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What COVID-19 Impacted on Artificial Blood Substitutes Market in Healthcare Industry ?

COVID-19 pandemic has influenced the whole planet with its major impacts on the economy and businesses across the globe. The COVID-19 spread worldwide in unprecedented ways due to its high infectious and contagious nature and lack of availability of its vaccine. As a result, the greatest medical challenge in the 21st century is yet to be faced by physicians worldwide. Though the emergence of the virus can be traced back to Asia, many European countries along with the U.S. have been struck massively by the pandemic. The virus has spread across all regions ranging from North America, Europe, Asia-Pacific, Middle East, and Africa up to South America. The COVID-19 has been declared as a pandemic by World Health Organization (WHO) due to its increased spread across the globe. After the declaration of the pandemic, various countries announced the complete lockdown such as India, China, and other Asian countries to decrease its spread. According to the latest situation report by World Health Organization (WHO) stated 175 million cases of the corona have been reported globally and 4 million patients are dead due to the coronavirus. On a slightly positive note, a total of 158 million people have recovered and total of 2 million vaccine doses have been administered as well.
The COVID-19 has led to the lockdown all around the world which has impacted the artificial blood substitute market tremendously. Moreover, the coronavirus leads to a drop in oxygen in the body, and artificial blood substitute may be the solution for that as it offers high oxygen-carrying capacity in comparison to the human blood. Although, rising awareness regarding the toxicity and side effects of artificial blood substitutes coupled with the low number of FDA approval for artificial blood substitute products may hamper the growth of the market on a global level.
The COVID-19 pandemic has affected the artificial blood substitute market positively on a global level. The persistence of COVID-19 for a longer period has affected the supply and demand chain of human blood and blood component. During the COVID-19 pandemic, manufacturers are expecting a boost in their market as the number of patients needing blood is also increasing with the ongoing diseases and the number of blood donor decreased. Due to this, the demand for artificial blood substitutes has increased which will propel the growth of the global artificial blood substitute market.

IMPACT ON SUPPLY AND DEMAND
With the ongoing pandemic, the government has put restrictions on the movement of citizens as well as industries, educational institutions, and social organizations. Due to which everything is closed across the country and majorly the blood donation camp are organized by these sectors but with the restriction on movement there is a hold on that. As there is no prior arrangement for blood donation which has worsened the supply of blood as people are not willing to visit blood centres for donation.
For instance,
· According to the International Society of Blood Transfusion, the survey has shown that blood donations have dropped in 32 countries, and the COVID-19 pandemic has reduced the overall supply of blood.
With the limited supply of human blood, the demand for artificial blood substitutes has increased, which will boost the growth of the market even in the future. People suffering from a disease such as a thalassemia, sickle cell anaemia, haemophilia, leukaemia cancer, and other blood-related diseases need regular blood transfusion even during COVID-19 condition which has increased the demand for artificial blood substitute. Even cancer patients, obstetric conditions, victims of accidents need blood products. The supply chain disruption of blood has driven the demand for artificial blood substitutes across the globe.

THE INCREASING DEMAND FOR BLOOD TRANSFUSION IS LEADING THE ARTIFICIAL BLOOD SUBSTITUTES MARKET.
The demand for artificial blood is increasing for the blood transfusion process as it offers various advantages over human blood. The artificial blood could be stored for a longer period even for 3 years at room temperature whereas the human blood could only be stored for 42 days. Artificial blood also reduces the risk of contamination of other diseases such as hepatitis, AIDS, and others. One of the main factors driving the artificial blood substitute market is its high oxygen-carrying capacity as one of the major crises in COVID-19 patients is the drop in oxygen level, which could be recovered with artificial blood substitutes as it has high oxygen-carrying capacity in comparison to the human blood. The rising incidence of blood-related diseases increases the demand for blood transfusion and the shortage of blood during a pandemic will push the growth of the global artificial blood substitutes market.
For instance,
· According to Zee Entertainment Enterprises Limited, American Red Cross has seen a 10% rise in demand for red blood cells for hospital trauma centers as compared with the demand in 2019.
The rising incidence of blood-related diseases and increase in the need for blood and blood transfusion will boost the market growth in the future. Also, the artificial blood substitute is preferred over the human blood as it is compatible with all blood types and can be given to the patients regardless of their blood type. Moreover, the vaccinated people are not donating blood which has affected the blood supply and will eventually boost the growth of artificial blood.
For instance,
· According to Cable News Network LP, LLLP, the regulations have been laid down that the vaccinated individual won’t be able to donate for at least 60 days, which could trigger a major shortage in the blood bank.
· In May 2021, According to Science Wire, National Blood Transfusion Council (NBTC) has issued an order stating a person cannot donate blood 28 days post-vaccination, and people who received Covaxin have to wait for 56 days and who received Covishield, up to 70 days.
The regulations for donating blood post-vaccination will affect the supply chain of blood and will lead to its increased demand and create a great opportunity for artificial blood substitutes.

AFTERMATH OF COVID-19
The COVID-19 outbreak has impacted the healthcare system and has led to a decrease in the supply of blood. As coronavirus caused severe acute respiratory syndrome and due to which a lot of people died. The crucial staff members of the hospital also died during the pandemic and along with that, there is a reduction in the number of donations of blood and blood component. Therefore, with decreased blood donation the demand for blood has been increased to support ongoing critical needs and to treat a large number of patients. Hence, the professionals are looking out for options for instance artificial blood substitutes to treat patients on time. The COVID-19 pandemic has majorly affected the healthcare system and blood supply and demand across the globe. For instance,
· According to World Health Organisation (WHO), a survey has been conducted in the African region which shows the impact of COVID-19 on blood supply and its demand, according to the data the total number of blood donations has dropped in 32 countries and rise in only 5 countries. Also, the proportion of blood drive has decreased in 21 countries.
With the rising incidence of blood-related diseases, the demand for blood will be increased and due to the lack of availability of fresh blood, the need for artificial blood will be increased after the COVID-19 outbreak.
The COVID-19 pandemic has led to the reduction of blood and blood-related activities, including demand and supply, and has affected the healthcare system on a major level.

CONCLUSION
Pandemic has taken a toll on every aspect of life, including the global economy. With the significant downfalls in many sectors, a collaborative effort of government, industry players, and consumers can win the fight against COVID-19.
COVID-19 pandemic has affected the artificial blood substitute market positively. The demand for blood has increased immensely especially in the COVID-19 crisis as the number of patients needing blood has increased whereas the number of donors decreased. This factor will boost the growth of the market. During the COVID-19 outbreak, the government has posed a ban on movement due to which the blood donation camps could not be organized, which is the main reason that the supply of human blood has decreased.
Although the demand for blood is much higher than the donation, it requires an alternate solution. The rising awareness regarding the advantages of artificial blood over human blood will propel market growth globally. Moreover, the incidence of blood-related diseases and the demand for blood transfusion has increased especially in COVID-19 time. Therefore, the need for artificial blood substitute which can be stored for a longer period and can be given to the patients irrespective of their blood type will drive the market growth even in the future. Therefore, the increasing prevalence of diseases will increase the demand for artificial blood substitutes and the market will grow even after the COVID-19 is over.
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Even though the demand for these devices was high, the availability was affected due to disruptions in the supply chain, trade, and travel restrictions. Supply of raw material was also affected, due to which the production was restricted. Veterinary services, such as routine vaccinations and testing and diagnostic instruments, were short supply for many farmers. As a result, animal illness control has emerged a new task that coincides with animal welfare concerns. However, the impact of COVID-19 on animal healthcare operations is not limited to the farm level; there are also national and international limitations. Due to funding constraints, several national and international animal health care programs/projects have been postponed or discontinued, limiting the success of disease elimination due to COVID 19. Several companies working on veterinary vaccines have indicated that the reductions in fluidity and foreign exchange were other significant factors affecting the sustainability of the livestock supply chain, specifically in developing countries during the pandemic. FOR INSTANCE: · The E.U. Executive Steering Group on Shortages of Medicines Caused by Major Events has provided strategic leadership for urgent and coordinated action to prevent and mitigate supply disruption during the pandemic The European Commission chairs the steering group. It consists of representatives of EMA, the European Commission, Heads of Medicines Agencies (HMA) and the Coordination groups for Mutual Recognition and Decentralised Procedures for human and veterinary medicines (CMDh and CMDv), as well as risk communication specialists PERSPECTIVE AND INITIATIVES: As the reality of COVID-19 dawned upon the world, the manufacturers and production units of companies involved in veterinary vaccines manufacturing industries and governments had various perspective and initiatives taken regarding the market. FOR INSTANCE: · In July 2021, Minister of Agriculture and Land Reclamation El Sayed El Quseir discussed investment in the production of veterinary vaccines and serums with Dr. Chris Nelson, Management Advisor of the Egyptian-American Middle East for Veterinary Vaccines (MEVAC) pharmaceutical company and President and CEO of the U.S. Kemin Industries · In July 2021, Zoetis donated more than 11,000 doses of its experimental COVID-19 vaccine to help protect the health and well-being of more than 100 mammalian species living in nearly 70 zoos, as well as more than a dozen conservatories, sanctuaries, academic institutions, and government organizations located in 27 states in new jersey CONCLUSION COVID-19 has impacted each sector with no exception. The veterinary vaccines market has been affected the same. With rising awareness around of vaccination against cattle diseases and improved health facilities for animal husbandry, there is a rise in demand for veterinary vaccines up to some extent. However, in the crisis call veterinary vaccine manufacturers, key players, government bodies, and healthcare organizations are working closely with healthcare professionals, customers, and patients for the betterment of animal health. Moreover, animal drugs and vaccines were approved for human use. Animals infected with the virus have been reported all around the world. Also, veterinary vaccine manufacturing facilities were used for production of human COVID vaccines around the worked. This is expected to impact the market for veterinary vaccines up to some extent.
Significant COVID-19 Impact on Non-Small Cell Lung Cancer Diagnostics in Healthcare Industry
COVID-19 Impact on Non-Small Cell Lung Cancer Diagnostics in Healthcare Industry The novel coronavirus has profoundly impacted all fields, including healthcare, medical device services, automotive, pharmaceutical and many others. This pandemic has led to shutdowns of mass production and disruptions in the supply chain that have impacted the economies of virtually every nation in the world. The pandemic also affected the non-small cell lung cancer diagnostic industry. The patient's fear of contracting the virus compels patients to stay home instead of undergoing diagnosis and treatment. During the COVID-19 pandemic, countries worldwide witnessed a large number of patients suffering from COVID-19 and post COVID-19 complications such as cardiovascular disease, diabetes and kidney problems. As the COVID-19 cases were rising, the healthcare system had shifted its focus in curbing the disease, thereby delaying diagnosis and treatment of other chronic conditions as cancer. Thus, a negative impact is expected on the non-small cell lung cancer diagnostics market due to the pandemic scenario As a result, the hospitals and clinics were filled up with COVID-19 patients and less preference was given to non-small cell lung cancer patients. Moreover, limited access to clinics, social distancing, the lockdown of the population, which results in a slow-down in patient flow and referrals, has also impacted the market growth. However, with the cases decreasing in number and increase in vaccination against COVID-19 across the globe, the market for non-small cell lung cancer diagnostics market may get a boost due to some relaxation in COVID-19 cases, which will result in increased demand for non-small cell lung cancer diagnosis with patients coming forward to clinics and hospitals for treatment. IMPACT ON DEMAND Various screening, diagnostic and surgical procedures were restricted and at hospitals and cancer treatment centers, which resulted in disruptions in the non-small cell lung cancer diagnostics market. However, even during the pandemic, the lung cancer cases were subsequent, which is expected to increase the demand for non-small cell lung cancer diagnostics market. For instance, · According to World Health Organization (WHO), in 2020, lung cancer accounted for 2,206 771 deaths among both sexes. The lung cancer statistics include both small cell lung cancer and non-small cell lung cancer. About 13% of all lung cancers are small cell lung cancer and 84% are non-small cell lung cancer. This proves an increase in the number of non-small cell lung cancer patients even during the COVID-19 pandemic. Moreover, according to the American Cancer Society, Inc., lung cancer patients are likely to get infected with coronavirus because of the changes in their immune system that control their body's defense systems. For instance, · According to a study published in PubMed, patients with lung cancer are at an increased risk of becoming infected with the virus and experience higher morbidity and mortality than the general population Thus, having cancer such as non-small cell lung cancer may also increase the risk of severe illness from COVID-19 as the cancer therapy treatment reduce the immune system of the body. . This has increased the demand for non-small cell lung cancer diagnostic tools, especially in cancer-dedicated hospitals and surgical centres, where all the patients of non-small cell lung cancer-related problems are treated. Thus, with the increased lung cancer cases, the demand for non-small cell lung cancer diagnostic will increase in the coming years. IMPACT ON SUPPLY CHAIN The supply chain was widely affected by the COVID-19 pandemic as acute restrictions and lockdowns produced many urgent situations in the early days of the pandemic, which needed immediate attention. The supply chain disruption has transformed many organizations' business environments, including the supply chain of non-small cell lung cancer diagnostics market. The supply chain disruption impacted the Asia-Pacific region initially, especially the demand from China due to challenges from restricted movement and quarantine period. For instance, · According to the FDA, 63 manufacturers representing 72 facilities in China that produce essential medical devices face obstacles in manufacturing medical devices and their supply, owing to citing workforce challenges and the necessary quarantine of workers. Moreover, closing borders of various countries is anticipated to diminish the supply chain business environment, as it may hamper export of the medical supplies To minimize supply chain crises, the FDA has been firmly monitoring the supply chain with the assumption that the COVID-19 outbreak may adversely impact the supply chain of medical products, including shortages of critical medical products in the U.S. or potential disruptions in supply chains. Many organizations and countries are looking forward to improving and diversified supply chain models in all aspects to manage such a crucial situation. A diversified supply chain model anticipated minimizing the export of medical products as well as increase end-to-end visibility. For instance, · The Brazilian government published a resolution eliminating import taxes on 141 medical products and hospital equipment · The European Commission made a decision for helping Member States affected by the pandemic to suspend customs duties and VAT on medical devices temporarily · Federal indirect tax body the Goods and Services Tax (GST) Council of India has decided to cut taxes on medical supplies IMPACT ON PRICE The coronavirus disease (COVID-19) pandemic does not significantly impact the global non-small cell lung cancer diagnostics market. But it is estimated that if COVID-19 continues to spread for a prolonged period, then the demand for non-small cell lung cancer diagnostic equipment and devices will highly upsurge for top importer countries. For therapies and the diagnostic United States solicit the huge number of medical devices, followed by China and Japan. For instance, · According to the General Administration of Customs (GAC), China's exports of medical machinery and devices increased 40.5 percent in 2020 compared to the previous year, reaching USD 18.138 billion · According to the World Trade Organisation, the U.S. imports and exports of medical goods increased by 16 %, reaching USD 1,139.00 billion in value Henceforth for diagnosis, dependency of these countries highly increases on other exporters and many countries solely depend on China and the U.S. for the non-small cell lung cancer diagnostic equipment. Consequently, this may lead to a rise in the overall non-small cell lung cancer diagnostic cost. This increase in the price of the non-small cell lung cancer diagnostic may hamper the market growth if it continues to be the same. Additionally, if the lockdown continues to stretch for a long period, then import of non-small cell lung cancer diagnostics market is estimated to get more restricted, which may further lead to a rise in the price of the these devices CONCLUSION It is estimated that the COVID-19 pandemic outbreak has significantly impacted the growth of non-small cell lung cancer diagnostics market as the rising cases of COVID-19 worldwide the healthcare system had shifted its focus in curbing the disease, thereby resulting in the delay of diagnosis and treatment of non-small cell lung cancer. Thus, a negative impact is expected on the non-small cell lung cancer diagnostics market due to the pandemic scenario. However, with the increase in lung cancer patients worldwide, the demand for non-small cell lung cancer diagnostics will increase in the coming years. Moreover, poor lifestyle, smoking, alcohol consumption, lack of physical activity and other factors will contribute to the incidence of chronic disease such as lung cancer, including non-small cell lung, which is anticipated to increase the global non-small cell lung cancer diagnostics market in the coming years.
What Causes Strawberry Legs And How To Get Rid Of It?
Summer is arrived, which means you're most likely showing a little more skin. As our gams finally receive their due, pants become shorts, maxi dresses become minis, and skirts become minis. Short hemlines, on the other hand, may be undesirable to those whose legs are spotted, bumpy, or spotty. Let's learn more about how a dermatologist treats and prevents skin diseases known as "strawberry legs." What Are 'Strawberry Legs,' Exactly? Strawberry legs refers to a dotty appearance of the legs, mainly around the hair follicles. The dots depict the buildup of common skin elements in and around the hair and oil glands. Keratin is a type of protein that is found in (the main protein in the skin) * Melanin is a pigment found in the skin (the source of pigment) * Sebum is a type of oil that is produced by (natural oil of the skin) * Bacteria are microorganisms (often, normal skin flora) The name "strawberry legs" refers to the dark pores and dots or red pimples that emerge on the lower thighs and resemble strawberry seeds. Strawberry legs are not hazardous in terms of health, but they are ugly. Strawberry Legs: What Causes Them and How to Treat Them While the appearance of strawberry legs is typically the same no matter what caused it, there are a number of causes. Knowing what's causing your dotted gams can allow you to address the appropriate ailment. The four most prevalent causes of strawberry legs, as well as how to cure them, are listed below. 1. Clogged Pores Clogged pores on your legs are just as common as clogged pores on your face. Because of heredity and thicker body hair, some people have larger pores, and while the pores themselves aren't inherently irritating, they can become problematic when they become blocked with germs, dead skin, and sebum. When clogged pores on the legs are exposed to air, the debris dries up and darkens, in the same way that a blackhead on the face does. Treat with: Chemical and physical exfoliation. Exfoliation, which is part of your facial skincare routine, can be used to cure congested pores on the legs or anyplace else on the body. My personal favourite for my patients is chemical exfoliation, which uses chemicals such as acids and retinols to stimulate skin cell turnover and clear pores. This eliminates keratin, oils, and other skin detritus gently, opening up pores and follicles and preventing secondary bacterial buildup. Acne and folliculitis bacteria grow in oil-clogged hair follicles, so eliminating that build-up is critical. Look for a body wash or moisturiser that contains alpha-hydroxy acids (AHAs) and beta-hydroxy acids (BHAs), notably glycolic acid and salicylic acid, to exfoliate dead skin cells and other debris that create clogged pores. These acids gently exfoliate the skin by minimising the'stickiness' of dead or dying skin cells. This helps to open up the pores while also giving the skin a great textural shift and radiance. 2. Folliculitis Folliculitis is a skin disorder that causes inflamed or infected hair follicles. The most common sign is little red pimples around the hair follicles. Hair loss or scarring in the affected area may occur in extreme situations. The majority of instances, however, are small and normally resolve within a few days. It's crucial to note that folliculitis is a catch-all term for inflammation of the hair follicle. This can be contagious due to microorganisms like staphylococcus or sterile due to oil buildup or shaving stress. Treat with: Antibiotics, both oral and topical. Folliculitis is a "tricky condition" to treat, which is why you should consult a dermatologist before trying any at-home therapies. Folliculitis can be sterile, with red, pus-filled pimples forming as a result of causes like clogged pores and shaving. They can, however, indicate a superficial skin infection caused by bacteria or yeast such as staph and pityrosporum. While the former can be treated with over-the-counter medications, the latter may require prescriptions for antibiotic creams or even pills to resolve. A simple swab can be used by a dermatologist to assess whether or not organisms should be targeted. If there are, it might save you a lot of time and effort in developing successful at-home habits. Treat with: Antibacterial skincare. At-home treatments range from lifestyle changes to skincare. To begin, change out of your sweaty training clothes and shower as quickly as possible. In the shower, lather up with antibacterial soap. Treat with: Laser hair removal treatment. You should also reconsider your shaving routine. Use a soothing shave cream in addition to converting from a multi-bladed razor to a disposable razor. In return for less rough skin, the closest shave is compromised. The risk of folliculitis is inversely associated to a close shave. He also suggests shaving with the grain rather than against it every two to three shaves. If you're prone to razor bumps, laser hair removal with a dermatologist will save you a lot of time and aggravation in the long run. 3. Keratosis Pilaris Keratosis pilaris (KP), popularly known as "chicken skin," is a skin disorder characterised by the appearance of small bumps on the skin. Keratosis pilaris most usually affects the upper outer arms, however it can also affect the thighs. Keratin accumulation in the hair follicles causes this. Treat with: Chemical exfoliation. Chemical exfoliants, like clogged pores, are frequently efficient in the treatment of keratosis pilaris, but prescription-strength treatments may also be beneficial. Exfoliative acids are my first line of defence against keratosis pilaris. If those don't work, a prescription-grade retinoid may be an option, but only after consulting with a dermatologist. While keratosis pilaris is usually a year-round condition, flare-ups are more likely in the winter when the skin is drier. Additionally, swimmers may aggravate the illness due to the dehydrating effects of chlorine and other pool chemicals. 4. Dry Skin Dry skin, as previously indicated, contributes to a number of skin diseases, including strawberry legs. Dehydrated skin is more susceptible to irritation, especially during shaving. Dry skin on the lower legs is more prone to razor burn, keratosis pilaris, folliculitis, and plugged pores, all of which can result in a spotty appearance. Treat with: Creams and moisturisers. For severely dry skin, a daily moisturising body lotion containing ammonium lactate is an excellent place to start, especially if it is scaly. Ichthyosis, or dry, scaly, or thickened skin, may not usually respond to regular creams and moisturisers, thus a dual-purpose formulation may be necessary. Because there is a thicker layer of dead skin on the surface, moisturising alone isn't always adequate. Exfoliating lotions gradually remove that layer, allowing richer moisturisers to penetrate deeper into the healthier layers beneath. In conclusion Strawberry legs are a catch-all name for a range of skin disorders, but there are a few things you can do at home and at the workplace to cure and prevent a bumpy or spotty appearance. Consult a board-certified dermatologist before attempting to treat yourself to ensure you understand the underlying cause of your illness.
How COVID-19 Impacted on Neurorehabilitation Devices in Healthcare Industry ?
COVID-19 Impact on Neurorehabilitation Devices in Healthcare Industry OVERVIEW AFTERMATH OF COVID-19 AND GOVERNMENT ROLE The first case of the COVID-19 pandemic was found in Wuhan, China. This pandemic has influenced the whole planet with its major impacts on the economy and businesses across the globe. The COVID-19 spread worldwide in unprecedented ways due to its high infectious and contagious nature. The virus has spread across all regions ranging from North America, Europe, Asia-Pacific, Middle East, and Africa up to South America. The COVID-19 has been declared as a pandemic by WHO due to its increased spread across the globe. Various countries announced the complete lockdown just after the declaration of COVID-19 as a pandemic, such as the U.S., India, Germany, and China, to protect them from the spread of the disease. The government imposed lockdown rules, and it had significantly impacted the market. The neurorehabilitation process makes a possible reduction in impairments and disabilities and eventually improves the life of the patient. Examples of neurorehabilitation devices are invasive stimulators, non-invasive stimulators, brain-computer interfaces, and neurorobotics, among others. Current rehabilitation is supported by advanced methods based on biofeedback, transcranial brain stimulation system, and BCI system. The prevalence of neurological diseases, rise in technological advancement, the emergence of robotic rehabilitation, and the effectiveness of gaming systems in neurorehabilitation are factors that are propelling the demand of the global neurorehabilitation devices market. However, the shortage of skilled personnel, the high cost of treatment, stringent government regulation may hamper the global neurorehabilitation devices market. IMPACT ON PRICE Neurological rehabilitation is a program designed for the treatment of people suffering from a disorder or any injury in the nervous system. The devices include non-invasive brain stimulators, robotic neuro systems, brain-computer interfaces, and wearable devices, among others. Due to the pandemic, there is the delay associated with various types of limitations faced by the manufacturers to fulfill the end product order, which has resulted in the less availability of neurorehabilitation devices in the market and due to which the cost of available devices has increased with the several factors. Also, due to the coronavirus disease (COVID-19) pandemic outbreak, manufacturers are forced to find new contract manufacturers and suppliers for more manufacturing activities to different or new facilities locations that are less impacted by the outbreak. IMPACT ON DEMAND Neurorehabilitation is an important part of the recovery process that has undergone some brain injury. In the COVID-19 pandemic, various charities have worked effortlessly to provide treatment and support to patients suffering from brain injury. During the pandemic, the demand for neurorehabilitation devices was high, but companies were not able to supply the devices to end-users as various restrictions were imposed by the government, such as a travel ban, closed borders, among others. Coronavirus disease (COVID-19) is an infectious disease caused by a SARS-CoV-2 virus, while a large pool of the population is affected by this COVID-19 virus. Coronavirus disease (COVID-19) causes acute respiratory illness ranges from mild to severe pneumonia with respiratory failure. In order to minimize the spread of COVID-19, nearly all the countries have taken action, such as the implementation of lockdown and social distancing restrictions. Due to affirmative restrictions, sudden shrink took place in various surgeries. Moreover, the decrease in the revenue of the key market players depicted in their quarterly results, such as Medtronic, among others, gave evidence of the decline in the demand for the medical device due to the emergence of the COVID-19 pandemic. For instance, · Medtronic reported a decline of 1% in its brain therapies net sales of the financial results of 2020 as compared to 2019. The reduction was largely motivated by the detrimental effects of the COVID-19 pandemic and the subsequent deferral to companies of medical procedures The decline in revenue of brain therapy suggests the detrimental effect of COVID 19 on the neurorehabilitation devices market and hence impacted the demand-supply concept. IMPACT ON SUPPLY CHAIN The consequences of COVID 19 cannot be underestimated. The product and service providers of neurorehabilitation have made efforts by providing services virtually to meet the demands as people were not frequently visiting the hospitals or clinics for the treatment. The COVID-19 pandemic has transformed many organizations’ business environments; supply availability has been hampered by a number of issues, including export and travel restrictions by some manufacturing countries and lockdowns that have forced suppliers to (temporarily) shut down. In various countries, neurorehabilitation units have reduced their number of beds, in-patients and out-patient neurorehabilitation centers are restricted to a particular area in order to tackle the pandemic situation To manage such a critical situation, many organizations are looking forward to improving and diversifying the supply chain model in all aspects. Diversified supply chain model anticipated minimizing the export of medical devices as well as increase end-to-end visibility STRATEGIC DECISIONS BY MANUFACTURERS As the reality of COVID-19 dawned upon the world, the manufactures and production units of the companies in the global neurorehabilitation devices market swiftly planned for strategies to cope with the effect of the crisis. Major players in the market took various initiatives to cope up with the situation. For instance, · In July 2020, Abbott announced that it had received FDA approval for the use of the Patient Controller App on compatible personal Apple smartphone devices. The approval will allow the patient living with neurological conditions to manage their therapy directly from the personal smartphone · In 2019, Mount Sinai Health System announced an innovative tele-neurorehabilitation program for stroke patients. This therapy can be taken by patients while at their homes with virtual backing from clinicians · In 2020, Esko Bionics Holdings, Inc. announced that it had received FDA 501(k) go-ahead to promote its EksoNRTM robotic exoskeleton for patients with acquired brain injury. It is cleared by FDA for spinal cord injury, stroke, or acquired brain injury rehabilitation These strategies helped the company in coping with the pandemic and ensure business operations, minimize the impact of COVID-19, and providing full support to the government in their efforts to combat the disease and help the front-line workers. CONCLUSION The market is expected to decline due to increased restrictions imposed by various governments leading to the closing of non-emergent healthcare facilities, including procedures such as neurorehabilitation procedures. It can be concluded that the COVID-19 pandemic situation has an adverse impact on the market, affecting the price, supply, and demand of neurorehabilitation devices. However, in the crisis call, market players, government bodies, and healthcare organizations are work closely with healthcare professionals, customers, and patients for the betterment of public health. The increasing need of neurorehabilitation devices with increasing number of neurological diseases is expected to drive the market in coming years.
CBD for Sleep, CBD Benefits, Side Effects, and Treatment
People have long used the cannabis plant for medicinal and recreational purposes. Compounds called cannabinoids in the plant are responsible for the effects on the brain, and the two most abundant of these are tetrahydrocannabinol (THC) and cannabidiol (CBD). People use CBD for a variety of reasons, including reducing seizures, anxiety, and pain. Some studies have demonstrated that CBD may also be a sleep aid. In this article, we look at whether it works and any associated risks. What the research says In the last decade, growing public interest in the benefits of marijuana, and CBD in particular, has encouraged researchers to study its effects. Early studies indicate that high dosages of CBD may support sleep. One investigation found that, compared with a placebo, a CBD dosage of 160 milligrams (mg) increased sleep duration. The researchers also concluded that the placebo, 5 mg of the insomnia drug nitrazepam, and 40, 80, and 160 mg of CBD helped the participants fall asleep. The stress hormone levels of cortisol are typically peak in the morning, but people with insomnia may have high cortisol levels at night. Independent of insomnia, having high cortisol levels at night is associated with an increased nighttime awakening. In one study on the effects of CBD, researchers found that cortisol levels decreased more significantly when participants took 300 or 600 mg of CBD oil. These results suggest that CBD affects the release of cortisol, possibly acting as a sedative. A more recent analysis of CBD and sleep recruited 103 participants who had anxiety or poor sleep. The researchers studied the effects of CBD combined with those of other prescribed medications. The CBD dosages ranged from 25–175 mg. The researchers found that 25 mg was the most effective dosage for anxiety and that addressing troubled sleep required higher dosages. During the 3-month study, the investigators followed up with the participants monthly. At the first follow-up, 66.7% reported an improvement in sleep, but 25% had worsened sleep. 56.1% of the participants reported improved sleep at the second, but 26.8% had worsened sleep. The researchers conclude that although CBD might help people sleep in the short term, the effects may not be sustained. Side effects and other risks of CBD Overall, the available evidence suggests that CBD is well-tolerated. Some people report fatigue and mental sedation with CBD use, but researchers believe this may be related to the dosage. Taking 10–400 mg of CBD per day for an extended period and by different routes did not have a toxic effect on participants in a large retrospective study. Even dosages of up to 1,500 mg per day were well-tolerated, other researchers report. However, determining whether there are long-term risks of CBD use will require further studies. So far, no reports of lethal CBD overdoses exist. Some researchers may be concerned about CBD abuse, but information on significant complications is limited. One study indicates that dosages of 400–700 mg of CBD, which is considered high, can aggravate cognitive deficits in people with schizophrenia. Combining CBD and THC may, however, improve cognition. Researchers do report that CBD may cause other adverse effects, including: alterations of cell viability in studies conducted in cell cultures decreased fertilization capacity inhibition of drug metabolism in the liver reduced activity of P-glycoprotein and other drug transporters If these effects on drug metabolism and transportation are confirmed, it would indicate that CBD interferes with other medications. Overall, more research is necessary. Still, it is suitable for anyone who wants to use CBD to speak with a healthcare provider first. Check out the best CBD for sleep at Sweet Dream Beauty website.
What Kind of Braces Work the Fastest?
There are so many different types of braces on the market today that it can be quite confusing. One of the most popular and most used is the AlignerCo Promo Code So what kind of braces work the fastest? What works best for your teeth? In this article, I will answer those questions for you and more. Straighten Out Your Teeth First off, let me explain what braces are for in detail. Braces are mechanical devices that are used to help straighten out your teeth. They are designed to do this by applying forces to your teeth over time. These forces are often used in conjunction with an orthodontist to help straighten your teeth into nice, even rows. Variety of Different Dental When your teeth are crooked or misaligned in any way, the natural tendency is for them to start coming in. This results in a variety of different dental conditions, such as crowded smiles, open mouths, overbite, underbite, gum receding, and other problems. Braces are used to treat these conditions. One thing they do is help to straighten your teeth. This comes in through the use of a mouthguard. An AlignerCo promotional advertisement shows a man with crooked teeth. He wears an Alignerco aligner device on his teeth while playing a game of bowling. As he bowls the aligner glides along the inside of the mouth. The video shows him successfully completing his first double-arm throw. Different Kinds of Braces In this example, the Alignerco mouth guard is what is used to straighten the teeth. Since the mouth guard does not move in any way, the teeth stay where they are. The Alignerco promotional shows many different kinds of braces that can be used, including traditional metal braces, invisible ones, ceramic aligners, and Invisalign. If you would like to know more about the differences between these products, watch this commercial. Ceramic Braces Ceramic braces Invisalign method of braces uses invisible aligners that do not require any type of oral hygiene, and they do not need to be cleaned. All they do is record the position of each tooth as it is moved, and the aligner fits into place. When the patient smiles, the aligner reflects the teeth' position. It is because of these advantages that Invisalign has become the most popular orthodontic treatment today. Metal braces traditional metal braces were designed to keep children's mouths closed so that they could not chew their meals or bite ice cream. These braces were not comfortable or safe. What kind of braces works the way they should? Minor Inconvenience The Invisalign aligner works by correcting an issue that many adults face: being able to eat and drink. Children do not have this problem because their mouths are closed at all times, but adults suffer from a minor inconvenience. The Invisalign aligner allows the person to eat and drink comfortably because the braces do not show up at all. This allows them to enjoy the foods that they want and the drinks that they enjoy, which is why the Invisalign has become the most popular choice for what kind of braces work the way they should. Traditional Metal Braces What kind of braces work the way they should? The traditional metal braces were bulky and uncomfortable, and there were too many things to break or get stuck in the wires. Children were unable to wear them because of the discomfort and they became even more unattractive to kids. These wires were also difficult to clean, because they had to be removed after every meal and every night. Even worse, some metal braces became hot to the touch, which made it uncomfortable for children to wear them. Invisalign Aligners The new Invisalign aligners work exactly the same way as the traditional metal braces. The aligner will be placed in your mouth, just like the traditional braces, but they do not need to be taken out during eating or drinking. The aligner stays in place and fits tightly against the teeth. The invisible aligners are molded to perfectly fit each individual tooth, so there is no worry about them coming out or becoming unattractive. The Invisalign aligners are completely removable, and it is a simple process to replace them with another aligner when your teeth have grown in. Highly Trained Professional So what kind of braces work the way they should? To answer that question, we have to take a look at what your orthodontist is going to recommend for your treatment. Your orthodontist is a highly trained professional who will take into consideration not only your mouth but also the muscles and bones in your mouth. He/she will then create a program to help correct all of the problems with your teeth. Metal braces are not going to give you the best results; your orthodontist will focus on creating brackets and aligners that will give you the best bite and the most comfortable smile possible. Advice To get started, you will need to make an appointment with your orthodontist. Ask him/her about the different kinds of braces available. If you want a less expensive option, your orthodontist might suggest ceramic braces. Ceramic braces do not require the same amount of maintenance as metal braces; however, they are not as effective at correcting malocclusion, which is the most common problem associated with Invisalign. If the braces that your orthodontist recommends are not effective, he/she may recommend metal braces or Invisalign braces. This depends heavily on the overall dental situation of your teeth and what options he/she feels are best for you.
How COVID-19 Impacted on Nutraceutical Packaging in Healthcare Industry ?
COVID-19 Impact on Nutraceutical Packaging in Healthcare Industry The COVID-19 pandemic has impacted the food and beverages industry including the nutraceutical market by up surging in their consumption globally. Each and every segment of nutraceutical industry has been impacted either positively or negatively due to the COVID-19 pandemic. The Nutraceutical packaging market is subjected to have the positive impacts due to the sudden outbreak of COVID- 19. This is mainly due to the consumer awareness about the importance of consuming the nutraceuticals in order to boost their immunity to fight the pandemic period. The demand for the nutraceuticals has been increasing across the globe due to the changing lifestyle of the health conscious consumers. This increase in the demand for the nutraceuticals have positively affected on the nutraceutical packaging market. AFTERMATH OF COVID-19 AND GOVERNMENTS INITIATIVE TO BOOST THE GROWTH OF THE MARKET The aftermath of the COVID- 19 has a very positive impact on the market of the nutraceutical packaging across the globe. As the consumers are more incline to buy health and wellness products such as nutraceutical products which further increased the sales and revenue of the market players. The post pandemic period people are more concerned towards the product’s safety and shelf life which further drive the demand for advanced and innovative packaging materials for nutraceuticals. Also, with the growing awareness and growing social media nutritional trends influencing population all around the world will increase drive the demand for nutraceutical which will further boost the growth of global market. Many governments have taken initiatives for the nutraceutical packaging as they have been focusing on ways to improve the consumer’s health and wellness. The government initiatives to support industries in order to manufacture innovative packaging products will boost the growth of the market. For example, · European Union (EU)- funded project NanoPack aims to develop packaging solutions that increase product life after packaging by using novel anti-microbial surface application on the food packaging product surface. The Nanopack antibacterial film extends the shelf life of the product by two days. This two day increase in shelf life increase product stability by 40%. Therefore, such initiatives taken up by the governments which aim to help the manufacturers to manufacture safe products for the nutraceutical packaging will propel the growth of the market. STRATEGIC DECISIONS OF MANUFACTURERS AFTER COVID-19 TO GAIN COMPETITIVE MARKET SHARE To deal with the COVID-19 outbreak challenges many nutraceutical packaging market players are creating new strategies. It is predicted that these strategies are providing high chances to escalate up company revenue and its growth in the forecast period. Similarly, growing opportunities in innovative packaging solutions is attracting a larger consumer base for the nutraceutical packaged products. Increase in the demand for the nutraceuticals has made companies to launch the new products in spite of the COVID- 19 challenges and to gain a larger market share. Despite of the COVID – 19 pandemic outbreak, the manufacturers have been creating new opportunities by themselves by participating in exhibitions in order to spread the awareness about the nutraceuticals and their nutritional benefits which helps in boosting the immunity of the consumers. For instance, · In 2021, MJS packaging announced that they will exhibit for the first time since the start of COVID- 19 pandemic at the 2021 Cannabusiness international market place Michigan summit and expo in Michigan. Therefore, such product launches, exhibition of the products at the expos and vents in order to increase their consumer base are the strategic decisions which are taken up the market players to gain larger market share. PRICE IMPACT The COVID-19 had a terrible impact on the global economy. Many establishments have to remain shut while others scale down their operations or put on hold expansion plans as they survive the unprecedented crisis. The other impact of the COVID-19 pandemic outbreak is the delay or fluctuation of raw material supply for nutraceutical packaging manufacturing. This fluctuation has resulted in increase in price of raw material, which has impacted the prices of nutraceutical packaging products. IMPACT ON DEMAND There is a rapid increase in demand for the nutraceuticals increasing popularity for the nutraceutical packaging as well. Demand for the increased shelf life of food products across the globe is expected to increase the growth of the market in the COVID-19 period as well. There is an increasing consciousness about health and weight management is playing a crucial role in the demand for the global nutraceutical packaging market. On an average, the consumers have increased have increased their monthly spending on vitamins, minerals and supplements products by 10-15% since the COVID- 19 began. The increase in the awareness among the consumers about the consumption of the nutraceuticals is that they can build the immunity that is highly required in the COVID- 19 pandemic period has positively affected on the nutraceutical packaging as well. With the rise in the consumption of the nutraceutical in order to maintain the good health and fitness, the demand for the nutraceutical packaging also increased. Therefore, there has been a constant increase in the demand for the nutraceuticals which positively affected on the nutraceuticals packaging market as the packaging of the vitamins, minerals and other dietary supplements is the major factor that attracted the attention of the consumers. IMPACT ON SUPPLY CHAIN During the pandemic situation, the supply chain was majorly disrupted due to a lack of resources and transportation. Also, the governments across the world have implemented various restrictions and lockdowns to prevent the spread of the disease. In the same way, many governments have restricted the movement of goods across the countries and the entire supply chain was distorted. Owing to the disrupted supply chain, the transportation of raw materials has been interrupted and the production of nutraceutical packaging products was halted. Similarly, the manufacturers aren’t able to visit the customers such as nutraceutical companies to provide them with the packaging materials due to the implementation of lockdowns across the various parts of the world. Thus the demand for nutraceutical products has been tremendously increasing whereas the packaging materials production has been disrupted. As a result, the COVID- 19 pandemic has negatively impacted on the supply chain of the nutraceuticals packaging market. CONCLUSION COVID- 19 pandemic has taken a toll on the population and economy. A collaborative effort on governments, public health departments and hospital fraternity to fight corona virus has led to the economic slowdowns, lockdowns and extreme public safety measures. Due to the increasing health conscious ness among the consumers, the demand for the nutraceuticals has been increasing constantly in the COVID – 19 pandemic periods. This is mainly because of precautionary measures which are followed by the consumers for the COVID-19 which in involves the intake of nutraceuticals. However, the supply chain has disrupted during the outbreak scenario because the demand is more for these products. As unlocking of the lockdown being started in various regions of the world, it is expected that the supply chain became normalized for the market.
How COVID-19 Impacted on Niemann-Pick Disease in Healthcare Industry ?
COVID-19 Impact on Niemann-Pick Disease in Healthcare Industry OVERVIEW A novel coronavirus, SARS-CoV-2, appeared in December 2019 in Wuhan, China, spreading much faster than its predecessors and has already infected millions of patients worldwide as of April 19, 2020. As the scope of the current COVID-19 outbreak has reached the proportion of pandemics, significant international efforts in public health are underway to control the epidemic. The covid-19 pandemic majorly impacted the rare diseases patients because, during the pandemic, the need to provide high-level care for a large number of patients with COVID-19 has affected resourcing and limited the routine maintenance of all other conditions. The impact of health emergencies particularly faced by the rare disease communities, organizations, clinics, and other healthcare providers. The health economic challenges faced by patients and their families, institutions, research organizations, and healthcare providers during the pandemic outbreak have demonstrated the importance of ensuring continuity of care in the management of rare diseases, including adequate diagnostics and monitoring protocols, and highlighted the need for a structured emergency strategy. Niemann-Pick disease is a rare, inherited disease that affects majorly body's ability to metabolize fats such as cholesterol and lipids within the cells. Over time, these cells got malfunctioned and died. The disease can affects the brain, spleen, nerves and, if get severe, may affect lungs, bone marrow, and other organs. The disease can occur at any age but majorly affects children. There is no known cure for the disease, and sometimes it may be fatal for children, the only treatment is focused on helping people live with their symptoms. IMPACT ON PRICE Various market players are facing a large number of challenges due to the coming of the novel coronavirus and different strains; one such issue is the uncertainty surrounding the impact of covid-19 on off label drugs demands. Due to the increased coronavirus cases and continuous lockdown, the costs of the drugs and their APIs increase automatically. On the one side, it will increase the revenue of the companies, but a patient may resist buying the products, which ultimately increases the stress level on the patients. Moreover, Due to the pandemic, there is the delay associated with various types of limitations faced by the manufacturers to fulfill the end product order, which has resulted in the less availability of medical devices in the market and due to which the cost of available devices has increased with the several factors. Also, due to the Coronavirus disease (COVID-19) pandemic outbreak, manufacturers are forced to find new contract manufacturers and suppliers for more manufacturing activities to different or unique facilities location that are less impacted by the outbreak. The impact of Covid-19 has created huge price impact on the government as well as on patient families that they have to buy the drugs on higher rate as compared to the average rate. IMPACT ON DEMAND The Coronavirus zone is the result of various markets around the world. This is the cause of the widespread closures and isolation that are affecting world economic activity. As the cases increases in the month of April 2020, the sudden surge in demand has seen, and drugs and medical devices went out of stock. Moreover, the decrease in the revenue of the key market players depicted in their quarterly results, such as Medtronic, among others, gave the evidence of decline in the demand for medical devices due to the emergence of the COVID-19 pandemic. For instance, · Medtronic reported a decline of 1% in its brain therapies net sales of the financial results of 2020 as compared to 2019. The reduction was primarily motivated by the detrimental effects of the COVID-19 pandemic and the subsequent deferral to companies of medical procedures. · Impact on rare disease organization also faced significant fundraising income loss, this consequential income loss may leads to loss of various people jobs associated with the organizations. The cutting or income loss leads to the reducing staff, canceling offices leases, and delay or cutting office programs. The impact of covid-19 majorly impacted the organizations if the revenues loss projections do not change, this will leads to temporarily or permanently shut down of small and middle foundations and organizations. IMPACT ON SUPPLY As the epidemic intensifies, supply chains can be at significant risk due to over-located locations that can potentially be disrupted. The supply chain of drugs, devices, and services has been disrupted. The spread of COVID-19 makes it difficult for governments to use these drugs; the availability of these systems faces constant challenges due to their components of use and limited initial needs. Moreover, as there is no cure for the disease, only physical activities/therapies may suppress the symptoms also affected by pandemics. According to the NORD (National Organization for Rare Disorders), in the U.S. stated that 74% of the population have had canceled medical appointments due to Covid-19 pandemic, 69% of population concerned about their medication and medical supplies. For instance, • In June, ResMed stated that, due to the Covid-19 pandemic company sleep apnea business segment adversely affected including sleep clinics, physician practices, HME suppliers. As new patients are prescribed sleep apnea devices such as PAP, CPAP devices for the treatment through hospitals that are directing their resources to critical care, including COVID-19 treatment. The covid 19 impacts may continue to decrease demand for the sleep apnea devices sale STRATEGIC DECISIONS OF GOVERNMENT AND MANUFACTURERS As such, market participants are involved in the production of drugs, expanding their business through a variety of programs, including collaboration, contracts, and pipeline development, collaboration, and market expansion. It is expected that the strategic decisions of these companies will provide significant opportunities for market participants operating in the Niemann-Pick Disease market. For instance, · In July 2020, Abbott announced that it had received FDA approval for the use of the Patient Controller App on compatible personal Apple smartphone devices. The approval will allow the patient living with neurological conditions to manage their therapy directly from personal smartphone. · In May 2020, Philips, a global leader in health technology, joined forces with the American Telemedicine Association (ATA) to help further the adoption of telehealth across the industry, demonstrating its commitment to connecting care across acute, post-acute, and home care settings. The continued collaboration spotlights telehealth's growing adoption and momentum amidst COVID-19 and the need to convey the exponential shift to telehealth capabilities. · In U.S., NIH supports the research survey of “CURE EPILEPSY ORGANIZATION” to examine the impact of Covid-19 on Rare Disease Community. The survey includes more than 200 rare diseases including the brain, immune system disorders, heart, lungs, brain development diseases, and more. CONCLUSION As this pandemic situation has resulted in many restrictions in different places around the world, still the market players of dealing in rare diseases therapy and services were able to manage their service stock. Different companies dealing in metabolic diseases therapy services were finding out their own way to deal with this pandemic situation. The government and companies around the globe are working together and have issued advice for those undergoing therapies centers during these unprecedented times during COVID 19 lockdown around the world. The supply chain was destroyed, but several steps were taken by the government and companies, which will help them, get their needed output for therapy service. By increasing the material price, the companies can maintain their overall revenue. Thus, different foundations, organizations,, and services center markets are finding ways to deal with this pandemic situation. Figure 1: Relationship between Coronavirus and Lysosome storage diseases : Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway