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What Impacted COVID-19 on Neurorehabilitation Devices ?
Impact of COVID-19 on Neurorehabilitation Devices in Healthcare Industry OVERVIEW AFTERMATH OF COVID-19 AND GOVERNMENT ROLE The first case of the COVID-19 pandemic was found in Wuhan, China. This pandemic has influenced the whole planet with its major impacts on the economy and businesses across the globe. The COVID-19 spread worldwide in unprecedented ways due to its high infectious and contagious nature. Various countries announced the complete lockdown just after the declaration of COVID-19 as a pandemic, such as the U.S., India, Germany, and China, to protect them from the spread of the disease. The government imposed lockdown rules, and it had significantly impacted the market. The virus has spread across all regions ranging from North America, Europe, Asia-Pacific, Middle East, and Africa up to South America. The COVID-19 has been declared as a pandemic by WHO due to its increased spread across the globe. The neurorehabilitation process makes a possible reduction in impairments and disabilities and eventually improves the life of the patient. Examples of neurorehabilitation devices are invasive stimulators, non-invasive stimulators, brain-computer interfaces, and neurorobotics, among others. Current rehabilitation is supported by advanced methods based on biofeedback, transcranial brain stimulation system, and BCI system. The prevalence of neurological diseases, rise in technological advancement, the emergence of robotic rehabilitation, and the effectiveness of gaming systems in neurorehabilitation are factors that are propelling the demand of the global neurorehabilitation devices market. However, the shortage of skilled personnel, the high cost of treatment, stringent government regulation may hamper the global neurorehabilitation devices market. IMPACT ON DEMAND Coronavirus disease (COVID-19) is an infectious disease caused by a SARS-CoV-2 virus, while a large pool of the population is affected by this COVID-19 virus. Coronavirus disease (COVID-19) causes acute respiratory illness ranges from mild to severe pneumonia with respiratory failure. In order to minimize the spread of COVID-19, nearly all the countries have taken action, such as the implementation of lockdown and social distancing restrictions. Neurorehabilitation is an important part of the recovery process that has undergone some brain injury. In the COVID-19 pandemic, various charities have worked effortlessly to provide treatment and support to patients suffering from brain injury. During the pandemic, the demand for neurorehabilitation devices was high, but companies were not able to supply the devices to end-users as various restrictions were imposed by the government, such as a travel ban, closed borders, among others. Due to affirmative restrictions, sudden shrink took place in various surgeries. Moreover, the decrease in the revenue of the key market players depicted in their quarterly results, such as Medtronic, among others, gave evidence of the decline in the demand for the medical device due to the emergence of the COVID-19 pandemic. For instance, · Medtronic reported a decline of 1% in its brain therapies net sales of the financial results of 2020 as compared to 2019. The reduction was largely motivated by the detrimental effects of the COVID-19 pandemic and the subsequent deferral to companies of medical procedures The decline in revenue of brain therapy suggests the detrimental effect of COVID 19 on the neurorehabilitation devices market and hence impacted the demand-supply concept. IMPACT ON PRICE Neurological rehabilitation is a program designed for the treatment of people suffering from a disorder or any injury in the nervous system. The devices include non-invasive brain stimulators, robotic neuro systems, brain-computer interfaces, and wearable devices, among others. Due to the pandemic, there is the delay associated with various types of limitations faced by the manufacturers to fulfill the end product order, which has resulted in the less availability of neurorehabilitation devices in the market and due to which the cost of available devices has increased with the several factors. Also, due to the coronavirus disease (COVID-19) pandemic outbreak, manufacturers are forced to find new contract manufacturers and suppliers for more manufacturing activities to different or new facilities locations that are less impacted by the outbreak. IMPACT ON SUPPLY CHAIN The consequences of COVID 19 cannot be underestimated. The product and service providers of neurorehabilitation have made efforts by providing services virtually to meet the demands as people were not frequently visiting the hospitals or clinics for the treatment. To manage such a critical situation, many organizations are looking forward to improving and diversifying the supply chain model in all aspects. Diversified supply chain model anticipated minimizing the export of medical devices as well as increase end-to-end visibility The COVID-19 pandemic has transformed many organizations’ business environments; supply availability has been hampered by a number of issues, including export and travel restrictions by some manufacturing countries and lockdowns that have forced suppliers to (temporarily) shut down. In various countries, neurorehabilitation units have reduced their number of beds, in-patients and out-patient neurorehabilitation centers are restricted to a particular area in order to tackle the pandemic situation STRATEGIC DECISIONS BY MANUFACTURERS As the reality of COVID-19 dawned upon the world, the manufactures and production units of the companies in the global neurorehabilitation devices market swiftly planned for strategies to cope with the effect of the crisis. Major players in the market took various initiatives to cope up with the situation. For instance, · In July 2020, Abbott announced that it had received FDA approval for the use of the Patient Controller App on compatible personal Apple smartphone devices. The approval will allow the patient living with neurological conditions to manage their therapy directly from the personal smartphone · In 2019, Mount Sinai Health System announced an innovative tele-neurorehabilitation program for stroke patients. This therapy can be taken by patients while at their homes with virtual backing from clinicians · In 2020, Esko Bionics Holdings, Inc. announced that it had received FDA 501(k) go-ahead to promote its EksoNRTM robotic exoskeleton for patients with acquired brain injury. It is cleared by FDA for spinal cord injury, stroke, or acquired brain injury rehabilitation These strategies helped the company in coping with the pandemic and ensure business operations, minimize the impact of COVID-19, and providing full support to the government in their efforts to combat the disease and help the front-line workers. CONCLUSION It can be concluded that the COVID-19 pandemic situation has an adverse impact on the market, affecting the price, supply, and demand of neurorehabilitation devices. However, in the crisis call, market players, government bodies, and healthcare organizations are work closely with healthcare professionals, customers, and patients for the betterment of public health. The increasing need of neurorehabilitation devices with increasing number of neurological diseases is expected to drive the market in coming years. The market is expected to decline due to increased restrictions imposed by various governments leading to the closing of non-emergent healthcare facilities, including procedures such as neurorehabilitation procedures.
High Healthcare Expenditure To Drive The Growth Of The Operating Room Management Market
The pandemic has led to a temporary ban on elective surgeries across the globe, which resulted in cancellations of elective surgeries worldwide. According to a report published by researchers of CovidSurg Collaborative, around 28 million surgeries were canceled across the globe during 12 weeks of peak disruption during the COVID-19 pandemic.   To handle the increased surgical volumes, hospitals are increasing OR hours and focusing on better utilization of OR. The COVID-19 will positively impact the ORM software market. It will increase the adoption rate of ORM software as most hospitals will now focus on increasing capacity by using technology to improve efficiency.  The overall cost of healthcare delivery has grown significantly over the last few decades, mainly due to increasing health insurance premiums, the rising demand for quality healthcare services, the rising geriatric population, and the increasing incidence of chronic disorders.  Another important factor attributing to rising healthcare costs is the high dependency on traditional and outdated methods such as paper-based patient records, which leads to an increase in readmission rates, medical errors, and administration costs.  Different governments and healthcare systems worldwide are now focusing on controlling rising healthcare costs by minimizing patient readmissions, medical errors, and administration costs with the effective utilization of various healthcare IT solutions. Operating rooms or ORs account for 40% of the total hospital expenses and constitute ~70% of the total revenue generated.   For More Information Download PDF Brochure @ https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=175407912 The adoption of ORM solutions has been particularly affected by its high installation and maintenance costs. ORM software, when once installed, also requires to be regularly updated as per the user’s requirement and software enhancements, thereby presenting recurring expenditure. Additionally, the maintenance of high-end IT-enabled systems typically costs more than the software itself.  The annual maintenance cost is estimated to be 20-25% of the initial cost of the software licenses. Subsequently, it can be expected that the high costs incurred from the purchase, installation, maintenance, and upgrade of ORM software and solutions may negatively affect their overall adoption among end-users, thus restraining market growth to a certain extent.  Brazil, Russia, India, China, and South Africa (BRICS) are among the fastest-growing economies in the world. According to the World Economic Forum, these emerging economies will account for around one-third of the global healthcare expenditure by 2020. More than half of the world’s population resides in India and China, owing to which these countries are home to a large patient base. The increasing burden of cancer, improvements in healthcare infrastructure, a less-stringent regulatory environment, and growing medical tourism are encouraging players in the operating room management market to increase their presence in emerging countries. Owing to the expansion of the patient population base, the number of hospitals and surgical centers is also expected to increase in emerging countries in the coming years. Also, currently, governments in these countries are undertaking initiatives to expand and modernize their respective healthcare infrastructures.  The number of independent health care providers has been decreasing as most healthcare providers are turning to mergers, acquisitions, and partnerships and are functioning under a health system rather than operating independently. On a 15-year basis, the percentage of hospitals functioning under a health system has increased from approximately 50% to approximately 65%. Today, over 70% of hospitals are operating as part of a health system rather than independently.  Data management communication solutions accounted for the largest share of the operating room management market in 2019 owing to the benefits such as easy sharing of patient status in perioperative care phases, tracking of the schedule compliance, and sharing of the media and information related to cases within different operating rooms or external hospital departments.  The high growth of this segment can primarily be attributed to advantages such as scalable data storage, scalable computing power, machine-learning capabilities, and faster data transfer between organizations of cloud platforms.
How Impacted COVID-19 on Neural Implant in Healthcare Industry ?
Impact of COVID-19 on Neural Implant in Healthcare Industry The COVID-19 pandemic has stood as a complex challenge in front of several healthcare companies and proved to be a global health threat. The first case of the COVID-19 pandemic was found in Wuhan, China. This virus had emerged in December 2019 and has been proven as a global pandemic by WHO in March 2020. Patients with other respiratory disorders such as Chronic Bronchitis, Lung Cancer, and Pneumonia are more susceptible to COVID-19. This pandemic has created a health crisis, and it has adversely affected our economies, healthcare and pharmaceutical sectors, and their core. As the number of COVID-19 (coronavirus) cases continues to rise in the U.S., Russia, France, and Brazil, life-threatening and rare brain diseases are being linked to the infection. This has brought companies in the brain implants market into the picture since their assistance is crucial in the already stressed healthcare facilities. Neural implant technology is highly innovative and is expected to influence the existing treatment modalities of neuropathic disorders and chronic neuropathic pain. The introduction of neural implants has been a significant breakthrough because of their high potential in minimizing the occurrence of adverse events associated with Parkinson's disease, chronic pain, epilepsy, and other neural disorders. Therefore, the adoption of neural implants is likely to increase at a phenomenal rate in the coming years. Healthcare professionals were often redeployed to emergency patterns of working, sometimes outside of their usual scope of practice. Thus, the urgent and routine care for millions of patients with non-COVID illnesses has been interrupted. IMPACT ON DEMAND The COVID-19 pandemic is expected to have a significant impact on the growth of the brain implants market globally, due to the suspension and postponement of most of the elective surgeries and treatment during the pandemic, to reserve the hospital infrastructure and staff in treating COVID-19, infected patients. According to the research article published in medRXiV, 2021, the prevalence of SARS-COV2 viral infection in patients with Parkinson's disease was found to be 11.28% and COVID-19 prevalence in Parkinson's disease patients with deep brain stimulation was found to be 18.18%. Additionally, as per the research study published in Frontiers in Neurology, 2020, the motor and psychiatric symptoms in Parkinson's Disease patients and dystonic patients treated with Deep Brain Stimulation was observed to have worsened during the lockdown restriction measure, and further, this had led to increased stress in the management of neurological disorders. Additionally, according to the research article published in JAMA Neurology, 2020, among 214 patients with COVID-19, neurologic symptoms were seen in 36.4% of patients. Thus, patients suffering from COVID-19 are prone to a high risk of developing neurological disorders during their hospital stays. Thus, owing to the strict lockdown restrictions and measures taken to contain the viral transmission, the chronic stress and burden of neurological disorders had increased, which required the urgent opening of the neurological outpatient services, and thus, the brain implants market is expected to have impacted significantly during the pandemic. The increase in the number of cases of neurological disorders, such as Alzheimer’s, epilepsy, Parkinson’s, depression, and essential tremors, is anticipated to propel the demand for brain implants. Brain implants are likely to reduce the need for drugs that relieve chronic pain and improve body movement in patients suffering from Parkinson’s or any other neurological disease. The growing geriatric population is also prone to order surgical disorders and thus, aging is the major factor that is driving the market growth for brain implants. According to the United Nations, World Population Ageing 2019 report, more than 703 million people were aged 65 years and above in 2019 and are expected to reaching 1.5 billion by 2050. IMPACT ON SUPPLY Due to the pertinacious COVID-19 lockdown in various countries, sanctions have been forced by administrations of different nations. These limitations and boundaries across the nation’s borders prompted a diminishing stockpile because of restricted materials and labor force and the halting of the assembly line. It has been found that certain individuals in their late ’50s are at risk of developing acute necrotizing encephalitis, which is a rare complication of influenza and other viral infections. This has fueled the growth of brain implants to maintain steady supply chains to meet the demand. Acute necrotizing encephalitis has the potential to cause seizures and confusion, and in serious cases, can lead to coma. This has triggered the need for developing strong research databases to address complications of COVID-19. STRATEGIC DECISIONS BY MANUFACTURERS The presence of key players in the region and the increasing number of product approvals is expected to drive the studied market growth. For instance, · In June 2020, US FDA approved Medtronic plc's Percept deep brain stimulation (DBS) for the treatment of Parkinson’s symptoms. The major market players are focusing on technological advancement to acquire maximum market share. For instance, · In January 2021, Abbott Laboratories launched its NeuroSphere my Path, a Digital Health app that was developed to track and report on pain relief in chronic pain patients and general well-being associated with spinal cord stimulation (SCS) or dorsal root ganglion (DRG) therapy. · In March 2021, Abbott Laboratories announced the launch of NeuroSphere Virtual Clinic, which is a remote neuromodulation patient-care technology in the United States. · In March 2020, LivaNova plc received CE Mark approval for its Vagus Nerve Stimulation Therapy (VNS Therapy) System, "Symmetry", for Difficult-to-Treat Depression (DTD). · BrainCom— a collaborative research project that aims to develop a new generation of neuroprosthetic devices is being funded by the European Union under the FET Proactive funding scheme to advance speech neural prostheses. Companies in the brain implants market are increasing the availability of solutions for people suffering from motor diseases and neurological conditions. Such implants are bolstering market growth, as they have the potential to eliminate the need for open brain surgeries. · Dell Technologies— a U.S. multinational computer technology company is gaining strong business grounds in transformative technologies for brain implants by collaborating with think tanks and neuroscientists. In June 2018, Medtronic plc announced that the US Food and Drug Administration approved Deep Brain Stimulation (DBS) Clinician Programmer and Activa(TM) Programming Application. The Activa Programming Application has been uniquely designed with the input of over a hundred clinicians from around the world and is managed on the Samsung Galaxy Tab S2 tablet interface. In February 2016, ALEVA NEUROTHERAPEUTICS SA announced a collaboration with Greatbatch for a next-generation device for Deep Brain Stimulation (DBS). Under the terms of the development agreement, Greatbatch’s design and development team QiG Group, which is expected to be spun off as Nuvectra Corporation, will provide Aleva with access to its unique implantable neurostimulation platform. Companies in the brain implants market are increasing the availability of less invasive solutions since the brain is one of the most delicate and sensitive body organs. They are decoding the symphony of neural activity to stimulate brain function. CONCLUSION Since the COVID-19 virus outbreak in December 2019, the disease has spread to almost every country around the globe with the World Health Organization declaring it a public health emergency. The global impacts of the coronavirus disease 2019 (COVID-19) are already starting to be felt, and will significantly affect the Brain Implants market in 2020.
Khám phá vẻ đẹp Tam Cốc - Bích Động Ninh Bình
Khu du lịch Tam Cốc – Bích Động là một trong khu du lịch rất nổi tiếng nằm trong quần thể di sản thế giới Tràng An. đây là 2 địa điểm du lịch khác nhau Tam Cốc được ví von là “Vịnh Hạ Long trên cạn” bởi vẻ đẹp của những dãy núi đá vôi hàng triệu năm. Đã hình thành nên 3 hang động bên dưới những dãy núi này và được nối liền nhau bởi dòng sông Ngô Đồng. Đây chính là điểm nổi bật nhất làm cho Tam Cốc trở nên khác biệt so với các danh lam thắng cảnh khác ở Ninh Bình Bích Động được biết đến là “Nam Thiên Đệ Nhị Động” (Hang động đẹp thứ nhì ở Việt Nam). Và nổi bật nhất tại đây chính là ngôi chùa Bích Động với 3 ngôi chùa độc đáo được xây dựng lại vào năm 1705. Và một hang động ướt đang ẩn mình bên dưới ngọn núi này. Cùng với Hang Múa và Trang An, đã tạo thành 3 khu du lịch ở Ninh Bình có phong cảnh đẹp nhất. Mà hầu hết mọi du khách đến đây đều không thể bỏ lỡ Ngoại trừ những ngày vào mùa mưa, thì hầu hết đi du lịch Tam Cốc và Bích Động ở Ninh Bình vào thời điểm nào cũng đẹp hết. Nhưng sẽ có một thời điểm mà nơi này trở nên đẹp nhất, bạn có biết là vào tháng nào không? Chính là khoảnh khắc giữa tháng 5 dương lịch, không chỉ có khí hậu và thời tiết ôn hòa. Mà cảnh quan của Tam Cốc Bích Động cũng trở nên đẹp hơn bởi những cánh đồng lúa chín vàng óng và những cánh sen hồng bắt đầu nở rộ. Khiến trải nghiệm của bạn trở nên thú vị hơn đó nha Nguồn: https://khamphavn.vn/
Places to Explore in Allahabad
Allahabad's influence on Indian religion, spiritualism, history, and politics cannot be overstated. To this day, both the holy Sangam and the Kumbh Mela are held here, according to Hinduism. Lord Brahma, the universe's creator, appointed it as the "lord of all pilgrimage locations." Akbar, one of India's most regal and powerful emperors, was given the name Ilahabad (Garden of Allah). Allahabad is a sparkling, multi-faceted jewel of Indian culture, full of old tombs, delightful people, fantastic restaurants, and exquisite parks, among other things. You can hire a taxi service in Allahabad for local transport or a ride outside of the city that is available 24 hours a day. Continue reading for a list of must-do activities and sights in this wonderful city. Triveni Sangam Triveni Sangam is a magnificent location that marks the confluence of three rivers: the Ganga, the Yamuna, and the mythical Saraswati. Each river is revered in Hinduism. The three rivers, on the other hand, preserve their individual identities, which may be distinguished by their distinctive hues and qualities: 1- The water of the Ganges is crystal pure. 2- The colour of the Yamuna is bluish-green. 3- Underwater, the Saraswati is said to have a strong presence. A dip in the Triveni is supposed to wash one of all sins, and it is the holiest site in Allahabad's spiritual city. Tourists visiting Sangam can rent boats and travel out to the holy water to immerse themselves. Every twelve years, it hosts the Kumbh Mela (the world's largest Hindu pilgrimage) and the Ardh Mela (which occurs every six years). Allahabad Anand Bhawan In the city's heart sits Anand Bhavan, the ancestral house of India's first Prime Minister, Jawaharlal Nehru. Indira Gandhi, the 'Iron Lady of India' and India's first female Prime Minister, lived in the Bhawan. Anand Bhavan has been transformed into an amazing museum where tourists may learn about the Nehru family, who was instrumental in India's independence and provided the country with three prime ministers. Guests can browse the museum's study's vast bookcases, which are brimming with volumes connected to Marx and Lenin, as well as look at memorabilia from the Nehru family. Another unusual feature is a special chamber dedicated to Mahatma Gandhi, where he used to stay on his trips to Allahabad. Allahabad Fort This ancient fort was established by the great monarch Ashoka, but it was restored by the Mughal Emperor Akbar in 1583, and it became one of the Mughal Empire's most prized citadels. The defence is presently administered by the Indian Army, however one portion is open to the public as a popular tourist destination. This fort is made up of three magnificent galleries surrounded by tall towers. Saraswati Koop (said to be the source of the holy river Saraswati) is one of the fort's most prominent attractions; other notable attractions include the Patalpuri Temple and Akshaya Vat, a fig tree revered sacred in Hindu mythology and thought to be everlasting. The Ashoka Pillar, constructed during the Mauryan Empire in 232 B.C., is a must-see for architecture enthusiasts. Khusro Bagh One of Allahabad's most well-known tourist attractions is the exquisite Khusro Bagh, which is located near the city's train station. The grave of Prince Khusro, one of Emperor Jahangir's sons, is located in this park, which is historically noteworthy. Aside from the martyred prince's grave, the walled garden also houses the tombs of Khusrau's mother, Shah Begum (died 1604), a Rajput princess and Jahangir's first wife, and Khusrau's sister, Princess Sultan Nithar Begam (died c.1624). With complex stone carvings and motifs, the tombs are excellent specimens of Mughal art and architecture. All Saints Cathedral Allahabad's All Saints Cathedral, popularly known as 'Patthar Girija,' is a revered sacred site and one of the city's most important cathedrals. One of imperial India's most revered structures is the massive church construction, which spans around 1250 square metres. The magnificent craftsmanship and embellishments on the marble altar distinguish the entire cathedral, which was built in the Gothic style in the 19th century. With a few mouse clicks on the Internet, you can simply book a cab service in Allahabad for a local city tour or anywhere close. Alfred Park / Chandra Shekhar Azad Park The largest park in Allahabad is Alfred Park. In the park's centre, a large George V and Victoria statue commemorate the park's historical role as a site for formal ceremonies during British control. During the Indian Freedom Struggle, Alfred Park became immensely important: one of India's most prominent revolutionaries, Chandra Shekhar Azad, was encircled while attempting to flee here, and a notable encounter between British police and Indian revolutionaries occurred here. Azad chose to shoot himself rather than give up his cause after an hour-long gunfight. The park was renamed Chandra Shekhar Azad Park after independence, and an honorary bust statue of Azad now stands where he died. Admission costs should be considered. Ashoka's Pillar One of the city's most renowned attractions is this pillar, which is located just outside the Allahabad fort and was built by Akbar in the 16th century at the confluence of the rivers Ganges and Yamuna. However, a detailed analysis of the pillar reveals an Ashokan inscription dating from 232 BC written in Brahmi. Inscriptions on this pillar were later attributed to Samudragupta, the Gupta Empire's second emperor. His description is written in Gupta script, which dates from around 375 CE and is a later version of Brahmi writing. Booking cabs in India has never been easier thanks to Bharat Taxi, which offers inexpensive rates for both local and outstation excursions around the country.
Antique glass candy containers
Glass candy containers were originally designed as treasure-filled toys or souvenirs; they still attract collectors nearly a century after they were introduced. When asked Jim Olean how he started his collection of glass candy containers, he said in the fall of 1985, I went out into the woods near my house in search of wild mushrooms. Despite my search for mushrooms, I found an old dump. There was a small glass candlestick telephone, a dog, and a Santa without ahead. These items were taken home, washed, and placed on a shelf in our game room. My uncle, who collects many old things, came over to visit me one day. He saw the glass items I showed him. I was told they were made about 30 minutes away, that they held candy, and that they were made of glass. It was a novelty that a toy and candy were all in one!" Since they were found in the dump, all the parts that came with them were gone. If I went to the local antique flea market, then I could find an all-original one, according to my uncle. The next spring, when the flea markets opened, I went to the best one in town. In the same dump, I also discovered a candlestick telephone. But this one was 100% original like the day it was made, some thirty years ago! My $15 purchase went on the shelf with the one I bought from the dump. Even the candy was still intact on the telephone, which was a far cry from the one from the dump. Due to this, I purchased as many as were available. Having made that purchase, I did not realize how far it would go! History of glass candy containers Where and when this industry began is somewhat dubious. There is some proof that glass toy sweets holders were delivered as right on time as the last part of the 1860s. The initially archived model was the 1876 Liberty Bell, delivered by Croft, a confectioner from Philadelphia, PA. Croft created candy on the grounds of the 1876 Philadelphia Centennial Fair and sold them in a glass gift Liberty Bell. Many more likely than not been sold, as this 145-year-old holder isn't uncommon and can be found for under $100 today. The focal point of the glass toy sweets holder industry was Jeannette, PA, a humble community outside of Pittsburgh, PA. It became home to many glass organizations as a result of the spotless consuming petroleum gas that was found there in the last part of the 1880s. The sweets holder industry didn't take off until George West, President of Westmoreland Glass, got included. In 1906, his organization began to patent glass toy sweets compartments for creation. These early Westmoreland holders were straightforward in plan and had a metal conclusion. Plans included trunks, bags, tickers, and horns made in milk glass. They were finished with paint and sold as keepsakes, denoting a year or spot. How many different glass candy container designs were produced over time? For around 100 years, about 550 distinctive glass treats compartments were delivered by no less than 13 organizations including vintage glass candy containers. A few compartments are extremely normal, while others are astoundingly uncommon, with just a couple of known models. I've been gathering these for a very long time and have most, yet not all, of them. No gatherer, past or present, has had the option to secure each model. It's simply excessively hard. In the broadest sense, current costs can go from USD 5 to $5,000, with the state of the compartment fundamentally impacting its worth. Costs expanded throughout the long term and topped around 2006. With the approach of web purchasing and selling, and eBay specifically, costs descended. Media Source: AuctionDaily
Fioricet Medication - Should Know About
Fioricet is a pain killer and it consists of acetaminophen, caffeine, and Butalbital. These components contribute to relaxing muscles, improving blood pressure, and relieving pain and high body temperature. This drug usually helps people calm moderate to severe medical conditions like tension headaches, fever, muscle contractions, etc. Uses of Fioricet Take Fioricet only by the advice of a physician. Make sure you have a prescription that is required to buy Fioricet 40mg online overnight or offline. Always follow the directions on the label and make it a habit while consuming any kind of medicinal formula. Take a note of your dosage as prescribed by your doctor. The overdose side effects might occur due to carelessness in the consumption of Fioricet. Keep your doctor posted about the changes in your body related to the reaction towards the medication. Do not share your medicine with anyone, especially someone with a drug abuse history. This medication isn’t supposed to be taken without the advice and the prescription of a doctor. Though you can buy Fioricet online. Keep it in a safe place and make sure to keep a track of the contents. Selling or giving out Fioricet without a prescription is illegal in many parts of the world. In case the drug upsets your stomach, ingest it with light food. Store it in a dry, well-lit area at room temperature. In case of a missed dose, do not consume double doses to make it up for a missed dose.   Precautions for Consumption Since this medication can make you feel drowsy, you can avoid doing things that require alertness. Try resting for a couple of hours and then doing whatever you feel like. Avoid alcohol as it can magnify the effects of the medication and it can also severely harm your liver. Certain medical combinations can react together and cause harm to the patient’s body so it is advisable to monitor if you are taking any other medication for cold or pain etc.  Inform your doctor and educate yourself on it. Avoid taking medications with APAP in them. Avoid caffeine pills, or ADHD-related medications, etc. while consuming Fioricet. Exercise caution if you suffer from hepatitis, porphyria, cardiovascular diseases, or anaemia. Though very rare, there are chances of severe skin allergies in patients due to Acetaminophen. Make sure your doctors are always updated with your medical condition and your response to certain medications. This way it will be easier to predict any upcoming progress in your condition. If there is a special risk patient like a senior citizen or a pregnant woman, caution should be taken if Fioricet is prescribed to them. Because the effects can be different in senior citizens and can be transferred to the unborn child in the case of pregnant women. Breastfeeding women also need to take care of this as the contents of the medication can be transferred to the child. Side Effects Even though Fioricet is quite a safe medication and has proven to be life-changing many times in medical history. But being a medication, it is bound to have some chemical side effects. A doctor always prescribes a medication keeping at par the risks of side effects.  Some of the side effects of Fioricet are- swelling in body parts, hives, unusual colored urine, rashes, vomiting, palpitations, drowsiness, nausea, etc. in case, there is any serious condition, you should immediately contact a doctor. Contact your doctor right away if, you observe any of the symptoms for instance- mood swings, palpitations, seizures, etc. even though serious allergic reactions are rare with the consumption of Fioricet, but in any case, if you observe rashes, swollen body parts, drowsiness, itching, etc. after the ingestion of the medication rush for medical help do not try to treat such situations on your own. Every drug has different reactions in different bodies, so if you feel uncanny and uncomfortable, see a doctor. Conclusion Patients can easily buy Fioricet online overnight fast shipping in USA,and make the best use of it, only when properly monitored and handled. Fioricet has changed lives, but only when properly utilized. So, make sure you know well about the medication before consuming it and make sure your health is in safe hands with Fioricet. ORIGINAL SOURCE: What All Should One Know About- Fioricet
Types Of Painting
Painting might seem an easy task to do with its definition being so simple, but there's poetry in every stroke of color and a story behind each picture that an artist or painter wants to portray. Painting has been a method of displaying art for a long period and there have been different techniques to do so. There are a variety of painting procedures and each of them is beautiful and unique on its own. A beginner needs great dedication and patience to pursue the journey of being an artist and to learn any painting technique completely. We have previously covered some of the painting techniques in our first blog about the same. Here we present other styles of painting that are currently popular that one can try and get along with. Watercolor Painting Watercolor painting is as common as oil and acrylic painting. This is a well-known technique in which the colors are mixed with water to create the art. The paper sheets are used to create watercolor art most of the time. Watercolors, on the other hand, can be used to create art on bark paper, soap sheets, wooden blocks, and papyrus. Even finger paintings with watercolors are done in many parts of the world, such as China. Pencil Sketches I am one of those people who are fond of watching pencil sketches. The depth and details can just blow away your mind. It takes effort to understand the tones and grades for each piece and part of the art. These are made from graphite materials. Pencils are most often used because of their simplicity and versatility. Graphite can be smudged like kohl and thus can enhance the beauty of anything depicted on paper; it simply brings your thoughts to life. Glass Paintings Ever visited monuments and wondered about the beauty of glass paintings? The Greek and Roman cultures have portrayed some delightful art through glass paintings. The multicolor display of images and thoughts is amazing and gets even more personified when the light passes through the medium. It simply illuminates the locations. You can find them at old monuments and churches as well. They are inspired by the concept of stained glass painting. Collage Painting It is a very beautiful form of art. It is formed by assembling various creative pieces to form a visual effect of an image. A collage can be made from a variety of materials, including paper scraps, ribbons, magazines, newspapers, paint colors, and so on. is the accumulation of different pieces of art brought together to represent a single entity. It can have various themes and requires less budget yet comes out as an astonishing piece of art. Spray Painting. These are made out of aerosol painting sprays and are specially used on walls. They are magnificent; the colored area is kept open, while the other area is closed to keep the color from spreading all around them. These are the other painting techniques that exist and are trending today. Visit sites like Shopify to buy your painting essentials.
Best Places to Visit in Lucknow for Day Trip
Lucknow is the capital of Uttar Pradesh, and it houses a diverse range of attractions. Any enthusiastic traveller can experience a tryst with history, culture, shopping, fun, spirituality, food, leisure, and more in the City of Nawabs. There are many locations to visit once you have checked into one of the best hotels in Lucknow, from centuries-old British and Mughal edifices to fun-filled amusement parks, gardens, street bazaars, museums, and temples. Lucknow, Uttar Pradesh's capital, is several things bundled into one. Any enthusiastic traveller can experience a tryst with history, culture, shopping, fun, spirituality, food, leisure, and more in the City of Nawabs. There are many locations to visit by taxi service in Lucknow. From centuries-old British and Mughal edifices to fun-filled amusement parks, gardens, street bazaars, museums, and temples. In Lucknow, there are a variety of places to visit. Ambedkar Park Ambedkar Park is a 107-acre public park and memorial in Gomti Nagar that celebrates Dr. Ambedkar, Jyotirao Phule, Kanshi Ram, Narayana Guru, and many other social reformers who fought for equality and social justice. The park's main characteristic is that it is entirely made of red sandstone imported from Rajasthan. The Ambedkar Stupa, Pratibimb Sthal with 62 elephant statues, the museum, and the Dr. Bhimrao Ambedkar Samajik Parivartan Gallery are among the main attractions here. Bara Imambara Bara Imambara aka Asafi Imambara is a historical landmark that goes back to 1784 and is considered one of Lucknow's most important historical sites. The complex was built by Asaf-ud-Daula, one of Awadh's most illustrious Nawabs, and includes a magnificent mosque (Asfi Mosque), a labyrinth (the Bhul Bhulaiya), and a stepwell with running water (Shahi Baoli). The edifice has two massive entrances that lead to the centre hall, which is said to be the world's largest vaulted room. Chota Imambara Muhammad Ali Shah, the third Nawab of Awadh, built the grand historical edifice of Chota Imambara in 1838. It was originally established as an assembly hall for Shia community devotees and is now known as Imambara Hussainabad Mubarak. However, the site later became the mausoleum for both the Nawab and his mother. The structure's interiors are ornately decorated with chandeliers and crystal lamps imported from Belgium, earning it the nickname 'the Palace of Lights.' The exteriors include exquisite Islamic calligraphy, which adds to the visual attractiveness. Rumi Darwaza Make your way to the Rumi Darwaza, an imposing gateway positioned between Bara Imambara and Chota Imambara, to see the grandeur of the Awadhi style of architecture. This 60-foot-tall gateway, erected in 1784 by Nawab Asaf-ud-Daula, is commonly used as the Lucknow city logo. The gate is sometimes referred to as the Turkish Gate because it is modelled after Istanbul's Sublime Porte. Husainabad Clock Tower Husainabad Clock Tower, near to the Rumi Darwaza, is another cultural relic dotting Lucknow's cityscape. The Hussainabad Trust built this 221-foot structure in 1881 at a cost of 1.75 lakhs, and it is styled after London's Big Ben Clock Tower. The clock is shaped like a flower, with 12 petals and a 14-foot-long pendulum. It is known as the country's tallest clock tower and features Gothic and Victorian architectural elements. Dilkusha Kothi Dilkusha Kothi is the ruins of a house erected in the early nineteenth century on the banks of the River Gomti. The structure was previously the Nawabs' hunting lodge and summer resort, and it was built in the English baroque style of architecture. The exterior walls, a few towers, and a lovely garden are all that remains of the structure today. Dilkusha Kothi, on the other hand, has earned a spot on the list of Lucknow tourist attractions due to its historical relevance and architectural splendour. Aminabad Market The Aminabad Market, which has been in existence since the time of the Nawabs, is one of the best places to shop in Lucknow. Embroidered chikan clothing, jewellery, and footwear, as well as rugs, bed linens, and local handicrafts, are all available. Also, don't forget to haggle for the best prices. After you've finished shopping, head to one of the area's top eateries, such as Wahid Biryani, Kalika Chat House, or Tunday Kababi, to refuel your motor with some delightful fare. Hazratganj Market The Hazratganj Market, a century-old shopping district in Lucknow's core, is where the city's pulsating soul can be found. The area is a shopper's paradise, with various showrooms, factory outlets, restaurants, retail complexes, malls, and theatres. The Ganj Carnival, which takes place on the second Sunday of every month, is a big draw. Don't forget to satisfy your hunger at the Royal Café, J.J Bakers, the Cherry Tree Café, or any of the other eateries in the vicinity while you're here. Book a cab service in Lucknow to explore in and around the city. Indira Gandhi Planetarium If you are a science buff or travelling with children, a visit to the Indira Gandhi Planetarium should be on your list of things to do in Lucknow. The planetarium is built to look like the planet Saturn, which distinguishes it from all other planetariums in the country. It's a terrific spot to spend a day studying about celestial bodies, thanks to its high-tech projection system and daily screenings that reveal the wonders of the universe. Nawab Wahid Ali Shah Zoological Garden Lucknow Zoo, also known as Nawab Wahid Ali Shah Zoological Garden, is one of the top locations to visit in Lucknow for nature enthusiasts and family vacationers. The park, which covers 71 acres and is home to over 440 animals, 340 bird species, many reptile species, and many other natural wonders, was founded in 1921. Enjoy miniature train rides and paddle boating while you're here, as well as the zoo's British-era antique train and the butterfly park and natural interpretation centre. The children's park is also a terrific place for your small ones to enjoy fun. State Museum Another important destination to add in your Lucknow itinerary is the state museum, which is housed within the Lucknow Zoo. Artifacts relating to Awadhi arts and culture, as well as antiquities excavated in and around the city, are among the main exhibitions. An Egyptian mummy and a wooden sarcophagus are also housed in this four-story structure. Ram Manohar Lohiya Park Dr. Ram Manohar Lohiya Park, a public park constructed by the Lucknow Development Authority, is one of Lucknow's top ten attractions. It was created in remembrance of the famous independence warrior and socialist political leader Dr. Ram Manohar Lohiya, as the name denotes. The park, which spans 76 acres and includes jogging tracks, acupressure tracks, a lake, a fish and duck pond, swings and chairs, an amphitheatre, a flower garden, and an outdoor workout area, is located in Gomti Nagar. The park is a great place to spend a calm evening wandering among the flowers or working up a sweat on the jogging paths. Janeshwar Mishra Park Janeshwar Mishra Park is an urban park in Gomti Nagar named to the late politician Janeshwar Mishra. It is modelled after London's Hyde Park and is one of the country's most environmentally friendly parks. Within the park, there are two huge water bodies that attract a great number of migrating birds throughout the year. The park acts as a green lung in the city, featuring jogging and cycling trails, walkways, children's play areas, gondola rides, and lush green landscapes. Book an affordable taxi service for your trip to India where you will get the cabs for local, outstation and one way.
How COVID-19 Impacted on Nivolumab in Healthcare Industry ?
Impact of COVID-19 on Nivolumab in Healthcare Industry COVID-19 (Coronavirus) has affected the day-to-day life of people and has slowed down the economies worldwide. The pandemic has affected millions of people who either got sick or died due to the spread of this disease. Within a few months, coronavirus disease (COVID-19), which originated from China, became a pandemic, with more than 30 million people being infected till date. There are now numerous vaccines in use. The first mass vaccination program commenced in early December 2020, and as of 15 February 2021, 175.3 million vaccine doses have been administered. There is an added complexity because of COVID-19 diagnosis in cancer patients, particularly while on active treatment with immunotherapy like nivolumab. COVID-19 could cause more harm to cancer patients. In order to prevent the infection from spreading, the patient’s number and new diagnosis have been less during the COVID 19. The COVID-19 pandemic has led to a dramatic loss of human life worldwide and presents an unprecedented challenge to public health, food systems, and the world of work. Still, there is an increase in the demand for cancer treatment with immunotherapy drugs like nivolumab during the second quarter of 2020 with the rise in awareness regarding health and new product launches in countries. STRATEGIC DECISIONS BY MANUFACTURERS To deal with the COVID-19 outbreak challenges and increasing demand for the drugs, many market players are creating new strategies such as new product development, telemedicine, and a different program to support patients and to raise their sales. It is predicted that these strategies are anticipated to escalate up the company revenue and its growth in the forecasted period. The government has provided drug FDA approvals of nivolumab for the treatment of cancer. For instance, · In May 2020, Bristol Myers Company announced that Opdivo (nivolumab) 3 mg/kg plus Yervoy (ipilimumab) 1 mg/kg (injections for intravenous use) was approved by the U.S. Food and Drug Administration (FDA) for the first-line treatment of adult patients with metastatic non-small cell lung cancer (NSCLC). · There are several ongoing potentially registrational studies that have been conducted by different manufacturing companies for Opdivo for the treatment of different tumor types and disease areas, in combination with various anti-cancer agents · Also, there are various ongoing clinical trials conducting on nivolumab with the combination of various anti-cancer agents and others to treat various types of cancer to decrease the demand for cancer treatment and to provide patients with more advanced drugs. For instance · In Japan, South Korea, and Taiwan, ONO pharmaceuticals are co-developing this drug nivolumab with the Bristol Myers Company IMPACT ON DEMAND Global economic development in 2020 has been severely impacted by the COVID-19 pandemic. The COVID-19 has given rise to risks such as a prolonged, significant decline in global demand as well as unfavorable geopolitical and macroeconomic effects. The coronavirus pandemic has provoked many strategical actions among healthcare providers on how to manage cancer patients when faced with the threat of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection. There has been a decrease in demand for nivolumab in some countries like the U.S., whereas many countries have seen an increase in sales with the rise in demand for the treatment and new cancer patients. With the rise in demand for the drug, FDA has provided approval to various drugs related to the immunotherapy nivolumab. For instance- · For the Bristol-Myers Squibb Company, the U.S. revenues of nivolumab decreased to 9% in 2020 due to lower demand caused by declining second-line eligibility across tumor indications and lower demand from COVID-19 (primarily lower new patient starts and patient visits). The U.S. has seen a decrease in sales in the first quarter of 2020. · However, the international revenues for nivolumab were increased up to 7% in 2020 due to higher demand as a result of additional indication launches in some countries with rising cancer patients globally. · In May 2021 -- Bristol-Myers Squibb Company has today announced that the U.S. Food and Drug Administration (FDA) had approved their Opdivo (nivolumab, injection for intravenous use) for the adjuvant treatment of completely resected esophageal or gastroesophageal junction (GEJ) cancer. · Similarly, FDA has approved Opdivo (nivolumab) for treating different types of cancer in many countries via various market players due to the rise in demand for this drug. IMPACT ON PRICE COVID-19 is significantly decreasing commercial activity in every area of the business sector. The economy has been decreased during the pandemic with the restricted and disrupted supply and sales of products and devices. The cost of medication and treatment of nivolumab has been increased due to the increasing demand for this drug during COVID-19. This contributed to the increased expenses and prices of immunotherapy drugs. Changes in the economy and other factors have caused consequences, including the decrease in the sales of the drug in some countries such as the U.S. With the rise of COVID-19 and decrease in new patients has also contributed to the increased cost and priced of some products and medication. · The price of Opdivo (nivolumab) drug which is a most common therapy treatment for various type of cancer or tumor have been increased to USD 1,172 for a supply of 4 milliliters of injection in 2020 with the rise in demand and increasing patients population in the second quarter of 2020. IMPACT ON SUPPLY CHAIN The COVID-19 pandemic has transformed many organizations’ business environments; supply availability has been hampered by a number of issues, including export and travel restrictions by some producing countries, and the lockdown has forced suppliers to (temporarily) shut down. The supply of nivolumab medication has a slight decrease in sales during the first quarter of 2020, partly due to negative factors mentioned above in connection with the COVID-19 pandemic, which particularly didn’t affect the overall yearly revenue. The pandemic and COVID-19 have affected every business activity in which the supply chain was affected the most. Because of the pertinacious COVID-19 lockdown, sanctions have been forced by administrations of different nations. These limitations and boundaries across the nation’s borders prompted a diminishing stockpile because of restricted materials and labor force and the halting of the assembly line. The supply chain and demand were positively affected by the COVID 19. The sales and supply of the drugs have been increased with the rise in demand for the drugs and diagnosis. Many major manufacturing companies have launched their drugs in different countries to fulfill the demand, and the government has provided approval for the sales of the drug nivolumab. For instance- Despite the pandemic, many market player of nivolumab has increased their sales globally. This is due to the ongoing increase in the patient population and rising awareness regarding their health. · The sales of ONO pharmaceuticals have been increased in the year 2020 as compared to 2019, which is 2656.05 USD Million in 2019 and 2809.23 USD million. · Similarly, sales of the drug Opdivo (Nivolumab) from the manufacturing company Bristol Myers Squibb Company have been increased globally (except the U.S.) from USD 2,860 million in 2019 to USD 3,047 million in 2020. This increase in sales in both of the major market players is due to the increase in cancer patients and the use of drugs in all areas of cancer. There is an increase in the sales of this nivolumab with the rise in prevalence of disease and early diagnosis & treatment. CONCLUSION As the pandemic of COVID-19 resulted in several restrictions throughout the borders, still, manufacturers and market players were able to manage their sales and revenue of oncology and drug nivolumab. Various manufacturers allowed their workers to work in a clean and safe environment so as to boost up the production at various manufacturing facilities across several regions of the world, thus, helping them to maintain a continuous supply chain with the increasing demand. Market players have come up with better strategies which have also created a positive impact on the growth of the nivolumab market globally.
Bát đĩa Bát Tràng là sự lựa chọn thông minh của những người tiêu dùng thông thái
Bữa cơm là khoảng thời gian quý báu để các thành viên trong gia đình cùng nhau sum họp. Vì điều này mà bộ đồ ăn chất lượng sẽ đóng một vai trò vô cùng quan trọng. Sản phẩm không chỉ tác động tới sức khỏe của gia đình mà còn giúp tạo thêm màu sắc cho món ăn, khiến chúng trở nên ngon hơn về mặt thị giác. Bát đĩa Bát Tràng là sự lựa chọn thông minh của những người tiêu dùng thông thái. Không chỉ vậy, đây còn là một món quà biếu, quà tặng người thân ý nghĩa trong các dịp đặc biệt. Ưu điểm nổi bật của bát đĩa Bát Tràng là: - Xương gốm sứ cao cấp, không chứa chất độc hại, an toàn với sức khỏe người dùng. - Được nung ở nhiệt độ cao trên 1200 độ C, đảm bảo chịu va đập tốt, bền màu theo thời gian. - Được phủ một lớp men bóng, giảm thiểu khả năng bám bụi, dễ lau chùi, vệ sinh. - Hoa văn vẽ tay tinh tế, sắc nét. - Mẫu mã, kích thước đa dạng, phong phú - Giá thành phải chăng. Chi tiết về sản phẩm: https://battrang24h.com/san-pham/bat-dia-su-bat-trang Bát đĩa Bát Tràng được chế tác từ những bàn tay nghệ nhân “lão làng”. Sản phẩm được làm thủ công 100% nên mọi đường nét, mỗi công đoạn đều mang cả tâm huyết và tâm tình của người làm gốm vào trong từng sản phẩm. Với mong muốn phục vụ mọi đối tượng, bát đĩa Bát Tràng có chi phí rất cạnh tranh, phù hợp với giá thành chung trên thị trường và phù hợp với điều kiện kinh tế của mọi người. Gốm Sứ Battrang24h là địa chỉ cung cấp những bộ đồ ăn Bát Tràng cao cấp, cam kết chất lượng hàng đầu với khả năng chống trầy xước, chịu va đập, khó bể, mẻ trong suốt quá trình sử dụng. Sản phẩm của chúng tôi luôn được đánh giá cao về thiết kế, toát lên vẻ sang trọng, góp phần cho bữa ăn gia đình thêm ấm áp.