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ADCs Effectively Targets Surface Protein Of Neuroblastoma In Children

Physician-scientists in the Cancer Center at Children’s Hospital of Philadelphia (CHOP) have developed a preclinical, potent therapy attached to an antibody that targets a surface protein expressed in most childhood neuroblastomas, effectively killing cancer cells.

The researchers published their findings in Science Translational Medicine on Mar. 14, 2019.

Antibody-drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. Unlike chemotherapy, ADCs are intended to target and kill tumor cells while sparing healthy cells.

“If there is an ultimate ‘bad guy’ of neuroblastoma cell surface proteins—present on most tumors, but not on healthy tissues, and also vulnerable to immunotherapeutic targeting—this just may be it,” said study leader Yael Mossé, MD, a pediatric oncologist and researcher at Children’s Hospital of Philadelphia (CHOP). “In 2008, we discovered mutations in the anaplastic lymphoma kinase (ALK) gene as the major cause of the inherited form of neuroblastoma and showed that these same mutations are present in about 14 percent of neuroblastoma tumors from patients with the most aggressive form of this disease. This established ALK as a druggable target in neuroblastoma and provided the rationale for the clinical development of ALK inhibition therapy. We now show that native ALK (in the absence of a mutation) is present on most neuroblastoma tumors, providing us with an exciting opportunity to target ALK in the majority of patients.”

Neuroblastoma, a pediatric cancer of the developing peripheral nervous system that usually occurs as a solid tumor in a child’s chest or abdomen, is the most common cancer in infants, and accounts for more than 10 percent of all childhood cancer deaths. Children with the high-risk form of the disease continue to have a poor prognosis, despite intensive drug therapy.

Mossé, along with other scientists in her lab, demonstrated that the ALK protein appears on the surface of most neuroblastoma cells and is not detectable on normal cells, indicating that ALK is a useful target for immunotherapy. Researchers worked with pharmaceutical colleagues to weaponize an antibody-drug conjugate (ADC), one of a rapidly growing class of anticancer agents. That ADC, called CDX-0125-TEI, combines a specific monoclonal antibody engineered to recognize ALK with a potent chemotherapy drug—an alkylating agent called thienoindole (TEI).

In cell cultures and animal models of neuroblastoma, the ADC-ALK approach killed neuroblastoma cells, with no discernible toxicity to healthy cells. “The goal of this approach is to harness the presence of ALK to precisely deliver a poison only to the cancer cell, without harming the healthy surrounding cells,” said Mossé.

“This study is proof of concept that the ALK protein is a good immunotherapy target and, as we optimize this approach for the clinic, has the potential to be useful for the majority of aggressive neuroblastomas and to minimize the harsh consequences of therapy,” said Mossé.

She added, “In addition, our research could have great relevance for other cutting-edge immunotherapeutic strategies, such as CAR T-cell therapy, that harness the immune system to kill cancer, and is currently showing tremendous efficacy in children with leukemia. Our new data support clinical development of an immunotherapy drug not just for neuroblastoma, but for other hard-to-cure childhood cancers expressing the ALK gene, including rhabdomyosarcomas.”

Over decades, CHOP clinicians and researchers have built one of the world’s leading programs in neuroblastoma. The Mossé laboratory is focused on the underlying molecular mechanisms by which ALK gene activation contributes to development and progression of pediatric neuroblastoma, and to identify targeted, less toxic cancer therapies for children with ALK-mediated disease.

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List of Best Pharmaceutical Companies In Singapore 2023
List of Best Pharmaceutical Companies In Singapore 2023 Singapore or the lion city is famous for its advanced pharmaceutical manufacturing, technological sectors, and booming economy. Singapore is home to a range of healthcare businesses, from hospitals and doctors’ practices to pharmaceutical companies For investors looking to invest in the sector, there are many listed companies that offer exposure to the local healthcare market. With comprehensive information about each company, investors can gain a better understanding of the opportunities available in Singapore’s healthcare sector. And with recent innovations and technology, Singapore has seen a significant amount of growth in the pharmaceutical sector. From pharmaceutical, cosmeceuticals, and nutraceuticals contributor to the delivery of these drugs and medicines, pharmaceutical and biotechnology companies in Singapore experimenting with different formulas and strategies to scale their business. 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Website : Singapore’s largest homegrown private healthcare provider Contact Details : +6563111111 Wave Life Sciences Wave life sciences is a pharmaceutical industry that is creating a powerful genetic toolbox with the potential to impact many serious conditions for which there are hardly any medicine or procedure. Besides, this company also bridging the gap between patients and the health community by providing excellent service in clinical trials and studies. And that’s how with innovation and new technology, Wave life sciences are emerging as the most prominent and largest pharmaceutical companies. Website : Home – Wave Life Sciences Contact Details : info@wavelifesci.com Sphaera Pharma Sphaera pharma is a pharmaceutical company that is leveraging the benefits of drug discovery and development capabilities to bring innovative products for patients’ health and well-being. Unlike other pharmaceutical companies, Sphaera pharma follows a target-based approach instead of focusing on specific disease and applications. This target-based approach enables the company to be flexible and easily adapt to the changing need of the biotechnology and the pharmaceutical industry. Moreover, Sphaera pharma focuses on translational components and networks with the scientific community that allows them to cater to a wide variety of therapeutic areas and identify the science that needs to be advanced. Website : Welcome to Sphaera Pharma Contact Details : +91 124 418 7500 MSD Singapore MSD Singapore is an innovative and global health leader whose vision is to make a difference in the life of people through the production of innovative medicine, vaccine, and animal health products. 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And the best part about the company is that via collaboration it also focuses on inflammation, infection, and neuroscience. Website : https://www.astrazeneca.com/ Contact Details : +65 9839 8164 GSK- Singapore GSK is another biggest contributor to the biomedical science industry with huge investments in the medical industry. And this company has a great presence in Singapore consisting of two manufacturing supply sites and one vaccine manufacturing facility. Moreover, the company deals in three key business areas such as prescription medicine, vaccines, and customer health products. In this way, GSK is driving scientific innovation to deliver the next generation of highly standard vaccines for patients. Website : Home | GSK Contact Details : +65 6232 8338 Beacons Pharmaceuticals Beacons pharmaceutical is one of the largest and biggest manufacturers of generic pharmaceuticals. Moreover, this company also provides a comprehensive suite of fully integrated one-stop contract manufacturing options. And the company also produces a wide range of solid, liquid, and semi-solid dosage products. Besides, the company works closely with the world’s top pharmaceutical companies with its team of highly skilled and experienced scientists and provides all innovative, testing, and commercialization tools to bring out the best product in the marketplace Website : Beacons Pharmaceuticals Contact Details : +65 6265 2336 Signup Now (No Credit Card Required) ITS Science & Medical ITS Science and Medical is another pharmaceutical company in Singapore that has 40+ years of experience in providing a comprehensive range of products in the medical industry. This pharmaceutical company is the largest provider of medical instruments and hospital infrastructure. And it also provides services in many domains such as analytical instruments, life sciences, pharmaceutical, animal research, and medical infrastructure. With the skill and experienced staff, it claims to provide the highest level of customer satisfaction. Website : ITS Science & Medical Pte Ltd. Contact Details : +65 62730898 iNova Pharmaceuticals iNova is a pharmaceutical company that has a long history of providing quality and trusted healthcare products. It also distributes a wide range of market-leading prescription medicines, and consumer healthcare products to over 20 countries across Australia, Asia, and Africa. Moreover, the company’s portfolio includes health supplements, dermatology, cardiology, respiratory health, allergy, and female health products. Website : iNova Pharmaceuticals – pharmacy products & prescription medicines Contact Details : +65 63403540 Healthcare Asia Healthcare Asia is a pharmaceutical company in Singapore that delivers therapeutic products at competitive prices without any compromise on quality. Moreover, Healthcare Asia is bridging the gap between manufacturers and stakeholders. And company’s business portfolio consists of a wide variety of products in different oncology areas such as blood cancer, prostate cancer, bone cancer, skin cancer, and other cancer drugs. Moreover, the company also monitors the list of new approved FDA drugs to keep up with the changing environment of the pharmaceutical industry. Website : Home Contact Details : +65 69092765 Why Invest in Healthcare Companies in Singapore? There are many reasons to invest in healthcare companies in Singapore. As a developed country with a strong economy, Singapore offers investors a stable and prosperous environment in which to do business. 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List of Listed Healthcare Companies in Singapore There are many healthcare companies that are listed on the Singapore Exchange (SGX). These companies cover a wide range of businesses including medical devices, pharmaceuticals, biotechnology, healthcare services, and more. The following is a list of some of the healthcare companies that are listed on SGX: – 3A Health care – Aoxin Q & M Dental Group – Acumen Research and Consulting – Adventa Berhad – Allied Tech Corporation Ltd – APAC Realty Limited – Asia Medic Holdings Pte Ltd – Asiapharm Laboratories Pte Ltd – Biolidics Limited – BioPolus Inc – Biosensors International Group, Ltd. – CapitaLand Commercial Trust Management Limited Conclusion In conclusion, healthcare listed companies in Singapore offer a wealth of potential investment opportunities. With the growing demand for medical care and technology, these companies are well-positioned to take advantage of the current market trends. 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LEMON JUICE: THE SURPRISING AND MAGICAL CURE FOR DANDRUFF
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TABLE OF CONTENTS Introduction: Lemon for Dandruff Causes of Dandruff Benefits of Lemon How to Use Lemon for Dandruff Tips & Precautions Home Remedies with Lemon Side Effects of Lemon Other Treatments for Dandruff Conclusion INTRODUCTION: LEMON FOR DANDRUFF Lemon juice has been used in cooking and as a natural home remedy for centuries. Recently, it’s also been gaining attention as an effective solution to fight dandruff.  If you’re looking for a natural way to get rid of your flaking scalp, lemon juice might just be the answer. Dandruff is caused by irritated and oily skin on the scalp that can lead to redness and flaking skin.  Common treatments for dandruff consist of over-the-counter shampoos or medicated creams, but these are not always successful or even necessary!  Lemon juice is increasingly becoming an alternative treatment due to its rich source of vitamins A and C; two essential nutrients that help combat inflammation, nourish the scalp and reduce oil production. 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Exam season is quickly approaching, so some students begin studying as soon as they can. Some are already in the middle of their first revision marathon, while others wait until the very last minute. Every student who decides to study for a test the day before always says, I wish I had begun earlier. The real prescription for Physics and Chemistry exam anxiety and subpar performance is to start later and to put off doing your review. Everyone is aware that studying enhances the likelihood of earning excellent grades and doing well on examinations. However, in addition to regular studies, revisions with the best Chemistry or Physics tutor in Singapore are always viewed as an additional burden. Revision involves going over the studied material once again. Let's examine why it is crucial to review before the JC physics and chemistry test since doing so not only lessens the workload associated with exam preparation but also helps you make the most of your revision time. Revision lowers anxiety before exams: Understanding what you have learned while studying in the process of revision. The majority of students believe that rewriting entails cramming for exams. Understanding the difference between reviewing content you have previously studied at the JC chemistry tuition and cramming for an exam is crucial. The former involves going over what you have already learned, while the latter involves reading a lot of material at once. Cramming never works, raises stress levels, and increases exam anxiety risk. The only method to prevent test anxiety is to review before the exam. Assists with active recall: As you go over it frequently, revision aids in idea retention. The brain processes new information that is learned and retains it in memory. When you read anything for the first time, it's possible that you won't remember it right away. It gets easier for the brain to actively access the knowledge from memory as you continuously review with efficient strategies. Enhances performance on exams: How frequently have you failed to remember a math formula, a history date, or a scientific equation simply because you did not practice enough or review early enough? How well you can recollect the material you have learned can have an impact on how well you do on tests. You can score better on tests the more actively you can retain information. Instead of merely memorizing facts for the exam, starting early gives you time to fully study and master the content. You'll start to enjoy your study sessions if you read and research the background of the subject matter on your own time rather of worrying about memorizing everything. Not only will your mindset alter, but you could stop dreading the idea of revision! Focusing on more difficult material is aided by revision: Studying earlier gives you more time to study all the subject's topics. Additionally, it enables students to concentrate on each subject in-depth beforehand, ensuring a comprehensive understanding of every idea. A student has a greater opportunity to improve on the topics in which he or she is poor when revising since it can assist identifies which subject requires more emphasis. Revision aids in self-evaluation: To evaluate oneself before the actual test, reviewing is also helpful. To gauge their present level of preparation and familiarize themselves with the test format, students might review question papers from prior years. Being ready for impending examinations is the best feeling a student can have, especially when they realize how much effort they have truly put in. Making headway on your revision early will not only result in significantly reduced tension and worry the week before the big day, but it will also ensure that you enter your examinations with calm and clarity of mind. Exam practice papers: Although indeed, practice does not make perfect, it may undoubtedly aid in being prepared. You'll have more time to finish practice papers from past years and acclimate to the format the earlier you begin revising. Too frequently, students have excellent topic knowledge but poor test practice, which has an impact on their final results. You may download and utilize a ton of practice papers from the internet, or your teacher can give you exams from prior years.
Apakah Impotensi Bisa Sembuh Total?
Apakah impotensi bisa sembuh total jika melakukan pengobatan? Masalah ereksi sangat umum, terutama pada pria di atas usia 40 tahun. Biasanya tidak ada yang perlu dikhawatirkan, tetapi harus mengkonsultasikannya dengan dokter jika hal itu terus terjadi. Impotensi adalah pengalaman pria yang sangat umum. Perubahan gaya hidup dan pengobatan dapat membantu. Kebanyakan pria mengalami setidaknya satu gejala ketidakmampuan untuk mencapai ereksi saat mereka inginkan. Dalam kasus yang ekstrim, seorang pria kemungkinan tidak dapat memiliki ereksi atau tidak dapat mempertahankan ereksinya. Hampir semua kasus impotensi dapat sembuh. Keengganan untuk mencari pengobatan tetap menjadi penghalang utama untuk memulihkan fungsi seksual penuh bagi pria yang mengalami impotensi. Impotensi bisa menjadi masalah yang sulit untuk didiskusikan dengan pasangan seksual atau bahkan dengan dokter. Cara Paling Ampuh Menyembuhkan Impotensi Pada kebanyakan pria terkadang gagal mendapatkan ereksi atau gagal mempertahankan ereksi. Penyebabnya biasanya karena stress, kelelahan, kecemasan atau minum terlalu banyak alkohol dan itu tidak perlu Anda khawatirkan. Jika itu terjadi lebih sering, itu kemungkinan karena kesehatan fisik atau masalah emosional. Ketika impotensi tidak dapat sembuh, pengobatan yang tepat dapat mengurangi gejala atau menghilangkan gejala. Dokter telah mengidentifikasi 2 jenis impotensi: > Impotensi primer terjadi ketika seorang pria tidak pernah mampu mempertahankan ereksi dan ini jarang terjadi. > Impotensi sekunder terjadi pada orang yang pernah memiliki fungsi ereksi teratur. Ini adalah tipe yang paling umum. Impotensi sekunder dapat dibalik dan seringkali bersifat sementara, sedangkan impotensi primer kemungkinan memerlukan pengobatan yang lebih intensif dan berbasis medis. Impotensi biasanya dapat teratasi dengan obat-obatan atau pembedahan. Namun, seseorang kemungkinan dapat mengobati penyebab yang mendasari dan membalikkan gejala tanpa pengobatan. Pengobatan terbaik kemungkinan tergantung pada orangnya. Beberapa orang menemukan bahwa pengobatan tradisional seperti pembedahan atau pengobatan tidak berhasil. Orang-orang ini kemungkinan berhasil menggunakan pompa penis yang menarik darah ke penis dan menginduksi ereksi. Metode Pengobatan Impotensi Pengobatan untuk impotensi biasanya efektif dan masalahnya sering hilang. Ada juga pengobatan khusus untuk beberapa penyebab impotensi dan dapat disembuhkan. Tetapi harus berkonsultasi dengan dokter untuk memastikan aman untuk dikonsumsi. Beberapa orang merasa frustrasi mengenai impotensi. Perlu Anda ingat, bahwa kondisi ini dapat teratasi. Impotensi sangat umum dan biasanya dapat dokter atasi dengan menggunakan pengobatan alami atau obat-obatan untuk mengobati penyebab yang mendasarinya. Pengobatan sejak dini seringkali dapat mendeteksi kondisi medis yang serius dan menentukan penyebab impotensi lebih awal dapat meningkatkan kemungkinan untuk membalikkannya. Konsultasikan dengan dokter mengenai pengobatan terbaik. Banyak pilihan medis dan bedah tingkat lanjut untuk mengatasi impotensi. Pengobatan untuk impotensi dapat meliputi: > Obat-obatan yang dapat mengendurkan sel-sel otot di penis dan meningkatkan aliran darah. > Perangkat ereksi vakum, ini dapat menarik darah ke penis dan menyebabkan ereksi. > Terapi injeksi dengan menggunakan jarum yang sangat kecil untuk menyuntikkan pengobatan langsung ke sisi penis. Ini melemaskan otot yang memungkinkan aliran darah dan sangat berhasil. > Operasi implan penis invasif minimal yang dilakukan oleh dokter berpengalaman secara rutin. Kebanyakan dapat memulihkan fungsi seksual penuh dalam 6 hingga 8 minggu. Dalam kebanyakan situasi dapat mengidentifikasi masalah fisik ringan yang mendasari untuk mengurangi kecemasan impotensi dan perbaikan lebih lanjut. Sumber: https://klinikapollojakarta.com/ Klinik Kelamin Klinik Kelamin Klinik Kelamin Klinik Kelamin Klinik Kelamin Klinik Kelamin Klinik Kelamin Klinik Kelamin Klinik Kelamin Klinik Kelamin Klinik Kelamin Klinik Kelamin Klinik Kelamin Klinik Kelamin Klinik Kelamin
This French City Is (Literally) Powered By Cheese.
By now, you've heard of alternative electricity sources like wind, water, and solar power, but have you ever heard of using cheese? For one French city, cheese production is responsible for a considerable amount of their electricity. But how exactly do they do it? When Albertville, a city in Beaufort's dairy manufacturing region, makes its cheese, they use special equipment to convert the whey's methane gas emissions into pure energy that can be used to power 7% of the region's electricity. According to the Smithsonian, this is enough to power roughly 1,500 of 20,000 homes. That may not sound like much, but when you consider its potential, the city might just be onto a new avenue for renewable power sources. In the picture above, you can see the Valbio power plant that produces the aforementioned 'cheese power'. While it's the largest of the company's dairy-powered energy plants (and the largest of such plant on Earth), it's not the only dairy plant around. The same company began building the generators over a decade ago and set up similar plants in Europe and Canada - with more to come! In fact, those in the States might be surprised to know that the Fage brand's Greek yogurt also plays a part in powering the region from where it's produced. When Fage is made at its Albany-based plant, the whey used is later pumped to a wastewater plant to produce energy from its fermentation. Pretty cool, huh? So I hope that all of you who decided you'd like to cut down on the dairy going into the New Year re-embrace your love for all things covered in cheese. You're doing it for the greater good of the environment. It's your personal duty to eat tons of cheese. Let me know what you think about this new, cheesy fuel source in the comments below. And for more WTF news, follow my WTF Street Journal collection.