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WHO’s International Clinical Trials Registry Platform (ICTRP)
People from more than one country and one medical or research institution can participate in a clinical trial. Different countries have different clinical research requirements, so one clinical trial may be enlisted on more than one registry. That clinical trial shall appear on the database of more than one registry. However, data on various clinical trial registries varies. . Take Clinical Research Course from the Best. The International Clinical Trials Registry Platform (ICTRP) is a global initiative by WHO, responsible for linking clinical trial registers worldwide for ensuring a single point of access and the apparent identification of clinical trials. This was done with the view that participants, patients, families, and patient groups have easy access to information. The ICTRP was established with the aim to make information about all clinical trials that involve humans publicly available. It also aims to achieve the following: ● Improving the comprehensiveness, completeness, and accuracy of registered clinical trials data; ● Communicating and raising awareness of the need for registering clinical trials; ● Ensuring the accessibility of registered data; ● Building capacity for clinical trial registration; ● Encouraging the utilization of registered data; and ● Ensuring the sustainability of the ICTRP. . Take the Best Training in Clinical Research. The Secretariat of the ICTRP is housed by the World Health Organization in its headquarters in Geneva and is responsible for the following: ● Publishes the ICTRP search portal: A database and website that makes it possible for every person in the world to search for free data provided by clinical trial registries around the world. The data is updated weekly and meets WHO’s criteria for content and quality. ● Supports the WHO registry network: A forum created to establish and work together for the purpose of clinical trial registries. It aims to establish best practices for clinical trial registration and the collection of high-quality, accurate data. ● Supports different countries and regions: It aims to establish clinical trial registries or policies on trial registration.
Integrative Balance Approach
Over the years of treating patients with various injuries and discomfort, we have clearly observed a persistent issue with our present-day health care practices. Most of the standard treatments for physiotherapy in Singapore and many other countries are focused on solving the immediate symptoms and injuries, but little effort has been spent on identifying and intervening the underlying root causes. This has lead to sub-optimal outcome for chronic injuries or recurring pain management.  Consolidating years of clinical experience and taking reference to the best practices in Chinese Medicine and Western medicine, our founder Mr Yan Yong (Michael) has conceptualized the Integrative Balance Approach of human function. We have been consistently helping thousands of patients recover from chronic injuries and body aches, and live a pain-free life. The Integrative Balance Approach of human function means that in order for our body to exert force effectively to complete various tasks, the body must achieve balance of several factors at the same time, as shown in the following diagram:  When the body position or movement habits are not following the integrative balance principle, certain parts of the body will have to bear excessive force loading, or move excessively beyond the healthy range, thus leading to injury and pain. Different error movement patterns will lead to different injuries. Based on the Integrative Balance Approach principles, we have formulated a streamlined treatment process that systematically helps our patients correct their movement errors, and adopt healthy habits that is optimized to perform their functional tasks. We use various manual therapy techniques and specific exercises training, with optional use of therapy modalities to treat our patients. Treatment plans will be set based on our findings from physiotherapy assessment, and customized to each patient.
Review các loại collagen nước uống có tốt không?
Một trong những cách bổ sung collagen mang lại hiệu quả nhanh chóng được hội chị em ưa chuộng chính là uống collagen dạng nước. Đó là lý do tại sao collagen nước của DHC lại được săn lùng nhiều đến như vậy. Thực tế, collagen DHC dạng nước có tốt như lời đồn hay không? Hãy cùng đọc bài review này của DHC Việt Nam để tìm câu trả lời nhé! >> Xem ngay: Collagen nước uống lúc nào thì tốt? Collagen dạng lỏng tốt nhất Tác dụng phụ của việc uống collagen là gì? 1. Collagen DHC dạng nước 7000mg là gì? Collagen nước của DHC có tên đầy đủ là DHC Collagen Beauty 7000 Plus chứa hàm lượng collagen lên tới 7000mg, đem lại hiệu quả dưỡng da căng mọng và chống lão hóa vượt trội. Sản phẩm chính thức đứng vào hàng ngũ những loại collagen nước chứa nhiều hàm lượng collagen nhất trên thị trường. Là một dòng collagen dạng nước chiết xuất từ cá, DHC collagen 7000 được các nhà nghiên cứu DHC sử dụng collagen loại 1 chiết xuất từ da và vảy cá kết hợp cùng quy trình xử lý để chúng có cấu tạo dạng collagen peptide với kích thước phân tử siêu nhỏ. Nhờ đó mà cơ thể dễ hấp thụ hơn so với collagen có nguồn gốc từ heo. Collagen nước DHC Collagen Beauty 7000 Plus có chiết xuất da và vảy cá Ngoài ra, DHC còn tăng cường thêm các thành phần làm đẹp khác như vitamin C, tiền HA, axit α-amin citrulline. Các thành phần này sẽ giúp nâng cao hiệu suất hấp thụ collagen nước đồng thời hỗ trợ dưỡng da từ bên trong, nhanh chóng đem lại cho bạn vẻ đẹp trẻ trung, tươi mới. Hiện nay, collagen nước DHC Collagen Beauty 7000 Plus đang được bán với giá niêm yết 1.200.000vnđ. 2. Thành phần của collagen dạng nước DHC có gì? Trong mỗi lọ collagen nước 50ml dành cho một ngày có chứa: Collagen peptide chiết xuất từ da và vảy cá: 7.000mg Vitamin C: 500mg Tiền HA: 200mg. Citrulline: 400 mg Collagen nước DHC còn được thêm vào thành phần chiết xuất nho muscat và mật ong để tạo hương vị hấp dẫn cho bạn khi sử dụng. Thành phần collagen nước DHC có chứa chiết xuất nho muscat tạo hương vị dễ uống >> Xem ngay: Cách dùng collagen dạng nước của Nhật 3. Công dụng của collagen nước DHC là gì? 3.1. Bổ sung hàm lượng collagen dồi dào giúp làn da nhanh chóng lấy lại vẻ trẻ trung, tươi mới Với hàm lượng collagen lên tới 7000mg, sản phẩm sẽ đem lại cho bạn trải nghiệm hiệu quả làm đẹp thần tốc. Hơn nữa, DHC sử dụng collagen peptide loại 1 chiết xuất từ cá - thành phần collagen có khả năng hấp thụ và hiệu quả dưỡng da cao. Uống collagen dạng nước đẹp da DHC mỗi ngày không chỉ nuôi dưỡng làn da trở nên trẻ trung, căng mọng mà còn giúp hạn chế gặp phải các dấu hiệu lão hóa như da kém đàn hồi, chảy xệ, xuất hiện nếp nhăn,... Collagen nước DHC bổ sung collagen cho da lấy lại vẻ trẻ trung >> Xem thêm: Collagen dạng nước bôi mặt cho tuổi 25 3.2. Duy trì độ ẩm cho làn da mềm mại, tránh bị khô ráp Không chỉ có collagen có khả năng duy trì độ ẩm cho da, collagen nước DHC còn có thành phần tiền HA với khối lượng phân tử nhỏ. Thành phần này có tác dụng cấp nước và dưỡng ẩm để duy trì sự mềm mại cho làn da, tránh tình trạng da bị khô ráp dẫn đến nhanh lão hóa. 3.3. Nuôi dưỡng làn da luôn căng mịn, tránh tình trạng lão hóa da Kết hợp cùng với collagen và tiền HA, sản phẩm còn có vitamin, mật ong, chiết xuất nho muscat để nâng cao hiệu quả nuôi dưỡng làn da luôn căng mịn, khỏe mạnh để tránh khỏi sự tấn công của các gốc tự do gây lão hóa da. Làn da căng mịn, hạn chế bị lão hóa sớm nhờ uống collagen nước DHC 4. Cách sử dụng collagen nước DHC đúng cách Theo khuyến nghị từ nhà sản xuất, mỗi ngày bạn chỉ nên uống 1 lọ collagen nước DHC và uống vào buổi tối trước khi đi ngủ để sản phẩm phát huy tối đa công dụng. Nếu bạn muốn có trải nghiệm tuyệt vời khi uống collagen nước DHC thì hãy để sản phẩm vào ngăn mát tủ lạnh trước khi uống và lắc đều trước khi uống để tăng hương vị thưởng thức. Bạn nhớ uống ngay sau khi mở nắp nhé! Mỗi ngày chỉ nên uống 1 lọ collagen nước DHC Một số lưu ý quan trọng khi uống collagen nước DHC: Sản phẩm này không phải là thuốc và không có tác dụng thay thế thuốc chữa bệnh. Uống đủ nước, mỗi ngày tối thiểu 2l nước. Tuân theo liều lượng dùng được khuyến nghị. Dừng uống khi phát hiện bất thường. Không nên làm nóng hoặc đông lạnh chai uống vì nó có thể bị vỡ. Không sử dụng sản phẩm nếu dị ứng với bất cứ thành phần nào của sản phẩm. Nếu bạn đang dùng sản phẩm khác, đang điều trị tại bệnh viện hoặc đang mang thai, hãy tham khảo ý kiến bác sĩ trước khi dùng. Để xa tầm tay trẻ em. Sử dụng ngay sau khi mở nắp. Đóng nắp chai ngay sau khi sử dụng. Kết hợp chế độ ăn uống cân bằng bao gồm ngũ cốc, protein và rau củ. Uống đủ nước mỗi ngày cho cơ thể và làn da khỏe mạnh >> Xem ngay: Uống collagen nước bao lâu có tác dụng 5. Uống collagen dạng nước DHC có bị nổi mụn không? Theo phản hồi từ các khách hàng đã sử dụng sản phẩm trên website của DHC Nhật Bản, hội nhóm làm đẹp ở Việt Nam, phần lớn mọi người đều đánh giá collagen nước DHC dễ uống, không có mùi vị lạ, không gây nóng trong, nổi mụn li ti. Tuy nhiên, để đảm bảo an toàn hơn khi sử dụng, bạn nhớ tuân theo liều lượng dùng được khuyến nghị, không nên tự ý tăng liều lượng uống. Bên cạnh đó, bạn hãy uống tối thiểu 2l nước mỗi ngày và ăn nhiều rau củ, trái cây giúp thanh nhiệt cho cơ thể. Kết hợp chế độ ăn uống có nhiều rau củ, trái cây tươi Tổng kết Thông qua bài viết review các loại collagen nước DHC chi tiết này, chắc hẳn bạn đã biết được collagen dạng nước của DHC có tốt hay không rồi nhỉ? Không chỉ chứa hàm lượng collagen vượt trội, sản phẩm còn có nhiều thành phần làm đẹp ưu tú khác. Đừng bỏ lỡ DHC Collagen Beauty 7000 Plus để có một làn da trẻ trung, rạng ngời bạn nhé! Nguồn: https://dhcvietnam.com.vn/blogs/lam-dep-cung-dhc/review-collagen-dang-nuoc-dhc-co-tot-khong
Top Health Issues Where Instant Medical Loans Is A Right Choice
Medical issues in life do not look for funds in the account. They always knock on the door in the most uncertain times. Not all the suffers are gifted with the medical cover to solve their health coverage and few medical treatments are not covered by insurance providers and such is the juncture where Instant Medical Loans turn to be a vital option for people to handle their treatments. Dental Problems Many people become the victims of dental problems. These health issues need immediate attention irrespective of your financial status. Though the problem is not a life-threatening issue, it hampers the quality of life. NO insurance provider is open to offering coverage to these recurrent problems, the treatments for dental issues in the countries like Australia are expensive to be paid from the pocket alone and you can take the help of an instant medical loan to handle the immediate problem and disburse the expenses over the loan tenure. Kidney Related Issues When you are a victim of a kidney-related problem, the expenses for the treatment are recurring. The insurance provider may offer coverage for major things like surgery but not for recurring expenses like dialysis. Instant Medical Loans can be used to pay any medical expenses related to any health disorder. If you feel like you run out of cash to pay the recurring expenses for health treatment in that particular month, you can avail these online loans. Cosmetic Surgery Beauty enhancement is always a way to lead a confident life especially if you are a public profile. Not only surgeries, pre, and post-medical treatments are expensive too. As there is no insurance coverage offered for such treatments, you can apply for Instant Medical Loans to adjust your finances during the treatment time. Any Emergency The purpose of these Online Cash Loans is not specific. You can spend the loan amount for any medical emergency that knocks on your door. On applying for the loan online, the amount is deposited into your account directly giving you full control over money sending.
Childhood Leukemia
Leukemia — Cancer of blood is called Leukemia. It develops in the bone marrow. Bone marrow is a soft inner part of the bone (such as thigh and hip bone) where new RBC, WBC & Platelets are formed. As we know, bone marrow also produces WBC or Leucocytes. As soon as the number of mature WBC is enough, then the body sends a signal to stop new cells’ formation. But in Leukemia, these newly formed cells stay immature for a long time. Consequently, the body cannot send any signal, so new cells form inside the bone marrow. The bone marrow becomes crowded with immature and abnormal WBC. Childhood Leukemia — Children of the age group of a newborn child to a 19-year-old. According to a study conducted in 2018, 29% of cancer in children is of childhood leukemia. The most common Leukemia in children is ALL (Acute Lymphoblastic Leukemia) and AML (Acute myeloid leukemia). Early Symptoms of Childhood Leukemia a. Dull or pale skin b. Weakness or feeling of tiredness c. Headaches and Dizziness d. Trouble in breathing e. Fever and frequent infection f. Bleeding gums or nosebleeds Types of Childhood Leukemia: Leukemia typically in kids can be categorized into two major types. A. Common types of Leukemia a. Acute lymphoblastic Leukemia (ALL), also called acute lymphocytic Leukemia is fast-growing Leukemia of lymphoid cells. This type is widespread in kids; it’s the proliferation of B and T cells lymphocyte precursor. Acute Lymphoblastic Leukemia (ALL) accounts for 75–85% of cases of childhood leukemia. b. Acute Myelogenous Leukemia (AML): AML is also a common type of childhood leukemia. This is the fast-growing Leukemia of myeloid cells. B. Rare types of Leukemia a. Hybrid or mixed-lineage Leukemia: This is chromosome-related Leukemia where part of chromosome 11 translocates to any other chromosome. Children having mixed-lineage Leukemia have a poor prognosis. b. Chronic Myelogenous Leukemia: This is slow-growing Leukemia of myeloid cells. c. Chronic lymphocytic Leukemia (CLL): CLL is very rare in children. This is the slow-growing Leukemia of lymphoid cells. d. Juvenile myelomonocytic Leukemia (JMML): This is a scarce type of childhood leukemia where WBC production in bone marrow is severely dysregulated. Diagnosis of Childhood Leukemia There are various tests to diagnose and confirm childhood leukemia. These tests also help in classifying the type of Leukemia. The initial tests include: a) Blood tests to measure the number of blood cells and see how they appear. b) Biopsy and Bone marrow aspiration test: To confirm Leukemia, a tissue sample is usually taken from the pelvic bone. c) Spinal Tap test or Lumbar puncture: This test is done to know the spread of cancer cells in the fluid (cerebrospinal fluid) present in the spinal cord or brain. These tests also determine the method of treatment to be followed. Risk factors of Childhood Leukemia More study is needed to explore the possible reasons, but few of them are environmental factors like exposure to radiation, smoking, genetic factors, inherited problems related to immune systems, etc. Treatment of Childhood Leukemia: Once the oncologist confirms the diagnosis, the child will undergo chemotherapy medicines. In highly developed countries, the cure rate for ALL (Acute lymphoblastic leukemia) is more than 80–90%, and for acute myeloid Leukemia, it is more than 60–70%. In developing countries, poor accessibility or affordability, malnutrition, poor tolerability to treatment, and delayed diagnosis bring down the cure rate to almost 70% in ALL and around 50% in AML. a) Chemotherapy: Chemotherapy uses powerful chemicals and is done to target and kill cancerous cells. Chemotherapy works throughout the body. b) Blood Transfusion: This is a process of transferring healthy blood components into a patient’s blood circulation system intravenously. This process helps in replacing red blood cells, platelets, and other blood components. c) Radiation Therapy: This is also known as Radiotherapy or RT or XRT. This therapy uses a beam of ionizing radiation to kill the cancer cells. d) Bone Marrow Transplant: BMT is performed to replace damaged or destroyed bone marrow. In this process, blood stem cells are transplanted into the circulation. Later on, these blood stem cells reach the bone marrow area to produce and promote new blood cells. Treatment of Relapsing Leukemia Despite chemotherapy, around 20% of ALL and about 40–50% of AML can come back with the disease within two to five years of initial diagnosis. This reoccurrence of infection is called relapse. Again, these children will go through a similar test like complete blood count, bone marrow evaluation to confirm the deterioration. After confirmation, they will have to undergo a higher dose of chemotherapy of a different combination or Bone Marrow Transplant. You can consult a well-experienced oncologist, or you can consult online on consultancy websites like Practo, DoctoriDuniya, etc. At DoctoriDuniya, You can book an appointment online with an oncologist or cancer specialist 24X7, with eOPd and an e-prescription facility. The cancer doctor may ask about the family history of the problem and symptoms associated with the disease. At DoctoriDuniya, you can download DoctoriDuniya — Free Medical App and create your online Personal Medical Account called NAINI. Here you can avail free follow-ups and online doctor consultation with oncologist or cancer specialist at NAINI.
Principles regulating clinical trials worldwide
Clinical research training Clinical research training programs are designed for clinicians and scientists around the world. These research training programs provide advanced training in healthcare methods and research. The training often incorporates in-person seminars and dynamic workshops. It focuses on enhancing clinicians’ and staff skills, knowledge, and ability at every phase of the research, particularly for pre-clinical research phases. The training includes writing grant proposals and launching new projects for analyzing data and presenting their clinical results. . Take the Best Training in Clinical Research. Principles regulating clinical trials worldwide Clinical trials are required to follow the following guidelines and more to ensure the safety of patients and efficacy of tests and treatments. However, stringent requirements may force clinical trials to shift to low-income and middle-income countries depriving the local population of the opportunity to benefit from international clinical research. ● Obtaining clear, transparent, and informed consent from participants. ● Allowing participants to withdraw at any point of time from a clinical trial. ● The outcome of the clinical research should provide benefits to society without doing any harm to the participants who volunteered to participate in the clinical trial. ● Any unintended response to a drug or medical product should be considered an adverse reaction. ● A declaration of confirmation by the auditor that an audit has been conducted. ● The auditor should provide a written evaluation of the results of the audit. ● A written description of a clinical trial or study. ● Report of placebo or any investigational product if used in the clinical trial. ● The ethical and moral obligation to protect patients and reap clinical research benefits. . Take Clinical Research Course from the Best. The conclusions derived from the results of a clinical trial conducted worldwide generally apply to all study centers and countries. It increases the pace of drug development and facilitates the approval process of the tests and treatments in foreign markets. However, clinical trials face several challenges that they should overcome to ensure optimal conduct and coordinate clinical trial sites that operate under different regulations, technical, cultural, and political conditions. Clinical trial sponsors are responsible for obtaining consensus among clinical experts and regulatory agencies regarding fundamental questions that include a consistent diagnosis.
Clinical trial phases
Clinical trials are a type of research conducted to study new tests, treatments, and drugs and evaluate their outcomes, side effects, and efficacy on human health. There are various medical interventions, including drugs, biological products, radiological procedures, devices, behavioral treatments, surgical procedures, and preventive care in which people volunteer to take part. Take the Best Training in Clinical Research. Clinical trial phases Biomedical, clinical trials include the following four clinical research phases: ● Phase I of clinical trials usually studies new drugs for the first time in a small group of people to evaluate a safe dosage range and identify side effects. ● Phase II of clinical trials studies test treatments that were found safe in phase I of clinical trials. However, phase II is conducted on a larger group of human subjects for monitoring any adverse effects. ● Phase III of clinical trials is conducted in different regions and countries and on larger populations. Phase III is the step conducted right before a new treatment or drug is approved. ● Phase IV of clinical trials is conducted after a country approves, but there is still a need for further testing efficacy in a larger population over a longer timeframe. . Take Clinical Research Course from the Best. There are various guidelines outlined by different international and national organizations for ensuring careful design, review, and completion of the process. Clinical trials require approval before they can even begin. People of all ages, including children, can volunteer to participate in clinical trials. However, various guidelines direct the participation of people in clinical trials. These guidelines can relate to underlying health conditions, side effects from other drugs, and so on.
Problems Faced in Automation in CDM
Standardization of data Data should be standardized before automated sharing. It will lead to a faster collection of trial evidence and better analysis, enhanced transparency, faster start-up times, increasing the predictability of data and processes, and easier reuse of case reports across different studies. Take Clinical Research Training to understand better about on ground Problems faced by the Industry. Interoperability of EHRs for automation Although the use of EHRs has not been optimal, they have yielded great benefits at low costs and less time and presented significant possibilities for research. The collection, organization, exchange, and automation of data depends on the effective use of electronic health records (EHRs). However, EHRs have a history of poor interoperability and insufficient quality control and security of data. The way data is stored in these records often varies across institutions and organizations. Sharing the data becomes a struggle since there is no standard format for EHRs. Learn the best Clinical Research Course. Improvement in AI and automation Artificial intelligence (AI) has great potential to identify eligible patients for clinical trials. However, the reality is quite different from expectations. The major problem has been the development of sophisticated algorithms. Other barriers include the unstructured format of data and how to integrate that data into the clinical workflow of stakeholders. Clinical trial stakeholders can indefinitely benefit from a data exchange network, particularly one established between clinical trial sites and sponsors. The network would collect and analyze data before sharing it with relevant stakeholders, improving overall quality. Sponsors shall be able to share important information with sites, including draft budgets and protocol documents. At the same time, sites shall be able to update sponsors in real-time on impending matters, such as patient registrations. This would ensure an unhindered flow of information through integrated systems. However, sites should remember that not all information can flow freely and should be careful while sharing protocol-specified data with sponsors. EHRs have protected health information (PHI) and non-protocol-specific data, which would put patients’ confidential data at risk if shared.