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What Impacted COVID-19 on the Global Active Pharmaceutical Ingredients (API) ?



WHO (World Health Organization) has characterized novel coronavirus as a global pandemic on March 11, 2020. This present pandemic has led to an intolerable impact on both the health and pharmaceutical structure which has ultimately created an ultimate issue on patients’ health.
APIs are the effective ingredient present in the medicine, and even small amount of active ingredients known to produce effective result. APIs are either used as single dose or as mixed dose combination in order to produce an effective medicine. However, raw materials are confused with the APIs used for making medicine, but the raw materials are the substances which are used for manufacturing of APIs and the chemical compound used for making the raw material is called as an intermediate. Even more than 10 kinds of intermediate chemical compounds are used for manufacturing of a single API. In order to manufacture API, the manufacturer has to first develop the chemical compound at first which is used for further processing of APIs. These API molecules are formed in large sized reactors. After manufacturing, these APIs are checked for purity and their effectiveness as API market is such a huge market and has a great application in the medical field there is a huge demand of close monitoring of manufacturing process. But due to continuous pandemic of COVID-19 and long term shut down has put an adverse effect on overall drug manufacturing companies. The government of several countries has reported that there is huge scarcity of APIs amid the COVID-19 pandemic. The reason behind that is the barrier across the countries border that has an ultimatum effect over the import and export facilities of medicinal product among others.
As the Indian pharmaceutical industry is largely dependent upon the China for procurement of APIs, as China is the first global leader involved in the manufacturing of low cost APIs. This has been reported that approximately 70% of APIs raw materials are imported from China to India. But the continuous pandemic of COVID-19 and barrier across the borders have a massive effect on export of good from one country to another and has led to the scarcity of APIs in India, the U.S. and the U.K. among other countries. As India is the world’s third largest supplier of low-cost and affordable generic drugs to millions of people all over the world and operates about 250 the U.S. FDA, the U.K Medicine and Healthcare product Regulatory Agency approved plants. Hence any impact on Indian APIs pharmaceutical industry led to a negative impact on overall global APIs manufacturing plants.
STRATEGIC DECISIONS FOR MANUFACTURERS
Sudden voluminous demand of APIs in order to fight against the COVID-19 has led the manufacturers to take several strategic initiatives. Large number of population affected with this COVID-19 virus and expanding spread across the world from last few months has enhanced the need of effective treatment options. To deal with the COVID-19 outbreak challenges, many APIs manufacturers are creating new strategies. To meet an actual as well as prompt increase in customer demand or to anticipated prospective increase in customer demand APIs market players are exclusively concentrating on gaining the production capacity. It is predicted that these strategies are anticipated to escalate up the company revenue and its growth in the forecasted period.
For instance;
· In January 2021, Sanofi had opened a new European company named EUROAPI which is engaged in the manufacturing and commercialization of APIs. The company established considered as one of the largest APIs manufacturing company in Europe. Through this initiative company has expanded its APIs business worldwide.
· In December 2020, DSM achieved ANVISA certification for its Colombia manufacturing plant. The certification achieved by the company allowed it to expand its commercialization of pharmaceutical premix products into other countries including Brazil among others. This certification boosted the company’s manufacturing activities.
· In October 2020, Recipharm AB signed an agreement with BIAL for boosting up the supply capabilities of APIs.
· In September 2020, Recipharm AB announced for the expansion of API facility in terms of capacity and financials in Israel. The company has invested USD 2.5 million in the clinical GMP API facility, in order to fulfill the increasing unmet demand of consumers in the API market.
· In September 2020, Jubilant Pharmova Limited signed an agreement with Saptagir Laboratories for the manufacturing of Remdesivir indicated for the treatment of COVID-19. The agreement signed helped the company to boost up the existing product portfolio and to earn a lucrative growth in the market amid COVID-19 pandemic.
· In May 2020, Sun Pharmaceutical Industries Ltd. initiated the product trial for the anti-coagulants and anti-inflammatory drugs. The clinical trial included the nafamostat and the other drug is plant based dengue drug. This initiative adopted by the company helped it to expand its business even during the COVID-19 pandemic.
· In May 2020, HIKAL ltd. has developed Favipiravir API and its intermediates. The product developed has been proved effective against the influenza viruses and is under various clinical trials for treatment of COVID-19. This initiative demonstrated the company’s strength for providing high quality medicines for its customer globally.
This signifies that various strategic initiatives adopted by the companies allow them to attain a lucrative growth even during the COVID-19 pandemic.
IMPACT ON DEMAND
Coronavirus disease (COVID-19) is one of the infectious diseases caused by a SARS-CoV-2 virus and has affected and still affecting a large pool of the population worldwide. Coronavirus disease (COVID-19) causes acute respiratory illness ranges from mild to severe pneumonia along with respiratory failure. As there is no specific and approved treatment to treat the coronavirus disease (COVID-19), the need of effective treatment is at high demand. Due to these all affirmative factors there is direct requirement of APIs for drugs manufacturing, which is indicating the future huge demand of API.
By recognizing the actual as well as prompt increase in customer demand or to anticipated prospective increase in customer demand, healthcare organization as well as government bodies’ calls on industry to increase manufacturing of APIs.
Moreover, several initiatives are taken by the government in order to meet the demand of drug manufacturing.
For instance,
· The department of pharmaceuticals (DoP, India) has announced for the proposal for the creation of new drug manufacturing facility with the investment of USD 397.13million in order to allow companies to set up the new manufacturing facilities for APIs
TABLE 1. WORLD –WIDE IMPACT OF COVID-19 ON THE PHARMACEUTICAL SECTOR
The increasing prescriptions for several kinds of illness including respiratory illness, mental illness among others has led to scarcity of drugs and API molecules used for drug manufacturing. Disproportionately high COVID-19 patient volumes putting strain on scarce drugs. Henceforth, it is estimated that global API market anticipated to boom up in the forecasted period.
IMPACT ON SUPPLY CHAIN
The COVID-19 pandemic has affected many organizations’ business environment; supply availability of various drugs has been hampered due to a large number of issues, including import and export restrictions across the countries, and continuous lockdowns that have forced suppliers to (temporarily) shut down the manufacturing facilities and supply capabilities. China occupies a predominant position in the global APIs market. China has secured a considerable market share of APIs market at global level and it exports about 17.87% of vitamin APIs among others to other countries.
Moreover, this has been reported that European pharmaceutical companies also rely on India for manufacturing of their products and India is largely dependent on China for 70% of APIs.
Since 1990, the U.S. is heavily relied on India and China for manufacturing of pharmaceutical products among others because China provides cheaper ingredients and those are not subjected to that much high regulatory rules and laws.
Moreover this has been projected out that UNICEF procures most of the pharmaceutical products from China and India and few of them from Europe as well. For Vitamin, a capsule containing Retinol UNICEF and CIK depend on same supplier and also procures from Canada.
Moreover, as the market players are totally aware of the loss that they may likely to suffer due to disruption of supply chain, they are continuously monitoring their product supplies and manufacturing capabilities in order to prevent the loss to their overall business.
For instance,
· Teva Pharmaceutical Industries Ltd., manufacturer of Accutane (Isotretinoin capsules) has announced that the company is enacting all appropriate measures in order to ensure the safe supply of their medicines and APIs.
This signifies that COVID-19 is disrupting the supply chain of APIs, it is also restricting the procurement procedure of APIs from different sources among other factors but several initiatives are taken by the manufacturers and government organizations is creating a hope for the improvement of supply chain of APIs.
PRICE IMPACT
The Coronavirus disease (COVID-19) pandemic has enormous impact on global pharmaceutical market involving APIs among others. The demand for APIs is on surge across the globe because of increasing prevalence of coronavirus disease (COVID-19) all over the world and demand of effective treatment options.
The COVID-19 pandemic has resulted in an immense increase in cost of drugs due to rising demand of drugs for treatment of several kinds of disease including HIV, cancer, epilepsy, malaria among others.
For instance,
· As per the data provided by the Pharmaceutical Export Promotion Council (PHARMEXCIL), the cost of Penicillin APIs has raised to USD 8.69 per unit in October 2020 from the USD 6.16 per unit in January 2020.
· Moreover the data procured by the APIs manufacturer suggested that there is an increase in about 13 to 18 percent of APIs prices for antibiotic involving Amikacin, Doxycycline, Azithromycin, Dexamethasone Sodium and Ornidazole among others as India imports most of them from China.
· Montelukast sodium (an anti-asthmatic drug) costs USD 705.93 to USD 787.38 per Kg in October 2020 as compared to USD 447.99 to USD 515.87 per Kg before few months.
· The prices of vitamins and penicillin have also attained a lucrative growth due to sudden rise in their prices by 40 to 50 percent as that of the original existing prices.
· India’s drug pricing regulator has also allowed pharmaceutical companies to enhance the prices of essential drugs by 50 percent including Heparin (an anticoagulant) which is in high demand to increasing risk of COVID-19 infection to patients suffering from heart attacks, strokes and lung or pulmonary embolism.
· As per the publication of April 2020, the cost of azithromycin, paracetamol, anti-inflammatory drug nimesulide APIs enhanced up to 60 to 190% during the pandemic of COVID-19. This price hike was due to shut down of China’s APIs production units. The increasing demand of several kinds of drug during COVID-19 pandemic has enhanced the demand of APIs that in turn led to APIs shortage. These shortages have an ultimatum effect on existing APIs prices.
This signifies that price of APIs hiked due to continuous coronavirus outbreak.
CONCLUSION
It is predicted that the COVID-19 pandemic outbreak has significant impact on the growth of global APIs market due to huge elevation in the demand of APIs. Moreover, many government and healthcare organization (United Nations Children's Fund (UNICEF), partners and World Health Organization are exclusively focusing on the supply of APIs and its manufacturing due to priorities and essential requirement in this crucial period. Moreover, several clinical trials also expected to provide market with a lucrative growth.
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Fungal Infections Market Foraying into Emerging Economies 2028
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The neurorehabilitation process makes a possible reduction in impairments and disabilities and eventually improves the life of the patient. Examples of neurorehabilitation devices are invasive stimulators, non-invasive stimulators, brain-computer interfaces, and neurorobotics, among others. Current rehabilitation is supported by advanced methods based on biofeedback, transcranial brain stimulation system, and BCI system. The prevalence of neurological diseases, rise in technological advancement, the emergence of robotic rehabilitation, and the effectiveness of gaming systems in neurorehabilitation are factors that are propelling the demand of the global neurorehabilitation devices market. However, the shortage of skilled personnel, the high cost of treatment, stringent government regulation may hamper the global neurorehabilitation devices market. IMPACT ON DEMAND Coronavirus disease (COVID-19) is an infectious disease caused by a SARS-CoV-2 virus, while a large pool of the population is affected by this COVID-19 virus. Coronavirus disease (COVID-19) causes acute respiratory illness ranges from mild to severe pneumonia with respiratory failure. In order to minimize the spread of COVID-19, nearly all the countries have taken action, such as the implementation of lockdown and social distancing restrictions. Neurorehabilitation is an important part of the recovery process that has undergone some brain injury. In the COVID-19 pandemic, various charities have worked effortlessly to provide treatment and support to patients suffering from brain injury. During the pandemic, the demand for neurorehabilitation devices was high, but companies were not able to supply the devices to end-users as various restrictions were imposed by the government, such as a travel ban, closed borders, among others. Due to affirmative restrictions, sudden shrink took place in various surgeries. Moreover, the decrease in the revenue of the key market players depicted in their quarterly results, such as Medtronic, among others, gave evidence of the decline in the demand for the medical device due to the emergence of the COVID-19 pandemic. For instance, · Medtronic reported a decline of 1% in its brain therapies net sales of the financial results of 2020 as compared to 2019. The reduction was largely motivated by the detrimental effects of the COVID-19 pandemic and the subsequent deferral to companies of medical procedures The decline in revenue of brain therapy suggests the detrimental effect of COVID 19 on the neurorehabilitation devices market and hence impacted the demand-supply concept. IMPACT ON PRICE Neurological rehabilitation is a program designed for the treatment of people suffering from a disorder or any injury in the nervous system. 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The product and service providers of neurorehabilitation have made efforts by providing services virtually to meet the demands as people were not frequently visiting the hospitals or clinics for the treatment. To manage such a critical situation, many organizations are looking forward to improving and diversifying the supply chain model in all aspects. Diversified supply chain model anticipated minimizing the export of medical devices as well as increase end-to-end visibility The COVID-19 pandemic has transformed many organizations’ business environments; supply availability has been hampered by a number of issues, including export and travel restrictions by some manufacturing countries and lockdowns that have forced suppliers to (temporarily) shut down. In various countries, neurorehabilitation units have reduced their number of beds, in-patients and out-patient neurorehabilitation centers are restricted to a particular area in order to tackle the pandemic situation STRATEGIC DECISIONS BY MANUFACTURERS As the reality of COVID-19 dawned upon the world, the manufactures and production units of the companies in the global neurorehabilitation devices market swiftly planned for strategies to cope with the effect of the crisis. Major players in the market took various initiatives to cope up with the situation. For instance, · In July 2020, Abbott announced that it had received FDA approval for the use of the Patient Controller App on compatible personal Apple smartphone devices. The approval will allow the patient living with neurological conditions to manage their therapy directly from the personal smartphone · In 2019, Mount Sinai Health System announced an innovative tele-neurorehabilitation program for stroke patients. This therapy can be taken by patients while at their homes with virtual backing from clinicians · In 2020, Esko Bionics Holdings, Inc. announced that it had received FDA 501(k) go-ahead to promote its EksoNRTM robotic exoskeleton for patients with acquired brain injury. It is cleared by FDA for spinal cord injury, stroke, or acquired brain injury rehabilitation These strategies helped the company in coping with the pandemic and ensure business operations, minimize the impact of COVID-19, and providing full support to the government in their efforts to combat the disease and help the front-line workers. CONCLUSION It can be concluded that the COVID-19 pandemic situation has an adverse impact on the market, affecting the price, supply, and demand of neurorehabilitation devices. However, in the crisis call, market players, government bodies, and healthcare organizations are work closely with healthcare professionals, customers, and patients for the betterment of public health. The increasing need of neurorehabilitation devices with increasing number of neurological diseases is expected to drive the market in coming years. The market is expected to decline due to increased restrictions imposed by various governments leading to the closing of non-emergent healthcare facilities, including procedures such as neurorehabilitation procedures.
How COVID-19 Impacted on Nivolumab in Healthcare Industry ?
Impact of COVID-19 on Nivolumab in Healthcare Industry COVID-19 (Coronavirus) has affected the day-to-day life of people and has slowed down the economies worldwide. The pandemic has affected millions of people who either got sick or died due to the spread of this disease. Within a few months, coronavirus disease (COVID-19), which originated from China, became a pandemic, with more than 30 million people being infected till date. There are now numerous vaccines in use. The first mass vaccination program commenced in early December 2020, and as of 15 February 2021, 175.3 million vaccine doses have been administered. There is an added complexity because of COVID-19 diagnosis in cancer patients, particularly while on active treatment with immunotherapy like nivolumab. COVID-19 could cause more harm to cancer patients. In order to prevent the infection from spreading, the patient’s number and new diagnosis have been less during the COVID 19. The COVID-19 pandemic has led to a dramatic loss of human life worldwide and presents an unprecedented challenge to public health, food systems, and the world of work. Still, there is an increase in the demand for cancer treatment with immunotherapy drugs like nivolumab during the second quarter of 2020 with the rise in awareness regarding health and new product launches in countries. STRATEGIC DECISIONS BY MANUFACTURERS To deal with the COVID-19 outbreak challenges and increasing demand for the drugs, many market players are creating new strategies such as new product development, telemedicine, and a different program to support patients and to raise their sales. It is predicted that these strategies are anticipated to escalate up the company revenue and its growth in the forecasted period. The government has provided drug FDA approvals of nivolumab for the treatment of cancer. For instance, · In May 2020, Bristol Myers Company announced that Opdivo (nivolumab) 3 mg/kg plus Yervoy (ipilimumab) 1 mg/kg (injections for intravenous use) was approved by the U.S. Food and Drug Administration (FDA) for the first-line treatment of adult patients with metastatic non-small cell lung cancer (NSCLC). · There are several ongoing potentially registrational studies that have been conducted by different manufacturing companies for Opdivo for the treatment of different tumor types and disease areas, in combination with various anti-cancer agents · Also, there are various ongoing clinical trials conducting on nivolumab with the combination of various anti-cancer agents and others to treat various types of cancer to decrease the demand for cancer treatment and to provide patients with more advanced drugs. For instance · In Japan, South Korea, and Taiwan, ONO pharmaceuticals are co-developing this drug nivolumab with the Bristol Myers Company IMPACT ON DEMAND Global economic development in 2020 has been severely impacted by the COVID-19 pandemic. The COVID-19 has given rise to risks such as a prolonged, significant decline in global demand as well as unfavorable geopolitical and macroeconomic effects. The coronavirus pandemic has provoked many strategical actions among healthcare providers on how to manage cancer patients when faced with the threat of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection. There has been a decrease in demand for nivolumab in some countries like the U.S., whereas many countries have seen an increase in sales with the rise in demand for the treatment and new cancer patients. With the rise in demand for the drug, FDA has provided approval to various drugs related to the immunotherapy nivolumab. For instance- · For the Bristol-Myers Squibb Company, the U.S. revenues of nivolumab decreased to 9% in 2020 due to lower demand caused by declining second-line eligibility across tumor indications and lower demand from COVID-19 (primarily lower new patient starts and patient visits). The U.S. has seen a decrease in sales in the first quarter of 2020. · However, the international revenues for nivolumab were increased up to 7% in 2020 due to higher demand as a result of additional indication launches in some countries with rising cancer patients globally. · In May 2021 -- Bristol-Myers Squibb Company has today announced that the U.S. Food and Drug Administration (FDA) had approved their Opdivo (nivolumab, injection for intravenous use) for the adjuvant treatment of completely resected esophageal or gastroesophageal junction (GEJ) cancer. · Similarly, FDA has approved Opdivo (nivolumab) for treating different types of cancer in many countries via various market players due to the rise in demand for this drug. IMPACT ON PRICE COVID-19 is significantly decreasing commercial activity in every area of the business sector. The economy has been decreased during the pandemic with the restricted and disrupted supply and sales of products and devices. The cost of medication and treatment of nivolumab has been increased due to the increasing demand for this drug during COVID-19. This contributed to the increased expenses and prices of immunotherapy drugs. Changes in the economy and other factors have caused consequences, including the decrease in the sales of the drug in some countries such as the U.S. With the rise of COVID-19 and decrease in new patients has also contributed to the increased cost and priced of some products and medication. · The price of Opdivo (nivolumab) drug which is a most common therapy treatment for various type of cancer or tumor have been increased to USD 1,172 for a supply of 4 milliliters of injection in 2020 with the rise in demand and increasing patients population in the second quarter of 2020. IMPACT ON SUPPLY CHAIN The COVID-19 pandemic has transformed many organizations’ business environments; supply availability has been hampered by a number of issues, including export and travel restrictions by some producing countries, and the lockdown has forced suppliers to (temporarily) shut down. The supply of nivolumab medication has a slight decrease in sales during the first quarter of 2020, partly due to negative factors mentioned above in connection with the COVID-19 pandemic, which particularly didn’t affect the overall yearly revenue. The pandemic and COVID-19 have affected every business activity in which the supply chain was affected the most. Because of the pertinacious COVID-19 lockdown, sanctions have been forced by administrations of different nations. These limitations and boundaries across the nation’s borders prompted a diminishing stockpile because of restricted materials and labor force and the halting of the assembly line. The supply chain and demand were positively affected by the COVID 19. The sales and supply of the drugs have been increased with the rise in demand for the drugs and diagnosis. Many major manufacturing companies have launched their drugs in different countries to fulfill the demand, and the government has provided approval for the sales of the drug nivolumab. For instance- Despite the pandemic, many market player of nivolumab has increased their sales globally. This is due to the ongoing increase in the patient population and rising awareness regarding their health. · The sales of ONO pharmaceuticals have been increased in the year 2020 as compared to 2019, which is 2656.05 USD Million in 2019 and 2809.23 USD million. · Similarly, sales of the drug Opdivo (Nivolumab) from the manufacturing company Bristol Myers Squibb Company have been increased globally (except the U.S.) from USD 2,860 million in 2019 to USD 3,047 million in 2020. This increase in sales in both of the major market players is due to the increase in cancer patients and the use of drugs in all areas of cancer. There is an increase in the sales of this nivolumab with the rise in prevalence of disease and early diagnosis & treatment. CONCLUSION As the pandemic of COVID-19 resulted in several restrictions throughout the borders, still, manufacturers and market players were able to manage their sales and revenue of oncology and drug nivolumab. Various manufacturers allowed their workers to work in a clean and safe environment so as to boost up the production at various manufacturing facilities across several regions of the world, thus, helping them to maintain a continuous supply chain with the increasing demand. Market players have come up with better strategies which have also created a positive impact on the growth of the nivolumab market globally.
How COVID-19 Impacted on Periodontitis in Healthcare Industry ?
COVID-19 Impact on Periodontitis in Healthcare Industry Overview The COVID-19 pandemic has posed immense pressure over the healthcare industry and proved to be an unprecedented challenge to global healthcare companies. The COVID-19 pandemic has deprived hundreds of medical services and hindered several ongoing clinical trials. With the introduction of COVID-19 vaccines, new COVID-19 infections have declined, but the attack of mutant corona strain and second COVID-19 wave has led to the overall increase in mortality rate and again badly affected the healthcare industry, among others. Moreover, the upcoming delta strain of the COVID-19 virus, which has affected Singapore, Indonesia, and France, is expected to hamper the market's growth in the future. The most common symptoms associated with coronavirus disease include cough, fever, diarrhea, sore throat, and loss of smell or taste. Patients affected with COVID-19 are at increased risk of developing hepatic manifestations and also experiences damage to liver tissues. COVID-19 has led to the closure and reduced hours of dental practices except for urgent and emergency services, thus limiting routine care and disease prevention. However, regardless of the pandemic of COVID-19, increasing dental disorders like periodontal disorders among the geriatric population have increased the demand for periodontitis treatment. Periodontitis treatment among dental diseases includes aerosol-generating procedures, including aerosol implants that can increase the chances of viral transmission. The pandemic offers an opportunity for the dental profession to shift more toward non-aerosolizing, prevention-centric approaches to care and away from surgical interventions. Direct effects of COVID-19 on oral health include periodontitis, vesiculobullous lesions, and necrotizing periodontal disease. IMPACT ON PRICE The outbreak of the coronavirus disease pandemic (COVID-19) is on the increase and is disrupting lives around the world. Lockdowns, isolation, and widespread closures are being implemented to slow the spread of the virus to millions of lives saved. Vaccination is going on at an accelerated pace so as to deal with such debilitating viral diseases. Several countries are facing a multi-layered crisis, including strains on health systems, among others. With the sudden increase in COVID-19 cases, the people's concerns for their better health have also increased, and the link between oral health and COVID-19 infection also expand the health to oral. The Asian healthcare industry heavily relies on medical devices manufactured in China, which significantly impacts costs as medical devices are not properly available. For instance, Moreover, a large number of medical devices are manufactured in different locations, and the supply of medical equipment is reduced due to restrictions on movement from one location to another. So, the costs have increased for dental devices, among other medical devices. Thus, it signifies that the COVID-19 pandemic has led to an increased price of periodontitis treatment products during the fiscal year 2019-2021. IMPACT ON DEMAND The outbreak of the coronavirus is a result of various markets around the world. It is the cause of lockdown and isolation, which ultimately has an impact on global economic activity. COVID-19 is expected to create a sharp drop for consumables and dental implants. However, due to accelerating demand, a rapid recovery is expected once the dust settles. It includes the orthopedics, cardiology, and dental product industries, among others. These factors have forced market players to strengthen further business continuity, manufacturing facilities, and the global supply chain. The rising awareness of oral hygiene amidst the COVID-19 pandemic has increased the demand for a product required for oral care. The increasing studies for SARS-COV-2 indicated that proper oral hygiene had been reported to decrease infection chances, increasing the demand for mouth care products. However, due to restrictions and aims to reduce COVID-19 transmission, 30% of respondents had visited a dentist less frequently during the pandemic. For instance, · In March 2020, Zimmer Biomet reported a significant and sudden global drop in the volumes of elective procedures. As a result, based on preliminary unaudited financial results, Zimmer Biomet estimated that revenue growth for the first quarter of 2020 would be approximately -9.5 to -10.5% on a reported basis and -8.5 to -9.5% on a constant currency basis compared to the first quarter of 2019. The company is engaged in manufacturing dental implants and dental membranes, and the closure of dental practices has impacted the overall company's sales Zimmer Biomet expects the decline in volumes of elective procedures seen in the first quarter to continue to have a significant negative impact in the second quarter of 2020. Given the continuing uncertainty, the company is currently unable to quantify the impact on its operating results, its financial situation, and its cash flows, which could be significant for 2020. The impact of COVID-19 has dramatically decreased the number of patients who go for dental procedures, including periodontitis treatment, as there is a high chance of adverse health effects of COVID-19. IMPACT ON SUPPLY Various companies are facing a large number of challenges due to the coming of the novel coronavirus. One such issue is the uncertainty surrounding the impact of COVID-19 on medical device industry supply chains. Amalgamation is expected in the dental industry. Manufacturers of large dental products can engage in small businesses. Dental firms involved in supply chain distribution can diversify by producing additional consulting firms or dental equipment and supplies. The companies are at risk, and the ability to retain independent agents and distributors who sell their products depends on a limited number of suppliers for key raw materials. Up till now, dentistry has been facing its darkest hour because of the growth and spread of the coronavirus pandemic. Dental clinics all over the U.S. have been closed for more than two months. Given that the pandemic is still on the growth curve, there is no revival hope anytime soon. It thus signifies that due to continuous lockdown and several restrictions by government authorities, the companies and patients are facing disruption of the supply chain for oral care. However, oral care is categorized under essential care, which lowers the effect of supply chain disruption during COVID-19. STRATEGIC DECISIONS OF MANUFACTURERS Collaboration, agreements, strategic initiatives, and product launches by market players will help them expand their product portfolio and provide appropriate products to the consumer. It will lead to increased product sales and, hence, will positively impact the overall company's revenue. · The COVID-19 has negatively impacted the dentistry market. According to the Health Policy Institute (HPI) March 23 survey report, except for emergency patients, 76 percent of dental practices were closed, 19 percent were completely closed, and 5 percent were open despite the decline. In the week of April 6, 79 percent of dental practices were closed, except for emergency patients, 16 percent were completely closed, and three percent were open despite a decrease in the number of patients During this time of COVID-19 challenge and disruption, Zimmer Biomet, Dentsply Sirona, among others, is adopting several steps to maintain their position in the market and continuously attain lucrative growth. For instances, · Zimmer Biomet has positioned the company to help healthcare systems, clients, and patients now. It has adopted steps to further strengthen the business continuity across its manufacturing facilities and overall supply chain, manufacturing modulation production · Dentsply Sirona has also stated that the company is closely monitoring its global manufacturing sites and raw material supply chains to avoid product delivery delays. Moreover, the company is taking appropriate precautions and implementing safety protocols in order to protect its employees in the context of COVID-19. The company has also launched an illness prevention and awareness intranet site for providing support and guidance to its employees Moreover, by keeping in mind the rising prevalence of periodontitis, market players are adopting initiatives to fulfill patient's and professional's demands. Thus, companies operating in the periodontitis market are adopting several strategies, including agreements and market expansion, thereby enhancing their business. These strategic decisions by the companies are expected to provide significant opportunities for the market players operating in the oral care market. CONCLUSION As the pandemic of COVID-19 has resulted in several restrictions throughout the borders, manufacturers of periodontitis products can still manage their stocks. Various manufacturers have allowed their employees to work in a clean and safe environment to boost the production of essential products at various manufacturing facilities across several regions of the world, helping them maintain a continuous supply chain. However, decreased patient visits have impacted the market, but the rising demand for periodontitis treatment leads to continuous demand for dental implants. Moreover, by raising the prices, the companies are gaining extra profit, helping them combat the negative effect on overall revenue.
Fioricet Medication - Should Know About
Fioricet is a pain killer and it consists of acetaminophen, caffeine, and Butalbital. These components contribute to relaxing muscles, improving blood pressure, and relieving pain and high body temperature. This drug usually helps people calm moderate to severe medical conditions like tension headaches, fever, muscle contractions, etc. Uses of Fioricet Take Fioricet only by the advice of a physician. Make sure you have a prescription that is required to buy Fioricet 40mg online overnight or offline. Always follow the directions on the label and make it a habit while consuming any kind of medicinal formula. Take a note of your dosage as prescribed by your doctor. The overdose side effects might occur due to carelessness in the consumption of Fioricet. Keep your doctor posted about the changes in your body related to the reaction towards the medication. Do not share your medicine with anyone, especially someone with a drug abuse history. This medication isn’t supposed to be taken without the advice and the prescription of a doctor. Though you can buy Fioricet online. Keep it in a safe place and make sure to keep a track of the contents. Selling or giving out Fioricet without a prescription is illegal in many parts of the world. In case the drug upsets your stomach, ingest it with light food. Store it in a dry, well-lit area at room temperature. In case of a missed dose, do not consume double doses to make it up for a missed dose.   Precautions for Consumption Since this medication can make you feel drowsy, you can avoid doing things that require alertness. Try resting for a couple of hours and then doing whatever you feel like. Avoid alcohol as it can magnify the effects of the medication and it can also severely harm your liver. Certain medical combinations can react together and cause harm to the patient’s body so it is advisable to monitor if you are taking any other medication for cold or pain etc.  Inform your doctor and educate yourself on it. Avoid taking medications with APAP in them. Avoid caffeine pills, or ADHD-related medications, etc. while consuming Fioricet. Exercise caution if you suffer from hepatitis, porphyria, cardiovascular diseases, or anaemia. Though very rare, there are chances of severe skin allergies in patients due to Acetaminophen. Make sure your doctors are always updated with your medical condition and your response to certain medications. This way it will be easier to predict any upcoming progress in your condition. If there is a special risk patient like a senior citizen or a pregnant woman, caution should be taken if Fioricet is prescribed to them. Because the effects can be different in senior citizens and can be transferred to the unborn child in the case of pregnant women. Breastfeeding women also need to take care of this as the contents of the medication can be transferred to the child. Side Effects Even though Fioricet is quite a safe medication and has proven to be life-changing many times in medical history. But being a medication, it is bound to have some chemical side effects. A doctor always prescribes a medication keeping at par the risks of side effects.  Some of the side effects of Fioricet are- swelling in body parts, hives, unusual colored urine, rashes, vomiting, palpitations, drowsiness, nausea, etc. in case, there is any serious condition, you should immediately contact a doctor. Contact your doctor right away if, you observe any of the symptoms for instance- mood swings, palpitations, seizures, etc. even though serious allergic reactions are rare with the consumption of Fioricet, but in any case, if you observe rashes, swollen body parts, drowsiness, itching, etc. after the ingestion of the medication rush for medical help do not try to treat such situations on your own. Every drug has different reactions in different bodies, so if you feel uncanny and uncomfortable, see a doctor. Conclusion Patients can easily buy Fioricet online overnight fast shipping in USA,and make the best use of it, only when properly monitored and handled. Fioricet has changed lives, but only when properly utilized. So, make sure you know well about the medication before consuming it and make sure your health is in safe hands with Fioricet. ORIGINAL SOURCE: What All Should One Know About- Fioricet
How COVID-19 Impacted on Bevacizumab in Healthcare Industry ?
COVID-19 Impact on Bevacizumab in Healthcare Industry In the city of Wuhan, China the Coronavirus disease (COVID-19) outbreak is originated. Coronavirus disease (COVID-19) has spread across the globe, with large number of cases having been reported worldwide. The Coronavirus disease (COVID-19) pandemic is not only creating health crisis but also it is unfavorably affecting on healthcare, economies and pharmaceutical sector as well as at their core. As COVID-19 is the infectious disease, its spread is endless. It have causes a nationwide outbreak as well as public health crisis. Cancer treatment and therapies drugs manufacturing companies have also faced some difficulties in manufacturing and distribution of the drugs and medication due to locked down, supply chain and social distancing restrictions. In some recent studies, it was stated that Bevacizumab, an anti-VEGF drug, approved by the FDA and widely used in clinical oncotherapy, is a promising drug for ALI/ARDS in COVID-19 through suppression of pulmonary edema which have increased its demand in the market and also increasing cancer patients have also driven the market demand and supply. PRICE IMPACT The Coronavirus disease (COVID-19) pandemic has an enormous impact on the global economy market. The demand for cancer treatment products has increased along with its prices in the treatment of COVID. In addition, the sum of research and development and marketing, selling, and administrative expenses have been increased in 2020, which is driven primarily by the development expenses for COVID-19 therapies. For instance, Bevacizumab plus standard care markedly improves the oxygen ratios in COVID 19 patients and shows improvement in oxygen-support status, patients were discharged, and none of the patients have shown worsen oxygen-support status nor die. Also, the demand for cancer treatment products will be increased, and the products are upgraded by top importer countries like U.S., which have increased the sales and prices of the bevacizumab. For instance, The drug Avast in (bevacizumab) has been increased to $842 for a supply of 4 milliliters dose in 2020. Due to the increase in demand, the use of bevacizumab in the COVID treatment and increase in production and manufacturing expenses have contributed to product prices. IMPACT ON SUPPLY CHAIN The COVID-19 pandemic has transformed many organizations’ business environment; several problems, including export and travel ban by some producing countries and lockdowns that have caused producers to (temporarily) shut down, have disrupted supply access. Difficulties or delays in manufacturing, sales, or marketing; supply disruptions, shortages, or stock-outs at our facilities; and legal or regulatory actions all are caused due to the COVID 19 pandemic. But it does not affect the sales and supply of the drug bevacizumab that much because of the rise in new diagnoses or cancer and the efficiency of the drug in treating the COVID patients. These are some of the reasons which have maintained the supply of the drug throughout the year With the rise in demand and supply of the drugs, many manufacturing companies have launched their new products, which have increased their sales. For instance- · The sales of the drug MVASI (bevacizumab) from the manufacturing company Amgen Inc. have increased more than 20% in the U.S., which is USD 121 million in 2019 to USD 650 million in 2020 and for the rest of the world, drug sales increased from USD 6 million in 2019 to USD 142 million in 2020. This increase in the supply of the drug is with the increasing treatment for cancer. · Similarly, the sales of the global segment generics, which include biologics drugs such as bevacizumab of the company Dr. Reddy’s Laboratories Ltd, have also been increased from USD 1,858.27 million in 2019 to USD 2,079.96 million in 2020. This increase in sales is due to the increase in healthcare and Research & Development due to COVID 19. IMPACT ON DEMAND Coronavirus disease (COVID-19) is an infectious disease caused by a SARS-CoV-2 virus, while a large population is affected by this COVID-19 virus. Coronavirus disease 2019 (Covid-19) is an ongoing worldwide pandemic; nearly all the countries have taken initiative action under locked down and social distancing restriction. Reduction in cancer treatment across the globe has affected the demand for cancer treatment and their drugs like bevacizumab, especially in the first quarter, but after the second quarter of 2020, the demand for the drug has increased because of its Efficacy and tolerability of in patients with severe COVID-19. For Instance- Recent evidence revealed higher blood Vascular Endothelial Growth Factor (VEGF) levels in COVID-19 patients compared with healthy controls. VEGF is considered the most potent vascular permeability inducer. Numerous studies have revealed that VEGF was a key factor and a potential therapeutic target in ALI and ARDS. Bevacizumab, an anti-VEGF drug, approved by the FDA on February 26, 2004, and widely used in clinical oncotherapy, is a promising drug for ALI/ARDS in COVID-19 through suppression of pulmonary edema. Also, the increase in cancer patients and the rise in the demand for the treatment of various types of drugs have propelled the market demand and sales of major market players. For instance, · There is an increase in the sales of biosimilar drugs which includes bevacizumab, for major market players. For instance, the manufacturing company Pfizer Inc., the sales of biosimilar segment is increased from USD 1,527 million to USD 911 million with the increase in demand for the drugs in COVID patients and the cancer treatment. STRATEGIC DECISIONS FOR MANUFACTURERS A large population is affected by this COVID-19 virus, and its spread is expanding worldwide for the last few months. To deal with the COVID-19 outbreak challenges, many bevacizumab and biosimilar market players are creating new strategies. The company is now opting for digital media such as telecommunication, mobile applications, webinars, and other digital media to support patient requirements to tackle the pandemic situation and increase the company sales with the increasing demand and growth. Moreover, to accomplish the market demand, small market players are utilizing the partnership agreement strategy. It is predicted that these strategies are anticipated to escalate up the company revenue and its growth in the forecasted period. They have launched new products and formed strategic alliances with each other to carry on the supply during the pandemic. For instance- · In 2020, Amgen Inc. had advanced their innovative pipeline, successfully integrated MVASI, acquired in November 2019, a biosimilar to Avast in (bevacizumab), and has advanced their international expansion continued to provide an uninterrupted supply of their medicines globally through the COVID-19 pandemic · In May 2020, the Food and Drug Administration approved atezolizumab in combination with bevacizumab (TECENTRIQ and AVASTIN, Genentech Inc.) for patients with unrespectable or metastatic hepatocellular carcinoma who have not received prior systemic therapy CONCLUSION It can be concluded that the COVID-19 pandemic has a positive impact on the global bevacizumab market with the increase in the price, supply, and demand of the bevacizumab. However, in the crisis call, pharmaceutical market players, government bodies, and healthcare organizations work closely with healthcare professionals, customers, and patients for the betterment of public health and to fulfill the demand. However, companies and government bodies exclusively concentrate on how they can make the most effective and best contribution to control the spread of the virus and save lives. They are also ramping up the production of essential medication to a new level and ensure that speed doesn’t affect or destroy the quality of products.
Medulloblastoma Drug Market Production, Sales and Consumption Status and acurate Research Report and Forecast 2028
Medulloblastoma drug market is expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market is growing at a healthy CAGR in the above-mentioned research forecast period. Rising prevalence of brain related disorders worldwide and emerging markets are the factors responsible for the growth of this market. Request Sample Copy @ https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-medulloblastoma-drug-market Due to presence of family history with brain disorders and exposure to radiation boost up the global medulloblastoma market. However, increased prevalence of brain tumor & other type of cancer worldwide will boost up the global medulloblastoma drug market. But, exact causes behind the occurrence of brain tumor and late symptoms of the cancer may hamper the global medulloblastoma drug market. Medulloblastoma is a type of brain tumor that starts in the lower back part of the brain, called the cerebellum. The cerebellum helps in muscle coordination, balance and movement. Medulloblastoma is an embryonal tumor that starts in the embryonic cells in the brain. Due to this patient suffer from headaches, nausea, vomiting, tiredness, dizziness, double vision, poor coordination; unsteady walk and pressure build up in the brain. The tumor rarely spreads to other areas of the body. Global Medulloblastoma Drug Market Scope and Market Size The medulloblastoma drug market is segmented on the basis of drugs, route of administration, end-users and distribution channel. The growth among segments helps to analyse niche pockets of growth and strategies to approach the market and determine your core application areas and the difference in your target markets. On the basis of drugs, the medulloblastoma drug market is chemotherapy, glucocorticoids, osmotic diuretics and others. Chemotherapy drug includes temozolomide. Glucocorticoids are further segmented into dexamethasone, methylprednisolone, prednisolone, prednisone, hydrocortisone, cortisone and others. Osmotic diuretics include mannitol, hypertonic saline and others. Route of administration segment of medulloblastoma drug market is segmented into oral, parenteral and others. On the basis of end-users, the medulloblastoma drug market is segmented into hospitals, specialty clinics and others. On the basis of distribution channel, the medulloblastoma drug market has also been segmented into hospital pharmacy, retail pharmacy, online pharmacy and others. Request for TOC @ https://www.databridgemarketresearch.com/toc/?dbmr=global-medulloblastoma-drug-market Medulloblastoma Drug Market Country Level Analysis Global medulloblastoma drug market is analysed and market size information is provided by country, drugs, route of administration, end-users and distribution channel as referenced above. The countries covered in the global medulloblastoma drug market report are U.S., Canada, Mexico, Brazil, Argentina, Peru, Rest of South America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Hungary, Lithuania, Austria, Ireland, Norway, Poland, Rest of Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Vietnam, Rest of Asia-Pacific, Saudi Arabia, U.A.E, Egypt, Israel, Kuwait, South Africa, Rest of Middle East and Africa. Inquiry Before Buy @ https://www.databridgemarketresearch.com/inquire-before-buying/?dbmr=global-medulloblastoma-drug-market Competitive Landscape and Medulloblastoma Drug Market Share Analysis Global medulloblastoma drug market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, company strengths and weaknesses, product launch, clinical trials pipelines, product approvals, patents, product width and breath, application dominance, technology lifeline curve. The above data points provided are only related to the companies’ focus related to medulloblastoma drug market. The major players covered in the medulloblastoma drug market are Merck & Co., Inc., Accord Healthcare, Sun Pharmaceuticals Industries Ltd., Zydus Pharmaceuticals, Inc., Amneal Pharmaceutical LLC., B. Braun Melsungen AG., Hikma Pharmaceutical PLC., Novartis AG., Jubilant Cadista., Mylan N.V., among other domestic and global players. Medulloblastoma drug market share data is available for global, North America, South America, Europe, Asia-Pacific (APAC) and Middle East and Africa (MEA) separately. DBMR analysts understand competitive strengths and provide competitive analysis for each competitor separately.
Injection Trays Market by Competitive Landscape, SWOT Analysis, Opportunities and Challenges, Growth by 2021-2028
Injection trays market is expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market to grow at a CAGR of 7.40% in the above-mentioned forecast period. The growing awareness among the patients regarding the availability of injection trays which will further create lucrative opportunities for the growth of the market. Request Sample Copy @ https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-injection-trays-market Rising demand of eco-friendly, lightweight, durable and recyclable material, prevalence of improved distribution channels, increasing application of trays during transportation and displaying product, easy availability of trays in pharmacies which will likely to enhance the growth of the injection trays market in the forecast period of 2020-2027. On the other hand, increasing innovation in product designing which will further bring various opportunities for the growth of the injection trays market in the above mentioned forecast period. Global Injection Trays Market Scope and Market Size Injection trays market is segmented on the basis of type, material and end user. The growth amongst these segments will help you analyse meagre growth segments in the industries, and provide the users with valuable market overview and market insights to help them in making strategic decisions for identification of core market applications. Based on type, injection trays market is segmented into hard, and soft. On the basis of material, injection trays market is segmented into polyethylene terephthalate (PET), PETG (polyethylene terephthalate with glycol), RPET (recycled polyethylene terephthalate), polyvinyl chloride, high density polyethylene (HDPE), polypropylene, and others. Injection trays market has also been segmented based on the end user into hospitals, ambulatory surgical centres, speciality clinic, and others. Request for TOC @ https://www.databridgemarketresearch.com/toc/?dbmr=global-injection-trays-market Injection Trays Market Country Level Analysis Injection trays market is analysed and market size insights and trends are provided by country, type, material and end user as referenced above. The countries covered in the injection trays market report are U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America. Inquiry Before buy @ https://www.databridgemarketresearch.com/inquire-before-buying/?dbmr=global-injection-trays-market Competitive Landscape and Injection Trays Market Share Analysis Injection trays market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to injection trays market. The major players covered in the injection trays market report are Krinsha Industries (Dedhia Group), AVA PACKAGING, Shanghai Leenol Industrial Co., Ltd., Hebei Shuangli Packaging Products Co., Ltd., Europack, Insulink Packaging Solutions Pvt. Ltd., Jal Extrusion Private Limited., Vinpac Innovations., Vintec Industries., among other domestic and global players. Market share data is available for Global, North America, Europe, Asia-Pacific (APAC), Middle East and Africa (MEA) and South America separately. DBMR analysts understand competitive strengths and provide competitive analysis for each competitor separately.
High Healthcare Expenditure To Drive The Growth Of The Operating Room Management Market
The pandemic has led to a temporary ban on elective surgeries across the globe, which resulted in cancellations of elective surgeries worldwide. According to a report published by researchers of CovidSurg Collaborative, around 28 million surgeries were canceled across the globe during 12 weeks of peak disruption during the COVID-19 pandemic.   To handle the increased surgical volumes, hospitals are increasing OR hours and focusing on better utilization of OR. The COVID-19 will positively impact the ORM software market. It will increase the adoption rate of ORM software as most hospitals will now focus on increasing capacity by using technology to improve efficiency.  The overall cost of healthcare delivery has grown significantly over the last few decades, mainly due to increasing health insurance premiums, the rising demand for quality healthcare services, the rising geriatric population, and the increasing incidence of chronic disorders.  Another important factor attributing to rising healthcare costs is the high dependency on traditional and outdated methods such as paper-based patient records, which leads to an increase in readmission rates, medical errors, and administration costs.  Different governments and healthcare systems worldwide are now focusing on controlling rising healthcare costs by minimizing patient readmissions, medical errors, and administration costs with the effective utilization of various healthcare IT solutions. Operating rooms or ORs account for 40% of the total hospital expenses and constitute ~70% of the total revenue generated.   For More Information Download PDF Brochure @ https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=175407912 The adoption of ORM solutions has been particularly affected by its high installation and maintenance costs. ORM software, when once installed, also requires to be regularly updated as per the user’s requirement and software enhancements, thereby presenting recurring expenditure. Additionally, the maintenance of high-end IT-enabled systems typically costs more than the software itself.  The annual maintenance cost is estimated to be 20-25% of the initial cost of the software licenses. Subsequently, it can be expected that the high costs incurred from the purchase, installation, maintenance, and upgrade of ORM software and solutions may negatively affect their overall adoption among end-users, thus restraining market growth to a certain extent.  Brazil, Russia, India, China, and South Africa (BRICS) are among the fastest-growing economies in the world. According to the World Economic Forum, these emerging economies will account for around one-third of the global healthcare expenditure by 2020. More than half of the world’s population resides in India and China, owing to which these countries are home to a large patient base. The increasing burden of cancer, improvements in healthcare infrastructure, a less-stringent regulatory environment, and growing medical tourism are encouraging players in the operating room management market to increase their presence in emerging countries. Owing to the expansion of the patient population base, the number of hospitals and surgical centers is also expected to increase in emerging countries in the coming years. Also, currently, governments in these countries are undertaking initiatives to expand and modernize their respective healthcare infrastructures.  The number of independent health care providers has been decreasing as most healthcare providers are turning to mergers, acquisitions, and partnerships and are functioning under a health system rather than operating independently. On a 15-year basis, the percentage of hospitals functioning under a health system has increased from approximately 50% to approximately 65%. Today, over 70% of hospitals are operating as part of a health system rather than independently.  Data management communication solutions accounted for the largest share of the operating room management market in 2019 owing to the benefits such as easy sharing of patient status in perioperative care phases, tracking of the schedule compliance, and sharing of the media and information related to cases within different operating rooms or external hospital departments.  The high growth of this segment can primarily be attributed to advantages such as scalable data storage, scalable computing power, machine-learning capabilities, and faster data transfer between organizations of cloud platforms.
Why Overnight Oatmeal is the Best Morning Meal for Diabetics?
We have all faced the agony of missing our early meal because of time scarcity in the morning. Overnight oats feel like dream come true for all those people who have to say no to their most important meal due to time troubles. Imagine having your breakfast already prepared when you get up and that even without lifting a thumb and most importantly, healthy. Exciting right?? But are overnight oats healthy for diabetics?? Oats are full of high fibers, protein, potassium, magnesium, omega 3 fatty acids. Above all, it has no added sugar consequently making it one of the best choices for a diabetic person. Even if we get highlights of overnight oats being healthy for diabetic people. Let’s get further into the depth of facts and do a quick reality check-up. Let’s firstly know what an overnight oat is and why it has captured the attention of a vast population. What is Overnight Oatmeal and Why is it a Boon? Overnight oats are the same oats soaked overnight in your treasured liquids like milk, yogurt, coconut milk, or whichever you like and topped with mouth-watering toppings like nuts and fruits. Overnight oats being easy to prepare, time saver, and having assorted health benefits manages to get a lot of attention from youth. Moreover, it can be personalized according to one’s taste and is available with delightful recipes. If you are a dessert lover and worried about your sugar control. With this meal get ready to live your dream in reality. Not just weight loss but overnight oats even increase insulin in the body and prove themselves to be good for the heart. Now coming to the question that why Overnight Oats for Diabetics? you may get your answers here: Overnight oats for diabetics are one of the best choices for their breakfast. There are a lot of factors that make overnight oats good for diabetics. Some of them are discussed below. Qualities That Make Overnight Oats Good For Diabetics Oats are already loaded with nutrients. There are no additives required. Despite being a high-carb food, oats are considered good for diabetics because of the certain benefits they give. You can easily prepare overnight oatmeal for diabetics at home. Certain straightforward benefits which make overnight oats good for diabetics: • Low GI score: Glycemic Index or GI score tells how likely a food can increase blood glucose. Having a low GI score, oatmeal is an ideal food for diabetics. • Rich in fiber: Fiber is an important player in the game of digestion. It also helps to break down sugar complexes in the blood. • Lower blood sugar: Beta-glucans present in oats is the specific fiber that is known to lower blood sugar levels. • Healthy for the heart: The same beta-glucans are also helpful in maintaining cholesterol levels which eventually lead to a healthy heart. Apart from all these benefits, oatmeal makes you feel full and counter the craving for food at regular intervals. It also raises the insulin level temporarily that makes overnight oats good for diabetics. As of now, we know that overnight oatmeal for diabetics is a good breakfast option. We will now learn to prepare good overnight oatmeal for breakfast. How To Prepare Overnight Oats? Preparing overnight oats is not rocket science. It’s as simple as that. • Take oats in a container that can be covered for the night. • Fill it with water, milk, coconut milk, almond milk, or any other such fluid you like. • Leave it covered for 4-6 hours or the whole night. • Open it in the morning. Your overnight oats are ready. Enjoy it with honey, fruits, and dry fruits. There are several overnight oatmeal recipes for diabetics. The recipes contain ingredients per the needs of a diabetic person. Moving ahead we’d explore some recipes of overnight oats diabetes patients can enjoy. Can Overnight Oat be Really Pivotal in Diabetes Control? Oats are known for their lower glycaemic response than other breakfasts present in the market. Oats are also rich in b-glucan, a highly viscous soluble dietary fiber. B-glucan reduces postprandial blood glucose and hence insulin responses by delaying the absorption of carbohydrates. Plus, soaking results in the natural breakage of starch present in the oats, therefore, making it easy to digest. During the procedure, it gets to absorb more nutrients and the acid in the meal breaks down making it lighter. Oats are also loaded with good-for-you bacteria which when soaked helps them to multiply those tiny friends. Now as we have advocated the aids of overnight oat let's check for some amazing overnight oatmeal recipes for diabetics. However overnight oats can be made in several ways according to one’s personal choices but here are some special recipes for diabetics. Recipes With a Pinch of Love and Loads of Care Diabetic cooking can’t be made more amazing than our first recipe: 1: Apple Spice and Everything Nice We are going to make this meal named apple spiced overnight oats with real quick and easy steps: Step-1: In a 2 -cup mason jar or similar sized container mix some hemp hearts, oats, chia seeds, and cinnamon. Step-2: Mix in the Greek yogurt and shredded apple. Step-3: Add milk of your own choice and stir everything together. Step-4: Place the oats in the refrigerator for at least 2 hrs or overnight to chill. Step-5: Top it up with some of your favorite nuts and serve. Well, that was easy, and trust me tastes better than any known dessert to me. Moving to our next recipe for vanilla lovers 2: Vanilla Wonders Vanilla is wonderful in its own ways to let's mix it with oats to make it magical. Step-1: Take a jar and add ½ cup of rolled oats, 1/3 cup of Greek yogurt, 2/3 cup of almond milk. ½ teaspoon vanilla extract and whisk them well. Step-2: Close the jar with an alright lid. Step-3: refrigerate it overnight. Enjoy it by serving it cold. 3: Overnight Oats with Chocolate Chip Banana The mix got just delicious. Ingredients required: ½ cup of rolled oats, ⅓ cup of greek yogurt, ⅔ cup of unsweetened milk, 1 tablespoon chia seeds, ½ teaspoon vanilla extract, A pinch of salt, Honey to taste, ½ banana, 2 tablespoons of chocolate chips. Step1: Add all the ingredients to an airtight container and whisk them well. Step 2: Close the lid and refrigerate overnight. There are certainly more ways to prepare the best oatmeal for diabetics. It is a versatile food. You can find more recipes and enjoy being on diet with these amazing overnight oats. Final Word The high nutrient value and easy-to-digest nature undoubtedly make overnight oats good for diabetics. So, enjoy in moderation, overnight oats for diabetics are really good. Other than being diabetic-friendly, oats are helpful in many ways in our body functions. They help to prevent heart diseases, can aid weight loss, accelerate hair growth, can boost brain function and immunity. So, switch to overnight oats once and for all. It is a magic potion for health.
Cleanroom Technology Market to Witness Impressive Growth
The increasing demand in developing economies and the growing focus on energy-efficient cleanrooms are expected to offer significant opportunities for market growth in the coming years. However, the high operational cost associated with the cleanrooms is expected to restrain market growth to a certain extent.  The global health crisis triggered by the COVID-19 pandemic has made it imperative that the pharmaceutical industry moves at a rapid pace alongside researchers, regulators, and contract research companies to develop a diagnosis, treatment, and vaccines. Cleanroom technologies and services play an important role in this scenario to ensure that quality, safety, and efficacy are being maintained.  In the current scenario, the healthcare industry is witnessing an unparalleled demand for diagnostic tests, personal protective equipment (PPE), medical ventilators, and other critical medical supplies. Facing the potentiality of a high risk of infection, healthcare professionals (HCPs) are also facing significant challenges in providing specific and effective care (often remotely).  In Hospital systems are becoming overwhelmed with the rapidly increasing number of COVID-19 patients, which is weighing heavily on the pharmaceutical industry. With the increasing demand for certified products, various quality certifications such as ISO checks and National Safety and Quality Health Standards (NSQHS) have been made mandatory for ensuring that the standards for manufacturing processes and products are being upheld. The quality certifications require products to be processed in a cleanroom environment to ensure minimum possible contamination.   Also, the price per square foot is not the same for ISO 6 and ISO 8 cleanrooms. This is because the amount of air supplied is different in both classes of cleanrooms. The air is 100 times cleaner in an ISO 6 cleanroom than in an ISO 8 cleanroom, thereby doubling the air conditioning capacity of the HVAC systems.   For More Information Download PDF Brochure @ https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=263122482 Cleanrooms are mostly designed according to customer requirements based on product specifications and customer-specific design requirements. However, there are no specific guidelines for cleanroom designs for different application areas or product types. This leads to several challenges for cleanroom manufacturers, as they need to follow different designs every time.  The consumables segment accounted for the larger market share in 2019. The high and growing number of pharmaceutical, biotech, and medical device companies facilitating the use of disposable protective clothing has resulted in the increased adoption of the consumables in the cleanroom technologies market. Also, the large number of RD activities in the healthcare industry is resulting in a stable demand for cleanroom consumables among end-users.   The hardwall cleanrooms segment is expected to witness the highest growth during the forecast period. This is mainly due to the higher demand for hardwall cleanrooms, as they are more design-flexible than standard and softwall cleanrooms, quick and easy to install, freestanding for easy portability, and easy to expand or reconfigure.   This is due to its favorable government regulations, increasing healthcare expenditure, and the growing base of pharma companies in the country, all of which are driving adoption of cleanroom solutions in the Asia Pacific. 
Particle Therapy Market worth USD 1,349 million by 2023 : Technological advancements in the field of Heavy Ion Therapy
The study involved four major activities to estimate the current market size for particle therapy. Exhaustive secondary research was done to collect information on the market and its different subsegments. The next step was to validate these findings, assumptions, and sizing with industry experts across the value chain through primary research. Both top-down and bottom-up approaches were employed to estimate the complete market size. Thereafter market breakdown and data triangulation was used to estimate the market size of segments and subsegments. According to the new market research report “Particle Therapy Market by Type (Heavy Ion, Proton Therapy), Products (Cyclotron, Synchrotron, Synchrocyclotron), Services, System (Single-room, Multi-room), Cancer Type (Pediatric, Prostate, Breast), Application (Treatment, Research) – Forecast to 2023“, published by MarketsandMarkets™, the global Particle Therapy Market is projected to reach USD 1,349 million by 2023 from USD 865 million in 2018, at a CAGR of 9.3%. Browse in-depth TOC on “Particle Therapy Market“ 80 – Tables 36 – Figures 138 – Pages Download PDF Brochure:  https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=12809137 The major factors driving the growth of the Particle Therapy Market are the growing global prevalence of cancer, growing adoption of particle therapy in clinical trials, advantages offered by particle therapy over photon therapy, and the increasing number of particle therapy centers worldwide. The pediatric cancer segment is expected to account for the largest share of the Particle Therapy Market, by cancer type, in 2018 Based on cancer type, the Particle Therapy Market is segmented into pediatric cancer, prostate cancer, breast cancer, lung cancer, head & neck cancer, and other cancers. The pediatric cancer segment is expected to account for the largest share of the Particle Therapy Market in 2018. The growing incidence of pediatric cancer and the high success rates and minimal long-term risks achieved with particle therapy are the major factors driving the growth of this market segment. Research applications to register the highest CAGR in the global Particle Therapy Market during the forecast period Based on applications, the Particle Therapy Market is segmented into treatment applications and research applications. The research applications segment is expected to witness the highest CAGR during the forecast period. Growing awareness about the research applications of particle therapy systems, development of cost-effective and technologically advanced diagnostic and therapeutic particle therapy systems, and increasing industry-academia collaborations in the field of research are the key factors driving the growth of this segment. Asia Pacific to dominate the Particle Therapy Market during the forecast period The Particle Therapy Market is segmented into four regional segments, namely, North America, Europe, Asia Pacific, and the Rest of the World. The Asia Pacific region is expected to account for the largest share of the global Particle Therapy Market in 2018, and this trend is expected to continue during the forecast period. The Asia Pacific region is expected to offer significant growth opportunities for players operating in the Particle Therapy Market owing to the increasing healthcare expenditure and growing initiatives to promote the use of advanced particle therapy technologies in Asia Pacific countries. Request for sample pages @ https://www.marketsandmarkets.com/requestsampleNew.asp?id=12809137 The major players operating in the Particle Therapy Market are Ion Beam Applications SA (Belgium), Varian Medical Systems, Inc. (US), Hitachi, Ltd. (Japan), Provision Healthcare (US), Mevion Medical Systems, Inc. (US), Sumitomo Heavy Industries, Ltd. (Japan), Optivus Proton Therapy, Inc. (US), ProTom International, Inc. (US), Advanced Oncotherapy plc (UK), and Danfysik A/S (Denmark). Browse Adjacent Markets @ Medical Devices Market Research Reports & Consulting Radiotherapy Market by Product (LINAC, CyberKnife, Gamma Knife, Tomotherapy, Particle Therapy, Cyclotron), Procedure (External (IMRT, IGRT, 3D-CRT) Internal (LDR, HDR)), Application (Prostate, Breast, Lung), End User (Hospitals) – Global Forecasts to 2026 https://www.marketsandmarkets.com/Market-Reports/radiotherapy-monitoring-devices-market-567.html Patient Positioning System Market by Product (Tables (Surgical Tables, Radiolucent Imaging Tables), Accessories), Application (Surgery, Cancer Therapy, Disease Diagnosis), and End User (Hospitals, Ambulatory Surgery Center) – Global Forecast to 2022 https://www.marketsandmarkets.com/Market-Reports/patient-positioning-system-market-12586699.html About MarketsandMarkets™ MarketsandMarkets™ provides quantified B2B research on 30,000 high growth niche opportunities/threats which will impact 70% to 80% of worldwide companies’ revenues. Currently servicing 7500 customers worldwide including 80% of global Fortune 1000 companies as clients. Almost 75,000 top officers across eight industries worldwide approach MarketsandMarkets™ for their painpoints around revenues decisions. Our 850 fulltime analyst and SMEs at MarketsandMarkets™ are tracking global high growth markets following the “Growth Engagement Model – GEM”. The GEM aims at proactive collaboration with the clients to identify new opportunities, identify most important customers, write “Attack, avoid and defend” strategies, identify sources of incremental revenues for both the company and its competitors. MarketsandMarkets™ now coming up with 1,500 MicroQuadrants (Positioning top players across leaders, emerging companies, innovators, strategic players) annually in high growth emerging segments. MarketsandMarkets™ is determined to benefit more than 10,000 companies this year for their revenue planning and help them take their innovations/disruptions early to the market by providing them research ahead of the curve. MarketsandMarkets’s flagship competitive intelligence and market research platform, “Knowledge Store” connects over 200,000 markets and entire value chains for deeper understanding of the unmet insights along with market sizing and forecasts of niche markets. Contact: Mr. Shelly Singh MarketsandMarkets™ INC. 630 Dundee Road Suite 430 Northbrook, IL 60062 USA: +1-888-600-6441 Email: sales@marketsandmarkets.com Research Insight: https://www.marketsandmarkets.com/ResearchInsight/particle-therapy-market.asp
Is it worth using Prozac (fluoxetine) as an antidepressant? Find out More!
Prozac is an antidepressant. It's also known as fluoxetine, which is its generic name. Prozac (fluoxetine) is efficient in improving your state of mind, energy levels, sleep, and appetite. This medication is likewise valuable in lessening fear, undesirable considerations, and tension. Prozac (Fluoxetine) is readily accessible as a liquid, tablet, capsule, and long-acting capsule with delayed release. It is advisable for grown-ups and can sometimes be used for children aged 10 years and older. What is Prozac (Fluoxetine) used for? Prozac (Fluoxetine) is an FDA-approved medication. It has been used to treat major depressive disorder (in people aged eight and up), panic attacks, eating disorders (bulimia and binge-eating disorders), bipolar disorder, and premenstrual dysphoric disorder. For treatment-restricted depression, Prozac (Fluoxetine) is also used in conjunction with olanzapine. Prozac (fluoxetine) non-FDA-authorized applications incorporate social anxiety disorder (also known as social phobia), borderline personality disorder, post-traumatic stress disorder, Raynaud phenomenon, and selective mutism. Is Prozac (Fluoxetine) an SSRI? Prozac (Fluoxetine) belongs to the selective serotonin reuptake inhibitors (SSRIs) class of antidepressants. Selective serotonin reuptake inhibitors (SSRIs) are considered "selective" because of their little impact on dopamine or norepinephrine. They exert their therapeutic effect by inhibiting serotonin reuptake. Prozac (fluoxetine) was the first SSRI to be sold in the United States. It has received significant interest among the press and has reduced the long-term stigma and dread of using antidepressants. Over 100 million individuals globally take selective serotonin reuptake inhibitors (SSRIs). One in ten people in the US and one in four women between 40 and 50 years old is supposed to take SSRI to improve their moods by enhancing their brain serotonin. What Does Prozac (Fluoxetine) Do These medications are supposed to operate by boosting serotonin levels, a mood-enhancing neurotransmitter in the brain. These drugs increase the accessibility of serotonin at synapses (associations between brain cells known as neurons) by forestalling the reuptake of serotonin by neurons. How Long Does it Take For Prozac (Fluoxetine) to work Because of its long half-life (4 to 6 days), the initial impact arises within two weeks to about a month. You'll likely continue to take Fluoxetine (Prozac) for several months after you feel better. Most specialists suggest you take antidepressants for a half year to a year after you presently don't feel depressed. Halting before that time can make anxiety return. Prozac (Fluoxetine) Dosage Peruse the medication guide given by your drug specialist before you use Prozac (Fluoxetine) and, each time, you get a top-up. If you have any inquiries, ask your primary care physician or drug specialist before taking this medication. The Prozac (Fluoxetine) dosage is determined by the patient's age and the treatment's goal. The average adult dose of Prozac (Fluoxetine) is 20 milligrams, given by mouth once daily in the morning. If the symptoms do not improve after a few weeks, specialists can increase the dose up to 60 mg. Geriatric or patients with co-morbidities may need to take Fluoxetine (Prozac) at a lesser dose or less frequently. The maintenance dose of Prozac (Fluoxetine) is 20-60 mg per day, while the highest dose is 80 mg. If you are using this medication twice a day, your doctor may tell you to take it once in the morning and then again in the afternoon. An individual who is taking a delayed-release oral capsule to treat depression will take once a 90 mg delayed-release oral capsule a week. If you're taking Prozac (Fluoxetine) in liquid form, use special measuring equipment to make sure you get the proper dose. Use a measuring spoon instead of a household spoon to ensure you get the right dose. What Should I Do If I Miss A Dose Of Prozac (Fluoxetine)? On the off chance that you sometimes neglect to take a dose, don't stress. Take your next dose the following day at the typical time. Never take two doses simultaneously to compensate for a failed to remember one. Prozac (Fluoxetine) Side Effects Prozac (Fluoxetine), like all drugs, can lead to negative consequences in some people, although many people experience no or moderate side effects. As your body adjusts to Fluoxetine (Prozac), many of the most typical harmful effects will fade away. Headaches, anxiety, insomnia, nausea, stomach discomfort, dry mouth, sleepiness, dizziness, trembling, yawning, lethargy, exhaustion, agitation, reduced sexual desire, difficulty or inability to climax, and ejaculation problems are all common side effects of Prozac (Fluoxetine). Joint discomfort, swelling of the face, tongue, and lips, QT prolongation, convulsions, glaucoma, redness of the eye, irregular heartbeat, breathing problems (dyspnea), and serotonin syndrome are all serious but rare side effects of Prozac (Fluoxetine). Prozac (Fluoxetine) Drug-Drug Interactions Medicines that cause bleeding, bruising, or act as blood thinners may react with Prozac (fluoxetine) including, antiplatelet drugs and warfarin. Taking MAO (monoamine oxidase inhibitors) alongside this prescription could cause a dangerous (potentially fatal) drug interaction. Patients should avoid MAO inhibitors for at least two weeks before and after Prozac (fluoxetine) treatment. When to begin or stop using this medicine, consult your doctor. For medicines that affect your heart rate, avoid taking Prozac (Fluoxetine) with them. It may interact with the medication and cause an elevated or abnormal heart rate. Antipsychotics, other SSRIs, and serotonergic drugs like lithium and St. John's Wort should not be combined with Prozac (Fluoxetine). They may cause severe drug-drug interactions. Prozac (Fluoxetine) In Pregnancy And Breastfeeding Prozac (Fluoxetine) transfers to the breast milk in a moderate amount. There is a low risk of harm to the infant according to the limited data available. The general recommendation however is to avoid unless necessary during lactation. It's significant for you and your child that you stay well during your pregnancy. If you become pregnant while taking Prozac (Fluoxetine), address your primary care physician. Try not to quit taking your medication except if your PCP advises you to. Experts have associated Prozac (Fluoxetine) with a modest increase in the chance of complications for your potential child. However, if you don't get help for your depression while you are pregnant, you're more likely to have issues. Offer your significant criticism with us on the off chance that you discover this subject instructive and need to study drugs used in emotional wellbeing. Or, if you are experiencing any mental health disorders, counsel our organization as it's anything but a group of specialists, clinicians, and advisors to take care of you.