When an erection happens, blood flows into the penis and this is what causes it to become firm. Erectile dysfunction, or ED, happens when there is a problem with blood flow. Various conditions including hypertension, high cholesterol, diabetes and anxiety can cause a disruption in blood flow. Lifestyle choices like physical inactivity, smoking and unhealthy eating habits can also cause ED. An effective PDE5 inhibitor like sildenafil can, however, act against this and restore erectile function.
How does sildenafil work in the body?
This medication basically works by blocking a natural chemical known as PDE5. This chemical is found in high concentrations in the smooth muscle tissue that lines blood vessels of the penis. PDE5 decreases levels of a molecule called cGMP and, as a result, reduces the body’s ability to produce nitric oxide. Nitric oxide promotes blood vessel dilation and enhanced blood flow. By decreasing levels of PDE5, sildenafil enhances nitric oxide levels and strengthens erections.
What is the efficacy rate?
Clinical studies have shown that approximately 82 percent of men achieve positive erection results. The strongest effects can be felt within the first four to six hours. How does sildenafil work once it takes it effect is a frequently asked question. A common misconception is that an erection may be present for the entire duration of action. In reality, this medication simply allows the user to achieve a satisfactory erection if sexual stimulation takes place.
When will generic Viagra be available?