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The Research and Application Progress of Transcriptome Sequencing Technology (II)

1.5. Full transcription sequencing
The transcription level of mRNA is affected by the regulation of lncRNA, small RNA and circRNA. Quantitative analysis of biomolecular networks and regulatory pathways in cells or specific tissues in a certain space-time requires quantitative and qualitative research on all RNA molecules in the entire transcriptome. Whole transcriptome sequencing can determine all complete transcripts in a sample, including mRNA and non-coding RNA (lncRNA, circRNA and miRNA). The difference between full transcript sequencing and conventional RNA-seq is the main way of library construction. The whole transcriptome sequencing requires the establishment of 2 libraries (mRNA + lncRNA + circRNA library and miRNA library) or 3 libraries (mRNA + lncRNA library, circRNA library and miRNA library) during the library construction process. Through the whole transcriptome data, not only the expression profiles of all types of transcripts can be obtained, on this basis, different RNA molecules are identified and annotated, their encoded proteins and regulatory functions are analyzed, and the interaction between RNA molecules is regulated Network analysis, comprehensively and systematically analyze the biological characteristics of specific cells in a specific time and space.
1.6. Single-cell transcriptome sequencing
Combining the complementary DNA (cDNAs) technology of in vitro transcription linear amplification and PCR exponential amplification of a single cell with high-throughput sequencing technology helps to derive single cell RNA-seq (scRNA-seq). Single-cell transcriptome sequencing technology is a technique to study the entire transcriptome at the single-cell level. It is used to assess the differences in gene expression between single cells, which can avoid false-negative results introduced by the confusion of cell types, and may identify the rare cell population failing to pass mixed cell detection. Common single-cell sequencing platforms currently include Fluidigm, WaferGen, 10 × Genomics, and Illumina / Bio-Rad. Unlike other RNA sequencing technologies, scRNA-seq needs to first isolate and obtain all transcriptomes within a single cell. Single cell separation is a key step in scRNA-seq, which is mainly achieved through serial dilution, micromanipulation separation, fluorescence activated cell sorting (FACS) and microfluidic technology.
2. Construction of Transcriptome Sequencing Library
When performing transcriptome sequencing, the total RNA in the sample is extracted, rRNA is removed, and the target sequencing RNA molecule is enriched to construct a sequencing library. Sequencing libraries are divided into non-strand-specific libraries and strand-specific libraries. The non-strand-specific library refers to a library in which RNA is reverse transcribed into double-stranded cDNA, and a linker and information that does not distinguish the RNA strand are randomly added. During sequencing, double-stranded cDNA is used for sequencing, which cannot distinguish the transcription direction of m RNA. Strand-specific libraries can be divided into two categories, one is to label one strand with a chemical modification, for example, to treat RNA molecules with bisulfate, or to introduce dUTP during the synthesis of the second strand cDNA, and then degrade the strand containing U; Different linkers are used to connect the 5 'and 3' ends of RNA molecules or synthetic cDNA strands to distinguish the positive and antisense strands.
In transcriptome sequencing, distinguishing the source of RNA molecular chains can avoid the interference of reads on the antisense strand of genes, and can improve the accuracy of gene transcript identification and transcript quantification. When using transcriptome data for de novo stitching, it helps to demarcate the boundaries of transcripts and determine the sense chain information of transcripts.
3. Transcriptome Data Processing
When transcript sequencing data is used to compare quantitative differences between gene levels or transcript levels between different groups, the basic analysis process includes raw data preprocessing, reads comparison, transcript assembly, new transcript prediction, and transcript expression level, analysis and other steps. According to the purpose of the experiment, we can further analyze the difference in transcript expression between the experimental group and the control group, cluster gene expression patterns between samples, and perform joint analysis with other omics data.
3.1. Raw data preprocessing
After obtaining the raw data of the second-generation sequencing, the quality of the data needs to be evaluated and quality control (QC) is performed. The evaluation content includes data output, GC content, rRNA content, base quality distribution, and repeated sequences. The low-quality reads and linker sequences are removed, and the clean data after quality control is obtained for subsequent analysis.
3.2. Reads comparison
The transcriptome data is mainly derived from the exon sequence of the genome. The transcriptome reads obtained by sequencing are aligned to the genomic sequence, which will be separated by the intron sequence.
3.3. Transcript assembly
Transcript assembly is the assembly of sequencing data into transcripts. For species with a reference genome, according to the results of the transcriptome comparison, the connection mode between the exons is clarified, thereby constructing the structure of the transcript. For transcriptome data without a reference genomic sequence, in order to obtain a complete transcript sequence, short reads obtained from RNA sequencing need to be assembled de novo. For transcriptome studies of non-parameter species, more sequencing data is often needed to meet the requirements of de novo assembly. The greater the amount of valid data for assembly, the better the number and completeness of the transcripts that are spliced, and the easier it is to detect transcripts with lower expression levels.
3.4. Transcript prediction
Most genes have multiple splicing forms and may produce multiple transcripts, thereby encoding different proteins, which may cause a gene to have multiple functions. After splicing and assembling the transcript sequencing data, not only will you get the known transcript information, but also new transcript sequences, you need to identify and annotate the new transcripts, especially the new ones that are less studied ncRNA transcript.
For species with reference genome and transcript reference information, the transcript structure is mainly based on sequencing to obtain reads for comparison. The reads cover all transcript sequences and rely on the genome sequence to assemble complete transcript information. For species without a reference genome, the transcript sequence of the gene needs to be assembled by itself. The obtained gene or transcript sequence can be compared with unigene and EST databases of the same species or near-source species to judge the reliability of the obtained gene or transcript sequence. In this process, the blast method is commonly used for comparison to quickly identify the similarity between sequences. In the identification and analysis of new lncRNA, transcripts with a total exon length of> 200 nt are extracted from the transcriptome data based on the characteristics of lncRNA molecules, and then predicted based on open reading frames and compared with known protein databases Further isolate lncRNA from mRNA.
3.5. The analysis of transcript expression levels
After comparing the reads to the corresponding genomic position or assembling the transcript from scratch, the number of reads on each gene or transcript can reflect the expression abundance to a certain extent. There may be significant differences in the total output of data between samples, the number of gene expressions between samples, the length of different genes in a sample, or even the distribution of different transcripts within the same gene. When comparing expression levels, you need to normalize the data between samples.
To be continued in Part III…
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The neurorehabilitation process makes a possible reduction in impairments and disabilities and eventually improves the life of the patient. Examples of neurorehabilitation devices are invasive stimulators, non-invasive stimulators, brain-computer interfaces, and neurorobotics, among others. Current rehabilitation is supported by advanced methods based on biofeedback, transcranial brain stimulation system, and BCI system. The prevalence of neurological diseases, rise in technological advancement, the emergence of robotic rehabilitation, and the effectiveness of gaming systems in neurorehabilitation are factors that are propelling the demand of the global neurorehabilitation devices market. However, the shortage of skilled personnel, the high cost of treatment, stringent government regulation may hamper the global neurorehabilitation devices market. IMPACT ON DEMAND Coronavirus disease (COVID-19) is an infectious disease caused by a SARS-CoV-2 virus, while a large pool of the population is affected by this COVID-19 virus. Coronavirus disease (COVID-19) causes acute respiratory illness ranges from mild to severe pneumonia with respiratory failure. In order to minimize the spread of COVID-19, nearly all the countries have taken action, such as the implementation of lockdown and social distancing restrictions. Neurorehabilitation is an important part of the recovery process that has undergone some brain injury. In the COVID-19 pandemic, various charities have worked effortlessly to provide treatment and support to patients suffering from brain injury. During the pandemic, the demand for neurorehabilitation devices was high, but companies were not able to supply the devices to end-users as various restrictions were imposed by the government, such as a travel ban, closed borders, among others. Due to affirmative restrictions, sudden shrink took place in various surgeries. Moreover, the decrease in the revenue of the key market players depicted in their quarterly results, such as Medtronic, among others, gave evidence of the decline in the demand for the medical device due to the emergence of the COVID-19 pandemic. For instance, · Medtronic reported a decline of 1% in its brain therapies net sales of the financial results of 2020 as compared to 2019. The reduction was largely motivated by the detrimental effects of the COVID-19 pandemic and the subsequent deferral to companies of medical procedures The decline in revenue of brain therapy suggests the detrimental effect of COVID 19 on the neurorehabilitation devices market and hence impacted the demand-supply concept. IMPACT ON PRICE Neurological rehabilitation is a program designed for the treatment of people suffering from a disorder or any injury in the nervous system. The devices include non-invasive brain stimulators, robotic neuro systems, brain-computer interfaces, and wearable devices, among others. Due to the pandemic, there is the delay associated with various types of limitations faced by the manufacturers to fulfill the end product order, which has resulted in the less availability of neurorehabilitation devices in the market and due to which the cost of available devices has increased with the several factors. Also, due to the coronavirus disease (COVID-19) pandemic outbreak, manufacturers are forced to find new contract manufacturers and suppliers for more manufacturing activities to different or new facilities locations that are less impacted by the outbreak. IMPACT ON SUPPLY CHAIN The consequences of COVID 19 cannot be underestimated. The product and service providers of neurorehabilitation have made efforts by providing services virtually to meet the demands as people were not frequently visiting the hospitals or clinics for the treatment. To manage such a critical situation, many organizations are looking forward to improving and diversifying the supply chain model in all aspects. Diversified supply chain model anticipated minimizing the export of medical devices as well as increase end-to-end visibility The COVID-19 pandemic has transformed many organizations’ business environments; supply availability has been hampered by a number of issues, including export and travel restrictions by some manufacturing countries and lockdowns that have forced suppliers to (temporarily) shut down. In various countries, neurorehabilitation units have reduced their number of beds, in-patients and out-patient neurorehabilitation centers are restricted to a particular area in order to tackle the pandemic situation STRATEGIC DECISIONS BY MANUFACTURERS As the reality of COVID-19 dawned upon the world, the manufactures and production units of the companies in the global neurorehabilitation devices market swiftly planned for strategies to cope with the effect of the crisis. Major players in the market took various initiatives to cope up with the situation. For instance, · In July 2020, Abbott announced that it had received FDA approval for the use of the Patient Controller App on compatible personal Apple smartphone devices. The approval will allow the patient living with neurological conditions to manage their therapy directly from the personal smartphone · In 2019, Mount Sinai Health System announced an innovative tele-neurorehabilitation program for stroke patients. This therapy can be taken by patients while at their homes with virtual backing from clinicians · In 2020, Esko Bionics Holdings, Inc. announced that it had received FDA 501(k) go-ahead to promote its EksoNRTM robotic exoskeleton for patients with acquired brain injury. It is cleared by FDA for spinal cord injury, stroke, or acquired brain injury rehabilitation These strategies helped the company in coping with the pandemic and ensure business operations, minimize the impact of COVID-19, and providing full support to the government in their efforts to combat the disease and help the front-line workers. CONCLUSION It can be concluded that the COVID-19 pandemic situation has an adverse impact on the market, affecting the price, supply, and demand of neurorehabilitation devices. However, in the crisis call, market players, government bodies, and healthcare organizations are work closely with healthcare professionals, customers, and patients for the betterment of public health. The increasing need of neurorehabilitation devices with increasing number of neurological diseases is expected to drive the market in coming years. The market is expected to decline due to increased restrictions imposed by various governments leading to the closing of non-emergent healthcare facilities, including procedures such as neurorehabilitation procedures.
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Impact of COVID-19 on Neural Implant in Healthcare Industry The COVID-19 pandemic has stood as a complex challenge in front of several healthcare companies and proved to be a global health threat. The first case of the COVID-19 pandemic was found in Wuhan, China. This virus had emerged in December 2019 and has been proven as a global pandemic by WHO in March 2020. Patients with other respiratory disorders such as Chronic Bronchitis, Lung Cancer, and Pneumonia are more susceptible to COVID-19. This pandemic has created a health crisis, and it has adversely affected our economies, healthcare and pharmaceutical sectors, and their core. As the number of COVID-19 (coronavirus) cases continues to rise in the U.S., Russia, France, and Brazil, life-threatening and rare brain diseases are being linked to the infection. This has brought companies in the brain implants market into the picture since their assistance is crucial in the already stressed healthcare facilities. Neural implant technology is highly innovative and is expected to influence the existing treatment modalities of neuropathic disorders and chronic neuropathic pain. The introduction of neural implants has been a significant breakthrough because of their high potential in minimizing the occurrence of adverse events associated with Parkinson's disease, chronic pain, epilepsy, and other neural disorders. Therefore, the adoption of neural implants is likely to increase at a phenomenal rate in the coming years. Healthcare professionals were often redeployed to emergency patterns of working, sometimes outside of their usual scope of practice. Thus, the urgent and routine care for millions of patients with non-COVID illnesses has been interrupted. IMPACT ON DEMAND The COVID-19 pandemic is expected to have a significant impact on the growth of the brain implants market globally, due to the suspension and postponement of most of the elective surgeries and treatment during the pandemic, to reserve the hospital infrastructure and staff in treating COVID-19, infected patients. According to the research article published in medRXiV, 2021, the prevalence of SARS-COV2 viral infection in patients with Parkinson's disease was found to be 11.28% and COVID-19 prevalence in Parkinson's disease patients with deep brain stimulation was found to be 18.18%. Additionally, as per the research study published in Frontiers in Neurology, 2020, the motor and psychiatric symptoms in Parkinson's Disease patients and dystonic patients treated with Deep Brain Stimulation was observed to have worsened during the lockdown restriction measure, and further, this had led to increased stress in the management of neurological disorders. Additionally, according to the research article published in JAMA Neurology, 2020, among 214 patients with COVID-19, neurologic symptoms were seen in 36.4% of patients. Thus, patients suffering from COVID-19 are prone to a high risk of developing neurological disorders during their hospital stays. Thus, owing to the strict lockdown restrictions and measures taken to contain the viral transmission, the chronic stress and burden of neurological disorders had increased, which required the urgent opening of the neurological outpatient services, and thus, the brain implants market is expected to have impacted significantly during the pandemic. The increase in the number of cases of neurological disorders, such as Alzheimer’s, epilepsy, Parkinson’s, depression, and essential tremors, is anticipated to propel the demand for brain implants. Brain implants are likely to reduce the need for drugs that relieve chronic pain and improve body movement in patients suffering from Parkinson’s or any other neurological disease. The growing geriatric population is also prone to order surgical disorders and thus, aging is the major factor that is driving the market growth for brain implants. According to the United Nations, World Population Ageing 2019 report, more than 703 million people were aged 65 years and above in 2019 and are expected to reaching 1.5 billion by 2050. IMPACT ON SUPPLY Due to the pertinacious COVID-19 lockdown in various countries, sanctions have been forced by administrations of different nations. These limitations and boundaries across the nation’s borders prompted a diminishing stockpile because of restricted materials and labor force and the halting of the assembly line. It has been found that certain individuals in their late ’50s are at risk of developing acute necrotizing encephalitis, which is a rare complication of influenza and other viral infections. This has fueled the growth of brain implants to maintain steady supply chains to meet the demand. Acute necrotizing encephalitis has the potential to cause seizures and confusion, and in serious cases, can lead to coma. This has triggered the need for developing strong research databases to address complications of COVID-19. STRATEGIC DECISIONS BY MANUFACTURERS The presence of key players in the region and the increasing number of product approvals is expected to drive the studied market growth. For instance, · In June 2020, US FDA approved Medtronic plc's Percept deep brain stimulation (DBS) for the treatment of Parkinson’s symptoms. The major market players are focusing on technological advancement to acquire maximum market share. For instance, · In January 2021, Abbott Laboratories launched its NeuroSphere my Path, a Digital Health app that was developed to track and report on pain relief in chronic pain patients and general well-being associated with spinal cord stimulation (SCS) or dorsal root ganglion (DRG) therapy. · In March 2021, Abbott Laboratories announced the launch of NeuroSphere Virtual Clinic, which is a remote neuromodulation patient-care technology in the United States. · In March 2020, LivaNova plc received CE Mark approval for its Vagus Nerve Stimulation Therapy (VNS Therapy) System, "Symmetry", for Difficult-to-Treat Depression (DTD). · BrainCom— a collaborative research project that aims to develop a new generation of neuroprosthetic devices is being funded by the European Union under the FET Proactive funding scheme to advance speech neural prostheses. Companies in the brain implants market are increasing the availability of solutions for people suffering from motor diseases and neurological conditions. Such implants are bolstering market growth, as they have the potential to eliminate the need for open brain surgeries. · Dell Technologies— a U.S. multinational computer technology company is gaining strong business grounds in transformative technologies for brain implants by collaborating with think tanks and neuroscientists. In June 2018, Medtronic plc announced that the US Food and Drug Administration approved Deep Brain Stimulation (DBS) Clinician Programmer and Activa(TM) Programming Application. The Activa Programming Application has been uniquely designed with the input of over a hundred clinicians from around the world and is managed on the Samsung Galaxy Tab S2 tablet interface. In February 2016, ALEVA NEUROTHERAPEUTICS SA announced a collaboration with Greatbatch for a next-generation device for Deep Brain Stimulation (DBS). Under the terms of the development agreement, Greatbatch’s design and development team QiG Group, which is expected to be spun off as Nuvectra Corporation, will provide Aleva with access to its unique implantable neurostimulation platform. Companies in the brain implants market are increasing the availability of less invasive solutions since the brain is one of the most delicate and sensitive body organs. They are decoding the symphony of neural activity to stimulate brain function. CONCLUSION Since the COVID-19 virus outbreak in December 2019, the disease has spread to almost every country around the globe with the World Health Organization declaring it a public health emergency. The global impacts of the coronavirus disease 2019 (COVID-19) are already starting to be felt, and will significantly affect the Brain Implants market in 2020.
What is a Rangefinder
If you need to know the distance you need a rangefinder. Rangefinders have been available for years and have worked in various ways. While most modern day rangefinders that are available to the public are categorized as being a laser rangefinder, they have also used sonar (sound) and radar. For now, lets focus on the laser rangefinder and the different purposes for which it can be used. The basic purpose of a rangefinder is to show you the distance from where the rangefinder is located to an object of some distance. They are used for such purposes as surveying, hunting and golfing but they also find a purpose in many other activities. The laser rangefinder works by sending out a beam of light and measuring the time it takes that light to reflect back to itself. It then can calculate from that round trip time how far away that object is. Typically, most hand held rangefinders have an effective range that varies from 400 to 1500 yards, depending on the type of rangefinder you purchase. Other factors that would affect the accuracy and range of a rangefinder are weather and atmospheric conditions as well as the reflectivity of the object being used to reflect the light. For most purposes it is fine for there to be some variation of a few feet or even several yards, but for other applications there is a need for great accuracy, as is the case of land surveying. Two of the most popular uses for rangefinders are hunting and golfing. Because each of these sports require a proper distance measurement in order to be accurate when aiming for the target, the rangefinder finds it's way into many golfer and hunters bag. Of course there are many different options to choose from when you are looking to purchase a rangefinder and they even have some that are sport specific. In this way you can easily find one that will contain many of the most popular options bundled in for the sport of your choice. It isn't always necessary to have a rangefinder to be good at your sport, but it is a tool that is not easy to get along without once you get used to using it. So when distance really counts, a rangefinder will give you what you need.
Online Education Degree Choices
When it comes to online education degree choices, the good news is that there are some fantastic options available to you. Online education has opened the doors for many individuals who are looking for a way to further their education and to still remain active in their lives. If you do not have time to go back to school in the traditional method, you may have the time to do so while exploring online education degree choices. What can you learn in these programs? You might be impressed that there are so many specialized as well as general options available to you in this form of education. Consider the following, which is only a very small list of choices that you may have. • Business management specializations in areas such as accounting, general business, strategy and innovation and organization and management • Health care specialization including tpm edblog nursing education, general counselor education, information technology, social and community services, finance, marketing, evaluation, human services • Higher education specializations such as educational leadership and management, instructional design, special education leadership, post secondary and adult education, curriculum and instruction • Human Capital Management Specializations such as organization and management leaderships, leadership coaching, human resource management, management of nonprofit agencies • Information technology specializations such as in information assurance and security, project management, general information technology, software architecture, health informatics • Education specialization K through 12 such as curriculum and instruction, leadership in educational administration, instructional design, early childhood education, sport psychology and educational psychology • Mental health specializations such as general counselor education and supervision, training and performance improvement and professional studies in education These are just some of the options you have in online education degree choices. Students can find online programs for virtually any type of educational goal they have through an online education degree.
Is A Breast Lift Right For You?
Our body ages as time passes. Breasts lose volume and fullness. They droop and make you self-conscious as a result of these changes. Continue reading to learn everything you need to know about a breast lift and the benefits you can expect. What Does a Breast Lift Entail? The breasts are lifted and firmed during a breast lift surgery. A lollipop incision is ideal for breasts that require a minimal bit of lift. If only the areola and nipple need to be elevated, a single incision around the areola can be used to obtain the desired effects. If your nipples and areola are below the level of the inframammary crease, you'll need a third incision to see results. Breast Lift Advantages A breast lift has numerous physical and psychological advantages. After significant weight gain or loss, many women notice that their breasts alter shape and sag. A breast lift can boost your self-esteem, which can improve your quality of life. Let's have a look at some of the physical advantages. Physical Advantages A breast lift has various physical advantages. Without augmentation, a breast lift can give you a larger appearance. This is due to the fact that the surgery makes your breasts appear firmer and larger. You can achieve a more youthful, renewed appearance by elevating your breasts. You can enjoy the results of your weight loss and feel proud of your successes and newly better physique by removing stretched out, superfluous, flabby skin and altering the location of the nipple. Is It True That I'm a Good Candidate? Your medical history will be reviewed by a cosmetic surgeon to evaluate if you are a good candidate for a breast lift. If your nipple and areola are located beneath the inframammary fold or the crease beneath your breast, you may be a suitable candidate for a breast lift. If your nipples appear to be pointing downward and you want them to face forward, you may benefit from a breast lift. Many women who have breast lifts are unhappy with how their breasts seem when they wear a bra. In a bra, a breast raise can make your breasts appear rounder, fuller, and more attractive. It can also treat asymmetry or a tuberous appearance of the breasts that may have developed since puberty or as a result of breastfeeding. If you're unhappy with the size of your breasts after your breast lift, talk to your doctor about a breast reduction or breast augmentation with fat. What Should I Anticipate? It will take a few months for your newly shaped breasts to settle into place after your breast lift. The benefits, on the other hand, are long-lasting. Your body will continue to age and be affected by gravity, but you will be able to enjoy the results of your treatment for decades. It is safe to nurse after a breast lift, although childbearing, breastfeeding, or gaining a lot of weight can make the treatment less effective. Maintain an active lifestyle and a healthy weight for the greatest outcomes.
[October-2021]Braindump2go New PL-900 PDF and VCE Dumps Free Share(Q179-Q195)
QUESTION 179 A company builds and sells residential apartments. The company uses Dynamics 365 Sales to manage sales opportunities. Management must receive notifications on their mobile devices when sales opportunities are created. You need to recommend the appropriate Power Platform components to address the requirements. Which two components should you recommend to invoke the notification process? Each correct answer presents part of the solution. NOTE: Each selection is worth one point. A.AI Builder B.Power Automate C.Common Data Service connector D.Power BI Answer: BC QUESTION 180 Hotspot Question You are creating a number of Power Automate flows. You need to select the triggers for the flows. Which flow types should you use? To answer, select the appropriate options in the answer area. NOTE: Each correct selection is worth one point. Answer: QUESTION 181 A company is building an interactive chatbot to answer questions about product and product warranties. You need to create conversation paths for questions about product warranties. Which tool should you use? A.Authoring canvas B.Azure Bot Framework C.Power Platform admin center D.Power Virtual Agents portal E.Conversation node Answer: D QUESTION 182 Hotspot Question You are developing a Power Virtual Agents chatbot for a company. For each of the following statements, select Yes if the statement is true. Otherwise, select No. NOTE: Each correct selection is worth one point. Answer: QUESTION 183 You are building a Power Virtual Agents chatbot for a company. You are working with an existing topic and would like to call an action. Which technology is available to perform the action? A.Power Virtual Agent Entity B.Power BI C.Power Apps D.Power Automate Answer: D QUESTION 184 A company uses Power Platform. You must ensure that users cannot share customer data with other users. You must also ensure that uses cannot connect to data sources unless you grant the user explicit permissions to access a data source. You need to recommend solutions to meet the company's security requirements. Which two types of policies should you recommend? Each correct answer presents part of the solution. NOTE: Each correct selection is worth one point. A.Office cloud policies B.Group Policy Objects C.environment-level policies D.tenant-level policies E.preset security policies Answer: CD QUESTION 185 You create a Power Virtual Agents chatbot. You need to share the bot with other team members so that they can try out the bot before you share the bot with customers. What should you use? A.demo website B.live production website C.test chat feature Answer: C QUESTION 186 You create a Power Bl dashboard that displays Common Data Model data. You need to share the Power Bl dashboard with coworkers and allow the coworkers to collaborate. What are two possible ways to achieve the goal? Each correct answer presents a complete solution. NOTE: Each correct selection is worth one point. A.Create a Power Automate flow to export the data into a SQL Server database. B.Publish the dashboard as an app to your coworkers. C.Export the data to Microsoft Excel. Make required changes and then re-import the data. D.Create a Power Bl workspace and grant coworkers permissions. Answer: AB QUESTION 187 You are a district manager for a large retail organization. You train each store manager to use Power BI to track sales and daily sales targets. A store manager remembers learning about the Analyze in Excel option but cannot find the option in their Power BI dashboard. You need to help the user resolve the issue. How should you advise the user? A.Install the Power Bl Desktop app. B.Navigate to the report used by the dashboard. C.Select the Spotlight button on the dashboard tile. D.Subscribe to the dashboard and follow the email link. Answer: B QUESTION 188 You are creating visuals in Power BI. You create area charts, pie charts, and donut charts that use your company's data. You need to display the charts to others at the company. Which two objects can you add the charts to? Each correct answer presents a complete solution. NOTE: Each correct selection is worth one point. A.Power Bl service B.Power Bl reports C.Power Bl desktop D.Power Bl dashboards Answer: BD QUESTION 189 You create a Power App portal. When a user signs into the portal the following error displays: user not found You confirm that the user's sign in information is correct. You need to determine the cause of the error. What should you do? A.Disable custom error messages. B.Create a custom error message. C.Enable diagnostic tools in Lifecycle Services. D.Enable Maintenance mode. Answer: C QUESTION 190 You create a canvas app that allows contractors to submit time they work against a project. Contractors must be able to use the canvas app to enter time. Contractors must not be able to perform any other actions in the app. You need to configure permissions for the contractors. Which type of permissions should you use? A.application-level B.task-level C.record-level D.field-level Answer: D QUESTION 191 Hotspot Question You have version 1.0.0.0 of a published Power Apps app. You create and publish version 2.0.0.0 of the app. A customer goes through the process of restoring the previous version of the app. How many versions of the app are displayed in the Version tab for the app? To answer, select the appropriate option in the answer area. Answer: QUESTION 192 Drag and Drop Question A company has locations in multiple regions. The company develops solutions based on Power Apps and Power Automate. You need to recommend features to support the implementation. Which Power Platform features should you recommend? To answer, drag the appropriate features to the correct requirements. Each feature may be used once, more than once, or not at all. You may need to drag the split bar between panes or scroll to view content. NOTE: Each correct selection is worth one point. Answer: QUESTION 193 Drag and Drop Question A travel company plans to use the Power Platform to create tools that help travel agents book customer travel. You need to recommend solutions for the company. What should you recommend? To answer, drag the appropriate tools to the correct requirements. Each tool may be used once, more than once, or not at all. You may need to drag the split bar between panes or scroll to view content. NOTE: Each correct selection is worth one point. Answer: QUESTION 194 Drag and Drop Question A manufacturing company is evaluating Al Builder. You need to select Al Builder models to address specified requirements. Which model types should you use? To answer, drag the appropriate model types to the correct requirements. Each model type may be used once, more than once, or not at all. You may need to drag the split bar between panes or scroll to view content. NOTE: Each correct selection is worth one point. Answer: QUESTION 195 Hotspot Question You are planning to use the Business Card Reader and Sentiment Analysis prebuilt AI models to build solutions. For each of the following statements, select Yes if the statement is true. Otherwise, select No. NOTE: Each correct selection is worth one point. Answer: 2021 Latest Braindump2go PL-900 PDF and PL-900 VCE Dumps Free Share: https://drive.google.com/drive/folders/1IOmmERLjCXhozbt-Vq8PQdAbCPhQMXPo?usp=sharing
Breast Reduction Surgery - Health Benefits And How To Know If You Need One
Although many women seek breast augmentation to increase their size by a cup size or two, just as many women seek breast reduction to reduce their size by a size or two. Besides this, breast reduction surgery has a variety of health benefits. Although many women are aware that breast reduction surgery is an option, they are unaware that breast reduction may be able to help them with some of their health problems. What Is The Problem? Many women who have large breasts endure pain in many parts of their bodies. The proportions of the body are frequently distorted by large breasts. This imbalance can put tension on various muscles and joints. With age, this becomes more difficult. The weight of the breasts pulls the shoulders forward naturally. Nerve fibres may be squeezed as a result of this. Women may have nagging, continuous discomfort as a result of the compression of nerves. What Are the Benefits of Breast Reduction? Breast reduction surgery can reduce the size and contour of the breasts, reducing the tension on the back muscles and spinal column. Many women see a reduction in back and even hip pain once they lose weight. Many women report a boost in self-confidence in addition to the physical benefits of breast reduction surgery. Many people believe that only small-breasted women have body concerns, but this is not true. Women with abnormally large breasts also have insecurities about their bodies. Having the physique of your dreams might help you gain the self-confidence you've always desired. Following their surgery, many ladies discover that they can finally exercise the way they've always wanted to. Because the weight of the breasts makes it difficult to move in certain directions, a woman's ability to work out as she likes may be hampered. How Do I Know Whether I Need a Breast Reduction? Consider breast reduction surgery if your breasts are large and they make you feel insecure. You may also have physical symptoms such as shoulder pain caused by your bra straps, which is a result of the bra supporting too much weight. Back and neck ache are additional symptoms that your body is trying to sustain your breasts' weight. Numbness in the hands and fingers, as well as headaches and, in severe cases, shortness of breath, have been reported by some women. Is Breast Reduction Surgery a Good Option for Me? Most women who are in good health are good candidates for breast reduction. There are a few things that could prevent you from having this surgery done. Schedule a consultation your plastic surgeon to see whether you're a good fit. Obtain started today by booking your consultation if you're ready to get the physique you've always wanted, relieve discomfort, and enhance your health.
How COVID-19 Impacted on Nivolumab in Healthcare Industry ?
Impact of COVID-19 on Nivolumab in Healthcare Industry COVID-19 (Coronavirus) has affected the day-to-day life of people and has slowed down the economies worldwide. The pandemic has affected millions of people who either got sick or died due to the spread of this disease. Within a few months, coronavirus disease (COVID-19), which originated from China, became a pandemic, with more than 30 million people being infected till date. There are now numerous vaccines in use. The first mass vaccination program commenced in early December 2020, and as of 15 February 2021, 175.3 million vaccine doses have been administered. There is an added complexity because of COVID-19 diagnosis in cancer patients, particularly while on active treatment with immunotherapy like nivolumab. COVID-19 could cause more harm to cancer patients. In order to prevent the infection from spreading, the patient’s number and new diagnosis have been less during the COVID 19. The COVID-19 pandemic has led to a dramatic loss of human life worldwide and presents an unprecedented challenge to public health, food systems, and the world of work. Still, there is an increase in the demand for cancer treatment with immunotherapy drugs like nivolumab during the second quarter of 2020 with the rise in awareness regarding health and new product launches in countries. STRATEGIC DECISIONS BY MANUFACTURERS To deal with the COVID-19 outbreak challenges and increasing demand for the drugs, many market players are creating new strategies such as new product development, telemedicine, and a different program to support patients and to raise their sales. It is predicted that these strategies are anticipated to escalate up the company revenue and its growth in the forecasted period. The government has provided drug FDA approvals of nivolumab for the treatment of cancer. For instance, · In May 2020, Bristol Myers Company announced that Opdivo (nivolumab) 3 mg/kg plus Yervoy (ipilimumab) 1 mg/kg (injections for intravenous use) was approved by the U.S. Food and Drug Administration (FDA) for the first-line treatment of adult patients with metastatic non-small cell lung cancer (NSCLC). · There are several ongoing potentially registrational studies that have been conducted by different manufacturing companies for Opdivo for the treatment of different tumor types and disease areas, in combination with various anti-cancer agents · Also, there are various ongoing clinical trials conducting on nivolumab with the combination of various anti-cancer agents and others to treat various types of cancer to decrease the demand for cancer treatment and to provide patients with more advanced drugs. For instance · In Japan, South Korea, and Taiwan, ONO pharmaceuticals are co-developing this drug nivolumab with the Bristol Myers Company IMPACT ON DEMAND Global economic development in 2020 has been severely impacted by the COVID-19 pandemic. The COVID-19 has given rise to risks such as a prolonged, significant decline in global demand as well as unfavorable geopolitical and macroeconomic effects. The coronavirus pandemic has provoked many strategical actions among healthcare providers on how to manage cancer patients when faced with the threat of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection. There has been a decrease in demand for nivolumab in some countries like the U.S., whereas many countries have seen an increase in sales with the rise in demand for the treatment and new cancer patients. With the rise in demand for the drug, FDA has provided approval to various drugs related to the immunotherapy nivolumab. For instance- · For the Bristol-Myers Squibb Company, the U.S. revenues of nivolumab decreased to 9% in 2020 due to lower demand caused by declining second-line eligibility across tumor indications and lower demand from COVID-19 (primarily lower new patient starts and patient visits). The U.S. has seen a decrease in sales in the first quarter of 2020. · However, the international revenues for nivolumab were increased up to 7% in 2020 due to higher demand as a result of additional indication launches in some countries with rising cancer patients globally. · In May 2021 -- Bristol-Myers Squibb Company has today announced that the U.S. Food and Drug Administration (FDA) had approved their Opdivo (nivolumab, injection for intravenous use) for the adjuvant treatment of completely resected esophageal or gastroesophageal junction (GEJ) cancer. · Similarly, FDA has approved Opdivo (nivolumab) for treating different types of cancer in many countries via various market players due to the rise in demand for this drug. IMPACT ON PRICE COVID-19 is significantly decreasing commercial activity in every area of the business sector. The economy has been decreased during the pandemic with the restricted and disrupted supply and sales of products and devices. The cost of medication and treatment of nivolumab has been increased due to the increasing demand for this drug during COVID-19. This contributed to the increased expenses and prices of immunotherapy drugs. Changes in the economy and other factors have caused consequences, including the decrease in the sales of the drug in some countries such as the U.S. With the rise of COVID-19 and decrease in new patients has also contributed to the increased cost and priced of some products and medication. · The price of Opdivo (nivolumab) drug which is a most common therapy treatment for various type of cancer or tumor have been increased to USD 1,172 for a supply of 4 milliliters of injection in 2020 with the rise in demand and increasing patients population in the second quarter of 2020. IMPACT ON SUPPLY CHAIN The COVID-19 pandemic has transformed many organizations’ business environments; supply availability has been hampered by a number of issues, including export and travel restrictions by some producing countries, and the lockdown has forced suppliers to (temporarily) shut down. The supply of nivolumab medication has a slight decrease in sales during the first quarter of 2020, partly due to negative factors mentioned above in connection with the COVID-19 pandemic, which particularly didn’t affect the overall yearly revenue. The pandemic and COVID-19 have affected every business activity in which the supply chain was affected the most. Because of the pertinacious COVID-19 lockdown, sanctions have been forced by administrations of different nations. These limitations and boundaries across the nation’s borders prompted a diminishing stockpile because of restricted materials and labor force and the halting of the assembly line. The supply chain and demand were positively affected by the COVID 19. The sales and supply of the drugs have been increased with the rise in demand for the drugs and diagnosis. Many major manufacturing companies have launched their drugs in different countries to fulfill the demand, and the government has provided approval for the sales of the drug nivolumab. For instance- Despite the pandemic, many market player of nivolumab has increased their sales globally. This is due to the ongoing increase in the patient population and rising awareness regarding their health. · The sales of ONO pharmaceuticals have been increased in the year 2020 as compared to 2019, which is 2656.05 USD Million in 2019 and 2809.23 USD million. · Similarly, sales of the drug Opdivo (Nivolumab) from the manufacturing company Bristol Myers Squibb Company have been increased globally (except the U.S.) from USD 2,860 million in 2019 to USD 3,047 million in 2020. This increase in sales in both of the major market players is due to the increase in cancer patients and the use of drugs in all areas of cancer. There is an increase in the sales of this nivolumab with the rise in prevalence of disease and early diagnosis & treatment. CONCLUSION As the pandemic of COVID-19 resulted in several restrictions throughout the borders, still, manufacturers and market players were able to manage their sales and revenue of oncology and drug nivolumab. Various manufacturers allowed their workers to work in a clean and safe environment so as to boost up the production at various manufacturing facilities across several regions of the world, thus, helping them to maintain a continuous supply chain with the increasing demand. Market players have come up with better strategies which have also created a positive impact on the growth of the nivolumab market globally.
Fioricet Medication - Should Know About
Fioricet is a pain killer and it consists of acetaminophen, caffeine, and Butalbital. These components contribute to relaxing muscles, improving blood pressure, and relieving pain and high body temperature. This drug usually helps people calm moderate to severe medical conditions like tension headaches, fever, muscle contractions, etc. Uses of Fioricet Take Fioricet only by the advice of a physician. Make sure you have a prescription that is required to buy Fioricet 40mg online overnight or offline. Always follow the directions on the label and make it a habit while consuming any kind of medicinal formula. Take a note of your dosage as prescribed by your doctor. The overdose side effects might occur due to carelessness in the consumption of Fioricet. Keep your doctor posted about the changes in your body related to the reaction towards the medication. Do not share your medicine with anyone, especially someone with a drug abuse history. This medication isn’t supposed to be taken without the advice and the prescription of a doctor. Though you can buy Fioricet online. Keep it in a safe place and make sure to keep a track of the contents. Selling or giving out Fioricet without a prescription is illegal in many parts of the world. In case the drug upsets your stomach, ingest it with light food. Store it in a dry, well-lit area at room temperature. In case of a missed dose, do not consume double doses to make it up for a missed dose.   Precautions for Consumption Since this medication can make you feel drowsy, you can avoid doing things that require alertness. Try resting for a couple of hours and then doing whatever you feel like. Avoid alcohol as it can magnify the effects of the medication and it can also severely harm your liver. Certain medical combinations can react together and cause harm to the patient’s body so it is advisable to monitor if you are taking any other medication for cold or pain etc.  Inform your doctor and educate yourself on it. Avoid taking medications with APAP in them. Avoid caffeine pills, or ADHD-related medications, etc. while consuming Fioricet. Exercise caution if you suffer from hepatitis, porphyria, cardiovascular diseases, or anaemia. Though very rare, there are chances of severe skin allergies in patients due to Acetaminophen. Make sure your doctors are always updated with your medical condition and your response to certain medications. This way it will be easier to predict any upcoming progress in your condition. If there is a special risk patient like a senior citizen or a pregnant woman, caution should be taken if Fioricet is prescribed to them. Because the effects can be different in senior citizens and can be transferred to the unborn child in the case of pregnant women. Breastfeeding women also need to take care of this as the contents of the medication can be transferred to the child. Side Effects Even though Fioricet is quite a safe medication and has proven to be life-changing many times in medical history. But being a medication, it is bound to have some chemical side effects. A doctor always prescribes a medication keeping at par the risks of side effects.  Some of the side effects of Fioricet are- swelling in body parts, hives, unusual colored urine, rashes, vomiting, palpitations, drowsiness, nausea, etc. in case, there is any serious condition, you should immediately contact a doctor. Contact your doctor right away if, you observe any of the symptoms for instance- mood swings, palpitations, seizures, etc. even though serious allergic reactions are rare with the consumption of Fioricet, but in any case, if you observe rashes, swollen body parts, drowsiness, itching, etc. after the ingestion of the medication rush for medical help do not try to treat such situations on your own. Every drug has different reactions in different bodies, so if you feel uncanny and uncomfortable, see a doctor. Conclusion Patients can easily buy Fioricet online overnight fast shipping in USA,and make the best use of it, only when properly monitored and handled. Fioricet has changed lives, but only when properly utilized. So, make sure you know well about the medication before consuming it and make sure your health is in safe hands with Fioricet. ORIGINAL SOURCE: What All Should One Know About- Fioricet
[October-2021]Braindump2go New SAA-C02 PDF and VCE Dumps Free Share(Q724-Q745)
QUESTION 724 A company is building a new furniture inventory application. The company has deployed the application on a fleet of Amazon EC2 instances across multiple Availability Zones. The EC2 instances run behind an Application Load Balancer (ALB) in their VPC. A solutions architect has observed that incoming traffic seems to favor one EC2 instance resulting in latency for some requests. What should the solutions architect do to resolve this issue? A.Disable session affinity (sticky sessions) on the ALB B.Replace the ALB with a Network Load Balancer C.increase the number of EC2 instances in each Availability Zone D.Adjust the frequency of the health checks on the ALB's target group Answer: B QUESTION 725 A startup company is using me AWS Cloud to develop a traffic control monitoring system for a large city. The system must be highly available and must provide near-real-time results for residents and city officials even during peak events. Gigabytes of data will come in daily from loT devices that run at intersections and freeway ramps across the city. The system must process the data sequentially to provide the correct timeline. However results need to show only what has happened in the last 24 hours. Which solution will meet these requirements MOST cost-effectively? A.Deploy Amazon Kinesis Data Firehose to accept incoming data from the loT devices and write the data to Amazon S3 Build a web dashboard to display the data from the last 24 hours B.Deploy an Amazon API Gateway API endpoint and an AWS Lambda function to process incoming data from the loT devices and store the data in Amazon DynamoDB Build a web dashboard to display the data from the last 24 hours C.Deploy an Amazon API Gateway API endpoint and an Amazon Simple Notification Service (Amazon SNS) tope to process incoming data from the loT devices Write the data to Amazon Redshift Build a web dashboard to display the data from the last 24 hours D.Deploy an Amazon Simple Queue Service (Amazon SOS) FIFO queue and an AWS Lambda function to process incoming data from the loT devices and store the data in an Amazon RDS DB instance Build a web dashboard to display the data from the last 24 hours Answer: D QUESTION 726 A company has designed an application where users provide small sets of textual data by calling a public API. The application runs on AWS and includes a public Amazon API Gateway API that forwards requests to an AWS Lambda function for processing. The Lambda function then writes the data to an Amazon Aurora Serverless database for consumption. The company is concerned that it could lose some user data it a Lambda function fails to process the request property or reaches a concurrency limit. What should a solutions architect recommend to resolve this concern? A.Split the existing Lambda function into two Lambda functions Configure one function to receive API Gateway requests and put relevant items into Amazon Simple Queue Service (Amazon SQS) Configure the other function to read items from Amazon SQS and save the data into Aurora B.Configure the Lambda function to receive API Gateway requests and write relevant items to Amazon ElastiCache Configure ElastiCache to save the data into Aurora C.Increase the memory for the Lambda function Configure Aurora to use the Multi-AZ feature D.Split the existing Lambda function into two Lambda functions Configure one function to receive API Gateway requests and put relevant items into Amazon Simple Notification Service (Amazon SNS) Configure the other function to read items from Amazon SNS and save the data into Aurora Answer: A QUESTION 727 A developer has a script lo generate daily reports that users previously ran manually. The script consistently completes in under 10 minutes. The developer needs to automate this process in a cost-effective manner. Which combination of services should the developer use? (Select TWO.) A.AWS Lambda B.AWS CloudTrail C.Cron on an Amazon EC2 instance D.Amazon EC2 On-Demand Instance with user data E.Amazon EventBridge (Amazon CloudWatch Events) Answer: CE QUESTION 728 A solution architect is creating a new Amazon CloudFront distribution for an application. Some of Ine information submitted by users is sensitive. The application uses HTTPS but needs another layer" of security. The sensitive information should be protected throughout the entire application stack end access to the information should be restricted to certain applications. Which action should the solutions architect take? A.Configure a CloudFront signed URL B.Configure a CloudFront signed cookie. C.Configure a CloudFront field-level encryption profile D.Configure CloudFront and set the Origin Protocol Policy setting to HTTPS Only for the Viewer Protocol Policy Answer: C QUESTION 729 A company has an Amazon S3 bucket that contains confidential information in its production AWS account. The company has turned on AWS CloudTrail for the account. The account sends a copy of its logs to Amazon CloudWatch Logs. The company has configured the S3 bucket to log read and write data events. A company auditor discovers that some objects in the S3 bucket have been deleted. A solutions architect must provide the auditor with information about who deleted the objects. What should the solutions architect do to provide this information? A.Create a CloudWatch Logs fitter to extract the S3 write API calls against the S3 bucket B.Query the CloudTrail togs with Amazon Athena to identify the S3 write API calls against the S3 bucket C.Use AWS Trusted Advisor to perform security checks for S3 write API calls that deleted the content D.Use AWS Config to track configuration changes on the S3 bucket Use these details to track the S3 write API calls that deleted the content Answer: B QUESTION 730 A company has three AWS accounts Management Development and Production. These accounts use AWS services only in the us-east-1 Region. All accounts have a VPC with VPC Flow Logs configured to publish data to an Amazon S3 bucket in each separate account. For compliance reasons the company needs an ongoing method to aggregate all the VPC flow logs across all accounts into one destination S3 bucket in the Management account. What should a solutions architect do to meet these requirements with the LEAST operational overhead? A.Add S3 Same-Region Replication rules in each S3 bucket that stores VPC flow logs to replicate objects to the destination S3 bucket Configure the destination S3 bucket to allow objects to be received from the S3 buckets in other accounts B.Set up an IAM user in the Management account Grant permissions to the IAM user to access the S3 buckets that contain the VPC flow logs Run the aws s3 sync command in the AWS CLl to copy the objects to the destination S3 bucket C.Use an S3 inventory report to specify which objects in the S3 buckets to copy Perform an S3 batch operation to copy the objects into the destination S3 bucket in the Management account with a single request. D.Create an AWS Lambda function in the Management account Grant S3 GET permissions on the source S3 buckets Grant S3 PUT permissions on the destination S3 bucket Configure the function to invoke when objects are loaded in the source S3 buckets Answer: A QUESTION 731 A company is running a multi-tier web application on AWS. The application runs its database on Amazon Aurora MySQL. The application and database tiers are in the us-easily Region. A database administrator who monitors the Aurora DB cluster finds that an intermittent increase in read traffic is creating high CPU utilization on the read replica. The result is increased read latency for the application. The memory and disk utilization of the DB instance are stable throughout the event of increased latency. What should a solutions architect do to improve the read scalability? A.Reboot the DB cluster B.Create a cross-Region read replica C.Configure Aurora Auto Scaling for the read replica D.Increase the provisioned read IOPS for the DB instance Answer: B QUESTION 732 A developer is creating an AWS Lambda function to perform dynamic updates to a database when an item is added to an Amazon Simple Queue Service (Amazon SOS) queue. A solutions architect must recommend a solution that tracks any usage of database credentials in AWS CloudTrail. The solution also must provide auditing capabilities. Which solution will meet these requirements? A.Store the encrypted credentials in a Lambda environment variable B.Create an Amazon DynamoDB table to store the credentials Encrypt the table C.Store the credentials as a secure string in AWS Systems Manager Parameter Store D.Use an AWS Key Management Service (AWS KMS) key store to store the credentials Answer: D QUESTION 733 A company has a service that reads and writes large amounts of data from an Amazon S3 bucket in the same AWS Region. The service is deployed on Amazon EC2 instances within the private subnet of a VPC. The service communicates with Amazon S3 over a NAT gateway in the public subnet. However, the company wants a solution that will reduce the data output costs. Which solution will meet these requirements MOST cost-effectively? A.Provision a dedicated EC2 NAT instance in the public subnet. Configure the route table for the private subnet to use the elastic network interface of this instance as the destination for all S3 traffic B.Provision a dedicated EC2 NAT instance in the private subnet. Configure the route table for the public subnet to use the elastic network interface of this instance as the destination for all S3 traffic. C.Provision a VPC gateway endpoint. Configure the route table for the private subnet to use the gateway endpoint as the route for all S3 traffic. D.Provision a second NAT gateway. Configure the route table foe the private subnet to use this NAT gateway as the destination for all S3 traffic. Answer: C QUESTION 734 A company has an application that uses an Amazon OynamoDB table lew storage. A solutions architect discovers that many requests to the table are not returning the latest data. The company's users have not reported any other issues with database performance Latency is in an acceptable range. Which design change should the solutions architect recommend? A.Add read replicas to the table. B.Use a global secondary index (GSI). C.Request strongly consistent reads for the table D.Request eventually consistent reads for the table. Answer: C QUESTION 735 A company wants lo share data that is collected from sell-driving cars with the automobile community. The data will be made available from within an Amazon S3 bucket. The company wants to minimize its cost of making this data available to other AWS accounts. What should a solutions architect do to accomplish this goal? A.Create an S3 VPC endpoint for the bucket. B.Configure the S3 bucket to be a Requester Pays bucket. C.Create an Amazon CloudFront distribution in front of the S3 bucket. D.Require that the fries be accessible only with the use of the BitTorrent protocol. Answer: A QUESTION 736 A company recently announced the deployment of its retail website to a global audience. The website runs on multiple Amazon EC2 instances behind an Elastic Load Balancer. The instances run in an Auto Scaling group across multiple Availability Zones. The company wants to provide its customers with different versions of content based on the devices that the customers use to access the website. Which combination of actions should a solutions architect take to meet these requirements7 (Select TWO.) A.Configure Amazon CloudFront to cache multiple versions of the content. B.Configure a host header in a Network Load Balancer to forward traffic to different instances. C.Configure a Lambda@Edge function to send specific objects to users based on the User-Agent header. D.Configure AWS Global Accelerator. Forward requests to a Network Load Balancer (NLB). Configure the NLB to set up host-based routing to different EC2 instances. E.Configure AWS Global Accelerator. Forward requests to a Network Load Balancer (NLB). Configure the NLB to set up path-based routing to different EC2 instances. Answer: BD QUESTION 737 A company has developed a new content-sharing application that runs on Amazon Elastic Container Service (Amazon ECS). The application runs on Amazon Linux Docker tasks that use the Amazon EC2 launch type. The application requires a storage solution that has the following characteristics: - Accessibility (or multiple ECS tasks through bind mounts - Resiliency across Availability Zones - Burslable throughput of up to 3 Gbps - Ability to be scaled up over time Which storage solution meets these requirements? A.Launch an Amazon FSx for Windows File Server Multi-AZ instance. Configure the ECS task definitions to mount the Amazon FSx instance volume at launch. B.Launch an Amazon Elastic File System (Amazon EFS) instance. Configure the ECS task definitions to mount the EFS Instance volume at launch. C.Create a Provisioned IOPS SSD (io2) Amazon Elastic Block Store (Amazon EBS) volume with Multi-Attach set to enabled. Attach the EBS volume to the ECS EC2 instance Configure ECS task definitions to mount the EBS instance volume at launch. D.Launch an EC2 instance with several Provisioned IOPS SSD (io2) Amazon Elastic Block Store (Amazon EBS) volumes attached m a RAID 0 configuration. Configure the EC2 instance as an NFS storage server. Configure ECS task definitions to mount the volumes at launch. Answer: B QUESTION 738 An airline that is based in the United States provides services for routes in North America and Europe. The airline is developing a new read-intensive application that customers can use to find flights on either continent. The application requires strong read consistency and needs scalable database capacity to accommodate changes in user demand. The airline needs the database service to synchronize with the least possible latency between the two continents and to provide a simple failover mechanism to a second AWS Region. Which solution will meet these requirements? A.Deploy Microsoft SQL Server on Amazon EC2 instances in a Region in North America. Use SOL Server binary log replication on an EC2 instance in a Region in Europe. B.Create an Amazon DynamoDB global table Add a Region from North America and a Region from Europe to the table. Query data with strongly consistent reads. C.Use an Amazon Aurora MySQL global database. Deploy the read-write node in a Region in North America, and deploy read-only endpoints in Regions in North America and Europe. Query data with global read consistency. D.Create a subscriber application that uses Amazon Kinesis Data Steams for an Amazon Redshift cluster in a Region in North America. Create a second subscriber application for the Amazon Redshift cluster in a Region in Europe. Process all database modifications through Kinesis Data Streams. Answer: C QUESTION 739 A company has a production web application in which users upload documents through a web interlace or a mobile app. According to a new regulatory requirement, new documents cannot be modified or deleted after they are stored. What should a solutions architect do to meet this requirement? A.Store the uploaded documents in an Amazon S3 bucket with S3 Versioning and S3 Object Lock enabled B.Store the uploaded documents in an Amazon S3 bucket. Configure an S3 Lifecycle policy to archive the documents periodically. C.Store the uploaded documents in an Amazon S3 bucket with S3 Versioning enabled Configure an ACL to restrict all access to read-only. D.Store the uploaded documents on an Amazon Elastic File System (Amazon EFS) volume. Access the data by mounting the volume in read-only mode. Answer: A QUESTION 740 A company has a Microsoft NET application that runs on an on-premises Windows Server. The application stores data by using an Oracle Database Standard Edition server. The company is planning a migration to AWS and wants to minimize development changes while moving the application. The AWS application environment should be highly available. Which combination of actions should the company take to meet these requirements? (Select TWO.) A.Refactor the application as serverless with AWS Lambda functions running NET Core. B.Rehost the application in AWS Elastic Beanstalk with the .NET platform in a Multi-AZ deployment. C.Replatform the application to run on Amazon EC2 with the Amazon Linus Amazon Machine Image (AMI). D.Use AWS Database Migration Service (AWS DMS) to migrate from the Oracle database to Amazon DynamoDB in a Multi-AZ deployment. E.Use AWS Database Migration Service (AWS DMS) to migrate from the Oracle database to Oracle on Amazon RDS in a Multi-AZ deployment. Answer: AD QUESTION 741 A company wants to enforce strict security guidelines on accessing AWS Cloud resources as the company migrates production workloads from its data centers. Company management wants all users to receive permissions according to their job roles and functions. Which solution meets these requirements with the LEAST operational overhead? A.Create an AWS Single Sign-On deployment. Connect to the on-premises Active Directory to centrally manage users and permissions across the company B.Create an IAM role for each job function. Require each employee to call the stsiAssumeRole action in the AWS Management Console to perform their job role. C.Create individual IAM user accounts for each employee Create an IAM policy for each job function, and attach the policy to all IAM users based on their job role. D.Create individual IAM user accounts for each employee. Create IAM policies for each job function. Create IAM groups, and attach associated policies to each group. Assign the IAM users to a group based on their Job role. Answer: D QUESTION 742 A company provides machine learning solutions .The company's users need to download large data sets from the company's Amazon S3 bucket. These downloads often take a long lime, especially when the users are running many simulations on a subset of those datasets. Users download the datasets to Amazon EC2 instances in the same AWS Region as the S3 bucket. Multiple users typically use the same datasets at the same time. Which solution will reduce the lime that is required to access the datasets? A.Configure the S3 bucket lo use the S3 Standard storage class with S3 Transfer Acceleration activated. B.Configure the S3 bucket to use the S3 Intelligent-Tiering storage class with S3 Transfer Acceleration activated. C.Create an Amazon Elastic File System (Amazon EFS) network Tile system. Migrate the datasets by using AWS DataSync. D.Move the datasets onto a General Purpose SSD (gp3) Amazon Elastic Block Store (Amazon EBS) volume. Attach the volume to all the EC2 instances. Answer: C QUESTION 743 A company needs to retain its AWS CloudTrail logs (or 3 years. The company is enforcing CloudTrail across a set of AWS accounts by using AWS Organizations from the parent account. The CloudTrail target S3 bucket is configured with S3 Versioning enabled. An S3 Lifecycle policy is in place to delete current objects after 3 years. After the fourth year of use of the S3 bucket, the S3 bucket metrics show that the number of objects has continued to rise. However, the number of new CloudTrail logs that are delivered to the S3 bucket has remained consistent. Which solution will delete objects that are older than 3 years in the MOST cost-effective manner? A.Configure the organization's centralized CloudTrail trail to expire objects after 3 years. B.Configure the S3 Lifecycle policy to delete previous versions as well as current versions. C.Create an AWS Lambda function to enumerate and delete objects from Amazon S3 that are older than 3 years. D.Configure the parent account as the owner of all objects that are delivered to the S3 bucket. Answer: B QUESTION 744 A company has a website hosted on AWS. The website is behind an Application Load Balancer (ALB) that is configured to handle HTTP and HTTPS separately. The company wants to forward all requests to the website so that the requests will use HTTPS. What should a solutions architect do to meet this requirement? A.Update the ALB's network ACL to accept only HTTPS traffic B.Create a rule that replaces the HTTP in the URL with HTTPS. C.Create a listener rule on the ALB to redirect HTTP traffic to HTTPS. D.Replace the ALB with a Network Load Balancer configured to use Server Name Indication (SNI). Answer: C QUESTION 745 A company is deploying an application that processes large quantities of data in batches as needed. The company plans to use Amazon EC2 instances for the workload. The network architecture must support a highly scalable solution and prevent groups of nodes from sharing the same underlying hardware. Which combination of network solutions will meet these requirements? (Select TWO.) A.Create Capacity Reservations for the EC2 instances to run in a placement group B.Run the EC2 instances in a spread placement group. C.Run the EC2 instances in a cluster placement group. D.Place the EC2 instances in an EC2 Auto Scaling group. E.Run the EC2 instances in a partition placement group. Answer: BC 2021 Latest Braindump2go SAA-C02 PDF and SAA-C02 VCE Dumps Free Share: https://drive.google.com/drive/folders/1_5IK3H_eM74C6AKwU7sKaLn1rrn8xTfm?usp=sharing
Salonpas Hisamitsu Heat Gel Hot Back, Muscle,Arthritis Pain Relief 🅾🅽🅻🆈 $5,9
#Directions Adults and children 2 years of age and over: – Clean and dry affected area. – Apply to affected area, not more than 3 to 4 times daily. Expiration Date 4 Years from Manufacture Date Details: Active Ingredients Methyl salicylate 15.0% l-menthol 7.0% Uses: For relief of aches and pains associated with: muscle fatigue, muscle pain, stiff shoulder, joint pains, simple backache, bruises, sprains, strains, arthritis. Do not use: On wounds or damaged skin if you are allergic to aspirin or salicylates Ask a doctor before use if you are allergic to external application products. Ask a doctor or pharmacist before use if you are taking other medicine. When using this product: Do not use otherwise than as directed. Avoid contact with the eyes, mucous membranes or rashes. Do not use with a heating pad. Do not bandage tightly. Do not swallow. Stop use and ask a doctor if conditions worsen. Symptoms persist for more than 7 days. Symptoms clear up and occur again with a few days. Rash, itching or excessive skin irritation occurs. https://shemartglobal.com/product/salonpas-hisamitsu-heat-gel-hot-back-musclearthritis-pain-relief/ Directions: Adults and children 2 years of age and over: clean and dry affected area. Apply to affected area not more than 3 to 4 times daily. Children under 2 years of age: consult a doctor. Keep out reach of children. If swallowed, get medical help or contact a doctor right away. https://shemartglobal.com/product/salonpas-hisamitsu-heat-gel-hot-back-musclearthritis-pain-relief/
Green Garden Natural Matcha Coconut Oil Lip Balm - 🅾🅽🅻🆈 5,9$
https://shemartglobal.com/product/green-garden-natural-matcha-coconut-oil-lip-balm/ Green Garden Natural Matcha Coconut Oil Lip Balm with the effect of softening, avoiding dark lips, brings a pleasant feeling when smelling. It’s fun to apply a layer of lipstick on your lips, it feels like you are sipping a cup of Matcha on a sunny day. Matcha powder + coconut oil + beeswax is an extremely creative combination to create a special lip balm – Matcha lipstick. Besides the softening effect, avoiding darkening of the lips, this lipstick also brings a pleasant feeling with a slight bitter taste and a cool scent from Matcha powder. Matcha powder ground from Japanese green tea leaves is not only an important part of culinary culture but also a leading beauty method of Japanese women. Containing high levels of Tea-catechins antioxidants, especially Epigallocatechin Gallate (EGCG), Matcha powder has the ability to resist the harmful effects of ultraviolet rays, environmental pollution, and prevent the formation of wrinkles on the lips. https://shemartglobal.com/product/green-garden-natural-matcha-coconut-oil-lip-balm/ The deeply moisturizing formula of Natural Matcha lipstick leaves lips soft and supple. A thin layer of Matcha lipstick on the lips before applying makeup is the simplest and most effective solution to “separate” the delicate skin of the lips from chemicals. Toxic, especially lead in lipstick. Now, girlfriends are free to beautify with many lipstick colors from bright red, deep red, lotus pink, nude pink or sweet orange without worrying about dry, dark lips thanks to the “bodyguard” of Matcha balm. 𝙃𝙤𝙬 𝙩𝙤 𝙪𝙨𝙚 𝙂𝙧𝙚𝙚𝙣 𝙂𝙖𝙧𝙙𝙚𝙣 𝙉𝙖𝙩𝙪𝙧𝙖𝙡 𝙈𝙖𝙩𝙘𝙝𝙖 𝘾𝙤𝙘𝙤𝙣𝙪𝙩 𝙊𝙞𝙡 𝙇𝙞𝙥 𝘽𝙖𝙡𝙢: Lip balm: Apply a thin layer to lips several times a day, especially before sun exposure or makeup. Heal lip damage: When lips are damaged, it is necessary to apply lip balm at night to moisturize and heal the skin. Exfoliate: Apply lipstick on lips, leave for about 15 minutes, use a soft-bristled toothbrush to gently scrub, rinse with water. Only do it once a week.