less preference was given to non-small cell lung cancer patients. Moreover, limited access to clinics, social distancing, the lockdown of the population, which results in a slow-down in patient flow and referrals, has also impacted the market growth. However, with the cases decreasing in number and increase in vaccination against COVID-19 across the globe, the market for non-small cell lung cancer diagnostics market may get a boost due to some relaxation in COVID-19 cases, which will result in increased demand for non-small cell lung cancer diagnosis with patients coming forward to clinics and hospitals for treatment. IMPACT ON DEMAND Various screening, diagnostic and surgical procedures were restricted and at hospitals and cancer treatment centers, which resulted in disruptions in the non-small cell lung cancer diagnostics market. However, even during the pandemic, the lung cancer cases were subsequent, which is expected to increase the demand for non-small cell lung cancer diagnostics market. For instance, · According to World Health Organization (WHO), in 2020, lung cancer accounted for 2,206 771 deaths among both sexes. The lung cancer statistics include both small cell lung cancer and non-small cell lung cancer. About 13% of all lung cancers are small cell lung cancer and 84% are non-small cell lung cancer. This proves an increase in the number of non-small cell lung cancer patients even during the COVID-19 pandemic. Moreover, according to the American Cancer Society, Inc., lung cancer patients are likely to get infected with coronavirus because of the changes in their immune system that control their body's defense systems. For instance, · According to a study published in PubMed, patients with lung cancer are at an increased risk of becoming infected with the virus and experience higher morbidity and mortality than the general population Thus, having cancer such as non-small cell lung cancer may also increase the risk of severe illness from COVID-19 as the cancer therapy treatment reduce the immune system of the body. . This has increased the demand for non-small cell lung cancer diagnostic tools, especially in cancer-dedicated hospitals and surgical centres, where all the patients of non-small cell lung cancer-related problems are treated. Thus, with the increased lung cancer cases, the demand for non-small cell lung cancer diagnostic will increase in the coming years. IMPACT ON SUPPLY CHAIN The supply chain was widely affected by the COVID-19 pandemic as acute restrictions and lockdowns produced many urgent situations in the early days of the pandemic, which needed immediate attention. The supply chain disruption has transformed many organizations' business environments, including the supply chain of non-small cell lung cancer diagnostics market. The supply chain disruption impacted the Asia-Pacific region initially, especially the demand from China due to challenges from restricted movement and quarantine period. For instance, · According to the FDA, 63 manufacturers representing 72 facilities in China that produce essential medical devices face obstacles in manufacturing medical devices and their supply, owing to citing workforce challenges and the necessary quarantine of workers. Moreover, closing borders of various countries is anticipated to diminish the supply chain business environment, as it may hamper export of the medical supplies To minimize supply chain crises, the FDA has been firmly monitoring the supply chain with the assumption that the COVID-19 outbreak may adversely impact the supply chain of medical products, including shortages of critical medical products in the U.S. or potential disruptions in supply chains. Many organizations and countries are looking forward to improving and diversified supply chain models in all aspects to manage such a crucial situation. A diversified supply chain model anticipated minimizing the export of medical products as well as increase end-to-end visibility. For instance, · The Brazilian government published a resolution eliminating import taxes on 141 medical products and hospital equipment · The European Commission made a decision for helping Member States affected by the pandemic to suspend customs duties and VAT on medical devices temporarily · Federal indirect tax body the Goods and Services Tax (GST) Council of India has decided to cut taxes on medical supplies IMPACT ON PRICE The coronavirus disease (COVID-19) pandemic does not significantly impact the global non-small cell lung cancer diagnostics market. But it is estimated that if COVID-19 continues to spread for a prolonged period, then the demand for non-small cell lung cancer diagnostic equipment and devices will highly upsurge for top importer countries. For therapies and the diagnostic United States solicit the huge number of medical devices, followed by China and Japan. For instance, · According to the General Administration of Customs (GAC), China's exports of medical machinery and devices increased 40.5 percent in 2020 compared to the previous year, reaching USD 18.138 billion · According to the World Trade Organisation, the U.S. imports and exports of medical goods increased by 16 %, reaching USD 1,139.00 billion in value Henceforth for diagnosis, dependency of these countries highly increases on other exporters and many countries solely depend on China and the U.S. for the non-small cell lung cancer diagnostic equipment. Consequently, this may lead to a rise in the overall non-small cell lung cancer diagnostic cost. This increase in the price of the non-small cell lung cancer diagnostic may hamper the market growth if it continues to be the same. Additionally, if the lockdown continues to stretch for a long period, then import of non-small cell lung cancer diagnostics market is estimated to get more restricted, which may further lead to a rise in the price of the these devices CONCLUSION It is estimated that the COVID-19 pandemic outbreak has significantly impacted the growth of non-small cell lung cancer diagnostics market as the rising cases of COVID-19 worldwide the healthcare system had shifted its focus in curbing the disease, thereby resulting in the delay of diagnosis and treatment of non-small cell lung cancer. Thus, a negative impact is expected on the non-small cell lung cancer diagnostics market due to the pandemic scenario. However, with the increase in lung cancer patients worldwide, the demand for non-small cell lung cancer diagnostics will increase in the coming years. Moreover, poor lifestyle, smoking, alcohol consumption, lack of physical activity and other factors will contribute to the incidence of chronic disease such as lung cancer, including non-small cell lung, which is anticipated to increase the global non-small cell lung cancer diagnostics market in the coming years.
How COVID-19 Impacted on Oral Care in Healthcare Industry ?
COVID-19 Impact on Oral Care in Healthcare Industry OVERVIEW The COVID-19 pandemic has posed a complex challenge in front of several healthcare companies and proved to be an unprecedented global health threat. This global pandemic has emerged in December 2019 which has been proved as a global pandemic by WHO in March 2020. With the development and introduction of novel coronavirus vaccine, COVID-19 cases have been declined but with the development of mutant coronavirus strain, the overall COVID-19 cases have been surged and are increasing at a rapid rate in India, and the U.K, and other European countries. The most common symptoms associated with this include cough, fever, diarrhea, sore throat, and loss of smell or taste. Patients affected with COVID-19 are at increased risk of developing hepatic manifestations and also experiences damage to liver tissues. COVID-19 has led to the closure and reduced hours of dental practices except for emergency and urgent services, limiting routine care and prevention. Dental care includes aerosol-generating procedures that can increase viral transmission. The pandemic offers an opportunity for the dental profession to shift more toward non-aerosolizing, prevention-centric approaches to care and away from surgical interventions. Direct effects of COVID-19 on oral health include ageusia (an official symptom of COVID-19) and case reports of vesiculobullous lesions and necrotizing periodontal disease. oral care product has a wide portfolio such as breath Fresheners, Mouth Wash, Dental Floss, among other products. The Article here shows the impact of COVID-19 on the oral care market. IMPACT ON PRICE As the mouth is an important place for bacterial colonization due to which it is necessary to use the product for oral hygiene. With the sudden increase in COVID-19 cases, people's concerns for better health had also increased and the link between oral health and COVID-19 infection also expand the health to oral. As India relies on China for 70% of API’s intermediates and bulk ingredients, COVID -19 is expected to hike the price of the ingredient used for an oral care product For instance, · In the year 2021, As Proctor & Gamble announced the third-quarter result in which the net sales increase by 5 %, and also mentioned that they are planning for a price hike in certain product divisions. This step is taken seeking to recover the revenue loss during COVID-19. · According to GlaxoSmithKline plc, the cost of dental consultation and treatment was cited as the concerning factor IMPACT ON DEMAND The coronavirus has affected the various regions of the world and caused the widespread closure of companies and local manufacturing plants. This lockdown and isolation have adversely impacted global economic activity. As studies around the world have shown the improving oral hygiene is expected to increase the chance of generating demand for the product. THE IMPACT OF COVID-19 INFECTION ON ORAL CARE The rising awareness of oral hygiene COVID-19 has increased the demand for a product requires for oral care as the increasing studies for SARS-COV-2 indicated that proper oral hygiene has been reported to decrease the chances of infection which increases the demand for mouth wash, oral povidone solution, novel gargle solution. · However, due to restrictions and aims to reduce COVID-19 transmission, 30% of respondents had visited a dentist less frequently during the pandemic The second cause of increasing demand for oral care products is that approximately 90% of the product used in oral care are over the counter which can be added as the plus point in maintaining the demand for oral care products. The market players in oral care are also focused on the research to bring novel products to interstate commerce. For instance, · Microbac Laboratories, an independent and internationally accredited testing facility worked on behalf of Unilever Research Laboratories, has found that rinsing with mouthwash containing CPC Technology for 30 seconds is effective in reducing the viral load of SARS-CoV-2, the virus that causes Covid-19, by 99.9%. This type of research surge the demand for the oral product · Colgate-Palmolive President mentioned in an interview that they have seen elevated demand for oral care related to viruses, which also boosted the innovative growth related to a premium product This suggests that the increasing prevalence of COVID-19 poses precautionary measures due to which the global population started to take concern for their health hence enhance the demand for oral care. This thus signifies that COVID-19 is accelerating the demand of the oral care market. IMPACT ON SUPPLY The COVID 19 pandemic has affected and badly disrupted the global drug supply chain due to the continuous shut down of manufacturing facilities and restrictions imposed by the government over import and export activities. As per global sources, it was found that the beauty care business is still facing a crisis due to COVID-19. However, oral care market players are in a strong position. The two main leaders Colgate-Palmolive and Johnson and Johnson had seen a lift in sales in Q1 2020. Colgate-Palmoliva has net sales of USD 415 million for Q3 2020, up by 5.5% from the previous year. The surge of demand for oral care increased during COVID-19 however, the global restriction, and state-wise travel restriction has caused challenges for the market player. Moreover, there are many local players also in the oral care market that continued to fulfill the demand in case of any disruption. Oral care is categorized under essential need products which leads to the easy flow of these products. The main challenges during the pandemic is the supply of API’s and Ingredient or excipient used in toothpaste, as China holds the major share in API’s and other chemicals used in oral care and global restriction has somehow affected the supply chain for these products too. This, thus signifies that due to continuous lockdown and several restrictions by government authorities the companies and patients are facing disruption of the supply chain for oral care. However, oral care is categorized under essential care which lowers the effect of supply chain disruption during COVID-19. STRATEGIC DECISIONS OF MANUFACTURERS Collaboration, agreements, strategic initiatives, product launches by market players such as Colgate Palmolive, Hindustan Unilever among others in the oral care market will help them to expand their product portfolio and to provide appropriate products to the consumer. This in turn will lead to increased product sales and hence will put a positive impact on the overall company’s revenue. Oral Care product manufacturing companies are taking so many strategic decisions to cope up with the current scenario of COVID-19. The companies engaged in the manufacturing of toothpaste, mouth wash, gargle solutions among others are adopting several initiatives to accelerate the development of newer products and efficiently supply the product to different end-users. Companies have done collaboration and product launches between 2019 -2020 which supports the sustainable growth in the oral care market For instance, · In September 2020, Colgate Palmolive launched as first-ever vedshakti mouth protect spray, seeking their focus on oral hygiene during COVID-19. · Hindustan Unilever also planned to launch a mouth wash with 99 % in reducing SARS-COV-2 virus and has recently shared the preliminary data. · In April 2020, GlaxoSmithKline Consumer Healthcare Limited (India) merged with Hindustan Unilever Limited (HUL), with HUL responsible for the distribution of GSK’s Consumer Healthcare brands in India, including its leading oral healthcare brand, Sensodyne. · In April 2020, Perrigo Company plc (Ireland) completed the acquisition of the oral care assets of High Ridge Brands (US), which includes Dr. Fresh, LLC. · In December 2019, Colgate-Palmolive Company launched Colgate Optic White Renewal Tooth Paste. · In 2020, Colgate-Palmolive comes up with a recyclable toothpaste tube which will increase the interest of the population and surge the demand for the product leading to growth in revenue of the company Thus, companies operating in the oral care market are adopting several strategies, including collaboration, agreements, acquisition, and market expansion to enhance their business. These strategic decisions by the companies are expected to provide significant opportunities for the market players operating in the oral care market. CONCLUSION As the pandemic of COVID-19 has resulted in several restrictions throughout the borders but still, manufacturers of oral care can manage their stocks. Various manufacturers have allowed their manufacturers to work in a clean and safe environment to boost up the production of oral care categorized under essential need products at various manufacturing facilities across several regions of the world helping them to maintain a continuous supply chain. However, a decrease in doctor’s visit has impacted the market but the majority of products used in oral care are over the counter product which leads to continuous demand for oral care, and by raising the prices the companies are gaining extra profit which is helping them to combat the negative effect on overall revenue.
Significant COVID-19 Impact on Nivolumab in Healthcare Industry
COVID-19 Impact on Nivolumab in Healthcare Industry COVID-19 (Coronavirus) has affected the day-to-day life of people and has slowed down the economies worldwide. The pandemic has affected millions of people who either got sick or died due to the spread of this disease. Within a few months, coronavirus disease (COVID-19), which originated from China, became a pandemic, with more than 30 million people being infected till date. There are now numerous vaccines in use. The first mass vaccination program commenced in early December 2020, and as of 15 February 2021, 175.3 million vaccine doses have been administered. There is an added complexity because of COVID-19 diagnosis in cancer patients, particularly while on active treatment with immunotherapy like nivolumab. COVID-19 could cause more harm to cancer patients. In order to prevent the infection from spreading, the patient’s number and new diagnosis have been less during the COVID 19. The COVID-19 pandemic has led to a dramatic loss of human life worldwide and presents an unprecedented challenge to public health, food systems, and the world of work. Still, there is an increase in the demand for cancer treatment with immunotherapy drugs like nivolumab during the second quarter of 2020 with the rise in awareness regarding health and new product launches in countries. IMPACT ON PRICE COVID-19 is significantly decreasing commercial activity in every area of the business sector. The economy has been decreased during the pandemic with the restricted and disrupted supply and sales of products and devices. The cost of medication and treatment of nivolumab has been increased due to the increasing demand for this drug during COVID-19. This contributed to the increased expenses and prices of immunotherapy drugs. Changes in the economy and other factors have caused consequences, including the decrease in the sales of the drug in some countries such as the U.S. With the rise of COVID-19 and decrease in new patients has also contributed to the increased cost and priced of some products and medication. · The price of Opdivo (nivolumab) drug which is a most common therapy treatment for various type of cancer or tumor have been increased to USD 1,172 for a supply of 4 milliliters of injection in 2020 with the rise in demand and increasing patients population in the second quarter of 2020. IMPACT ON DEMAND Global economic development in 2020 has been severely impacted by the COVID-19 pandemic. The COVID-19 has given rise to risks such as a prolonged, significant decline in global demand as well as unfavorable geopolitical and macroeconomic effects. The coronavirus pandemic has provoked many strategical actions among healthcare providers on how to manage cancer patients when faced with the threat of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection. There has been a decrease in demand for nivolumab in some countries like the U.S., whereas many countries have seen an increase in sales with the rise in demand for the treatment and new cancer patients. With the rise in demand for the drug, FDA has provided approval to various drugs related to the immunotherapy nivolumab. For instance- · For the Bristol-Myers Squibb Company, the U.S. revenues of nivolumab decreased to 9% in 2020 due to lower demand caused by declining second-line eligibility across tumor indications and lower demand from COVID-19 (primarily lower new patient starts and patient visits). The U.S. has seen a decrease in sales in the first quarter of 2020. · However, the international revenues for nivolumab were increased up to 7% in 2020 due to higher demand as a result of additional indication launches in some countries with rising cancer patients globally. · In May 2021 -- Bristol-Myers Squibb Company has today announced that the U.S. Food and Drug Administration (FDA) had approved their Opdivo (nivolumab, injection for intravenous use) for the adjuvant treatment of completely resected esophageal or gastroesophageal junction (GEJ) cancer. · Similarly, FDA has approved Opdivo (nivolumab) for treating different types of cancer in many countries via various market players due to the rise in demand for this drug. IMPACT ON SUPPLY CHAIN The pandemic and COVID-19 have affected every business activity in which the supply chain was affected the most. Because of the pertinacious COVID-19 lockdown, sanctions have been forced by administrations of different nations. These limitations and boundaries across the nation’s borders prompted a diminishing stockpile because of restricted materials and labor force and the halting of the assembly line. The COVID-19 pandemic has transformed many organizations’ business environments; supply availability has been hampered by a number of issues, including export and travel restrictions by some producing countries, and the lockdown has forced suppliers to (temporarily) shut down. The supply of nivolumab medication has a slight decrease in sales during the first quarter of 2020, partly due to negative factors mentioned above in connection with the COVID-19 pandemic, which particularly didn’t affect the overall yearly revenue. The supply chain and demand were positively affected by the COVID 19. The sales and supply of the drugs have been increased with the rise in demand for the drugs and diagnosis. Many major manufacturing companies have launched their drugs in different countries to fulfill the demand, and the government has provided approval for the sales of the drug nivolumab. For instance- Despite the pandemic, many market player of nivolumab has increased their sales globally. This is due to the ongoing increase in the patient population and rising awareness regarding their health. · The sales of ONO pharmaceuticals have been increased in the year 2020 as compared to 2019, which is 2656.05 USD Million in 2019 and 2809.23 USD million. · Similarly, sales of the drug Opdivo (Nivolumab) from the manufacturing company Bristol Myers Squibb Company have been increased globally (except the U.S.) from USD 2,860 million in 2019 to USD 3,047 million in 2020. This increase in sales in both of the major market players is due to the increase in cancer patients and the use of drugs in all areas of cancer. There is an increase in the sales of this nivolumab with the rise in prevalence of disease and early diagnosis & treatment. STRATEGIC DECISIONS BY MANUFACTURERS To deal with the COVID-19 outbreak challenges and increasing demand for the drugs, many market players are creating new strategies such as new product development, telemedicine, and a different program to support patients and to raise their sales. It is predicted that these strategies are anticipated to escalate up the company revenue and its growth in the forecasted period. The government has provided drug FDA approvals of nivolumab for the treatment of cancer. For instance, · In May 2020, Bristol Myers Company announced that Opdivo (nivolumab) 3 mg/kg plus Yervoy (ipilimumab) 1 mg/kg (injections for intravenous use) was approved by the U.S. Food and Drug Administration (FDA) for the first-line treatment of adult patients with metastatic non-small cell lung cancer (NSCLC). · There are several ongoing potentially registrational studies that have been conducted by different manufacturing companies for Opdivo for the treatment of different tumor types and disease areas, in combination with various anti-cancer agents · Also, there are various ongoing clinical trials conducting on nivolumab with the combination of various anti-cancer agents and others to treat various types of cancer to decrease the demand for cancer treatment and to provide patients with more advanced drugs. For instance · In Japan, South Korea, and Taiwan, ONO pharmaceuticals are co-developing this drug nivolumab with the Bristol Myers Company CONCLUSION As the pandemic of COVID-19 resulted in several restrictions throughout the borders, still, manufacturers and market players were able to manage their sales and revenue of oncology and drug nivolumab. Various manufacturers allowed their workers to work in a clean and safe environment so as to boost up the production at various manufacturing facilities across several regions of the world, thus, helping them to maintain a continuous supply chain with the increasing demand. Market players have come up with better strategies which have also created a positive impact on the growth of the nivolumab market globally.