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The most advanced industrial floor construction equipment--concrete laser screed

Since the 20s century, much advanced technology reach to significant progress and are applied in various traditional industrial. Today we will introduce a successful application example of laser technology in industry floor, that is laser screed.
What is laser screed
Although laser screed is an excellent advanced machine, it was came into being in 80s of last century. As bulk production of laser equipment in resent years, its price is constantly decreased, it is more and more common in construction of industrial floor. It uses laser emitter to launch a standard laser flat,then it use laser receiver on the machine to react the position where the laser flat is on. Then controller on the machine adjusts and controls leveling head of the machine according to laser position, so as to conduction leveling operation to concrete. So laser screed is a high-precision leveling equipment for concrete, it takes laser launched by emitter as datum plane and controls leveling head through laser receiver on laser screed machine.
Application area--widely in various various floor
Laser screed machine can be widely used in various indoor and outdoor floor projects. Indoor floor includes various industrial plant, workshop, warehouse, large shopping center, logistic center, exhibition center, underground parking and so on. Outdoor floor includes various wharf, container warehouse, logistics freight yard, airport landing field, outdoor parking, square, residence floor and municipal administration pavement and so on. Laser screed is applicable for various construction of large concrete floor.
Low investment, high precision, fast construction for floor, economical labor.
Recent years, laser positioning equipment is widely used in various large and small projects, which makes it is produced in bulk, and its price is constantly decreased. Cost of laser screed machine is gradually decreased, now to obtain a laser screed machine you only need a small investment, and its usage investment is also very low. Taking hiking ev850-2t walk behind laser screed as an example. The machine is produced by Hiking machinery, it has a high quality and low price. The machine uses Leica laser system, it is totally controlled by computer system, its quality and precision are excellent, but its price no more than 20 thousand dollars. The machine applies Honda power system, so it has perfect stability, its breakdown is 0 within three years. Its fuel consumption is also low so investment after purchase of the machine is low. The machine uses laser positioning system, so it saves lots of formwork during construction. Meanwhile is will saves lots of labor costs, shorten construction period. So compared with saved labor cost, machine investment is insignificant.
As mentioned above, the machine uses Leica laser system, it has excellent precision. Precision of laser system can reach to about 1mm, application of laser screed machine will greatly increase FL value of floor. Independent layout and large area whole pouring of laser emitter ensure consistency of ground level. Partitioning construction of large area will decrease construction joint, greatly decrease later maintenance cost of floor. What’s more, the machine can set slope. It can construct on floor with slope, so it is applicable for various floor project.  
Construction speed with laser screed is very fast, especially when the machine is used cooperate with ride on power trowel. Generally speaking, construction area can reach to 3000sq/day it those two machines are used together. It only needs 6-8 constructors, construction speed is very fast, it can save labor investment.
As we said above, applications of laser screed and trowel machine greatly enhance construction speed and quality of industry floor. If you are concrete floor contractor in 2020, you should know about those advanced construction equipment. Increasing construction efficiency, saving labor cost and enhancing construction quality are only part of advantages of laser screed of ride on power trowel. The most important is that they are a good advertisement, they are the symbol of your enterprise, which can help you obtain more projects.
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How can I recover the Google account Password without security question? Google account is used by numerous people across the world to cherish the benefits associated with it. This account is locked with a password which you may need to recover. If you forget the password and security question, then you need to recover it with other recovery methods. How to recover Google Account with an alternate email address? You can easily recover your account by using the alternate email ID associated with your account. Follow this process to complete the Google account recovery with an email ID. Visit the Google account website. Enter the Email or Phone. Click the Forgot Password to launch the recovery process. Choose the Email ID as your recovery method. Select Send option and receive the verification code via email. Prove your identity to Google and create a new password of your account. Re-enter the new password to confirm it. How to recover Google account by phone number? You can also use the linked phone number to recover your account without using the security questions. Use the following process to successfully recover the account. Launch the Google account website. Enter the username and click on Forgot Password option. Select your phone number and choose either call or text button. Receive the verification code on your phone number by text or voice call. Enter that code to prove your ownership of the account. Create a new password of the google account and confirm it. You can also recover your account with the trusted device to eliminate the security question(s) method. On facing any problem to Recover Google Password Without Security Question, contact the Google customer service to gain the required details.
Types and Applications of Bispecific Antibodies
At present, bispecific antibodies are widely used in the field of tumor therapy. For example, by combining anti-CD3 antibodies with tumor-targeting antibodies, the constructed bispecific antibodies can recruit T cells to approach tumor cells and mediate T cells to kill tumor cells. In addition, bispecific antibodies are also used in the treatment of osteoporosis, hemophilia, autoimmune diseases and other fields. Compared with monoclonal antibodies, the advantages of bispecific antibodies include: (1) Bispecific antibodies target effector cells directly to tumor cells and enhance their cytotoxicity. (2) Bispecific antibodies can recognize two molecules at the same time, which improves the selectivity and functional affinity of the antibody, and improves the safety and effectiveness of the drug. (3) Compared with the combination therapy of two monoclonal antibody drugs, bispecific antibody drugs reduce development and clinical trial costs. Preparation method of bispecific antibody (1) Chemical conjugation method: This method was first used in 1985. Its principle is to couple two complete monoclonal antibodies or Fab2 fragments into a bispecific antibody through a chemical conjugation agent. (2) Two-hybridoma fusion method: Two hybridoma cell lines are synthesized by the cell fusion method of two hybridoma cells, and stable target cell lines with two antibody functions are screened out. (3) Genetic engineering method: The antibody is modified by genetic engineering technology to form various forms of bispecific antibodies. So far, only two bispecific antibodies have been approved for use, one is Blinatumomab, and the other is Catumaxomab. Currently, 60 types of bispecific antibodies are in preclinical research, and 30 types of bispecific antibodies are in clinical trials. Blinatumomab was approved by the US FDA at the end of 2014 for the treatment of Fischer-negative precursor B-cell acute lymphoblastic leukemia. It was registered in the European Union in 2015. Blinatumomab is a bispecific antibody based on BITE technology. It is composed of two scFvs containing only variable regions connected by polypeptides, one targeting the CD19 antigen on the surface of tumor cells and the other targeting CD3 on the surface of cytotoxic T lymphocytes. Clinical trials have proved that Blinatumomab can still recruit T cells to kill tumor cells at very low concentrations (~10-100pg/mL), but due to the single-chain structure of Blinatumomab, it lacks Fc Due to the fact that the half-life of the drug in the body is very short, the actual use requires an additional continuous infusion device. Clinical trials have shown that adult patients with recurrent acute lymphoblastic leukemia can obtain 72% complete positive results after Blinatumomab treatment, and the average life expectancy after treatment is more than nine months; in the treatment of non-Hodgkin’s lymphoma, Blinatumomab is more simple Clonal antibody therapy has also shown good curative effects. In the case of achieving the same therapeutic effect, the concentration of Blinatumomab in plasma is much lower than that of monoclonal antibodies; however, it is used in the treatment of lymphatic surface CD19 loss and recurrence of extramedullary hematopoiesis. In acute lymphocytic leukemia, Blinatumomab treatment is ineffective. Catumaxomab was approved by the European Drug Administration in 2009 for the treatment of malignant ascites. It is the world's first bispecific antibody to be marketed. Catumaxomab is a bispecific antibody based on quadroma (hybrid-hybridoma) technology that combines the expression of rat antibody (IgG2b) targeting tumor EpCAM and mouse antibody (IgG2a) targeting CD3 in a bispecific molecule. Catumaxomab also contains the Fc fragment. Catumaxomab recognizes the EpCAM antigen on the tumor surface and recruits T cells. At the same time, Catumaxomab can bind to the receptor on the surface of the killer cell through the Fc fragment to mediate the direct killing of the killer cell. The target cell can realize the "three-function" antibody activity and improve the patient's immune activity against tumor cells. Clinical trials show that low-dose therapeutic concentrations (10-100mg) are administered intraperitoneally 4-5 times with an interval of 10-14 days. The results show that Catumaxomab has a high therapeutic potential and its safety is within an acceptable range. Catumaxomab is currently undergoing clinical trials for ovarian cancer, gastric cancer, and epithelial cancer in addition to being approved for the treatment of malignant ascites. In ovarian cancer trials, it has shown that it can reduce the formation of ascites. Like other treatments for tumors, bispecific antibodies can also cause different side effects during treatment, the most common of which are nausea, vomiting, abdominal pain, leukopenia and neutropenia. Many bispecific antibodies are currently undergoing clinical trials for the treatment of tumors, most of which are combinations similar to Catumaxomab and Blinatumomab, containing an anti-CD3 antigen binding site to recruit T cells to the vicinity of tumor cells. Another binding site targets tumor surface antigens such as CD19, CD20, CD33, HER1, HER2, etc. In addition, there are other combinations of bispecific antibodies, such as HER2+HER3, IL1α+IL1β, IL13+IL17, etc. Application of bispecific antibodies (1) Immunotherapy of tumor In order to develop new anti-tumor drugs, improve therapeutic effects and reduce side effects, it is necessary to find bispecific antibodies that target new targets in the future. At the same time, bispecific antibodies can also be used in combination with other drugs, such as drugs that control the cell cycle. Indoleamine dioxygenase inhibitors, etc., help improve the efficacy. The design of the new bispecific antibody aims to increase the targeting specificity to reduce the killing effect on non-tumor cells. In addition, during the production process of bispecific antibodies, their random combination will reduce the yield, so it is necessary to optimize the design to improve the binding of the target bispecific antibody, increase the recovery rate, and reduce the cost of medicine. (2) Clinical diagnosis Due to the high sensitivity and specificity of bispecific antibodies, they can be used for clinical diagnosis. For the detection of bispecific antibody drugs, one of the binding domains binds to the detected pathogen, virus or tumor cell, and the other binding domain binds to root peroxidase or alkaline phosphatase. Bispecific antibodies simplify detection methods and are therefore very promising in diagnostic tools. (3) Medical imaging Tumor imaging with bispecific antibodies can be completed in two steps, using bispecific antibodies to pre-label tumor cells, and then inject radioisotopes for imaging. Compared with radioisotope-labeled antibody imaging, this method has better specificity, sensitivity, and low background signal, because unbound radioisotopes can be quickly eliminated. (4) Bispecific antibodies are currently also used to develop simple, fast and highly sensitive bacterial virus infections and cancer diagnosis. Summary Clinical studies have found that bispecific antibody drugs block several biological pathways at the same time, showing a synergistic effect that cannot be achieved by the combination of monoclonal antibodies. At the same time, bispecific antibodies can also be developed into "next generation" diagnostic equipment. The ability to detect a collection of several antigens or to connect the antigen binding site with the assay marker makes bispecific antibodies an important object for further research in biomedicine, pharmacology and diagnostics.
LAPTOP DELL CORE I3 CŨ – ĐÂU LÀ SỰ LỰA CHỌN HOÀN HẢO?
Laptop Dell core i3 cũ có mức giá rẻ, khả năng hoạt động ổn định, đủ đáp ứng nhu cầu sử dụng cơ bản của người dùng. Chính vì điểm này, sản phẩm đang trở thành lựa chọn hàng đầu của nhiều đối tượng khách hàng. Được ra mắt từ năm 1984 với định hướng đáp ứng tối ưu nhu cầu sử dụng của khách hàng, Dell dần trở nên quen thuộc, gây thiện cảm tốt trong ấn tượng người dùng. Ở phân khúc tầm trung, thương hiệu này vẫn sở hữu nhiều sản phẩm đặc trưng với khả năng hoạt động ổn định. Cùng điểm qua một số mẫu sản phẩm laptop Dell core i3 cũ với mức giá cực hợp lý dưới đây nhé. Dell – Thương hiệu của sự đảm bảo chất lượng Thị trường các sản phẩm công nghệ luôn có sự cạnh tranh gay gắt từ những thương hiệu lớn, có xuất xứ từ nhiều quốc gia khác nhau. Tuy nhiên, với sự nghiêm túc trong từng sản phẩm được đưa đến tay người tiêu dùng, Dell luôn giữ vững được vị thế bền vững. Chẳng cần có sự đột phá quá sáng tạo, những công nghệ mới được trình làng, thương hiệu này chủ yếu đánh trúng tâm lý khách hàng, đem đến sự hài lòng nhất cho người dùng trong mỗi sản phẩm được ra mắt. Thương hiệu Dell có thể xem là sự đảm bảo cao nhất về măt chất lượng Sản phẩm từ Dell được phân thành nhiều phân khúc khác nhau, từ các dòng sản phẩm tầm trung như Dell Inspiron, Dell Vostro,... đến các dòng cao cấp như  Laptop Dell Latitude, Laptop Dell Precision. Như vậy, với đối tượng nào, bạn cũng dễ dàng tìm thấy một sản phẩm phù hợp đến từ thương hiệu này. Đáng chú ý, không phải tập trung về ngoại hình mà chất lượng mới là điều mà Dell hướng tới và không ngừng nâng cao, cải thiện từng ngày. Vì thế, dù là sản phẩm laptop Dell cũ core i3  hay sản phẩm mới thì khách hàng vẫn hoàn toàn có thể yên tâm về khả năng vận hành, hoạt động cùng độ bền lâu của máy theo thời gian. Mua laptop Dell core i3 cũ – Nên chọn sản phẩm nào? Dù chỉ trang bị bộ xử lý core i3, tuy nhiên, hiệu năng hoạt động của các dòng sản phẩm này vẫn đảm bảo tuyệt đối, phù hợp với khả năng sử dụng cho đại đa số người dùng. Một số dòng sản phẩm laptop Dell cũ core i3 đáng lưu tâm hiện nay có thể kể đến như: Laptop Dell core i3 thuộc dòng Inspiron Inspiron thuộc phân khúc phổ thông với mức giá khá rẻ. Đây cũng là dòng sản phẩm cạnh tranh nhất trên thị trường của thương hiệu này. Cấu hình máy i3 nhưng cho khả năng hoạt động khá ổn định, mượt mà Laptop Dell core i3 thuộc dòng Inspiron cho khả năng vận hành ổn định, thời lượng pin tốt. Máy phù hợp cho đối tượng là sinh viên, những ai thường sử dụng máy với các công việc văn phòng, lướt web, nghe nhạc,... Mức giá không cao, tuy nhiên cũng đừng quá lo lắng, bởi chất lượng đi kèm thật sự sẽ khiến bạn ngạc nhiên đấy. Một số dòng Inspiron i3 cũ được đánh giá cao mà bạn có thể tham khảo là: Dell Inspiron 3576 – N3576C, Dell Inspiron 3567-N3567H, Dell Inspiron 14 3476-8J61P1,... Laptop Dell core i3 thuộc dòng Vostro Tương tự Inspiron, Dell Vostro cũng nằm trong phân khúc phổ thông cực kỳ được ưa chuộng. Dòng máy này có vẻ ngoài tương đối mạnh mẽ, có phần đơn giản, cứng cáp nhưng vẫn mang đặc trưng từ thương hiệu Dell. Các dòng Dell Vostro thường đem lại cảm giác khá đằm tay khi sử dụng. Cấu hình máy cũng có sự tương đồng với Inspiron, nhưng lợi thế lớn ở thời lượng sử dụng pin dài lâu, độ bảo mật cũng được đánh giá ở mức tuyệt vời. Cấu hình core i3, nhưng với những máy được trang bị chip xử lý thế hệ mới, sản phẩm vẫn cho khả năng hoạt động ưu việt, không thua kém gì core i5. Một số sản phẩm đáng lưu tâm cho bạn có thể kể đến như: Dell Vostro 3468 (F3468-70159379), Dell Vostro 3568-VTI321072,... Dòng Vostro có thiết kế cứng cáp nhưng vẫn mang đặc trưng riêng từ Dell Thị trường công nghệ đang không ngừng có sự nâng cấp, phát triển. Tuy nhiên, nhờ sự đảm bảo về chất lượng, tính bền lâu, laptop dell cũ vẫn được chào đón nồng nhiệt. Nếu bạn đang có nhu cầu tham khảo và chọn mua sản phẩm này, hãy nhanh tay liên hệ với Laptop Nano để được tư vấn, hỗ trợ tận tình và chuyên nghiệp nhất nhé. source: http://laptopmientay.com/laptop-dell-core-i3-cu-dau-la-su-lua-chon-hoan-hao.html
A00-260 Study Guide for SAS Data Integration Developer Certification?
SAS certification is quite important to open up new vistas of opportunities in your professional career. It all begins with credibility. The moment your prospective employer will see your resume, SAS certification A00-260 on SAS Data Integration Developer status will grab his eyeballs, without any doubt. SAS certification helps win better job prospects in the industry and even makes you comparatively superior to other candidates. Besides, you might even grab higher salaries to those who are not certified. So, what are you waiting for? Make up your mind for an SAS certification and move further in your career. Here are some things that you should know before you begin the preparation: Before the A00-260 Preparation begins: ● Keep in mind that the preparation for SAS Certification is a little consuming, irrespective of the fact that you are an experienced SAS professional ● Through regular study and training, the journey to give the SAS exam helps improve the programming skills to a great extent ● It is required that both the training and test are attempted in nothing but the English language. The resources available in this language are very vast and of high quality. ● Please do not care about the score. Just prepare by giving your best, and the results will follow. SAS Data Integration Developer Certification is the key to success of your professional career. Candidates armed with SAS certification go a long way in their career and stand out in the average crowd. Here is a comprehensive guideline that will help you score better in the A00-260 exam. 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Every candidate will need to know ‘how to do’ the questions rather than just answer them theoretically. SAS Certified Data Integration Developer Exam Guide - How to begin preparation? Chart out a path for the preparation of SAS Data Integration Developer. Make sure that you stick to this road to score well in the exam. Here are the steps that will help you: ● Go through the syllabus of the A00-260 exam of the A00-260 exam. Prepare a study plan based on the time duration that you have till the actual exam date ● You need to study every topic of A00-260 from the study guide, in detail ● SAS Data Integration Developer exams are known for asking actual exam-based questions. Hence, while you are preparing, try to relate every concept with the real-time business scenario. 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These tests are far better than holding A00-260 dumps of the VCE software available online Please Note: SAS does not support questions available from dumps or those from VCE software. Strict Action is taken against the websites that sell A00-260 questions pdf with false promises Resources Available for SAS Certification Preparation There are several resources available online and offline to prepare for SAS Data Integration Developer A00-260 certification examination. The ones that help you prepare better for the exam are: Self-Study Guide The candidates for SAS certification can opt for Analyticsexam.com self-study resource. The site has A00-260 Sample Questions and online practice exams that are very close to the actual test. The practice tests on the site are simulated. Giving these tests helps a candidate prepare for the real exams in an organized manner. Books Books are still the most loved resource for studying for any exam. You can get hold of good books for preparation of A00-260 certification exam. Practical Programming SAS Data Integration Developer Certification exam is practical oriented, and the theory questions are limited. To answer such questions quickly and correctly, functional programming helps a lot. Training The topics in the SAS exam often correspond to the training courses that a candidate takes. Candidates can either opt for instructor-led training or even virtual delivery online training. ● Recommended Training ○ SAS Data Integration Studio: Fast Track ○ SAS Data Integration Studio 1: Essentials ○ SAS Data Integration Studio 2: Additional Topics Reasons to Choose Analyticsexam.com to crack A00-260 exam ● Analyticsexam.com has a credible history of 10 years. 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Things to Remember on SAS Certified Data Integration Developer for SAS 9 ● If you desire to score well in the SAS Data Integration Developer exam, you need to have sufficient time for preparation. ● You need to improve your category-wise skills for answering tricky, faulty and non-practical questions ● You need to select the language of the exam based on the resources available in that language ● You should focus on the preparation and cover the syllabus rather than the score in the beginning Before you give A00-260 exam ● Source information about the Prometric Test Center ● You should select the date, time and place of the exam, based on your convenience as there are several Prometric test centers around the world ● Visit the Prometric test center before registering for the exam. There is no quality assurance for minor technical issues with used hardware and ambiance of the test center ● You need to clarify the invoice details if you desire to have it in the name of your company. A00-260 Exam Registration: ● Registration for Exam: Pearson VUE At the End SAS Data Integration Developer A00-260 certification exam will become a cakewalk for you if you keep the above-mentioned things in mind. Remember time is money and the earlier you begin, the better it will be for you.