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Impact of COVID-19 on Vaccine in Healthcare Industry

COVID-19 Impact on Vaccine in Healthcare Industry
OVERVIEW
The COVID-19 has posed a complex challenge in front of different biotech companies, which has badly impacted the worldwide market. However, it has boosted the growth of companies involved in vaccine development, as there is great need of vaccine which can act against coronavirus and prevent this deadly disease.
Along with COVID-19 vaccines, there are various kinds of vaccines which are administered to people of different age groups in order to prevent them from different kinds of infectious diseases. These vaccines manufacturing process and administration process has been affected due to limited access to healthcare facilities and fear of getting COVID-19 infections.
For instance,
· In July 2020, around 80 million children who are under the age of one year have been reported to face some kind of disturbance mainly because of limited healthcare facilities access and threat of getting COVID-19 infections.
· In July 2020, WHO and UNICEF warned against the rapid decline in the number of children who have received life-saving vaccines and had stated that all this has happened due to disruptions in uptake and delivery of immunization services as a result of COVID-19 pandemic.
COVID-19 disease is a major threat to people who already have existing medical complications such as diabetes, pneumonia, and tuberculosis among others. This thus enhances the people attention towards preventing themselves from such infectious disease so that the chances of getting COVID-19 infection reduce.
As the prevalence of infectious disease is increasing worldwide, it has become important to provide patients with proper vaccination during the prevailing pandemic of COVID-19, this is the reason why biotech companies and government are taking several steps in order to deal with cumbersome conditions.
PRICE IMPACT:
As no treatment has been discovered yet for coronavirus, the fear of getting infection led the people to remain safe at their home, as a result of which various businesses around the world are suffering a lot involving biotech companies among others.
Various companies are working on vaccine development process, on other hand, several companies have signed deals with government of other countries in order to reserve their vaccine distribution, so as to earn benefit.
The cost of COVID-19 vaccines is likely to decrease due to high concern towards remaining prevented from deadly infectious diseases even during such a pandemic.
For instance,
· As per the news of 2020, Moderna Inc., a company recently working on mRNA-1273 vaccine which will act against the deadly coronavirus, stated that it will provide its vaccine at a cost of USD 32.00 to USD 37.00 to public.
· According to the news of August, 2020, Pfizer Inc. has signed an agreement with government to provide 100 million doses of coronavirus vaccine at a cost of USD 1.95 billion. This agreement will allow government to access coronavirus vaccine at a cost of USD 20.00 per dose.
Moreover, increasing prevalence of COVID-19 all around the world is also responsible for increasing the demand of COVID-19 vaccines at low cost.
All these factors thus signifies that increasing cases of COVID-19 led to the enhanced concern for government authorities and many other healthcare organizations towards the welfare of country people. This concern allowed the vaccine manufacturing companies to sign deal for vaccines at lower costs.
Thus, COVID-19 impact has expected to decrease the price of vaccines in the market.

IMPACT ON DEMAND

The coronavirus has affected the various regions of the world and caused widespread closure of companies and local manufacturing plants. This lockdown and isolation has adversely impacted the global economic activity.
Surge in COVID-19 cases is expected to enhance the number of deaths caused by HIV, tuberculosis and malaria. This concern puts a major emphasis over the need of vaccination.
In order to prevent tuberculosis and malaria among many more diseases, children are provided with vaccination.
The demand of vaccination has decreased due to several reasons which include fear of parents towards their children health which makes them not to take them to clinics and other government organizations in order to receive effective vaccination.
Moreover vaccine administrators have also been diverted from their responsibility, as they are scared of coronavirus.
Lack of protective equipment is one of the other major reason which poses challenge in front of physicians to treat a large number of people.
This signifies that increasing fear among people led to few vaccinations in 2020 which demonstrates the decrease in vaccine demand for various types of infectious diseases except COVID-19 due to prevailing coronavirus infections.
IMPACT ON SUPPLY
Due to pertinacious COVID-19 lockdown, sanctions have been imposed by governments of various countries. These restrictions and barriers across countries borders led to a decrease in supply of vaccines across the borders.
As per the report published by UNICEF on June 2020, it has been stated that in week of March 22nd, a collapse has been taken place in airline industry which has adversely impacted the shipment of vaccines. The report also suggested that currently the improvement in airline and shipments is increasing but up to a limited extent.
Due to supply disruption of vaccines, the countries across West and Central Africa, East and Southern Africa, East Asia and South Asia had reported that the vaccine stocks of their countries has reached to critical levels, these includes various types of vaccines involving pentavalent (diphtheria, tetanus, pertussis (whooping cough), bacillus calmette-guérin (BCG), hepatitis B and haemophilus influenza (type b), rotavirus and pneumococcal conjugate vaccine (PCV).
Moreover, UNICEF, WHO and GAVI had reported suspension of their vaccination programs due to delay in shipments.
For instance,
· In July 2020, a new published entitled “COVID-19 Disrupted Pneumococcal Vaccine Procurement, MOH Still Working On Supply”, this has been depicted that pandemic of COVID-19 has led to delay in the procurement process of pneumococcal vaccine which can be proved to be a cause of rising pneumococcal infection to vast children population present worldwide.
· In May 2020, a total of 99 countries have been reported the delay of immunization program due to inefficient vaccine supply because of constant lockdown.
· In May 2020, World Health Organization (WHO) warned about the risk to millions of children which are unable to get routine vaccination just because of the prevailing COVID-19 pandemic all over. This healthcare organization suggested that lockdowns and cutbacks in commercial flights have led to delayed supply of vaccines, which is one of the major factors responsible for children not achieving proper vaccination.
This thus signifies that due to continuous lockdown and several restrictions by government authorities, the companies and patients are facing disruption of supply chain for various kinds of vaccines. Moreover, delay in vaccine supply leads to extreme loss to vaccine manufacturing companies because of vaccine expiry during such a long term period.
STRATEGIC DECISIONS OF MANUFACTURERS
Collaboration, agreements, strategic initiatives by market players such as Novartis AG, AstraZeneca and Vaxxas among others in the vaccine market will help them to expand their product portfolio and to provide with the most innovative and appropriate vaccine involving COVID-19 vaccine to physicians and patients. This in turn will lead to increasing product sales and hence will put a positive impact on overall company’s revenue.
Vaccine manufacturing companies are taking so many strategic decisions in order to cope up with the current scenario of COVID-19. The companies engaged in manufacturing of vaccines are collaborating so as to accelerate the development of various kinds of vaccines.
The companies have already taken several kinds of strategic initiatives in order to cope up with the corona virus situation.
For instance,
· In August 2020, European Commission has signed an agreement with AstraZeneca, a pharmaceutical company for purchase of COVID-19 vaccine. As per the agreement, the commission will purchase 300 million diseases of COVID-19 vaccines from AstraZeneca. This initiative helped the company to earn more benefit and to enhance its overall revenue.
· In July 2020, Vaxxas went under partnership with Merck and Harro Hofliger with an aim to commercialize its HD-MAP technology, used for vaccine delivery via nanopatch, a needle free vaccine delivery technology. Through this partnership, the company has received USD 18.00 million from Merck, which helped it to boost up its vaccine development procedure.
· In June 2020, Novartis AG went under partnership with Massachusetts Eye and Ear General Hospital for producing a novel vaccine against the coronavirus. As per the deal, AveXis will provide with its expertise and technology needed for vaccine development procedure. This initiative has helped the company to enhance its platform with the addition of new coronavirus vaccine in its product portfolio.
· In April 2020, AJ Vaccines received pre-qualification for Picovax, an inactivated polio vaccine from WHO. This initiative helped the company to boost its product portfolio amid COVID-19 against the most threatening polio disease.
· In March 2020, CureVac has signed a deal with the U.S. President Donald Trump for development of CoV vaccine by utilizing its mRNA platform. This initiative helped the company to raise its potential for vaccine development.
· In March 2020, Inovio Pharmaceuticals Inc. received USD 5.00 million from Bill & Melinda Gates Foundation for accelerating the manufacturing process of CELLECTRA 3PSP proprietary smart device for delivery of COVID-19 vaccine.
With the increasing demand of effective COVID-19 vaccines, the urgent need of COVID-19 vaccine among other vaccines is increasing which is responsible for fueling up the growth of the vaccine market.
Thus, the companies operating in the vaccine market are adopting several strategies including collaboration, agreements, partnership and market expansion to enhance their business. These strategic decisions by the companies are expected to provide significant opportunities for the market players operating in the vaccine market.
CONCLUSION
The pandemic of COVID-19 has resulted in several restrictions throughout the borders which led to decline in vaccine stocks, such as vaccines for polio, tuberculosis among others. However, the urgent demand of COVID-19 vaccine allowed the manufacturers to boost up their vaccine manufacturing activities, which allows them to compensate their decline of revenue. Moreover, various kinds of strategic initiatives taken by market players also helped them to make a constant position in the vaccine market.
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Bioprocess Containers expected to register a CAGR of 26.3% during 2021-2026
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Significant Impact of COVID-19 on Bioresorbable Scaffolds in Healthcare Industry
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Even before the pandemic, the bioresorbable scaffolds were in high demand due to rising chronic coronary artery diseases and advanced methods for treatments of these diseases like vascular restorations globally. For instance, · As per the American College of Cardiology in 2018, the use of stent scaffolds in cardio surgeries started back in mid-1980s. But due to many adverse reactions of metallic scaffolds, which resist the natural vascularization process in arteries, researchers showed wide interest in bioresorbable scaffolds The rising transmission rate of coronavirus in the recent scenario has made high hospital admissions for various chronic diseases and respective demand for surgical scaffolds. The most widely used bioresorbable scaffold is ‘Absorb BVS’, made of PLLA scaffold coated with Everolimus-Eluting PDLLA. This is 150 micron size which can reabsorb for 4 years altogether. Coronary artery disease is major heart disease that affects both men and women irrespective of age globally. For instance, · According to the Center for Disease Control CDC; coronary heart disease has been estimated to be around 18.2 million in adults aged 20 and above. In 2017, the mortality rate was 365,914 due to coronary artery diseases. About 2 out of 10 individuals are killed due to the disorder in adults who are less than 65 years of age. This increases the demand for surgeries and vascular restoration for the timely treatment of most coronary disease conditions. Several companies operating in other domains are eager to enter, and some have already entered the landscape of bioresorbable scaffold market to increase their revenue by meeting the emergent need of various hospitals for coronary artery surgeries. The demand is further rising in local clinics and small laboratories due to high awareness of the disease and their advancements in surgical procedures. Impact on Supply Chain The COVID-19 has created a great impact on the supply chain of bioresorbable scaffolds. The sudden attack of COVID-19 and its subsequent impact on restrictions on trade and movement of goods has resulted in a shutdown of vast countries globally, resulting in disrupted supply chains due to limited raw materials and workforce, and slow down or stopping of manufacturing. Moreover, several manufacturing companies are retooling priority manufacturing to produce other essential medical supplies and equipment such as ventilators. But considering the need of these scaffolds in coronary heart diseases surgery and an increase in order from the consumers, the government allows the movements of transport vehicles to import and export the medical and surgical scaffold or implants products which is highly required by hospitals and other healthcare sectors. Additionally, the manufacturers are also taking crucial steps to ensure the availability of raw materials and look into the quality of products. Manufacturers need to take necessary steps about production processes, shifting to other facilities if required, changes in quality assurance, costs and procedures related to screening of workforce and offering care if needed, changes in working hours, and others in order to maintain their supply chain. To minimize supply chain crises, the government has been firmly monitoring the supply chain to assume that the COVID-19 outbreak may adversely impact the supply chain of medical products, including shortages of bioresorbable scaffolds for various surgical purposes to coronary healthcare sectors in countries globally or potential disruptions in supply chains. To manage such a crucial situation, many organizations are looking forward to improving and diversifying the supply chain model in all aspects. The resulting COVID-19 pandemic has shown the various ways for supply chain management, which may be effective by innovative solutions initiated by market players. STRATEGIC DECISIONS OF GOVERNMENT AND MANUFACTURERS The key players engaged in the global bioresorbable scaffolds market are making improvements to keep the speed during COVID-19. They are cautiously taking every single step so the development can be expanded on a consistent schedule for the market. Organizations working in the bioresorbable scaffolds market embrace a few systems, including joint effort, arrangements, association, and market development to improve their business. For instance, · On September 3, 2020, Abbott, the primary key player in the bioresorbable scaffolds market, announced that they had initiated a LIFE-BTK clinical trial for evaluating the effectiveness of Esprit BTK Everolimus Eluting Resorbable Scaffold, which was used for people battling with late stages of peripheral artery disease (PAD). Even during the pandemic, the company is making many initiatives to resume their products manufacturing and trial over the market to strengthen their position. Conclusion The impact of the novel COVID-19 virus is expected to leave a long-lasting impact on each healthcare sector. The virus poses a risk to human life and has caused economic distress and severe emotional strain. It produced a ripple effect that gave rise to a new collection of requirements and needs that were not much needed earlier. The most essential one being the bioresorbable scaffolds and medicinal products, which are highly needed in hospitals, clinics, laboratories due to rising chronic cardiovascular and coronary artery diseases and surgical emergence globally. It is estimated that the COVID-19 pandemic has a negative impact on the market's growth due to the surgery cases of coronary diseases being halted unless emergence. The current priority in most hospitals is given for COVID-19 treatments as the surge of COVID-19 cases keeps increasing each day. Moreover, many International governments, including U.S, Europe and Asia’s healthcare organizations, have supported the supply of these scaffold products due to high priority in this crucial health crisis period. Many government bodies and significant market players are closely associated with patients and pharma industries for safe packaging of products considering contagious nature of the virus and improvement of future economics.
The Future of Cell & Gene Therapy Manufacturing Services - Trends And Analysis
Growth in cell & gene therapy manufacturing services market is primarily driven by the high incidence of cancer and other target diseases, increasing investments in pharmaceutical R&D, investments in advanced technologies by CDMOs, and increasing partnerships & agreements between pharmaceutical companies and CDMOs. However, the high operational costs associated with cell & gene therapy manufacturing are expected to restrain the growth of cell & gene therapy manufacturing services market to a certain extent. According to GEP Worldwide, more than 1,200 clinical trials across the globe were disrupted by June 2020. Nearly 61% of clinical trials were disrupted due to the suspension of patient enrolment. The impact varied due to changes in COVID-19 case volumes throughout the year, but the worst effect was seen in April 2020. Trials involving respiratory disease, oncology, ID/anti-infectives, and cardiovascular disease were the worst-hit during this time. The trend suggests that the top pharma companies are increasing their R&D efficiencies through heavy R&D investments to see returns on their investment in the long run and through collaborative R&D efforts. According to an EvaluatePharma report, the worldwide pharmaceutical R&D spending was valued at USD 136 billion in 2012; this increased to USD 186 billion in 2019. The increase in pharmaceutical R&D has resulted in a sharp increase in the number of cell & gene therapy candidates under development. This has made it necessary to outsource manufacturing services to develop cost-effective and efficient cell & gene therapies For More Information Download PDF Brochure @ https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=180609441 Most viral vectors are produced using adherent manufacturing, which is expensive to operate—a vial of 20 million cells can cost USD 20,000 to USD 30,000 to make. The cost of manufacturing for gene therapy can be between USD 500,000 and USD 1 million, excluding the costs for R&D, the costs to run crucial clinical trials, or the costs to build the commercial infrastructure necessary to provide access to patients. According to a 2020 PhRMA report on the cell & gene therapy pipeline in 2018, there were 289 cell & gene therapies in clinical development by biopharmaceutical companies. This number increased by 25% in 2020, with 362 cell & gene therapies in clinical development. In addition to this, according to data released by CGT Catapult, there were 154 ATMP clinical trials ongoing in the UK in 2020 compared to the 127 trials reported in 2019, indicating an increase of more than 20%.  
Protein Engineering : Future, Trends, And Scope
The growth of this market is majorly driven by factors such as the increasing investments in synthetic biology and the growing focus on protein-based drug development by pharmaceutical and biotechnology companies.  The rational protein design segment accounted for the largest share of the market in 2019. The large share of this segment can be attributed to the increasing use and continuous upgrades of bioinformatics platforms and software for protein analysis.  The global market is segmented into four major regions, namely, North America, Europe, the Asia Pacific, and the Rest of the World. In 2019, North America accounted for the largest share of the global market, closely followed by Europe.  Factors such as the presence of well-established CROs, rising R&D expenditure, and the availability of the latest techniques and instruments for drug discovery research are responsible for the large share of the North American market. However, the Asia Pacific market is estimated to grow at the highest CAGR during the forecast period.  Download PDF Brochure @ https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=898  Monoclonal antibodies accounted for the largest share of the protein engineering market in 2019, majorly due to the high and growing demand for monoclonal antibodies for the treatment of cancer, neurological diseases, and infectious diseases.  The rational protein design segment accounted for the largest share of the market, majorly due to the increasing use and continuous upgrades of bioinformatics platforms and software for protein analysis.  The protein engineering market is segmented into biopharmaceutical companies, contract research organizations, and academic research institutes. Biopharmaceutical companies use protein engineering products extensively in their drug discovery and development activities as these products help in designing models to develop a broad range of protein-based drugs. As a result, biopharmaceutical companies were the largest end-users in this market in 2019.  The major companies operating in the global protein engineering market include Thermo Fisher Scientific (US), Danaher Corporation (US), Agilent Technologies (US), and Bio-Rad Laboratories (US).  Market Research Developments: In 2019, Creative Biolabs (US) launched the cd25 monoclonal antibody. In 2019, Waters Corporation (US) launched Vanguard FIT Cartridge Technology. In 2019, Agilent Technologies (US) acquired BioTek Instruments (US), which helped the company to expand its expertise in cell analysis and establish its position in the immuno-oncology and immunotherapy markets. In 2019, Merck KGaA signed a license agreement with Amunix Pharmaceuticals, Inc. (US). Under this agreement, Amunix will gain the rights to develop therapeutics using the protease-triggered immune activator (ProTIA) technology platform.
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Particle Therapy Market worth USD 1,349 million by 2023 : Technological advancements in the field of Heavy Ion Therapy
The study involved four major activities to estimate the current market size for particle therapy. Exhaustive secondary research was done to collect information on the market and its different subsegments. The next step was to validate these findings, assumptions, and sizing with industry experts across the value chain through primary research. Both top-down and bottom-up approaches were employed to estimate the complete market size. Thereafter market breakdown and data triangulation was used to estimate the market size of segments and subsegments. According to the new market research report “Particle Therapy Market by Type (Heavy Ion, Proton Therapy), Products (Cyclotron, Synchrotron, Synchrocyclotron), Services, System (Single-room, Multi-room), Cancer Type (Pediatric, Prostate, Breast), Application (Treatment, Research) – Forecast to 2023“, published by MarketsandMarkets™, the global Particle Therapy Market is projected to reach USD 1,349 million by 2023 from USD 865 million in 2018, at a CAGR of 9.3%. Browse in-depth TOC on “Particle Therapy Market“ 80 – Tables 36 – Figures 138 – Pages Download PDF Brochure:  https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=12809137 The major factors driving the growth of the Particle Therapy Market are the growing global prevalence of cancer, growing adoption of particle therapy in clinical trials, advantages offered by particle therapy over photon therapy, and the increasing number of particle therapy centers worldwide. The pediatric cancer segment is expected to account for the largest share of the Particle Therapy Market, by cancer type, in 2018 Based on cancer type, the Particle Therapy Market is segmented into pediatric cancer, prostate cancer, breast cancer, lung cancer, head & neck cancer, and other cancers. The pediatric cancer segment is expected to account for the largest share of the Particle Therapy Market in 2018. The growing incidence of pediatric cancer and the high success rates and minimal long-term risks achieved with particle therapy are the major factors driving the growth of this market segment. Research applications to register the highest CAGR in the global Particle Therapy Market during the forecast period Based on applications, the Particle Therapy Market is segmented into treatment applications and research applications. The research applications segment is expected to witness the highest CAGR during the forecast period. Growing awareness about the research applications of particle therapy systems, development of cost-effective and technologically advanced diagnostic and therapeutic particle therapy systems, and increasing industry-academia collaborations in the field of research are the key factors driving the growth of this segment. Asia Pacific to dominate the Particle Therapy Market during the forecast period The Particle Therapy Market is segmented into four regional segments, namely, North America, Europe, Asia Pacific, and the Rest of the World. The Asia Pacific region is expected to account for the largest share of the global Particle Therapy Market in 2018, and this trend is expected to continue during the forecast period. The Asia Pacific region is expected to offer significant growth opportunities for players operating in the Particle Therapy Market owing to the increasing healthcare expenditure and growing initiatives to promote the use of advanced particle therapy technologies in Asia Pacific countries. Request for sample pages @ https://www.marketsandmarkets.com/requestsampleNew.asp?id=12809137 The major players operating in the Particle Therapy Market are Ion Beam Applications SA (Belgium), Varian Medical Systems, Inc. (US), Hitachi, Ltd. (Japan), Provision Healthcare (US), Mevion Medical Systems, Inc. (US), Sumitomo Heavy Industries, Ltd. (Japan), Optivus Proton Therapy, Inc. (US), ProTom International, Inc. (US), Advanced Oncotherapy plc (UK), and Danfysik A/S (Denmark). Browse Adjacent Markets @ Medical Devices Market Research Reports & Consulting Radiotherapy Market by Product (LINAC, CyberKnife, Gamma Knife, Tomotherapy, Particle Therapy, Cyclotron), Procedure (External (IMRT, IGRT, 3D-CRT) Internal (LDR, HDR)), Application (Prostate, Breast, Lung), End User (Hospitals) – Global Forecasts to 2026 https://www.marketsandmarkets.com/Market-Reports/radiotherapy-monitoring-devices-market-567.html Patient Positioning System Market by Product (Tables (Surgical Tables, Radiolucent Imaging Tables), Accessories), Application (Surgery, Cancer Therapy, Disease Diagnosis), and End User (Hospitals, Ambulatory Surgery Center) – Global Forecast to 2022 https://www.marketsandmarkets.com/Market-Reports/patient-positioning-system-market-12586699.html About MarketsandMarkets™ MarketsandMarkets™ provides quantified B2B research on 30,000 high growth niche opportunities/threats which will impact 70% to 80% of worldwide companies’ revenues. Currently servicing 7500 customers worldwide including 80% of global Fortune 1000 companies as clients. Almost 75,000 top officers across eight industries worldwide approach MarketsandMarkets™ for their painpoints around revenues decisions. Our 850 fulltime analyst and SMEs at MarketsandMarkets™ are tracking global high growth markets following the “Growth Engagement Model – GEM”. The GEM aims at proactive collaboration with the clients to identify new opportunities, identify most important customers, write “Attack, avoid and defend” strategies, identify sources of incremental revenues for both the company and its competitors. MarketsandMarkets™ now coming up with 1,500 MicroQuadrants (Positioning top players across leaders, emerging companies, innovators, strategic players) annually in high growth emerging segments. MarketsandMarkets™ is determined to benefit more than 10,000 companies this year for their revenue planning and help them take their innovations/disruptions early to the market by providing them research ahead of the curve. MarketsandMarkets’s flagship competitive intelligence and market research platform, “Knowledge Store” connects over 200,000 markets and entire value chains for deeper understanding of the unmet insights along with market sizing and forecasts of niche markets. Contact: Mr. Shelly Singh MarketsandMarkets™ INC. 630 Dundee Road Suite 430 Northbrook, IL 60062 USA: +1-888-600-6441 Email: sales@marketsandmarkets.com Research Insight: https://www.marketsandmarkets.com/ResearchInsight/particle-therapy-market.asp