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Buy Xanax Online Overnight Delivery


· What is Xanax?

Xanax (alprazolam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that alprazolam works by enhancing the activity of certain neurotransmitters in the brain.
Xanax is used to treat anxiety disorders and anxiety caused by depression.
Xanax is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia).
It is dangerous to purchase Xanax on the Internet or outside the United States. The sale and distribution of medicines outside the U.S. does not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distributed by a licensed pharmacy.




· How should I take Xanax?

Take Xanax exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides. Your doctor may occasionally change your dose. Never use Xanax in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of this medicine.
Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.
Swallow the extended-release Xanax XR tablet whole and do not crush, chew, or break it.
Xanax is usually taken for no longer than 4 months to treat anxiety disorder, and for no longer than 10 weeks to treat panic disorder. Follow your doctor's dosing instructions very carefully.
Call your doctor if your symptoms do not improve, or if they get worse.
If you use this medicine long-term, you may need frequent medical tests.
Do not stop using Xanax suddenly, or you could have unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose.
Store at room temperature away from moisture, heat, and light. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.



· Dosing information

Usual Adult Dose for Anxiety:
Immediate-release tablets: 0.25 to 0.5 mg orally administered 3 times a day
-Maximum dose: 4 mg/day
Usual Adult Dose for Panic Disorder:
Immediate-release tablets: 0.5 mg orally administered 3 times a day
-Maximum dose: 10 mg/day

Extended-release tablets:
-Initial dose: 0.5 to 1 mg orally once a day
-Maintenance dose: 3 to 6 mg orally per day, preferably in the morning
-Maximum dose: 10 mg/day

Comments:
-The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently.
-Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage.
-The daily dosage may be decreased by no more than 0.5 mg every 3 days; however, some patients may require an even slower dosage reduction.
-The dose of extended-release tablets may be increased at intervals of 3 to 4 days in increments of no more than 1 mg per day.
-The times of administration should be distributed as evenly as possible throughout the waking hours.
Usual Geriatric Dose for Anxiety:
Elderly or debilitated patients:
Immediate-release tablets: 0.25 mg orally administered 2 or 3 times a day.
Usual Geriatric Dose for Panic Disorder:
Elderly or debilitated patients:
Immediate-release tablets:
-Initial dose: 0.25 mg orally administered 2 or 3 times a day

Extended-release tablets:
-Initial dose: 0.5 mg orally once a day

Comments:
-If side effects develop, the dose may be lowered.
-The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently.
-Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage.

· Symptoms

There are many similarities between the symptoms of stress and anxiety. When someone is stressed, they may experience:
faster heartbeat
faster breathing
anxious thoughts
moodiness, irritability, or anger
general unhappiness
a feeling of being overwhelmed
loneliness
nausea
dizziness
diarrhea or constipation

When someone is anxious, they might experience:
faster heartbeat
faster breathing
a feeling of unease or dread
sweating
diarrhea or constipation
nervousness


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6 Easy Ways To A Smooth Neck
Because the skin on your neck is some of the thinnest on your body, it is also one of the first places to show signs of ageing. Here are six ways to make your neck look younger and address everything from sun damage to sagging on this delicate area. 1. WEAR SUNSCREEN EVERY SINGLE DAY. Your dermatologist will agree that a nickel-sized amount of sunscreen applied to your neck and chest every day will help prevent collagen breakdown and the formation of sunspots. Don't forget to massage the sides and back of your neck. 2. MAINTAIN YOUR SKIN'S MOISTURIZATION. Again, the skin on your neck is thinner and has fewer oil glands than the rest of your body, so keeping the area hydrated is essential for a smoother overall texture. Look for peptide-containing creams (which can help stimulate new collagen growth) and apply them in gentle, upward strokes from your chest to your jawline. 3. RECLAIM YOUR BEAUTY SLEEP. Do you always wake up with pillow lines on the side of your neck? Apply one of these silicone patches before going to bed to keep your skin from crinkling while you sleep. You'll wake up with a smoother neck and less chance of further damage. 4. FOCUS ON CORRECT POSTURE. The amount of time we spend looking down at our phones and screens has resulted in what we now refer to as "tech neck." The simplest solution would be to limit screen time entirely, but more realistically, you should keep everything as close to eye level as possible to avoid unnecessary wrinkling. 5. GIVE LASER TREATMENTS A GO AHEAD. Still have fine lines on your neck? Fraxel lasers, stimulate your body's natural repair process to promote collagen growth. Fraxel can also be used to treat any dark spots or broken capillaries in the area, giving you a more even complexion. 6. ULTRASOUND TREATMENT FOR SERIOUS REPAIR. Ultherapy or Ultracel is your best non-surgical option for deeper, more stubborn lines and sagging. The FDA-approved treatment uses heat generated by focused sonic waves to penetrate deeper into the skin and stimulate the production of new collagen. Take note that the effect is gradual, and most patients notice a lifting effect three to six months after the initial treatment, so be patient.
Medical Supplies Market - Future Growth, Comprehensive Analysis & Key Players
According to the new market research report “Medical Supplies Market by Type (Diagnostic, Dialysis, Wound Care, Disinfectants, PPE, Radiology, Sterilization, Catheters), Application (Urology, Cardiology, Infection Control), End User (Hospitals, Clinics & Physician Offices) – Global Forecast to 2025″, published by MarketsandMarkets™, is projected to reach USD 133.5 billion by 2025 from USD 132.6 billion in 2020. Browse in-depth TOC on “Medical Supplies Market“ 126 – Tables 45 – Figures 227 – Pages Download PDF Brochure: https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=64344238 The increasing prevalence of chronic diseases across the globe, increasing government and corporate investments in healthcare projects and infrastructure development, rising demand for infection control measures to curb the occurrence of HAIs, and the rising demand for medical devices are driving the growth of the global medical supplies market. Moreover, the rising medical tourism and emerging markets are expected to offer significant growth opportunities to players operating in the market for coming years. Catheters accounted for the largest share of the medical supplies market, by type, in 2019 By type, segmented into diagnostic supplies, infusion & injectable supplies, intubation & ventilation supplies, disinfectants, personal protective equipment, sterilization consumables, wound care consumables, dialysis consumables, radiology consumables, catheters, sleep apnea consumables, and other medical supplies. The intubation & ventilation supplies segment is expected to grow at the highest growth rate during the forecast period. The growth of this segment is driven mainly by the rising prevalence of respiratory diseases such as asthma and COPD across the globe. The other applications segment accounted for the largest market share in 2019 The applications market is categorized into urology, wound care, radiology, respiratory, infection control, cardiology, IVD, and other applications. The other applications segment held the largest market share in 2019, due to factors such as the increasing number of surgical procedures, rising prevalence of dental diseases, and the increasing focus on adhering to proper waste disposal methods. Hospitals accounted for the largest share of the medical supplies market, by end user, in 2019 The end-user segment of this market is categorized into hospitals, clinics/physician offices, and other end users. Hospitals form the largest and the fastest-growing end-user segment in the medical supply market. This can be attributed to the increasing investments in healthcare systems and the high prevalence of infectious and chronic diseases. Request Research Sample Pages: https://www.marketsandmarkets.com/requestsampleNew.asp?id=64344238 North America was the largest regional market for medical supplies in 2019 The global medical supplies market is segmented into North America, Europe, the Asia Pacific, and the Rest of the World. In 2019, North America accounted for the largest market share, followed by Europe. The increasing incidence of COVID-19 in the US and the implementation of various supportive initiatives by the Canadian Government are the major factors driving the growth of the market in North America. The prominent players operating in the global medical supplies market include Medtronic (Ireland), Cardinal Health, Inc. (US), BD (US), Johnson & Johnson (US), B. Braun Melsungen AG (Germany), Boston Scientific Corporation (US), Thermo Fisher Scientific, Inc. (US), Baxter International, Inc. (US), Avanos Medical, Inc. (US), 3M (US), Smith & Nephew (Ireland), ConvaTec Group Plc. (UK), Abbott (US), Cook Medical (US), Merit Medical Systems (US), Stryker (US), Terumo Corporation (Japan), Teleflex Incorporated (US), Fresenius Medical Care AG & Co. KGaA (Germany), and Coloplast Group (Denmark).
Significant COVID-19 Impact on Non-Small Cell Lung Cancer Diagnostics in Healthcare Industry
COVID-19 Impact on Non-Small Cell Lung Cancer Diagnostics in Healthcare Industry The novel coronavirus has profoundly impacted all fields, including healthcare, medical device services, automotive, pharmaceutical and many others. This pandemic has led to shutdowns of mass production and disruptions in the supply chain that have impacted the economies of virtually every nation in the world. The pandemic also affected the non-small cell lung cancer diagnostic industry. The patient's fear of contracting the virus compels patients to stay home instead of undergoing diagnosis and treatment. During the COVID-19 pandemic, countries worldwide witnessed a large number of patients suffering from COVID-19 and post COVID-19 complications such as cardiovascular disease, diabetes and kidney problems. As the COVID-19 cases were rising, the healthcare system had shifted its focus in curbing the disease, thereby delaying diagnosis and treatment of other chronic conditions as cancer. Thus, a negative impact is expected on the non-small cell lung cancer diagnostics market due to the pandemic scenario As a result, the hospitals and clinics were filled up with COVID-19 patients and less preference was given to non-small cell lung cancer patients. Moreover, limited access to clinics, social distancing, the lockdown of the population, which results in a slow-down in patient flow and referrals, has also impacted the market growth. However, with the cases decreasing in number and increase in vaccination against COVID-19 across the globe, the market for non-small cell lung cancer diagnostics market may get a boost due to some relaxation in COVID-19 cases, which will result in increased demand for non-small cell lung cancer diagnosis with patients coming forward to clinics and hospitals for treatment. IMPACT ON DEMAND Various screening, diagnostic and surgical procedures were restricted and at hospitals and cancer treatment centers, which resulted in disruptions in the non-small cell lung cancer diagnostics market. However, even during the pandemic, the lung cancer cases were subsequent, which is expected to increase the demand for non-small cell lung cancer diagnostics market. For instance, · According to World Health Organization (WHO), in 2020, lung cancer accounted for 2,206 771 deaths among both sexes. The lung cancer statistics include both small cell lung cancer and non-small cell lung cancer. About 13% of all lung cancers are small cell lung cancer and 84% are non-small cell lung cancer. This proves an increase in the number of non-small cell lung cancer patients even during the COVID-19 pandemic. Moreover, according to the American Cancer Society, Inc., lung cancer patients are likely to get infected with coronavirus because of the changes in their immune system that control their body's defense systems. For instance, · According to a study published in PubMed, patients with lung cancer are at an increased risk of becoming infected with the virus and experience higher morbidity and mortality than the general population Thus, having cancer such as non-small cell lung cancer may also increase the risk of severe illness from COVID-19 as the cancer therapy treatment reduce the immune system of the body. . This has increased the demand for non-small cell lung cancer diagnostic tools, especially in cancer-dedicated hospitals and surgical centres, where all the patients of non-small cell lung cancer-related problems are treated. Thus, with the increased lung cancer cases, the demand for non-small cell lung cancer diagnostic will increase in the coming years. IMPACT ON SUPPLY CHAIN The supply chain was widely affected by the COVID-19 pandemic as acute restrictions and lockdowns produced many urgent situations in the early days of the pandemic, which needed immediate attention. The supply chain disruption has transformed many organizations' business environments, including the supply chain of non-small cell lung cancer diagnostics market. The supply chain disruption impacted the Asia-Pacific region initially, especially the demand from China due to challenges from restricted movement and quarantine period. For instance, · According to the FDA, 63 manufacturers representing 72 facilities in China that produce essential medical devices face obstacles in manufacturing medical devices and their supply, owing to citing workforce challenges and the necessary quarantine of workers. Moreover, closing borders of various countries is anticipated to diminish the supply chain business environment, as it may hamper export of the medical supplies To minimize supply chain crises, the FDA has been firmly monitoring the supply chain with the assumption that the COVID-19 outbreak may adversely impact the supply chain of medical products, including shortages of critical medical products in the U.S. or potential disruptions in supply chains. Many organizations and countries are looking forward to improving and diversified supply chain models in all aspects to manage such a crucial situation. A diversified supply chain model anticipated minimizing the export of medical products as well as increase end-to-end visibility. For instance, · The Brazilian government published a resolution eliminating import taxes on 141 medical products and hospital equipment · The European Commission made a decision for helping Member States affected by the pandemic to suspend customs duties and VAT on medical devices temporarily · Federal indirect tax body the Goods and Services Tax (GST) Council of India has decided to cut taxes on medical supplies IMPACT ON PRICE The coronavirus disease (COVID-19) pandemic does not significantly impact the global non-small cell lung cancer diagnostics market. But it is estimated that if COVID-19 continues to spread for a prolonged period, then the demand for non-small cell lung cancer diagnostic equipment and devices will highly upsurge for top importer countries. For therapies and the diagnostic United States solicit the huge number of medical devices, followed by China and Japan. For instance, · According to the General Administration of Customs (GAC), China's exports of medical machinery and devices increased 40.5 percent in 2020 compared to the previous year, reaching USD 18.138 billion · According to the World Trade Organisation, the U.S. imports and exports of medical goods increased by 16 %, reaching USD 1,139.00 billion in value Henceforth for diagnosis, dependency of these countries highly increases on other exporters and many countries solely depend on China and the U.S. for the non-small cell lung cancer diagnostic equipment. Consequently, this may lead to a rise in the overall non-small cell lung cancer diagnostic cost. This increase in the price of the non-small cell lung cancer diagnostic may hamper the market growth if it continues to be the same. Additionally, if the lockdown continues to stretch for a long period, then import of non-small cell lung cancer diagnostics market is estimated to get more restricted, which may further lead to a rise in the price of the these devices CONCLUSION It is estimated that the COVID-19 pandemic outbreak has significantly impacted the growth of non-small cell lung cancer diagnostics market as the rising cases of COVID-19 worldwide the healthcare system had shifted its focus in curbing the disease, thereby resulting in the delay of diagnosis and treatment of non-small cell lung cancer. Thus, a negative impact is expected on the non-small cell lung cancer diagnostics market due to the pandemic scenario. However, with the increase in lung cancer patients worldwide, the demand for non-small cell lung cancer diagnostics will increase in the coming years. Moreover, poor lifestyle, smoking, alcohol consumption, lack of physical activity and other factors will contribute to the incidence of chronic disease such as lung cancer, including non-small cell lung, which is anticipated to increase the global non-small cell lung cancer diagnostics market in the coming years.
How COVID-19 Impacted on Nutraceutical Packaging in Healthcare Industry ?
COVID-19 Impact on Nutraceutical Packaging in Healthcare Industry The COVID-19 pandemic has impacted the food and beverages industry including the nutraceutical market by up surging in their consumption globally. Each and every segment of nutraceutical industry has been impacted either positively or negatively due to the COVID-19 pandemic. The Nutraceutical packaging market is subjected to have the positive impacts due to the sudden outbreak of COVID- 19. This is mainly due to the consumer awareness about the importance of consuming the nutraceuticals in order to boost their immunity to fight the pandemic period. The demand for the nutraceuticals has been increasing across the globe due to the changing lifestyle of the health conscious consumers. This increase in the demand for the nutraceuticals have positively affected on the nutraceutical packaging market. AFTERMATH OF COVID-19 AND GOVERNMENTS INITIATIVE TO BOOST THE GROWTH OF THE MARKET The aftermath of the COVID- 19 has a very positive impact on the market of the nutraceutical packaging across the globe. As the consumers are more incline to buy health and wellness products such as nutraceutical products which further increased the sales and revenue of the market players. The post pandemic period people are more concerned towards the product’s safety and shelf life which further drive the demand for advanced and innovative packaging materials for nutraceuticals. Also, with the growing awareness and growing social media nutritional trends influencing population all around the world will increase drive the demand for nutraceutical which will further boost the growth of global market. Many governments have taken initiatives for the nutraceutical packaging as they have been focusing on ways to improve the consumer’s health and wellness. The government initiatives to support industries in order to manufacture innovative packaging products will boost the growth of the market. For example, · European Union (EU)- funded project NanoPack aims to develop packaging solutions that increase product life after packaging by using novel anti-microbial surface application on the food packaging product surface. The Nanopack antibacterial film extends the shelf life of the product by two days. This two day increase in shelf life increase product stability by 40%. Therefore, such initiatives taken up by the governments which aim to help the manufacturers to manufacture safe products for the nutraceutical packaging will propel the growth of the market. STRATEGIC DECISIONS OF MANUFACTURERS AFTER COVID-19 TO GAIN COMPETITIVE MARKET SHARE To deal with the COVID-19 outbreak challenges many nutraceutical packaging market players are creating new strategies. It is predicted that these strategies are providing high chances to escalate up company revenue and its growth in the forecast period. Similarly, growing opportunities in innovative packaging solutions is attracting a larger consumer base for the nutraceutical packaged products. Increase in the demand for the nutraceuticals has made companies to launch the new products in spite of the COVID- 19 challenges and to gain a larger market share. Despite of the COVID – 19 pandemic outbreak, the manufacturers have been creating new opportunities by themselves by participating in exhibitions in order to spread the awareness about the nutraceuticals and their nutritional benefits which helps in boosting the immunity of the consumers. For instance, · In 2021, MJS packaging announced that they will exhibit for the first time since the start of COVID- 19 pandemic at the 2021 Cannabusiness international market place Michigan summit and expo in Michigan. Therefore, such product launches, exhibition of the products at the expos and vents in order to increase their consumer base are the strategic decisions which are taken up the market players to gain larger market share. PRICE IMPACT The COVID-19 had a terrible impact on the global economy. Many establishments have to remain shut while others scale down their operations or put on hold expansion plans as they survive the unprecedented crisis. The other impact of the COVID-19 pandemic outbreak is the delay or fluctuation of raw material supply for nutraceutical packaging manufacturing. This fluctuation has resulted in increase in price of raw material, which has impacted the prices of nutraceutical packaging products. IMPACT ON DEMAND There is a rapid increase in demand for the nutraceuticals increasing popularity for the nutraceutical packaging as well. Demand for the increased shelf life of food products across the globe is expected to increase the growth of the market in the COVID-19 period as well. There is an increasing consciousness about health and weight management is playing a crucial role in the demand for the global nutraceutical packaging market. On an average, the consumers have increased have increased their monthly spending on vitamins, minerals and supplements products by 10-15% since the COVID- 19 began. The increase in the awareness among the consumers about the consumption of the nutraceuticals is that they can build the immunity that is highly required in the COVID- 19 pandemic period has positively affected on the nutraceutical packaging as well. With the rise in the consumption of the nutraceutical in order to maintain the good health and fitness, the demand for the nutraceutical packaging also increased. Therefore, there has been a constant increase in the demand for the nutraceuticals which positively affected on the nutraceuticals packaging market as the packaging of the vitamins, minerals and other dietary supplements is the major factor that attracted the attention of the consumers. IMPACT ON SUPPLY CHAIN During the pandemic situation, the supply chain was majorly disrupted due to a lack of resources and transportation. Also, the governments across the world have implemented various restrictions and lockdowns to prevent the spread of the disease. In the same way, many governments have restricted the movement of goods across the countries and the entire supply chain was distorted. Owing to the disrupted supply chain, the transportation of raw materials has been interrupted and the production of nutraceutical packaging products was halted. Similarly, the manufacturers aren’t able to visit the customers such as nutraceutical companies to provide them with the packaging materials due to the implementation of lockdowns across the various parts of the world. Thus the demand for nutraceutical products has been tremendously increasing whereas the packaging materials production has been disrupted. As a result, the COVID- 19 pandemic has negatively impacted on the supply chain of the nutraceuticals packaging market. CONCLUSION COVID- 19 pandemic has taken a toll on the population and economy. A collaborative effort on governments, public health departments and hospital fraternity to fight corona virus has led to the economic slowdowns, lockdowns and extreme public safety measures. Due to the increasing health conscious ness among the consumers, the demand for the nutraceuticals has been increasing constantly in the COVID – 19 pandemic periods. This is mainly because of precautionary measures which are followed by the consumers for the COVID-19 which in involves the intake of nutraceuticals. However, the supply chain has disrupted during the outbreak scenario because the demand is more for these products. As unlocking of the lockdown being started in various regions of the world, it is expected that the supply chain became normalized for the market.
What Are the Benefits of Using Lavender Oil on Your Hair?
Essential oils are becoming more popular as home remedies. Among these, lavender has become a popular essential oil. Lavender essential oils are extracted directly from the lavender plant and have a heavenly scent. The end result of using special distillation techniques is a highly concentrated extract of lavender's useful compounds, full of health benefits and more. These include benefits such as pain relief, migraine relief, air freshening, cleaning, and even hair care. According to research, it has numerous benefits for hair and healthy, beautiful locks. How does lavender oil benefits hair health? Lavender oil has a variety of beneficial properties that may help with hair health, some of which are listed below. 1. It promotes hair growth. The lavender essential oil has recently gained popularity for its ability to promote hair growth. According to a 2016 study According to a reliable source, applying lavender oil to mice caused them to grow more hair. Their hair grew thicker and faster than usual as well. This benefit is far more effective when the oil can penetrate the skin. According to these studies, lavender oil may aid in the treatment of conditions such as pattern baldness or alopecia. Human studies are needed to prove this, though people can safely try the oil in their hair. 2. It has antimicrobial properties According to this 2014 review, lavender also has antimicrobial properties. This means it aids in the prevention of the growth of bacteria and fungi. When applied to the hair or scalp, this may help to prevent common hair and scalp problems. It may help to prevent itchy scalp, dandruff, and even infections. 3. It may aid in the prevention or eradication of head lice According to a 2011 study, the lavender essential oil can help prevent head lice. It may even be effective against head lice. The lavender essential oil was tested alongside another essential oil, tea tree oil, in the study. Though more research is needed, using lavender oil may reduce the risk of getting lice. It could be even more effective if you combine it with tea tree oil. However, these oils should not be used in place of your prescribed treatment plan; you should not rely solely on oils to treat head lice. 4. It may help to reduce skin inflammation Lavender is sometimes used as a natural treatment for skin inflammation and burns. Its essential oil form may be beneficial for scalp inflammation and dryness. Lavender oil was successfully used topically on skin inflammations and ulcers in a 2012 study. It reduced inflammation and sped up the healing process. 5. It has a calming effect as well as a divine fragrance Lavender has a wonderful smell as an added bonus. Its aroma has the ability to literally calm your nervous system. In this 2012 study, human subjects reported feeling more relaxed, pleasurable, and in better moods after inhaling the fragrance. Is there anything bad about lavender oil? Make sure not to use too much oil on your scalp or on your products. Excessive use of essential oils can irritate the skin. To avoid this, always combine plain oils with a carrier oil. If you develop a rash, hives, or dermatitis despite using carrier oils, discontinue use immediately. It could be an indication that you are allergic to lavender. A lot of people are. Never consume undiluted essential oils or get them in your eyes. If you get them in your eyes, immediately flush them out with cool water. If this Blog Finds Helpful. Must Share and Comment Your Views., Thank you!! Also Read: Lavender oil lavender oil for skin Also Read About: Rosemary essential oil Visit: how to use rosemary oil for hair growth how to use rosemary essential oil for face
CBD for Sleep, CBD Benefits, Side Effects, and Treatment
People have long used the cannabis plant for medicinal and recreational purposes. Compounds called cannabinoids in the plant are responsible for the effects on the brain, and the two most abundant of these are tetrahydrocannabinol (THC) and cannabidiol (CBD). People use CBD for a variety of reasons, including reducing seizures, anxiety, and pain. Some studies have demonstrated that CBD may also be a sleep aid. In this article, we look at whether it works and any associated risks. What the research says In the last decade, growing public interest in the benefits of marijuana, and CBD in particular, has encouraged researchers to study its effects. Early studies indicate that high dosages of CBD may support sleep. One investigation found that, compared with a placebo, a CBD dosage of 160 milligrams (mg) increased sleep duration. The researchers also concluded that the placebo, 5 mg of the insomnia drug nitrazepam, and 40, 80, and 160 mg of CBD helped the participants fall asleep. The stress hormone levels of cortisol are typically peak in the morning, but people with insomnia may have high cortisol levels at night. Independent of insomnia, having high cortisol levels at night is associated with an increased nighttime awakening. In one study on the effects of CBD, researchers found that cortisol levels decreased more significantly when participants took 300 or 600 mg of CBD oil. These results suggest that CBD affects the release of cortisol, possibly acting as a sedative. A more recent analysis of CBD and sleep recruited 103 participants who had anxiety or poor sleep. The researchers studied the effects of CBD combined with those of other prescribed medications. The CBD dosages ranged from 25–175 mg. The researchers found that 25 mg was the most effective dosage for anxiety and that addressing troubled sleep required higher dosages. During the 3-month study, the investigators followed up with the participants monthly. At the first follow-up, 66.7% reported an improvement in sleep, but 25% had worsened sleep. 56.1% of the participants reported improved sleep at the second, but 26.8% had worsened sleep. The researchers conclude that although CBD might help people sleep in the short term, the effects may not be sustained. Side effects and other risks of CBD Overall, the available evidence suggests that CBD is well-tolerated. Some people report fatigue and mental sedation with CBD use, but researchers believe this may be related to the dosage. Taking 10–400 mg of CBD per day for an extended period and by different routes did not have a toxic effect on participants in a large retrospective study. Even dosages of up to 1,500 mg per day were well-tolerated, other researchers report. However, determining whether there are long-term risks of CBD use will require further studies. So far, no reports of lethal CBD overdoses exist. Some researchers may be concerned about CBD abuse, but information on significant complications is limited. One study indicates that dosages of 400–700 mg of CBD, which is considered high, can aggravate cognitive deficits in people with schizophrenia. Combining CBD and THC may, however, improve cognition. Researchers do report that CBD may cause other adverse effects, including: alterations of cell viability in studies conducted in cell cultures decreased fertilization capacity inhibition of drug metabolism in the liver reduced activity of P-glycoprotein and other drug transporters If these effects on drug metabolism and transportation are confirmed, it would indicate that CBD interferes with other medications. Overall, more research is necessary. Still, it is suitable for anyone who wants to use CBD to speak with a healthcare provider first. Check out the best CBD for sleep at Sweet Dream Beauty website.
How COVID-19 Impacted on Niemann-Pick Disease in Healthcare Industry ?
COVID-19 Impact on Niemann-Pick Disease in Healthcare Industry OVERVIEW A novel coronavirus, SARS-CoV-2, appeared in December 2019 in Wuhan, China, spreading much faster than its predecessors and has already infected millions of patients worldwide as of April 19, 2020. As the scope of the current COVID-19 outbreak has reached the proportion of pandemics, significant international efforts in public health are underway to control the epidemic. The covid-19 pandemic majorly impacted the rare diseases patients because, during the pandemic, the need to provide high-level care for a large number of patients with COVID-19 has affected resourcing and limited the routine maintenance of all other conditions. The impact of health emergencies particularly faced by the rare disease communities, organizations, clinics, and other healthcare providers. The health economic challenges faced by patients and their families, institutions, research organizations, and healthcare providers during the pandemic outbreak have demonstrated the importance of ensuring continuity of care in the management of rare diseases, including adequate diagnostics and monitoring protocols, and highlighted the need for a structured emergency strategy. Niemann-Pick disease is a rare, inherited disease that affects majorly body's ability to metabolize fats such as cholesterol and lipids within the cells. Over time, these cells got malfunctioned and died. The disease can affects the brain, spleen, nerves and, if get severe, may affect lungs, bone marrow, and other organs. The disease can occur at any age but majorly affects children. There is no known cure for the disease, and sometimes it may be fatal for children, the only treatment is focused on helping people live with their symptoms. IMPACT ON PRICE Various market players are facing a large number of challenges due to the coming of the novel coronavirus and different strains; one such issue is the uncertainty surrounding the impact of covid-19 on off label drugs demands. Due to the increased coronavirus cases and continuous lockdown, the costs of the drugs and their APIs increase automatically. On the one side, it will increase the revenue of the companies, but a patient may resist buying the products, which ultimately increases the stress level on the patients. Moreover, Due to the pandemic, there is the delay associated with various types of limitations faced by the manufacturers to fulfill the end product order, which has resulted in the less availability of medical devices in the market and due to which the cost of available devices has increased with the several factors. Also, due to the Coronavirus disease (COVID-19) pandemic outbreak, manufacturers are forced to find new contract manufacturers and suppliers for more manufacturing activities to different or unique facilities location that are less impacted by the outbreak. The impact of Covid-19 has created huge price impact on the government as well as on patient families that they have to buy the drugs on higher rate as compared to the average rate. IMPACT ON DEMAND The Coronavirus zone is the result of various markets around the world. This is the cause of the widespread closures and isolation that are affecting world economic activity. As the cases increases in the month of April 2020, the sudden surge in demand has seen, and drugs and medical devices went out of stock. Moreover, the decrease in the revenue of the key market players depicted in their quarterly results, such as Medtronic, among others, gave the evidence of decline in the demand for medical devices due to the emergence of the COVID-19 pandemic. For instance, · Medtronic reported a decline of 1% in its brain therapies net sales of the financial results of 2020 as compared to 2019. The reduction was primarily motivated by the detrimental effects of the COVID-19 pandemic and the subsequent deferral to companies of medical procedures. · Impact on rare disease organization also faced significant fundraising income loss, this consequential income loss may leads to loss of various people jobs associated with the organizations. The cutting or income loss leads to the reducing staff, canceling offices leases, and delay or cutting office programs. The impact of covid-19 majorly impacted the organizations if the revenues loss projections do not change, this will leads to temporarily or permanently shut down of small and middle foundations and organizations. IMPACT ON SUPPLY As the epidemic intensifies, supply chains can be at significant risk due to over-located locations that can potentially be disrupted. The supply chain of drugs, devices, and services has been disrupted. The spread of COVID-19 makes it difficult for governments to use these drugs; the availability of these systems faces constant challenges due to their components of use and limited initial needs. Moreover, as there is no cure for the disease, only physical activities/therapies may suppress the symptoms also affected by pandemics. According to the NORD (National Organization for Rare Disorders), in the U.S. stated that 74% of the population have had canceled medical appointments due to Covid-19 pandemic, 69% of population concerned about their medication and medical supplies. For instance, • In June, ResMed stated that, due to the Covid-19 pandemic company sleep apnea business segment adversely affected including sleep clinics, physician practices, HME suppliers. As new patients are prescribed sleep apnea devices such as PAP, CPAP devices for the treatment through hospitals that are directing their resources to critical care, including COVID-19 treatment. The covid 19 impacts may continue to decrease demand for the sleep apnea devices sale STRATEGIC DECISIONS OF GOVERNMENT AND MANUFACTURERS As such, market participants are involved in the production of drugs, expanding their business through a variety of programs, including collaboration, contracts, and pipeline development, collaboration, and market expansion. It is expected that the strategic decisions of these companies will provide significant opportunities for market participants operating in the Niemann-Pick Disease market. For instance, · In July 2020, Abbott announced that it had received FDA approval for the use of the Patient Controller App on compatible personal Apple smartphone devices. The approval will allow the patient living with neurological conditions to manage their therapy directly from personal smartphone. · In May 2020, Philips, a global leader in health technology, joined forces with the American Telemedicine Association (ATA) to help further the adoption of telehealth across the industry, demonstrating its commitment to connecting care across acute, post-acute, and home care settings. The continued collaboration spotlights telehealth's growing adoption and momentum amidst COVID-19 and the need to convey the exponential shift to telehealth capabilities. · In U.S., NIH supports the research survey of “CURE EPILEPSY ORGANIZATION” to examine the impact of Covid-19 on Rare Disease Community. The survey includes more than 200 rare diseases including the brain, immune system disorders, heart, lungs, brain development diseases, and more. CONCLUSION As this pandemic situation has resulted in many restrictions in different places around the world, still the market players of dealing in rare diseases therapy and services were able to manage their service stock. Different companies dealing in metabolic diseases therapy services were finding out their own way to deal with this pandemic situation. The government and companies around the globe are working together and have issued advice for those undergoing therapies centers during these unprecedented times during COVID 19 lockdown around the world. The supply chain was destroyed, but several steps were taken by the government and companies, which will help them, get their needed output for therapy service. By increasing the material price, the companies can maintain their overall revenue. Thus, different foundations, organizations,, and services center markets are finding ways to deal with this pandemic situation. Figure 1: Relationship between Coronavirus and Lysosome storage diseases : Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway
Significant COVID-19 Impact on Nivolumab in Healthcare Industry
COVID-19 Impact on Nivolumab in Healthcare Industry COVID-19 (Coronavirus) has affected the day-to-day life of people and has slowed down the economies worldwide. The pandemic has affected millions of people who either got sick or died due to the spread of this disease. Within a few months, coronavirus disease (COVID-19), which originated from China, became a pandemic, with more than 30 million people being infected till date. There are now numerous vaccines in use. The first mass vaccination program commenced in early December 2020, and as of 15 February 2021, 175.3 million vaccine doses have been administered. There is an added complexity because of COVID-19 diagnosis in cancer patients, particularly while on active treatment with immunotherapy like nivolumab. COVID-19 could cause more harm to cancer patients. In order to prevent the infection from spreading, the patient’s number and new diagnosis have been less during the COVID 19. The COVID-19 pandemic has led to a dramatic loss of human life worldwide and presents an unprecedented challenge to public health, food systems, and the world of work. Still, there is an increase in the demand for cancer treatment with immunotherapy drugs like nivolumab during the second quarter of 2020 with the rise in awareness regarding health and new product launches in countries. IMPACT ON PRICE COVID-19 is significantly decreasing commercial activity in every area of the business sector. The economy has been decreased during the pandemic with the restricted and disrupted supply and sales of products and devices. The cost of medication and treatment of nivolumab has been increased due to the increasing demand for this drug during COVID-19. This contributed to the increased expenses and prices of immunotherapy drugs. Changes in the economy and other factors have caused consequences, including the decrease in the sales of the drug in some countries such as the U.S. With the rise of COVID-19 and decrease in new patients has also contributed to the increased cost and priced of some products and medication. · The price of Opdivo (nivolumab) drug which is a most common therapy treatment for various type of cancer or tumor have been increased to USD 1,172 for a supply of 4 milliliters of injection in 2020 with the rise in demand and increasing patients population in the second quarter of 2020. IMPACT ON DEMAND Global economic development in 2020 has been severely impacted by the COVID-19 pandemic. The COVID-19 has given rise to risks such as a prolonged, significant decline in global demand as well as unfavorable geopolitical and macroeconomic effects. The coronavirus pandemic has provoked many strategical actions among healthcare providers on how to manage cancer patients when faced with the threat of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection. There has been a decrease in demand for nivolumab in some countries like the U.S., whereas many countries have seen an increase in sales with the rise in demand for the treatment and new cancer patients. With the rise in demand for the drug, FDA has provided approval to various drugs related to the immunotherapy nivolumab. For instance- · For the Bristol-Myers Squibb Company, the U.S. revenues of nivolumab decreased to 9% in 2020 due to lower demand caused by declining second-line eligibility across tumor indications and lower demand from COVID-19 (primarily lower new patient starts and patient visits). The U.S. has seen a decrease in sales in the first quarter of 2020. · However, the international revenues for nivolumab were increased up to 7% in 2020 due to higher demand as a result of additional indication launches in some countries with rising cancer patients globally. · In May 2021 -- Bristol-Myers Squibb Company has today announced that the U.S. Food and Drug Administration (FDA) had approved their Opdivo (nivolumab, injection for intravenous use) for the adjuvant treatment of completely resected esophageal or gastroesophageal junction (GEJ) cancer. · Similarly, FDA has approved Opdivo (nivolumab) for treating different types of cancer in many countries via various market players due to the rise in demand for this drug. IMPACT ON SUPPLY CHAIN The pandemic and COVID-19 have affected every business activity in which the supply chain was affected the most. Because of the pertinacious COVID-19 lockdown, sanctions have been forced by administrations of different nations. These limitations and boundaries across the nation’s borders prompted a diminishing stockpile because of restricted materials and labor force and the halting of the assembly line. The COVID-19 pandemic has transformed many organizations’ business environments; supply availability has been hampered by a number of issues, including export and travel restrictions by some producing countries, and the lockdown has forced suppliers to (temporarily) shut down. The supply of nivolumab medication has a slight decrease in sales during the first quarter of 2020, partly due to negative factors mentioned above in connection with the COVID-19 pandemic, which particularly didn’t affect the overall yearly revenue. The supply chain and demand were positively affected by the COVID 19. The sales and supply of the drugs have been increased with the rise in demand for the drugs and diagnosis. Many major manufacturing companies have launched their drugs in different countries to fulfill the demand, and the government has provided approval for the sales of the drug nivolumab. For instance- Despite the pandemic, many market player of nivolumab has increased their sales globally. This is due to the ongoing increase in the patient population and rising awareness regarding their health. · The sales of ONO pharmaceuticals have been increased in the year 2020 as compared to 2019, which is 2656.05 USD Million in 2019 and 2809.23 USD million. · Similarly, sales of the drug Opdivo (Nivolumab) from the manufacturing company Bristol Myers Squibb Company have been increased globally (except the U.S.) from USD 2,860 million in 2019 to USD 3,047 million in 2020. This increase in sales in both of the major market players is due to the increase in cancer patients and the use of drugs in all areas of cancer. There is an increase in the sales of this nivolumab with the rise in prevalence of disease and early diagnosis & treatment. STRATEGIC DECISIONS BY MANUFACTURERS To deal with the COVID-19 outbreak challenges and increasing demand for the drugs, many market players are creating new strategies such as new product development, telemedicine, and a different program to support patients and to raise their sales. It is predicted that these strategies are anticipated to escalate up the company revenue and its growth in the forecasted period. The government has provided drug FDA approvals of nivolumab for the treatment of cancer. For instance, · In May 2020, Bristol Myers Company announced that Opdivo (nivolumab) 3 mg/kg plus Yervoy (ipilimumab) 1 mg/kg (injections for intravenous use) was approved by the U.S. Food and Drug Administration (FDA) for the first-line treatment of adult patients with metastatic non-small cell lung cancer (NSCLC). · There are several ongoing potentially registrational studies that have been conducted by different manufacturing companies for Opdivo for the treatment of different tumor types and disease areas, in combination with various anti-cancer agents · Also, there are various ongoing clinical trials conducting on nivolumab with the combination of various anti-cancer agents and others to treat various types of cancer to decrease the demand for cancer treatment and to provide patients with more advanced drugs. For instance · In Japan, South Korea, and Taiwan, ONO pharmaceuticals are co-developing this drug nivolumab with the Bristol Myers Company CONCLUSION As the pandemic of COVID-19 resulted in several restrictions throughout the borders, still, manufacturers and market players were able to manage their sales and revenue of oncology and drug nivolumab. Various manufacturers allowed their workers to work in a clean and safe environment so as to boost up the production at various manufacturing facilities across several regions of the world, thus, helping them to maintain a continuous supply chain with the increasing demand. Market players have come up with better strategies which have also created a positive impact on the growth of the nivolumab market globally.
Liposuction Vs. Non-Surgical Fat Removal
Many cosmetic surgery patients are concerned about areas of unwanted, diet- and exercise-resistant fat. Localized fat can be difficult to get rid of permanently, whether it appears as a persistent stomach "pooch" after pregnancy, areas of fat around the thighs that won't budge, or bulges along the flanks and back. For many years, liposuction has been one of the most popular and frequently performed cosmetic procedures, and for good reason. This surgical procedure reduces fat and refines body contours in a safe, effective, and permanent manner. Nonsurgical or minimally invasive alternatives to liposuction have grown in popularity in recent years. These body contouring treatments usually do not require an incision or anaesthesia, and they have a shorter recovery time. Continue reading to learn about the differences between the two fat-loss methods and to determine which one is best for you. What exactly is liposuction? Liposuction is a surgical fat removal procedure that rose to prominence in the 1980s. A board-certified cosmetic surgeon carefully and precisely removes excess fat during the procedure using a small, hollow tube called a cannula. As the surgeon moves the cannula through the fat deposit, suction is applied, removing excess fat cells and sculpting a slimmer body contour. Liposuction is especially useful for removing fat from the legs, abdomen, back, arms, face, and neck. It produces more dramatic results than other noninvasive fat reduction procedures; however, it requires a recovery period of about four weeks and is typically more expensive than nonsurgical alternatives. CoolSculpting®, BodyTite®, and Other Nonsurgical Procedures: How Do They Work? Nonsurgical fat reduction treatments employ a variety of modalities to target and eliminate unwanted fat cells via a topical, rather than surgical, procedure. Nonsurgical body contouring treatments that are popular include: CoolSculpting. Allergan's CoolSculpting is a good choice for people who are close to their ideal weight but want to reduce small, localised trouble spots on the hips, abdomen, or thighs. A specialised cryolipolysis device is used in this treatment to cool unwanted fat cells to the point of death without affecting surrounding tissues. Fat cells that have died are flushed from the body in the days and weeks following the procedure. After three months, the final result is visible. TruSculpt. Cutera's truSculpt treatment is similar in that it uses controlled radiofrequency technology to eliminate fat cells on the hips, thighs, buttocks, and abdomen. The average treatment lasts about an hour, and most patients require one to two treatments to see noticeable results. BodyTite. BodyTite by inMode is a minimally invasive procedure that uses radiofrequency energy to tighten skin and reduce unwanted fat deposits. An internal probe delivers thermal energy to help melt fat and strengthen collagen bands beneath the skin's surface, while an external applicator delivers radiofrequency energy to the skin for additional tightening. BodyTite is considered minimally invasive because a small incision is required to insert the internal applicator probe by your surgeon; however, it is a less invasive procedure than liposuction. BodyTite is an excellent choice for people who have small to moderate amounts of excess fat and loose skin and want to avoid the extensive downtime associated with surgery. Most patients report seeing results within a few days, with final results appearing after 2 to 3 weeks. Patients can expect to see continued skin tightening in the months following their procedure because BodyTite stimulates collagen production in the skin. SmartLipo. SmartLipo by Cynosure, also known as “laser liposuction,” is a non-surgical procedure that uses triple wavelength laser technology to remove unwanted fat around the muscles and tighten loose, sagging skin. SmartLipo's laser gets to work dissolving body and/or facial fat, which your body then processes and excretes naturally. To remove any excess liquid that may accumulate during the procedure, a very small tube is inserted into the treatment area. SmartLipo is ideal for areas of the face that traditional liposuction cannot adequately address, such as the jowls, chin, jaw, and neck, due to the small tube used. SmartLipo is also excellent for contouring areas of the body that retain stubborn fat, such as the abs, back, flanks, thighs, buttocks, and upper arms. Because SmartLipo is less invasive than liposuction, there is less tissue damage at the treatment sites. The results of SmartLipo treatment are visible immediately, and there is little downtime required. SculpSure. SculpSure by Cynosure is a non-invasive laser body contouring treatment that removes unwanted fat beneath the chin (submental fat), love handles, the back, the stomach, and the inner and outer thighs. SculpSure, like CoolSculpting and truSculpt, is ideal for patients who are nearing their ideal weight but want to reduce stubborn, exercise- and diet-resistant fat pockets. Unlike CoolSculpting, which freezes fat cells, SculpSure uses heat to destroy fat cells (a process known as apoptosis). SculpSure has been shown in studies to be effective at permanently removing up to 24 percent of fat cells in a treated area. A series of 25-minute treatments is beneficial to the majority of patients. Nonsurgical Fat Reduction vs. Liposuction Both liposuction and nonsurgical body contouring have advantages and disadvantages. Invasiveness Liposuction is a more aggressive method of fat removal that causes trauma in the treatment area. For up to 10 days after the procedure, patients will experience soreness, bruising, and swelling. CoolSculpting, truSculpt, and SculpSure treatments are typically gentle and cause little discomfort during and after treatment. Results Although the final result of liposuction is not visible until 6 months after the swelling has subsided and the treated area has healed. CoolSculpting and other noninvasive fat reduction treatments take longer to produce results, which become more visible in the weeks and months following the procedure. While neither liposuction nor nonsurgical body contouring treatments can replace weight loss, liposuction does provide more dramatic and longer-lasting results, as well as some skin shrinkage. Downtime The healing process after liposuction necessitates that patients limit their daily activities for several days following the procedure and exercise with caution. CoolSculpting, truSculpt, and SculpSure do not require a lengthy recovery period, and patients can resume normal activities right away, though mild soreness and swelling are to be expected. Though the results of nonsurgical fat reduction will be less noticeable, you will be able to return to work and resume your life much sooner. Is Liposuction or Nonsurgical Body Contouring the Best Option for Me? For larger deposits of excess fat, liposuction may be an excellent option. It has the potential to significantly improve your figure in multiple areas at the same time. Some disadvantages include a higher cost and a higher risk of health complications when compared to noninvasive techniques. If you are already at your ideal weight, have good skin elasticity, and want to target smaller, stubborn trouble spots, nonsurgical fat reduction may be a better option. The results, however, will not be as dramatic, and multiple treatments may be required. Making an Appointment for Liposuction or Nonsurgical Fat Removal The best way to decide between liposuction, CoolSculpting, truSculpt, BodyTite, and other non-invasive fat reduction procedures is to consult with a board certified cosmetic surgeon. During a personalised cosmetic surgery consultation, they can walk you through your options and help you decide which is the best fit for you.