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Sacituzumab Govitecan Approval for Advanced or Metastatic Urothelial Cancer

On April 13, 2021, the U.S. Food and Drug Administration (FDA) has granted accelerated approval to Sacituzumab Govitecan (from Gilead Sciences) for use in adult patients with locally advanced or metastatic urothelial cancer who have previously received platinum-containing chemotherapy and either a programmed death receptor-1 (PD-1) or a programmed death-ligand 1 (PD-L1) inhibitor.
Sacituzumab govitecan is a first-in-class Trop-2-directed antibody-drug conjugated to a topoisomerase I inhibitor (SN-38). Trop-2 receptor, a protein frequently expressed in multiple types of epithelial tumors, including metastatic triple-negative breast cancer (TNBC) and metastatic urothelial cancer, where high expression is associated with poor survival and relapse.
The drug was created by site-specifically conjugating a TROP-2-targeting antibody with a drug to antibody ratio of 7.6 (which is about twice that of other antibody-drug conjugates) of the moderately toxic drug, SN-38, the active metabolite of irinotecan, using a pH-sensitive linker.
Bladder cancer
Urothelial cancer is the most common type of bladder cancer and occurs when the urothelial cells that line the inside of the bladder and other parts of the urinary tract grow unusually or uncontrollably.
Earlier this year, the American Cancer Society published the annual Facts and Figures report which showed while the organization expects a decline in some cancers, cases of bladder cancer are expected to increase in 2021.
According to the American Cancer Society, an estimated 83,720 people in the United States will be diagnosed with bladder cancer in 2021, and almost 90% of those diagnoses will be Urothelial cancer. The data shows an increase of approximately 3% compared to the prior year. That means that on average, 228 people will hear the devastating words, “You have bladder cancer,” each day this year.  Furthermore, an estimated 17,000 patients will not survive the disease and there are thought to be more than 600,000 people living with bladder cancer in the United States, more than the population of the state of Wyoming.
“[Altough] we celebrate the decline in certain cancer types as well as the progress against them,” said Andrea Maddox-Smith, Chief Executive Officer of the Bladder Cancer Advocacy Network (BCAN).
“The American Cancer Society’s report is a stark reminder that while bladder cancer is still one of the most commonly diagnosed cancers in the United States, rising expected case numbers in 2021 speaks to the urgent need for more and better treatments and expanded assistance for bladder cancer patients,” she added.
The relative five-year survival rate for patients with metastatic urothelial cancer is 5.5%.
“Cases of urothelial cancer continue to rise in the U.S., yet prognosis remains the same for the vast majority of patients,” Maddox-Smith said
“Bladder cancer patients need as many treatment options as possible, and we are pleased that Sacituzumab Govitecan can be a potentially viable treatment for them,” she concluded.
Treatment options
“Only a fraction of patients derive long-term benefit from previously approved cytotoxic therapy or immunotherapy, leaving a great unmet need for treatment options for patients with advanced urothelial cancer who have progressed on first- and second-line therapies,” said Scott T. Tagawa, MD, MS, FACP, Professor of Medicine and Urology at Weill Cornell Medicine, an oncologist at New York-Presbyterian/Weill Cornell Medical Center and principal investigator of the TROPHY study and a paid consultant for Gilead Sciences.
“The response rate and tolerability seen with Sacituzumab Govitecan may provide physicians an effective new treatment option for patients whose cancer continues to progress even after multiple therapies,” Tagawa added.
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Hyaluronic Acid - The Natural Skin Plumping Sugar
Despite its tough pronunciation and even more complicated spelling; hyaluronic acid is an important part of your daily skin care routine. It's widely used in serums, sheet masks, and moisturisers. This is because HA, a naturally occurring molecule in the skin, binds to water and plumps the face, giving it a dewy, glowing appearance. It's clear that word of its benefits has spread, as it's one of the most sought-after ingredients in skin-care products. Aside from increasing skin moisture levels, hyaluronic acid serves other functions. What is hyaluronic acid, exactly? Hyaluronic acid is a naturally occurring sugar molecule in the skin that helps water bind to collagen, keeping it in place and giving the skin a plumper, dewier, and more hydrated appearance. Essentially, hyaluronic acid improves skin hydration, which helps to maintain the skin's youthful, full, and bouncy appearance. Collagen in our dermis determines the structure of our skin. Natural hyaluronic acid is covalently linked to water molecules on one side and collagen on the other, providing plumpness to the skin. What is hyaluronic acid's function? As we age, our collagen and hyaluronic acid levels gradually decline, causing our skin to become increasingly dry. Furthermore, winter heaters, specific skin care products, and underlying skin disorders can cause microscopic tears in the protective skin barrier, allowing water to escape. As a result, implementing a customised skin care regimen that includes moisturising products could be extremely beneficial. Hyaluronic acid, glycerin, colloidal oatmeal, urea, propylene glycol, and sorbitol are humectants, which draw water to the skin to hydrate it. These chemicals can be found in a variety of products, such as moisturisers, eye creams, and serums. The use of HA-containing products tightens the skin around the eyes, increases moisture to reduce puffiness, and softens fine wrinkles throughout the face. Hyaluronic acid is effective when applied topically due to its ease of penetration. Our skin is the largest organ in the body, soaking up up to 60% of the nutrients applied to it. Furthermore, the lightweight, fluid nature of hyaluronic acid, as well as its ability to retain moisture from the environment and deeper dermis to completely hydrate the skin, are benefits. Who should benefit from hyaluronic acid? All skin types benefit from hyaluronic acid. It is non-irritating in general and does not aggravate acne, rosacea, or allergic skin conditions. However, there is a very small chance of experiencing any negative consequences. Individuals with dry and/or older skin will benefit the most from the application of hyaluronic acid. Because our bodies produce less hyaluronic acid as we age, people in their forties and fifties will benefit the most from applying it topically. Despite the fact that the term "acid" appears in the term of hyaluronic acid, those with sensitive skin should not be worried; it is completely safe for everyone. Because hyaluronic acid is naturally produced in our bodies, there are no known side effects from using it. If you have an allergic reaction to it or a product that contains it, contact your dermatologist immediately; the reaction could be caused by another active or inactive ingredient. Injectable Hyaluronic Acid Injections of hyaluronic acid are also available. Hyaluronic acid is a gel-like substance found in dermal fillers that attracts water after injection to replenish volume and restore lost structure. This helps to smooth the appearance of lines and wrinkles while also reducing the overall sunken or drooping appearance of the face. These dermal fillers can be used to treat nasolabial folds, marionette lines, cheek augmentation, chin augmentation, undereyes, lips, and back of the hands, among other things. Because the quality of fillers varies, it's critical to consult with your dermatologist about your options to ensure you get the best one for you. A cosmetic surgeon compares different types of hyaluronic acid fillers to different types of paintbrushes. They all contain the same component, but the density, lift-ability, and durability of the molecules vary depending on their size and arrangement. Additionally, it is reversible. Because it is injected into your face, it is not permanent. Because hyaluronic acid dermal fillers are reversible, your dermatologist can dissolve the filler quickly using the enzyme hyaluronidase if you are dissatisfied with the results or if a blood artery is blocked during the injection process. The enzyme works quickly; the substance dissolves quickly and is completely destroyed within 24 to 48 hours. Individuals who are allergic to bees, on the other hand, should proceed with caution — and consult a dermatologist — before attempting hyaluronidase-based therapy because the enzyme is found in bee venom. Hyaluronic acid fillers, on the other hand, are not for everyone. Except for pregnant women, the vast majority of people can benefit from hyaluronic acid fillers. Pregnancy and fillers have not been thoroughly studied, but dermatologists generally avoid injecting pregnant women due to uncertainty. Furthermore, if you have a current skin infection, you should avoid these fillers. First, treat the infection, and then return to your appointment once your dermatologist has given you the all-clear. If you're thinking about using hyaluronic fillers, there are a few minor risks to be aware of. Bruising and swelling are the most common side effects of any injectable treatment. The good news is that these shortfalls will only last a short time. Tenderness should subside within a few days. To reduce the risk of bruising, blood-thinning medications such as aspirin, ibuprofen, and red wine should be avoided for about a week before treatment. Furthermore, arnica and bromelain may aid in the reduction of swelling and bruising.
9 Effective Skincare Tips For Teenagers With Acne
A pimple develops when the pores of the skin become clogged with sebum; a type of oil that normally lubricates the skin and hair. Acne is common during puberty, when hormones kick in and the skin produces an abnormally high amount of sebum. Because the forehead, nose, and chin contain so many oil-producing glands, this area, dubbed the T-zone, is the most prone to pimples. Here are a few pointers to help you avoid and treat breakouts quickly: Wash your face twice daily with warm water and a gentle acne-specific cleanser (no more). Massage your face gently in circular motions. No scrubbing is required. Excessive washing and scrubbing can irritate the skin. After cleansing, apply a low-strength benzoyl peroxide lotion. Never squeeze your pimples. It's tempting, but here are some reasons why you should avoid it: Pimple popping can result in the push of infected material deeper into the skin, causing swelling, redness, and acne scarring. If you notice a pimple developing prior to a significant event, such as a wedding, a dermatologist can frequently treat it with minimal scarring or infection. Don't touch your face or lean your face against objects that collect sebum and skin residue, such as your phone. By touching your face, you can spread bacteria and cause inflamed and irritated pores. Wash your hands before applying anything to your face, such as your acne treatment creams or makeup, to keep bacteria at bay. Clean your pair of glasses or sunglasses to avoid clogging the pores around your eyes and nose with oil. Avoid tight fitting clothes if you have acne on your body. They obstruct the skin's ability to breathe and may irritate it. On scarves, headbands, and caps, dirt and oil can also accumulate. Remove your makeup before going to bed. When shopping for makeup, look for brands that list "non-comedogenic" or "non-acnegenic" on the label. Remove any old makeup that has a different smell or appearance than the day you purchased it. Keep your hair clean and away from your face to avoid clogging your pores with dirt and oil. Never skip sunscreen. While a tan may appear to conceal acne, this is only temporary. A tan may aggravate your acne rather than help it. Additionally, tanning wreaks havoc on the skin, causing wrinkles and increasing your risk of developing skin cancer. Consult a dermatologist if you are concerned about acne. Dermatologists offer a variety of acne treatment options for acne scar prevention and treatment. A dermatologist can assist you in determining the most effective treatment method for you and provide you with a wealth of useful advice on how to manage acne and care for your particular skin type.
5 Things To Know Before Your Tummy Liposuction For 6 Pack Abs
There are two types of fat to consider when doing tummy liposuction: subcutaneous and visceral. Subcutaneous fat is the jiggly, pinchable fat found just beneath the skin. It's generally harmless, but not always appealing. Visceral fat is fat stored in the abdomen. "Skinny-fat" is a term used to describe people with a lot of visceral fat. Not only is it unhealthy, but it's also dangerous. Because visceral fat is stored near your organs, it is more likely to disrupt organ functions, leading to increased insulin resistance (type 2 diabetes), blood pressure, bad cholesterol (LDL), and heart disease and stroke risk. Tummy liposuction removes subcutaneous fat. Visceral fat is insoluble in water and cannot be suctioned out. Diet and exercise can safely reduce visceral fat. Visceral fat does not prevent you from having liposuction, but it does affect the results. The patient had liposuction of the abdomen, waist, and hips. The patient was pleased with the visible results. However, visceral fat remains in the tummy , which liposuction cannot remove. Without an MRI or CAT scan, you can't tell how much visceral fat you have. Visceral fat makes up about 10% of total body fat. Your visceral fat may start to affect your health if your waist circumference is 40 inches or 35 inches for a man and 35 inches for a woman. Tummy liposuction does not always require general anaesthesia. It's true for all body parts, but not always! In fact, some surgeons still prefer general anaesthesia, especially for abdominal surgery. Your plastic surgeon will almost certainly use the tumescent method, which has long been the gold standard for safe and effective liposuction. Tummy fat is removed by injecting tumescent fluid (saline and epinephrine with sodium bicarbonate as a buffer) into the skin-to-abdominal cavity area. The saline solution fills the fatty layer beneath the skin, making it easier to sculpt (hence the name Liposculpture). Epinephrine is a vasoconstrictor, reducing bruising and blood loss. For tummy liposuction under local anaesthesia, your surgeon will add lidocaine (a numbing agent) to the tumescent fluid. In addition to avoiding the risks associated with general anaesthesia, this allows your cosmetic surgeon to perform lipo without putting patients to sleep. Watch for Loose Skin and Belly Hang. As we age, our bodies produce less collagen, causing our skin to lose elasticity and bounce back. Now anyone can have liposuction! Remember that skin laxity is more likely to be an issue with tummy lipo as you age. Loose skin can occur after extreme weight loss, as well as after liposuction. With SmartLipo, laser-assisted liposuction in Mumbai tightens skin better than liposuction alone. In some cases, due to the size of the abdomen or lack of skin elasticity, a tummy tuck may be required. You can gain weight even if fat doesn't move. Liposuction is an investment in your body that requires maintenance. Tummy liposuction will not prevent you from gaining weight. Even if you gain weight, your tummy will still be slimmer! Liposuction is not a weight loss solution and should not be used as such. Tummy liposuction permanently removes abdominal fat. Those cells don't regenerate, move, or change where they store fat. After tummy liposuction, your body has fewer fat cells in the abdomen (about 70 percent less). If you gain weight after tummy liposuction, your body will store fat in the same places. Because we removed so much fat from your tummy , other areas may appear larger. That you can eat whatever you want and never gain weight just because your tummy is smaller after lipo means nothing. Again, liposuction is not a quick fix and should not be used as such. 6 pack abs are made in the gym and the kitchen. "Abs are made in the kitchen, not the gym," you've probably heard. That's a lot of truth. Subcutaneous fat hides abdominal muscles, no matter how big and strong they are. Or does it remove subcutaneous fat? So why don't all lipo patients have six-pack abs? The answer is simple: abs come from the kitchen and the gym. There's the gym and the operating room for tummy lipo. You've probably seen a flat tummy . They don't have much belly fat and have good muscle definition, but no six-pack. As previously shown, having a lot of visceral fat can prevent you from getting a flat tummy from lipo. You won't get abs from liposuction in Mumbai unless you first build strong ab muscles through exercise and weight training.
How To Pick The Best Plastic Surgeon For Your Rhinoplasty
Recent advancements in cosmetic surgery have allowed surgeons to achieve more natural, aesthetically pleasing, and elegant results. But no amount of advanced technology or surgical techniques can replace a skilled facial plastic surgeon's artistic eye and skill. Simply put, not all surgeons are equal. This is especially true of Rhinoplasty (also known as a "nose job"). The nose, along with the eyes and smile, is one of the most noticeable facial features. While you want a surgeon who will perform a safe procedure with minimal recovery time, you also want a surgeon who has the experience, artistic ability, and knowledge of nose anatomy to produce a stunning result. However, some surgeons lack the training and experience required to perform exceptional facial surgery. It is better to find out well before surgery! Before choosing a surgeon for your Rhinoplasty in Mumbai, do your homework well. Find out about the procedure and the surgeon from those who have had a successful Nose Job. Check reviews and inquire. Your experience will suffer if you are afraid to ask questions or communicate clearly. Before selecting a surgeon for your Rhinoplasty, consider asking her/ him the following: What are your qualifications? You can usually look up a surgeon's education, training, and board certifications online. A lack of a website by your plastic surgeon may be a red flag. Choose a Board certified surgeon. These surgeons have undergone extensive specialised training and are truly dedicated to facial plastic surgery. The number of rhinoplasties performed? A good surgeon will have performed hundreds, if not thousands, of these procedures over the course of his career. Like anything else, practise makes perfect. Choose a surgeon with the "numbers" to develop advanced technique and expertise. Please share your before and after photos? This is a fair and common request. Verify that your surgeon's photos are of actual patients, not stock photos. This will help you understand the surgeon's skills. Please show me some happy Rhinoplasty patients' testimonials? Reputable surgeons should be able to easily produce patient testimonials and before and after photos. If a surgeon refuses to provide these, he may simply lack them. Can you make my nose look like a famous person's? If you have a celebrity "nose crush," ask the surgeon if you can have your nose shaped like theirs. Be wary of a surgeon who claims to be able to duplicate another's nose. It may not be possible or desirable to give you an exact copy unless your nose and face share the same shape and bone structure. Responsable nose surgeons will work with you to develop a plan that meets your needs while remaining realistic. What is the procedure's cost? The cost of Rhinoplasty in Mumbai should be fairly consistent if you choose surgeons with similar levels of expertise. If a surgeon quotes you a price significantly lower than others, proceed with caution. You get what you pay for in life, and a Rhinoplasty is not something you want to skimp on. While a new, well-done nose can boost patients' confidence, a new, poorly done nose can do the opposite. Remember that paying another surgeon to fix it later isn't saving you any money.
Dimpleplasty - Get Dimples With A Quick And Easy Procedure
Cher, Mario Lopez, and Jennifer Garner are all famous for their dimpled smiles. They recently inspired fans to get their own dimples. “Everyone in Hollywood has them, and everyone wants them,” say plastic surgeons. Men who want the “Mario Lopez” look are also interested in the procedure. So, what is Dimpleplasty? Natural dimples are caused by skin adhering to underlying tissue. If someone smiles, a dimple appears. While some dimples last into adulthood, many disappear as a child grows and the cheek muscle matures. The latest cosmetic surgery trend is Dimpleplasty in Mumbai. Cosmetic surgeons now create four times as many dimples as they did a few years ago. What is Dimpleplasty? A tiny incision inside the patient's cheek creates dimples. No cuts on the outside of the face. The remaining cheek muscle is sutured to the skin's underside with dissolvable suture. An incision on the inside of the cheek creates a dimple. One local anaesthetic is used for the entire outpatient procedure. The dimples will be deeper at first, but will look natural after a few months. Initially visible whenever the patient smiles, the dimples gradually fade away. What is the Dolly Dimple? Dr. Siddharth Prakash, one of the few cosmetic surgeons who offers the service, says the “Dolly Dimple” is an updated version of the original dimple creation surgery in Mumbai that is more predictable. "Dimples can be more personalised," said Dr. Siddharth. “Patients can design their own dimples, long, short, deep, shallow, etc.” The patient can also choose the location of the dimples on their cheeks. Dimples are cute and brighten a person's smile. They are even lucky in some cultures.
This French City Is (Literally) Powered By Cheese.
By now, you've heard of alternative electricity sources like wind, water, and solar power, but have you ever heard of using cheese? For one French city, cheese production is responsible for a considerable amount of their electricity. But how exactly do they do it? When Albertville, a city in Beaufort's dairy manufacturing region, makes its cheese, they use special equipment to convert the whey's methane gas emissions into pure energy that can be used to power 7% of the region's electricity. According to the Smithsonian, this is enough to power roughly 1,500 of 20,000 homes. That may not sound like much, but when you consider its potential, the city might just be onto a new avenue for renewable power sources. In the picture above, you can see the Valbio power plant that produces the aforementioned 'cheese power'. While it's the largest of the company's dairy-powered energy plants (and the largest of such plant on Earth), it's not the only dairy plant around. The same company began building the generators over a decade ago and set up similar plants in Europe and Canada - with more to come! In fact, those in the States might be surprised to know that the Fage brand's Greek yogurt also plays a part in powering the region from where it's produced. When Fage is made at its Albany-based plant, the whey used is later pumped to a wastewater plant to produce energy from its fermentation. Pretty cool, huh? So I hope that all of you who decided you'd like to cut down on the dairy going into the New Year re-embrace your love for all things covered in cheese. You're doing it for the greater good of the environment. It's your personal duty to eat tons of cheese. Let me know what you think about this new, cheesy fuel source in the comments below. And for more WTF news, follow my WTF Street Journal collection.
Cumar Gold – Nano Curcumin, Anti inflammatory and Pain reliever – 30 capsules
#Cumar_Gold supports the treatment of gastric ulcer – duodenal ulcer, helps to restore health and beauty to women after childbirth, helps wounds, ... https://shemartglobal.com/product/combo-02-boxes-cumar-gold-nano-curcumin-turmeric-herbal-supplements-anti-inflammatory-pain-reliever-60-capsules/ DESCRIPTION CumarGold to contain super NanoCurcumin bioavailability, combined with piperin (black pepper extract) may enhance absorption, decrease metabolism and excretion of curcumin in the body. Use CumarGold oral absorption of curcumin for up to 90%, so just use the normal dose (2 -4 capsules / day) have achieved high efficiency in the prevention and treatment support most chronic diseases. Nano Crystal is pure curcumin from turmeric, is formulated with Nano super mini size (30-100 nm), to enhance the bioavailability (absorption and increase efficiency effects) up 50-55 times with ordinary curcumin extract. In nanotechnology, the active ingredient Curcumin is enclosed in tiny polymer, forming the Nano particle size of 30nm-100nm super small, dispersed in water, is rapidly absorbed into the blood and birth 50-55 times higher availability than conventional curcumin (the Kansai et al, 2012) so effectively treated with low-dose superior and safe, non-toxic and side effects.   BENEFITS  OF CUMARGOLD To support the treatment of duodenal ulcer. Help restore health and beauty for women after childbirth. Help improve the healing process and remove its dark pigmentation. Inprove the body resistance and support for patients who are undergoing the chemo- or radiation therapy. Reduce the risk of tumor due to free radicals. Protect liver and improve its function. INDICATION Duodenal ulcer patients. Woman after giving childbirth. Patients after being operated or who have wounds. Patients who are using chemo/radiation therapy. Patients who have chronic diseases, diabetes, hypertention, cardiovascular disease, osteoarthritis, mental disorders. Patients who are having hepatitis, fatty liver, cirrhosis. DOSAGE AND ADMINISTRATION It should be given orally 30 minutes before meals or 1 hour after meals.  – Preventing diseases: Adult and children more than 12 years: 01 capsule, twice a day. Children 6 to 12 years: 01 capsule, once a day. – Supporting for therapy: Adult and children more than 12 years: 02 capsules, twice a day. Children 6 to 12 years: 01 capsule, twice a day. COMPOSITION OF 1 CAPSULE:   Radix Curcumae longae essences. Extracted nano technology for 1 capsule. Nano Curcumin: 150mg Piperine: 0.3mg 1 (One) box of 3 blisters. Each blister contains 10 capsules.
How A Breast Lift Surgery Improves Your Quality Of Life And Self Esteem
Has pregnancy or significant weight loss caused sagging or loose skin in your breasts? Do sagging breasts cause skin irritation? Do you mind your breasts' appearance (due to age-related volume loss)? In this case, a breast lift may be beneficial. This procedure rejuvenates your breasts by repositioning your skin, nipple, and areola. Aside from cosmetic concerns, a breast lift may help with a variety of health issues. What exactly is a breast lift surgery? A breast lift, or “mastopexy,” elevates the nipple and areola. It also removes excess skin and tightens remaining breast tissues, addressing sagging and droopy breasts. If your areola is too big for your breasts, the procedure can fix that too! Why Do Breasts Sag? Breasts can change shape due to age, breastfeeding, and other factors. Underlying health issue Genetics Pregnancy Weight changes Breast Lift Benefits Reverse Breast Sagging Breast ptosis means drooping or sagging breasts. This condition can cause physical, emotional, and cosmetic issues. Fortunately, a breast lift surgery in Mumbai can help. The effects of breast lift on women with significant drooping were studied. Women who had abreast lift surgery between 2002 and 2016 were included. After surgery, patients were asked to rate their experience. The majority of patients reported not only an improvement in breast sagging but also high levels of satisfaction. Another study examined the effects of breast lift on women who had sagging breasts augmented. A questionnaire was used to assess patient satisfaction four years after surgery. The researchers found that breast lifts are safe and provide satisfactory long-term results. Most patients liked their breast shape, size, and symmetry. A third study examined the long-term effects of breast lift surgery on sagging breasts. Patients' before and after photos were taken as well as standardised breast measurements. Following surgery, patients reported increased overall satisfaction and upper pole fullness. Self Confidence Sagging breasts not only cause physical discomfort but also lower self-esteem. This condition limits clothing options and social interaction. A breast lift may help you regain your self-esteem. In one study, researchers evaluated patients' psychological health after cosmetic breast surgery. A 12-item short-form health survey was given to breast lift patients four times: immediately after surgery, one, six, and twelve months later. During this time, patients' self-esteem grew. Anxiety and depression symptoms decreased. From 2002 to 2016, researchers found that 85.6% of patients' self-esteem improved after having consecutive breast lifts. Patients were more satisfied with their results and less sagging of the breasts. Another study examined the psychological effects of various breast lift techniques on sagging women. One month after surgery, the patients' self-esteem improved, according to questionnaires and in-person interviews. The researchers concluded that this improvement was linked to increased satisfaction and decreased physical discomfort after surgery. Better Life Quality Several studies show that breast lift can improve patients' quality of life. This improvement is due to several factors, including body image. Physical aches and pains are gone. Also, it boosts self-esteem. A study compared patients who had breast augmentation with implants to those who had a breast lift. Both patient groups completed a 47-question survey about their post-operative quality of life. The responses were then returned via return mail to the authors. These two groups were pleased with the overall cosmetic outcome, including enlargement and symmetry. A study assessing the effects of combining breast augmentation and breast lift on patients' quality of life discovered an improvement in various aspects of surgery. Patients were pleased with the symmetry correction, scar quality, breast shape, nipple/areola size, and overall result, according to patient satisfaction surveys. A study comparing the effects of various breast lift techniques on patients with sagging breasts found significant improvements in quality of life. After surgery, patients were interviewed in person for six categories. Over the course of this study, the researchers assessed patients' medical and psychological conditions. Less nipple numbness and improved self-esteem were reported by patients. Thus, people's lives have improved. Would a Breast Lift Help? During your initial consultation, your plastic surgeon will examine your health to determine your candidacy for surgery. To design a treatment plan that meets your specific cosmetic and health needs. Large, heavy breasts are a good candidate for mastopexy in Mumbai. The lift is often combined with the reduction. You can benefit from a breast lift if you are troubled by: Low set breasts. Nipples pointing down. Stretched areola. Sagging and deflated breasts. One breast is higher than the other. Your outlook is positive and realistic. You are in good mental and physical health.
Five Revelations From the Near-Perfect 'Breaking Bad' Finale
I decided to post this card based on @LauraFisher amazing card on Which TV Finale Disappointed You The Most? At first, I thought I would make a list of my favourite TV finales, but decided to go a bit deeper into Breaking Bad final, which in my case was amazing. I am not one of those super hardcore breaking bad fans, but I truly like the finale. Breaking Bad premiered its first episode on AMC in January 2008. Five years, five seasons and 62 episodes later, one of the greatest television dramas of all time came to an end as Vince Gilligan's landmark series took its final, bloody bow. In a TV landscape that has, in recent years, found it difficult to satisfyingly wrap up beloved shows in a way that hits the right emotional notes while also tying up loose ends, Breaking Bad's final episode may prove to be one of the most fulfilling and well-made farewells ever. And while we're sure to keep "Felina" on our DVRs for repeated close inspection of the episode over the next few weeks, here are a few quick takeaways. Music, Once Again, Tells the Story Breaking Bad's final moments come courtesy of Badfinger's song "Baby Blue," from their 1971 album Straight Up, and it's easy to imagine Gilligan sitting at his desk while conceiving his hit series and sticking a Post-It Note on the wall with the title of this tune in bold marker. The song's lyrics fit Walter White's journey (and its ultimate conclusion) nearly perfectly: "Guess I got what I deserve . . . / That special love I have for you / My baby blue." It's also worth noting the Marty Robbins song that plays near the beginning of the episode while Walter is stuck inside the snow-covered car he's stealing. While seemingly entombed by snow, cold breath streaming from his mouth like his soul escaping from his body, Walt opens the glove box and pulls out a Marty Robbins cassette. Once he finds the keys and gets the car started, Robbins' song "El Paso" starts playing on the stereo. Here, again, Gilligan lets the music tell Walt's story: "Maybe tomorrow / A bullet may find me. / Tonight nothing's worse than this / Pain in my heart." This is Walter White's Episode We get to visit with nearly every remaining major player in the Breaking Bad universe during the finale, but make no mistake about it: "Felina" is Walter White's episode. Skyler, Flynn, Todd and Jesse all had big (mostly devastating) moments in the penultimate episode "Granite State," and Uncle Jack and his crew got theirs in "Ozymandias." The series finale, as it rightfully should, belongs to Walter White. It's his story to finish and, through him, we get to witness the tormenting and use of his nemeses (Gretchen and Elliot), the delivery of the truth that will finally let his wife move on with her life, and the destruction of his enemies (Lydia, Todd, Uncle Jack and the rest of his gang). Jesse gets his moment to shine near the episode's conclusion, but the series ends right where it was meant to end: focused solely on Walter White. Breaking Bad Learned from Other Series Finales One of the things that have made many recent series finales so divisive is their inability to tie up loose ends, answer questions and provide closure while also delivering a deeply moving, emotional conclusion. For every fan out there that loves the mystery and intrigue of the controversial endings of Lost and The Sopranos, there are just as many (if not more) folks who cried foul because they didn't get the answers they wanted. Breaking Bad's finale pulled in nearly every net the show had cast during its five-season run. Walt's family will get his money. Gretchen and Elliot get their comeuppance (in the words of Walter White: "This is where you get to make it right."). Badger and Skinny Pete are happy. We know where the ricin capsule went. We know what Walt needed that enormous gun for. Walt finally admits the truth: that he did it all for himself, not his family. Jesse gets to kill Todd. Jesse lives. Walt dies. All of the series' big questions were answered and that makes for a very satisfying way to end a show's run. If there are a few threads left dangling, they're minor (What happens to Brock, for instance, now that Andrea is gone? Does Jesse go find him?). Unless, of course, you're Huell and you're still hanging out in that safe house wondering what the hell is going on. What Does Jesse Have Left? That extremely cathartic moment when Jesse Pinkman speeds through the gates, alive, and begins his primal scream that's a mixture of happiness, sadness, frustration, relief and elation is so incredibly telling of the character's newfound freedom. Sure, he's made it out alive. He's got his life. But what else does Pinkman have left? He has no money. His girlfriend is dead. He's been beaten both physically and psychologically, and he's a shell of the human being he was once was. Yes, Jesse got his long-awaited retribution against his former teacher when he refused to kill him even though that's what Walt wanted. Jesse is going to live, but at what cost? Maybe he'll find Brock and raise him so the kid has the life that Jesse never had. Maybe he'll meet up with Badger and Skinny Pete, or maybe he'll make that trip to Alaska after all, erasing any evidence of the life he's left behind. Who knows? Walter White Finally Accepted His Fate Breaking Bad has always been about Walter White fighting for his life. He started by fighting cancer and moved on to fighting people like Gus Fring and Uncle Jack, but no matter what he's always been fighting. On top of that, Walt was constantly lying, either to himself or to someone else. "Felina" finally put a stop to that. Walt may have come up with a plan to see certain things through in this final episode (the money, the ricin, the Nazis, etc.), but he knew all along that this was a suicide mission. Walter White didn't, for a minute, expect to make it out alive. He had finally accepted his fate. "I did it for me," he told Skyler in their final meeting. "I liked it. I was good at it. And I was really . . . I was alive." For the first time, Walt was able to admit what we all knew all along: that his meth business (and all the various criminal activity that came along with it) was for his own benefit. Cooking meth transformed him into a superhero kingpin named Heisenberg. Meth, though he never used it in the traditional sense of the word, was Walter White's drug of choice, and it killed him just like it does your common junkie. He died alone, with nothing and no one left to care about him, and surrounded by nothing but the tools that got him high.