Rose (Radha Mitchell) cannot accept the knowledge that her daughter Sharon is dying of a fatal disease. Over the protests of her husband, she flees with her child, intending to take the girl tp a faith healer. On the way, she ends up driving through a portal in reality, which takes her to eerie and deserted town of Silent Hill. Sharon disappears in Silent Hill and Rose follows what she thinks is her daughter's silhouette all over town. It's soon clear the town is not like any place she's ever been before.